Reviewed, UniProtKB/Swiss-Prot Q6MHT3 (HEMH_BDEBA)

Names and origin

Protein names

Recommended name:
    Ferrochelatase
    EC=4.99.1.1
Alternative name(s):
    Protoheme ferro-lyase
    Heme synthetase

Gene names

Name:	hemH
Ordered Locus Names:	Bd3456

Organism

Bdellovibrio bacteriovorus [Complete proteome] [HAMAP]

Taxonomic identifier

959 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Deltaproteobacteria › Bdellovibrionales › Bdellovibrionaceae › Bdellovibrio

Protein attributes

Sequence length	335 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Catalyzes the ferrous insertion into protoporphyrin IX. HAMAP MF_00323
Catalytic activity	Protoheme + 2 H+ = protoporphyrin + Fe2+. HAMAP MF_00323
Pathway	Porphyrin metabolism; protoheme biosynthesis; protoheme from protoporphyrin-IX: step 1/1. HAMAP MF_00323
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the ferrochelatase family.

Ontologies

Keywords
Biological process	Heme biosynthesis Porphyrin biosynthesis
Cellular component	Cytoplasm
Ligand	Iron Metal-binding
Molecular function	Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	heme biosynthetic process Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ferrochelatase activity Inferred from electronic annotation. Source: HAMAP iron ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 335	335	Ferrochelatase HAMAP MF_00323		PRO_0000175115
Sites
	Metal binding	192	1	Iron By similarity
	Metal binding	291	1	Iron By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q6MHT3-1 [UniParc]. Last modified July 5, 2004. Version 1. Checksum: 97F3516A4A05369C	FASTA	335	37,482
	10 20 30 40 50 60 MGKKGLLLIN IGSPKSYQVN DVKKYLSEFL MDEDVITLPY VLRWPLVNLL IVPRRAPFSA 70 80 90 100 110 120 ENYKKVWMKE GSPIAVYTRR FAALLQEELK DQFVVKVGLQ YSEPSVESAL KDLQQAGVDE 130 140 150 160 170 180 ILVAPMFPQY AEATNGSSFK LAERMAKKLH LTAPLRRLPA FFDDASFVGT SVKLVEETLQ 190 200 210 220 230 240 DKEVDHYLFS FHGLPESHVR KIPGCLTTED CCFEKNACAK NCYRAQCFAT ATAIAESLNL 250 260 270 280 290 300 APSHWSVAFQ SRLGRAEWLK PATDHSLEVL AKTGKKNIAV ICPSFVADCI ETLEEIGIGG 310 320 330 QETFHEHGGD QYYLVPCVND NPKWVQGFAD LVKSI

References

[1]

"A predator unmasked: life cycle of Bdellovibrio bacteriovorus from a genomic perspective." Rendulic S., Jagtap P., Rosinus A., Eppinger M., Baar C., Lanz C., Keller H., Lambert C., Evans K.J., Goesmann A., Meyer F., Sockett R.E., Schuster S.C. Science 303:689-692(2004) [PubMed: 14752164] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 15356 / HD100 / DSM 50701 / NCIB 9529.

Cross-references

Sequence databases
EMBLGenBankDDBJ	BX842655 Genomic DNA. Translation: CAE78249.1.
RefSeq	NP_970190.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	2737114.
GenomeReviews	Gene locus Bd3456 in contig BX842601_GR.
KEGG	bba:Bd3456.
NMPDR	fig|264462.1.peg.3163.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q6MHT3.
OMA	FQSRLGR.
Enzyme and pathway databases
BioCyc	BBAC264462:BD3456-MON.
BRENDA	4.99.1.1. 3459.
Family and domain databases
HAMAP	MF_00323. [Tree]
InterPro	IPR001015. Ferrochelatase. IPR019772. Ferrochelatase_AS. [Graphical view]
PANTHER	PTHR11108. Ferrochelatase. 1 hit.
Pfam	PF00762. Ferrochelatase. 1 hit. [Graphical view]
ProDom	PD002792. Ferrochelatase. 2 hits. [Graphical view] [Entries sharing at least one domain]
TIGRFAMs	TIGR00109. hemH. 1 hit.
PROSITE	PS00534. FERROCHELATASE. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

HEMH_BDEBA

Accession

Primary (citable) accession number: Q6MHT3

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 2005
Last sequence update:	July 5, 2004
Last modified:	November 3, 2009
This is version 36 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)