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Protein

Bromodomain-containing protein 2

Gene

Brd2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Binds hyperacetylated chromatin and plays a role in the regulation of transcription, probably by chromatin remodeling. Regulates transcription of the CCND1 gene. Plays a role in nucleosome assembly (By similarity). May play a role in spermatogenesis or folliculogenesis (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionChromatin regulator
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-RNO-8951936 RUNX3 regulates p14-ARF

Names & Taxonomyi

Protein namesi
Recommended name:
Bromodomain-containing protein 2
Alternative name(s):
Protein RING3
Gene namesi
Name:Brd2
Synonyms:Ring3
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 20

Organism-specific databases

RGDi1303324 Brd2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002740061 – 798Bromodomain-containing protein 2Add BLAST798

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1
Modified residuei6PhosphothreonineBy similarity1
Modified residuei36PhosphoserineBy similarity1
Modified residuei297PhosphoserineCombined sources1
Modified residuei300PhosphoserineBy similarity1
Modified residuei304PhosphoserineBy similarity1
Modified residuei631PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiQ6MGA9
PRIDEiQ6MGA9

PTM databases

iPTMnetiQ6MGA9
PhosphoSitePlusiQ6MGA9

Expressioni

Gene expression databases

BgeeiENSRNOG00000000461
ExpressionAtlasiQ6MGA9 baseline and differential
GenevisibleiQ6MGA9 RN

Interactioni

Subunit structurei

Homodimer. Interacts with E2F1 and with histone H4 acetylated at 'Lys-13' (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000056940

Structurei

3D structure databases

ProteinModelPortaliQ6MGA9
SMRiQ6MGA9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini90 – 162Bromo 1PROSITE-ProRule annotationAdd BLAST73
Domaini363 – 435Bromo 2PROSITE-ProRule annotationAdd BLAST73
Domaini630 – 712NETPROSITE-ProRule annotationAdd BLAST83

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi553 – 557Nuclear localization signalSequence analysis5

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi60 – 63Poly-Pro4
Compositional biasi228 – 331Pro-richAdd BLAST104
Compositional biasi478 – 523Glu-richAdd BLAST46
Compositional biasi549 – 557Poly-Lys9
Compositional biasi589 – 592Poly-Gly4
Compositional biasi632 – 636Poly-Glu5
Compositional biasi761 – 797Ser-richAdd BLAST37

Domaini

One bromodomain is sufficient for a partial interaction with histone H4 acetylated at 'Lys-13'.By similarity

Keywords - Domaini

Bromodomain, Repeat

Phylogenomic databases

eggNOGiKOG1474 Eukaryota
COG5076 LUCA
GeneTreeiENSGT00760000119206
HOGENOMiHOG000231200
HOVERGENiHBG004896
InParanoidiQ6MGA9
KOiK08871
OMAiPTGYDSE
OrthoDBiEOG091G01QC
PhylomeDBiQ6MGA9
TreeFamiTF317345

Family and domain databases

Gene3Di1.20.1270.220, 1 hit
1.20.920.10, 2 hits
InterProiView protein in InterPro
IPR001487 Bromodomain
IPR036427 Bromodomain-like_sf
IPR018359 Bromodomain_CS
IPR027353 NET_dom
IPR038336 NET_sf
PfamiView protein in Pfam
PF17035 BET, 1 hit
PF00439 Bromodomain, 2 hits
PRINTSiPR00503 BROMODOMAIN
SMARTiView protein in SMART
SM00297 BROMO, 2 hits
SUPFAMiSSF47370 SSF47370, 2 hits
PROSITEiView protein in PROSITE
PS00633 BROMODOMAIN_1, 2 hits
PS50014 BROMODOMAIN_2, 2 hits
PS51525 NET, 1 hit

Sequencei

Sequence statusi: Complete.

Q6MGA9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLQNVTPHKL PGEGNAGLLG LGPEAAAPGK RIRKPSLLYE GFESPTMASV
60 70 80 90 100
PALQLAPANP PPPEVSNPKK PGRVTNQLQY LHKVVMKALW KHQFAWPFRQ
110 120 130 140 150
PVDAVKLGLP DYHKIIKQPM DMGTIKRRLE NNYYWAASEC MQDFNTMFTN
160 170 180 190 200
CYIYNKPTDD IVLMAQTLEK IFLQKVASMP QEEQELVVTI PKNSHKKGAK
210 220 230 240 250
LAALQGSITS AHQVPAVSSV SHTALYTPPP EIPTTVLNIP HPSVISSPLL
260 270 280 290 300
KSLHSAGPPL LAVSAAPPAQ PLAKKKGVKR KADTTTPTPT AILAPGSPAS
310 320 330 340 350
PPGSLEPKAA RLPPMRRESG RPIKPPRKDL PDSQQQHQSS KKGKLSEQLK
360 370 380 390 400
HCNGILKELL SKKHAAYAWP FYKPVDASAL GLHDYHDIIK HPMDLSTVKR
410 420 430 440 450
KMENRDYRDA QEFAADVRLM FSNCYKYNPP DHDVVAMARK LQDVFEFRYA
460 470 480 490 500
KMPDEPLEPG PLPVSTALPP GLAKSSSESS SEESSSESSS EEEEEEDEED
510 520 530 540 550
EEEESESSDS EEERAHRLAE LQEQLRAVHE QLAALSQGPI SKPKRKREKK
560 570 580 590 600
EKKKKRKAEK HRGRIGIDED DKGPRAPRPL QPKKSKKAGG GGSNATTLSH
610 620 630 640 650
PGFGTSAGSS NKLPKKAQKT APPVLPTGYD SEEEEESRPM SYDEKRQLSL
660 670 680 690 700
DINKLPGEKL GRVVHIIQAR EPSLRDSNPE EIEIDFETLK PSTLRELERY
710 720 730 740 750
VLSCLRKKPR KPYTIRKPVG KTKEELALEK KRELEKRLQD VSGQLNSTKK
760 770 780 790
PPKKASEKTE SSAQQVAVSR LSASSSSSDS SSSSSSSSSS DTSDSDSG
Length:798
Mass (Da):88,051
Last modified:July 5, 2004 - v1
Checksum:iA6A530A04AB12EC9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX883042 Genomic DNA Translation: CAE83937.1
RefSeqiNP_997660.1, NM_212495.1
XP_017443518.1, XM_017588029.1
XP_017457067.1, XM_017601578.1
XP_017457068.1, XM_017601579.1
XP_017457351.1, XM_017601862.1
UniGeneiRn.98146

Genome annotation databases

EnsembliENSRNOT00000000535; ENSRNOP00000000535; ENSRNOG00000000461
GeneIDi108348112
294276
KEGGirno:108348112
rno:294276
UCSCiRGD:1303324 rat

Similar proteinsi

Entry informationi

Entry nameiBRD2_RAT
AccessioniPrimary (citable) accession number: Q6MGA9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 23, 2007
Last sequence update: July 5, 2004
Last modified: April 25, 2018
This is version 99 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health