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Q6MHW4

- KITH_BDEBA

UniProt

Q6MHW4 - KITH_BDEBA

Protein

Thymidine kinase

Gene

tdk

Organism
Bdellovibrio bacteriovorus (strain ATCC 15356 / DSM 50701 / NCIB 9529 / HD100)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 63 (01 Oct 2014)
      Sequence version 1 (05 Jul 2004)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + thymidine = ADP + thymidine 5'-phosphate.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei92 – 921Proton acceptorUniRule annotation
    Metal bindingi148 – 1481ZincUniRule annotation
    Metal bindingi151 – 1511ZincUniRule annotation
    Metal bindingi180 – 1801ZincUniRule annotation
    Metal bindingi183 – 1831ZincUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi18 – 258ATPUniRule annotation
    Nucleotide bindingi91 – 944ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. thymidine kinase activity Source: UniProtKB-HAMAP
    3. zinc ion binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. DNA replication Source: UniProtKB-KW

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Biological processi

    DNA synthesis

    Keywords - Ligandi

    ATP-binding, Metal-binding, Nucleotide-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Thymidine kinaseUniRule annotation (EC:2.7.1.21UniRule annotation)
    Gene namesi
    Name:tdkUniRule annotation
    Ordered Locus Names:Bd3420
    OrganismiBdellovibrio bacteriovorus (strain ATCC 15356 / DSM 50701 / NCIB 9529 / HD100)
    Taxonomic identifieri264462 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaBdellovibrionalesBdellovibrionaceaeBdellovibrio
    ProteomesiUP000008080: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 204204Thymidine kinasePRO_0000174965Add
    BLAST

    Interactioni

    Subunit structurei

    Homotetramer.UniRule annotation

    Protein-protein interaction databases

    STRINGi264462.Bd3420.

    Structurei

    3D structure databases

    ProteinModelPortaliQ6MHW4.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the thymidine kinase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1435.
    HOGENOMiHOG000076390.
    KOiK00857.
    OMAiQAICLSC.
    OrthoDBiEOG69D3J2.

    Family and domain databases

    HAMAPiMF_00124. Thymidine_kinase.
    InterProiIPR027417. P-loop_NTPase.
    IPR001267. Thymidine_kinase.
    IPR020633. Thymidine_kinase_CS.
    IPR020634. Thymidine_kinase_subgr.
    [Graphical view]
    PANTHERiPTHR11441. PTHR11441. 1 hit.
    PfamiPF00265. TK. 1 hit.
    [Graphical view]
    PIRSFiPIRSF035805. TK_cell. 1 hit.
    SUPFAMiSSF52540. SSF52540. 1 hit.
    PROSITEiPS00603. TK_CELLULAR_TYPE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q6MHW4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSEFSYVHTR GWVEVVVGSM FSGKTEELIR RLRRAEFARL QIQVFKPIID    50
    KRYNEMAVTS HDLTTIDSTP IHDAEEIWNL LKPNTKVVGI DEGQFFGQNL 100
    VQIAQDLADR GLRVIIAGLD TDWQGKPFEP MPTLMAVAES VTKQHAVCVV 150
    CGAPASRTQR TAGGDGQVLV GTHDAYEARC RQHFKPEVDA PTLDWKLKRE 200
    MEIS 204
    Length:204
    Mass (Da):22,951
    Last modified:July 5, 2004 - v1
    Checksum:iED2985B1D5181132
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BX842655 Genomic DNA. Translation: CAE78218.1.
    RefSeqiNP_970159.1. NC_005363.1.
    WP_011165756.1. NC_005363.1.

    Genome annotation databases

    EnsemblBacteriaiCAE78218; CAE78218; Bd3420.
    GeneIDi2737077.
    KEGGibba:Bd3420.
    PATRICi21081148. VBIBdeBac73187_3129.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BX842655 Genomic DNA. Translation: CAE78218.1 .
    RefSeqi NP_970159.1. NC_005363.1.
    WP_011165756.1. NC_005363.1.

    3D structure databases

    ProteinModelPortali Q6MHW4.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 264462.Bd3420.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAE78218 ; CAE78218 ; Bd3420 .
    GeneIDi 2737077.
    KEGGi bba:Bd3420.
    PATRICi 21081148. VBIBdeBac73187_3129.

    Phylogenomic databases

    eggNOGi COG1435.
    HOGENOMi HOG000076390.
    KOi K00857.
    OMAi QAICLSC.
    OrthoDBi EOG69D3J2.

    Family and domain databases

    HAMAPi MF_00124. Thymidine_kinase.
    InterProi IPR027417. P-loop_NTPase.
    IPR001267. Thymidine_kinase.
    IPR020633. Thymidine_kinase_CS.
    IPR020634. Thymidine_kinase_subgr.
    [Graphical view ]
    PANTHERi PTHR11441. PTHR11441. 1 hit.
    Pfami PF00265. TK. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF035805. TK_cell. 1 hit.
    SUPFAMi SSF52540. SSF52540. 1 hit.
    PROSITEi PS00603. TK_CELLULAR_TYPE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A predator unmasked: life cycle of Bdellovibrio bacteriovorus from a genomic perspective."
      Rendulic S., Jagtap P., Rosinus A., Eppinger M., Baar C., Lanz C., Keller H., Lambert C., Evans K.J., Goesmann A., Meyer F., Sockett R.E., Schuster S.C.
      Science 303:689-692(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 15356 / DSM 50701 / NCIB 9529 / HD100.

    Entry informationi

    Entry nameiKITH_BDEBA
    AccessioniPrimary (citable) accession number: Q6MHW4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 1, 2005
    Last sequence update: July 5, 2004
    Last modified: October 1, 2014
    This is version 63 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3