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Q6MGA9 (BRD2_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 63. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Bromodomain-containing protein 2
Alternative name(s):
Protein RING3
Gene names
Name:Brd2
Synonyms:Ring3
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length798 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Binds hyperacetylated chromatin and plays a role in the regulation of transcription, probably by chromatin remodeling. Regulates transcription of the CCND1 gene. Plays a role in nucleosome assembly By similarity. May play a role in spermatogenesis or folliculogenesis By similarity.

Subunit structure

Homodimer. Interacts with E2F1 and with histone H4 acetylated at 'Lys-13' By similarity.

Subcellular location

Nucleus By similarity. Note: Detected on chromatin and nucleosomes By similarity.

Domain

One bromodomain is sufficient for a partial interaction with histone H4 acetylated at 'Lys-13' By similarity.

Sequence similarities

Contains 2 bromo domains.

Contains 1 NET domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 798798Bromodomain-containing protein 2
PRO_0000274006

Regions

Domain90 – 16273Bromo 1
Domain363 – 43573Bromo 2
Domain630 – 71283NET
Motif553 – 5575Nuclear localization signal Potential
Compositional bias60 – 634Poly-Pro
Compositional bias228 – 331104Pro-rich
Compositional bias478 – 52346Glu-rich
Compositional bias549 – 5579Poly-Lys
Compositional bias589 – 5924Poly-Gly
Compositional bias632 – 6365Poly-Glu
Compositional bias761 – 79737Ser-rich

Amino acid modifications

Modified residue11N-acetylmethionine By similarity
Modified residue61Phosphothreonine By similarity
Modified residue361Phosphoserine By similarity
Modified residue2971Phosphoserine By similarity
Modified residue3001Phosphoserine By similarity
Modified residue3041Phosphoserine By similarity
Modified residue6311Phosphoserine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q6MGA9 [UniParc].

Last modified July 5, 2004. Version 1.
Checksum: A6A530A04AB12EC9

FASTA79888,051
        10         20         30         40         50         60 
MLQNVTPHKL PGEGNAGLLG LGPEAAAPGK RIRKPSLLYE GFESPTMASV PALQLAPANP 

        70         80         90        100        110        120 
PPPEVSNPKK PGRVTNQLQY LHKVVMKALW KHQFAWPFRQ PVDAVKLGLP DYHKIIKQPM 

       130        140        150        160        170        180 
DMGTIKRRLE NNYYWAASEC MQDFNTMFTN CYIYNKPTDD IVLMAQTLEK IFLQKVASMP 

       190        200        210        220        230        240 
QEEQELVVTI PKNSHKKGAK LAALQGSITS AHQVPAVSSV SHTALYTPPP EIPTTVLNIP 

       250        260        270        280        290        300 
HPSVISSPLL KSLHSAGPPL LAVSAAPPAQ PLAKKKGVKR KADTTTPTPT AILAPGSPAS 

       310        320        330        340        350        360 
PPGSLEPKAA RLPPMRRESG RPIKPPRKDL PDSQQQHQSS KKGKLSEQLK HCNGILKELL 

       370        380        390        400        410        420 
SKKHAAYAWP FYKPVDASAL GLHDYHDIIK HPMDLSTVKR KMENRDYRDA QEFAADVRLM 

       430        440        450        460        470        480 
FSNCYKYNPP DHDVVAMARK LQDVFEFRYA KMPDEPLEPG PLPVSTALPP GLAKSSSESS 

       490        500        510        520        530        540 
SEESSSESSS EEEEEEDEED EEEESESSDS EEERAHRLAE LQEQLRAVHE QLAALSQGPI 

       550        560        570        580        590        600 
SKPKRKREKK EKKKKRKAEK HRGRIGIDED DKGPRAPRPL QPKKSKKAGG GGSNATTLSH 

       610        620        630        640        650        660 
PGFGTSAGSS NKLPKKAQKT APPVLPTGYD SEEEEESRPM SYDEKRQLSL DINKLPGEKL 

       670        680        690        700        710        720 
GRVVHIIQAR EPSLRDSNPE EIEIDFETLK PSTLRELERY VLSCLRKKPR KPYTIRKPVG 

       730        740        750        760        770        780 
KTKEELALEK KRELEKRLQD VSGQLNSTKK PPKKASEKTE SSAQQVAVSR LSASSSSSDS 

       790 
SSSSSSSSSS DTSDSDSG

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References

[1]"The genomic sequence and comparative analysis of the rat major histocompatibility complex."
Hurt P., Walter L., Sudbrak R., Klages S., Mueller I., Shiina T., Inoko H., Lehrach H., Guenther E., Reinhardt R., Himmelbauer H.
Genome Res. 14:631-639(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Brown Norway.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		BX883042 Genomic DNA. Translation: CAE83937.1.
IPIIPI00422052.
RefSeqNP_997660.1. NM_212495.1.
XP_003751971.1. XM_003751923.1.
UniGeneRn.98146.

3D structure databases

HSSPHSSP built from PDB template 1X0J based on UniProtKB P25440.
ProteinModelPortalQ6MGA9.
SMRQ6MGA9. Positions 72-185, 347-454, 635-712.
ModBaseSearch...

Protein-protein interaction databases

STRING10116.ENSRNOP00000000535.

PTM databases

PhosphoSiteQ6MGA9.

Proteomic databases

PaxDbQ6MGA9.
PRIDEQ6MGA9.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSRNOT00000000535; ENSRNOP00000000535; ENSRNOG00000000461.
ENSRNOT00000060194; ENSRNOP00000056940; ENSRNOG00000045877.
GeneID100909544.
294276.
KEGGrno:100909544.
rno:294276.
UCSCRGD:1303324. rat.

Organism-specific databases

CTD6046.
RGD1303324. Brd2.

Phylogenomic databases

eggNOGCOG5076.
GeneTreeENSGT00700000104261.
HOGENOMHOG000231200.
HOVERGENHBG004896.
InParanoidQ6MGA9.
KOK08871.
OMAPVSTAMP.

Gene expression databases

ArrayExpressQ6MGA9.
GenevestigatorQ6MGA9.

Family and domain databases

Gene3D1.20.920.10. 2 hits.
InterProIPR001487. Bromodomain.
IPR018359. Bromodomain_CS.
IPR027353. NET_dom.
[Graphical view]
PfamPF00439. Bromodomain. 2 hits.
[Graphical view]
PRINTSPR00503. BROMODOMAIN.
SMARTSM00297. BROMO. 2 hits.
[Graphical view]
SUPFAMSSF47370. Bromodomain. 2 hits.
PROSITEPS00633. BROMODOMAIN_1. 2 hits.
PS50014. BROMODOMAIN_2. 2 hits.
PS51525. NET. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio637874.

Entry information

Entry nameBRD2_RAT
AccessionPrimary (citable) accession number: Q6MGA9
Entry history
Integrated into UniProtKB/Swiss-Prot: January 23, 2007
Last sequence update: July 5, 2004
Last modified: May 1, 2013
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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