Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein
Submitted name:

MHC class II antigen

Gene

RT1-Ba

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processImmunity

Enzyme and pathway databases

ReactomeiR-RNO-202424. Downstream TCR signaling.
R-RNO-202427. Phosphorylation of CD3 and TCR zeta chains.
R-RNO-202430. Translocation of ZAP-70 to Immunological synapse.
R-RNO-202433. Generation of second messenger molecules.
R-RNO-2132295. MHC class II antigen presentation.
R-RNO-389948. PD-1 signaling.

Names & Taxonomyi

Protein namesi
Submitted name:
MHC class II antigenImported
Submitted name:
RCG60724, isoform CRA_aImported
Submitted name:
RT1 class II, B alphaImported
Submitted name:
RT1 class II, locus BaImported
Submitted name:
RT1-BaImported
Submitted name:
Rano class II histocompatibility antigen, B alpha chainImported
Gene namesi
Name:RT1-BaImported
Synonyms:Arrb2-psImported, BA1Imported, Hla-dmaImported, Hla-dmbImported, Psmb9Imported, RT1-BbImported, RT1-DaImported, RT1-Db1Imported, RT1-Db2Imported, RT1-DObImported, Tap1Imported, Tap2Imported, TesbImported
ORF Names:rCG_60724Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 20

Organism-specific databases

RGDi1595867. RT1-Ba.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei222 – 240HelicalSequence analysisAdd BLAST19

Keywords - Cellular componenti

Membrane, MHC IISAAS annotation

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23Sequence analysisAdd BLAST23
ChainiPRO_501410644824 – 255Sequence analysisAdd BLAST232

Keywords - PTMi

Disulfide bondSAAS annotation

Expressioni

Gene expression databases

BgeeiENSRNOG00000000451.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000000523.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini107 – 193Ig-likeInterPro annotationAdd BLAST87

Sequence similaritiesi

Belongs to the MHC class II family.UniRule annotationSAAS annotation

Keywords - Domaini

SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiENOG410IZMF. Eukaryota.
ENOG410YHX9. LUCA.
GeneTreeiENSGT00900000140882.
HOVERGENiHBG006862.
KOiK06752.
OMAiCFDSSDT.
OrthoDBiEOG091G0IC9.
TreeFamiTF333797.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
3.10.320.10. 1 hit.
InterProiView protein in InterPro
IPR007110. Ig-like_dom.
IPR036179. Ig-like_dom_sf.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
IPR011162. MHC_I/II-like_Ag-recog.
IPR014745. MHC_II_a/b_N.
IPR001003. MHC_II_a_N.
PfamiView protein in Pfam
PF07654. C1-set. 1 hit.
PF00993. MHC_II_alpha. 1 hit.
SMARTiView protein in SMART
SM00407. IGc1. 1 hit.
SM00920. MHC_II_alpha. 1 hit.
SUPFAMiSSF48726. SSF48726. 1 hit.
SSF54452. SSF54452. 1 hit.
PROSITEiView protein in PROSITE
PS50835. IG_LIKE. 1 hit.
PS00290. IG_MHC. 1 hit.

Sequencei

Sequence statusi: Complete.

Q6MGA0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPLSRALILG VLALTTMLSP CGGQDDIEAD HVAAYGINMY QYYESRGQYT
60 70 80 90 100
HEFDGDEEFY VDLDKKETIW RIPEFGQLTS FDPQGGLQEI ATAKYNLEIL
110 120 130 140 150
MKSNSTPATN KVPEATVFSK SPVLLGQPNT LICFVDNIFP PAINITWLRN
160 170 180 190 200
SKPVTEGTFE TSFLSNPDHS FHKMAYLTFI PSNDDIYDCK VEHWGLDEPV
210 220 230 240 250
LKHWEPEIPA PMSELTETVV CALGLSVGLV GIVVGTIFII QGLRSGGPSR

HPGPL
Length:255
Mass (Da):28,237
Last modified:July 5, 2004 - v1
Checksum:iC1F7D2870DEA39E4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR07072809 Genomic DNA. No translation available.
BC086448 mRNA. Translation: AAH86448.1.
AY626197 mRNA. Translation: AAV40626.1.
KC222945 mRNA. Translation: AGV39042.1.
BX883043 Genomic DNA. Translation: CAE83946.1.
CH473988 Genomic DNA. Translation: EDL96801.1.
RefSeqiNP_001008831.1. NM_001008831.3.
UniGeneiRn.25717.

Genome annotation databases

EnsembliENSRNOT00000000523; ENSRNOP00000000523; ENSRNOG00000000451.
GeneIDi309621.
KEGGirno:309621.

Similar proteinsi

Entry informationi

Entry nameiQ6MGA0_RAT
AccessioniPrimary (citable) accession number: Q6MGA0
Entry historyiIntegrated into UniProtKB/TrEMBL: July 5, 2004
Last sequence update: July 5, 2004
Last modified: March 28, 2018
This is version 146 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported