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Q6MG89

- Q6MG89_RAT

UniProt

Q6MG89 - Q6MG89_RAT

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Protein
Submitted name: Notch homolog 4, [Drosophila]
Gene
Notch4, Ager, Btnl6, Cyp21a1-ps, Ng5, Rnf5, Stk19-ps, Tnx, rCG_38227
Organism
Rattus norvegicus (Rat)
Status
Unreviewed - Annotation score: 3 out of 5 - Protein predictedi

Functioni

GO - Molecular functioni

  1. calcium ion binding Source: InterPro
  2. receptor activity Source: RGD

GO - Biological processi

  1. Notch signaling pathway Source: InterPro
  2. endothelial cell differentiation Source: RGD
  3. endothelial cell morphogenesis Source: RGD
  4. mammary gland development Source: Ensembl
  5. regulation of developmental process Source: InterPro
Complete GO annotation...

Enzyme and pathway databases

ReactomeiREACT_194281. Signaling by NOTCH4.
REACT_198789. Pre-NOTCH Processing in Golgi.
REACT_198791. Pre-NOTCH Processing in the Endoplasmic Reticulum.

Names & Taxonomyi

Protein namesi
Submitted name:
Notch homolog 4, [Drosophila]Imported
Submitted name:
Notch homolog 4, isoform CRA_bImported
Submitted name:
Protein Notch4Imported
Gene namesi
Name:Notch4Imported
Synonyms:AgerImported, Btnl6Imported, Cyp21a1-psImported, Ng5Imported, Rnf5Imported, Stk19-psImported, TnxImported
ORF Names:rCG_38227Imported
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 20

Organism-specific databases

RGDi1303282. Notch4.

Subcellular locationi

GO - Cellular componenti

  1. cell surface Source: Ensembl
  2. integral component of membrane Source: InterPro
Complete GO annotation...

PTM / Processingi

Keywords - PTMi

Disulfide bondSAAS annotations

Expressioni

Gene expression databases

GenevestigatoriQ6MG89.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000000513.

Family & Domainsi

Sequence similaritiesi

Contains 5 ANK repeats.UniRule annotation

Keywords - Domaini

ANK repeatUniRule annotation, EGF-like domainUniRule annotationSAAS annotations, RepeatUniRule annotationSAAS annotations

Phylogenomic databases

eggNOGiCOG0666.
GeneTreeiENSGT00730000110611.
HOGENOMiHOG000234369.
HOVERGENiHBG052650.
InParanoidiQ6MG89.
KOiK02599.
OMAiEGHACEH.
OrthoDBiEOG7992RD.
TreeFamiTF351641.

Family and domain databases

Gene3Di1.25.40.20. 1 hit.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR000742. EG-like_dom.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR018097. EGF_Ca-bd_CS.
IPR003645. Fol_N.
IPR009030. Growth_fac_rcpt_N_dom.
IPR008297. Notch.
IPR022355. Notch_4.
IPR000800. Notch_dom.
IPR011656. Notch_NODP_dom.
[Graphical view]
PfamiPF12796. Ank_2. 2 hits.
PF00008. EGF. 14 hits.
PF07645. EGF_CA. 3 hits.
PF12661. hEGF. 3 hits.
PF07684. NODP. 1 hit.
PF00066. Notch. 3 hits.
[Graphical view]
PIRSFiPIRSF002279. Notch. 1 hit.
PRINTSiPR01452. LNOTCHREPEAT.
PR01987. NOTCH4.
SMARTiSM00248. ANK. 5 hits.
SM00181. EGF. 15 hits.
SM00179. EGF_CA. 12 hits.
SM00274. FOLN. 6 hits.
SM00004. NL. 3 hits.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
SSF57184. SSF57184. 3 hits.
SSF90193. SSF90193. 2 hits.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 5 hits.
PS00010. ASX_HYDROXYL. 10 hits.
PS00022. EGF_1. 28 hits.
PS01186. EGF_2. 21 hits.
PS50026. EGF_3. 27 hits.
PS01187. EGF_CA. 9 hits.
PS50258. LNR. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6MG89-1 [UniParc]FASTAAdd to Basket

« Hide

MQRQWLLLLL LPLSFPVILT RELLCGGSPE PCANGGTCLR LSQGQGTCQC     50
APGFLGETCQ FPDPCWDTQL CENGGSCQAL LPTAPSSHSP TSPLTPHFSC 100
TCPSGFTGDR CQSPLEELCP PSFCSNGGHC SVQVSGRPQC SCEPGWTGEQ 150
CQLRDFCSAN PCANGGVCLA TYPQIQCRCP TGFEGHICER DVNECFLEPG 200
PCPRGTSCHN TLGSFQCLCP VGQEGPQCKL RKGACLPGTC LNGGTCQLVP 250
EGDTTFHLCL CPPGFTGLNC EMNPDDCVRN QCQNGATCQD GLGTYTCLCP 300
KTWKGWDCSE DIDECEAQGP PRCRNGGTCQ NSAGGFHCVC VSGWGGEGCD 350
ENLDDCAAAT CALGSTCIDR VGSFSCLCPP GRTGLLCHLE DMCLRQPCHV 400
NAQCSTNPLT GSTLCICQPG YSGPTCHQDL DECQMAQQGP SPCEHGGSCI 450
NTPGSFNCLC LPGYTGSRCE ADHNECLSQP CHPGSTCLDL LATFQCLCPP 500
GLEGRLCEVE INECASNPCL NQAACHDQLN GFLCLCLPGF TGARCEKDMD 550
ECSSAPCANG GHCQDQPGAF HCECLPGFEG PRCETEADEC RSDPCPVGAS 600
CLDLPGAFLC LCRPGFTGQL CEVPLCSPIL CQPGQQCQDQ EHRAPCLCPD 650
GSPGCVPAED DCPCHHGHCQ RSLCVCNEGW TGPECETELG GCLSTPCAHG 700
GTCHPQPSGY NCSCLAGYTG LTCSEEITAC HSGPCLNGGS CSIHPEGYSC 750
TCPPSHTGPH CQTAVDHCAS ASCLNGGTCM SKPGTFFCHC ATGFQGLHCE 800
KKIHPSCADN PCRNKATCQD TPRGARCLCS PGYTGSSCQT LIDLCARKPC 850
PHTARCLQSG PSFHCLCHQG WTGSLCDLPL SCQAAAMSQG VEISNLCQNG 900
GLCIDTGSSY FCRCPPGFEG KLCQDTVNPC TSKPCLHGAT CVPQPNGYVC 950
QCAPGYEGQN CSKVHDACQS GPCHNHGTCT PRPGGFHCAC PPGFVGLRCE 1000
GDVDECLDRP CHPSGTASCH SLANAFYCQC LPGHTGQRCE VEMDLCQSQP 1050
CSNGGSCEVT TGPPPGFTCR CPEGFEGPTC SRKAPACGNH HCHNGGLCLP 1100
SPKPGSPPLC ACLSGFGGPD CLTPPAPPGC GPPSPCMHNG SCTETPGLGN 1150
PGFQCTCPPD SPGPRCQRPG ANGCEGRGGD GACDAGCSGP GGDWDGGDCS 1200
LGVPDPWKGC PPHSQCWLLF RDGRCHPQCD SEECLFDGYD CEIPPTCTPA 1250
YDQYCRDHFH NGHCEKGCNN AQCGWDGGDC RPEGDDSEGG PSLALLVVLS 1300
PPALDQQLLA LARVLSLTLR VGLWVRKDSE GRNMVFPYPG TRAKEELSGT 1350
RDSSSWERQA PHTQTPGKET ESLGAGFVVV MGVDLSRCGP EHPASRCPRD 1400
SGLLLRFLAA MAAVGALEPL LPGPLLAAHP QAGTGSPATR LPWPILCSPV 1450
VGVLLLALGA LLVLQLIRRR RREHGALWLP PGFIRRPQTQ QAPHRRRPPL 1500
GEDNIGLKAL KPEAEVDEDG VVMCSGPEEG EAEKTASASR CQLWPLRSGC 1550
EGLPQAVMLT PPQECESELP DSDTCGPDGV TPLMSAVFCG GVQSTTVQRL 1600
GLGNPEPWEP LLDRGACPQA HTVGTGETPL HLAARFSRPT AARRLLEAGA 1650
NPNQPDRAGR TPLHTAVAAD AREVCQLLLA SRQTAVDART DDGTTPLMLA 1700
ARLAVEDLVE ELIAARADVG ARDKRGKTAL HWAAAVNNAR AARCLLQTGA 1750
DKDAQDSREQ TPLFLAAREG AVEVAQLLLE IGAARGLRDQ AGLAPADVAR 1800
QRSHWDLLTL LEGAGPITQE ARSHARNTPG GGAAPRCRTL SAGARPRGGG 1850
ACLQARTWSV DLGARRGAVY ARCRSRSGGS GGPSMRGRRL SADSRGRRGA 1900
RVSQDDWPRD WVALEACGSA CSAPIPPPSL TPSPERGSPQ VSWGLPVHQE 1950
VPLNSGGRNQ N 1961
Length:1,961
Mass (Da):206,076
Last modified:July 5, 2004 - v1
Checksum:i5B1034E29EE07A3C
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AABR06099863 Genomic DNA. No translation available.
BX883044 Genomic DNA. Translation: CAE83957.1.
CH474121 Genomic DNA. Translation: EDL83377.1.
RefSeqiNP_001002827.1. NM_001002827.1.
UniGeneiRn.12967.

Genome annotation databases

EnsembliENSRNOT00000000513; ENSRNOP00000000513; ENSRNOG00000000442.
GeneIDi406162.
KEGGirno:406162.
UCSCiRGD:1303282. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AABR06099863 Genomic DNA. No translation available.
BX883044 Genomic DNA. Translation: CAE83957.1 .
CH474121 Genomic DNA. Translation: EDL83377.1 .
RefSeqi NP_001002827.1. NM_001002827.1.
UniGenei Rn.12967.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10116.ENSRNOP00000000513.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000000513 ; ENSRNOP00000000513 ; ENSRNOG00000000442 .
GeneIDi 406162.
KEGGi rno:406162.
UCSCi RGD:1303282. rat.

Organism-specific databases

CTDi 4855.
RGDi 1303282. Notch4.

Phylogenomic databases

eggNOGi COG0666.
GeneTreei ENSGT00730000110611.
HOGENOMi HOG000234369.
HOVERGENi HBG052650.
InParanoidi Q6MG89.
KOi K02599.
OMAi EGHACEH.
OrthoDBi EOG7992RD.
TreeFami TF351641.

Enzyme and pathway databases

Reactomei REACT_194281. Signaling by NOTCH4.
REACT_198789. Pre-NOTCH Processing in Golgi.
REACT_198791. Pre-NOTCH Processing in the Endoplasmic Reticulum.

Miscellaneous databases

NextBioi 696070.
PROi Q6MG89.

Gene expression databases

Genevestigatori Q6MG89.

Family and domain databases

Gene3Di 1.25.40.20. 1 hit.
InterProi IPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR000742. EG-like_dom.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR018097. EGF_Ca-bd_CS.
IPR003645. Fol_N.
IPR009030. Growth_fac_rcpt_N_dom.
IPR008297. Notch.
IPR022355. Notch_4.
IPR000800. Notch_dom.
IPR011656. Notch_NODP_dom.
[Graphical view ]
Pfami PF12796. Ank_2. 2 hits.
PF00008. EGF. 14 hits.
PF07645. EGF_CA. 3 hits.
PF12661. hEGF. 3 hits.
PF07684. NODP. 1 hit.
PF00066. Notch. 3 hits.
[Graphical view ]
PIRSFi PIRSF002279. Notch. 1 hit.
PRINTSi PR01452. LNOTCHREPEAT.
PR01987. NOTCH4.
SMARTi SM00248. ANK. 5 hits.
SM00181. EGF. 15 hits.
SM00179. EGF_CA. 12 hits.
SM00274. FOLN. 6 hits.
SM00004. NL. 3 hits.
[Graphical view ]
SUPFAMi SSF48403. SSF48403. 1 hit.
SSF57184. SSF57184. 3 hits.
SSF90193. SSF90193. 2 hits.
PROSITEi PS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 5 hits.
PS00010. ASX_HYDROXYL. 10 hits.
PS00022. EGF_1. 28 hits.
PS01186. EGF_2. 21 hits.
PS50026. EGF_3. 27 hits.
PS01187. EGF_CA. 9 hits.
PS50258. LNR. 3 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: Brown NorwayImported.
  2. "The genomic sequence and comparative analysis of the rat major histocompatibility complex."
    Hurt P., Walter L., Sudbrak R., Klages S., Mueller I., Shiina T., Inoko H., Lehrach H., Guenther E., Reinhardt R., Himmelbauer H.
    Genome Res. 14:631-639(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: Brown NorwayImported.
  3. "Genome sequence of the Brown Norway rat yields insights into mammalian evolution."
    Rat Genome Sequencing Project Consortium
    Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., Morgan M.
    , Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., Collins F.S.
    Nature 428:493-521(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Brown NorwayImported.
  4. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: BNImported.
  5. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: BNImported.
  6. Ensembl
    Submitted (FEB-2012) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: Brown NorwayImported.

Entry informationi

Entry nameiQ6MG89_RAT
AccessioniPrimary (citable) accession number: Q6MG89
Entry historyi
Integrated into UniProtKB/TrEMBL: July 5, 2004
Last sequence update: July 5, 2004
Last modified: September 3, 2014
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

External Data

Dasty 3

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