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Protein
Submitted name:

Notch homolog 4, [Drosophila]

Gene

Notch4

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein predictedi

Functioni

GO - Molecular functioni

  1. calcium ion binding Source: InterPro
  2. receptor activity Source: RGD

GO - Biological processi

  1. endothelial cell differentiation Source: RGD
  2. endothelial cell morphogenesis Source: RGD
  3. mammary gland development Source: Ensembl
  4. Notch signaling pathway Source: InterPro
Complete GO annotation...

Enzyme and pathway databases

ReactomeiREACT_274348. Notch-HLH transcription pathway.
REACT_295660. Pre-NOTCH Processing in the Endoplasmic Reticulum.
REACT_296822. Pre-NOTCH Processing in Golgi.
REACT_321246. Signaling by NOTCH4.

Names & Taxonomyi

Protein namesi
Submitted name:
Notch homolog 4, [Drosophila]Imported
Submitted name:
Notch homolog 4, isoform CRA_bImported
Submitted name:
Protein Notch4Imported
Gene namesi
Name:Notch4Imported
Synonyms:AgerImported, Btnl6Imported, Cyp21a1-psImported, Ng5Imported, Rnf5Imported, Stk19-psImported, TnxImported
ORF Names:rCG_38227Imported
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494 Componenti: Chromosome 20

Organism-specific databases

RGDi1303282. Notch4.

Subcellular locationi

GO - Cellular componenti

  1. cell surface Source: Ensembl
  2. integral component of membrane Source: InterPro
Complete GO annotation...

PTM / Processingi

Keywords - PTMi

Disulfide bondSAAS annotation

Proteomic databases

PaxDbiQ6MG89.

Expressioni

Gene expression databases

GenevestigatoriQ6MG89.

Interactioni

Protein-protein interaction databases

IntActiQ6MG89. 3 interactions.
STRINGi10116.ENSRNOP00000000513.

Structurei

3D structure databases

ProteinModelPortaliQ6MG89.
SMRiQ6MG89. Positions 429-544, 1606-1812.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains 5 ANK repeats.UniRule annotation

Keywords - Domaini

ANK repeatUniRule annotation, EGF-like domainUniRule annotationSAAS annotation, RepeatUniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiCOG0666.
GeneTreeiENSGT00760000118786.
HOGENOMiHOG000234369.
HOVERGENiHBG052650.
InParanoidiQ6MG89.
KOiK02599.
OMAiPSCGLHH.
OrthoDBiEOG7992RD.
PhylomeDBiQ6MG89.
TreeFamiTF351641.

Family and domain databases

Gene3Di1.25.40.20. 1 hit.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR000742. EG-like_dom.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR018097. EGF_Ca-bd_CS.
IPR003645. Fol_N.
IPR009030. Growth_fac_rcpt_N_dom.
IPR022355. Notch_4.
IPR000800. Notch_dom.
IPR011656. Notch_NODP_dom.
[Graphical view]
PfamiPF12796. Ank_2. 2 hits.
PF00008. EGF. 14 hits.
PF07645. EGF_CA. 3 hits.
PF12661. hEGF. 3 hits.
PF07684. NODP. 1 hit.
PF00066. Notch. 3 hits.
[Graphical view]
PRINTSiPR01452. LNOTCHREPEAT.
PR01987. NOTCH4.
SMARTiSM00248. ANK. 5 hits.
SM00181. EGF. 15 hits.
SM00179. EGF_CA. 12 hits.
SM00274. FOLN. 6 hits.
SM00004. NL. 3 hits.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
SSF57184. SSF57184. 3 hits.
SSF90193. SSF90193. 2 hits.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 5 hits.
PS00010. ASX_HYDROXYL. 10 hits.
PS00022. EGF_1. 28 hits.
PS01186. EGF_2. 21 hits.
PS50026. EGF_3. 27 hits.
PS01187. EGF_CA. 9 hits.
PS50258. LNR. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6MG89-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQRQWLLLLL LPLSFPVILT RELLCGGSPE PCANGGTCLR LSQGQGTCQC
60 70 80 90 100
APGFLGETCQ FPDPCWDTQL CENGGSCQAL LPTAPSSHSP TSPLTPHFSC
110 120 130 140 150
TCPSGFTGDR CQSPLEELCP PSFCSNGGHC SVQVSGRPQC SCEPGWTGEQ
160 170 180 190 200
CQLRDFCSAN PCANGGVCLA TYPQIQCRCP TGFEGHICER DVNECFLEPG
210 220 230 240 250
PCPRGTSCHN TLGSFQCLCP VGQEGPQCKL RKGACLPGTC LNGGTCQLVP
260 270 280 290 300
EGDTTFHLCL CPPGFTGLNC EMNPDDCVRN QCQNGATCQD GLGTYTCLCP
310 320 330 340 350
KTWKGWDCSE DIDECEAQGP PRCRNGGTCQ NSAGGFHCVC VSGWGGEGCD
360 370 380 390 400
ENLDDCAAAT CALGSTCIDR VGSFSCLCPP GRTGLLCHLE DMCLRQPCHV
410 420 430 440 450
NAQCSTNPLT GSTLCICQPG YSGPTCHQDL DECQMAQQGP SPCEHGGSCI
460 470 480 490 500
NTPGSFNCLC LPGYTGSRCE ADHNECLSQP CHPGSTCLDL LATFQCLCPP
510 520 530 540 550
GLEGRLCEVE INECASNPCL NQAACHDQLN GFLCLCLPGF TGARCEKDMD
560 570 580 590 600
ECSSAPCANG GHCQDQPGAF HCECLPGFEG PRCETEADEC RSDPCPVGAS
610 620 630 640 650
CLDLPGAFLC LCRPGFTGQL CEVPLCSPIL CQPGQQCQDQ EHRAPCLCPD
660 670 680 690 700
GSPGCVPAED DCPCHHGHCQ RSLCVCNEGW TGPECETELG GCLSTPCAHG
710 720 730 740 750
GTCHPQPSGY NCSCLAGYTG LTCSEEITAC HSGPCLNGGS CSIHPEGYSC
760 770 780 790 800
TCPPSHTGPH CQTAVDHCAS ASCLNGGTCM SKPGTFFCHC ATGFQGLHCE
810 820 830 840 850
KKIHPSCADN PCRNKATCQD TPRGARCLCS PGYTGSSCQT LIDLCARKPC
860 870 880 890 900
PHTARCLQSG PSFHCLCHQG WTGSLCDLPL SCQAAAMSQG VEISNLCQNG
910 920 930 940 950
GLCIDTGSSY FCRCPPGFEG KLCQDTVNPC TSKPCLHGAT CVPQPNGYVC
960 970 980 990 1000
QCAPGYEGQN CSKVHDACQS GPCHNHGTCT PRPGGFHCAC PPGFVGLRCE
1010 1020 1030 1040 1050
GDVDECLDRP CHPSGTASCH SLANAFYCQC LPGHTGQRCE VEMDLCQSQP
1060 1070 1080 1090 1100
CSNGGSCEVT TGPPPGFTCR CPEGFEGPTC SRKAPACGNH HCHNGGLCLP
1110 1120 1130 1140 1150
SPKPGSPPLC ACLSGFGGPD CLTPPAPPGC GPPSPCMHNG SCTETPGLGN
1160 1170 1180 1190 1200
PGFQCTCPPD SPGPRCQRPG ANGCEGRGGD GACDAGCSGP GGDWDGGDCS
1210 1220 1230 1240 1250
LGVPDPWKGC PPHSQCWLLF RDGRCHPQCD SEECLFDGYD CEIPPTCTPA
1260 1270 1280 1290 1300
YDQYCRDHFH NGHCEKGCNN AQCGWDGGDC RPEGDDSEGG PSLALLVVLS
1310 1320 1330 1340 1350
PPALDQQLLA LARVLSLTLR VGLWVRKDSE GRNMVFPYPG TRAKEELSGT
1360 1370 1380 1390 1400
RDSSSWERQA PHTQTPGKET ESLGAGFVVV MGVDLSRCGP EHPASRCPRD
1410 1420 1430 1440 1450
SGLLLRFLAA MAAVGALEPL LPGPLLAAHP QAGTGSPATR LPWPILCSPV
1460 1470 1480 1490 1500
VGVLLLALGA LLVLQLIRRR RREHGALWLP PGFIRRPQTQ QAPHRRRPPL
1510 1520 1530 1540 1550
GEDNIGLKAL KPEAEVDEDG VVMCSGPEEG EAEKTASASR CQLWPLRSGC
1560 1570 1580 1590 1600
EGLPQAVMLT PPQECESELP DSDTCGPDGV TPLMSAVFCG GVQSTTVQRL
1610 1620 1630 1640 1650
GLGNPEPWEP LLDRGACPQA HTVGTGETPL HLAARFSRPT AARRLLEAGA
1660 1670 1680 1690 1700
NPNQPDRAGR TPLHTAVAAD AREVCQLLLA SRQTAVDART DDGTTPLMLA
1710 1720 1730 1740 1750
ARLAVEDLVE ELIAARADVG ARDKRGKTAL HWAAAVNNAR AARCLLQTGA
1760 1770 1780 1790 1800
DKDAQDSREQ TPLFLAAREG AVEVAQLLLE IGAARGLRDQ AGLAPADVAR
1810 1820 1830 1840 1850
QRSHWDLLTL LEGAGPITQE ARSHARNTPG GGAAPRCRTL SAGARPRGGG
1860 1870 1880 1890 1900
ACLQARTWSV DLGARRGAVY ARCRSRSGGS GGPSMRGRRL SADSRGRRGA
1910 1920 1930 1940 1950
RVSQDDWPRD WVALEACGSA CSAPIPPPSL TPSPERGSPQ VSWGLPVHQE
1960
VPLNSGGRNQ N
Length:1,961
Mass (Da):206,076
Last modified:July 5, 2004 - v1
Checksum:i5B1034E29EE07A3C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR06099863 Genomic DNA. No translation available.
BX883044 Genomic DNA. Translation: CAE83957.1.
CH474121 Genomic DNA. Translation: EDL83377.1.
RefSeqiNP_001002827.1. NM_001002827.1.
UniGeneiRn.12967.

Genome annotation databases

EnsembliENSRNOT00000000513; ENSRNOP00000000513; ENSRNOG00000000442.
GeneIDi406162.
KEGGirno:406162.
UCSCiRGD:1303282. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR06099863 Genomic DNA. No translation available.
BX883044 Genomic DNA. Translation: CAE83957.1.
CH474121 Genomic DNA. Translation: EDL83377.1.
RefSeqiNP_001002827.1. NM_001002827.1.
UniGeneiRn.12967.

3D structure databases

ProteinModelPortaliQ6MG89.
SMRiQ6MG89. Positions 429-544, 1606-1812.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ6MG89. 3 interactions.
STRINGi10116.ENSRNOP00000000513.

Proteomic databases

PaxDbiQ6MG89.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000000513; ENSRNOP00000000513; ENSRNOG00000000442.
GeneIDi406162.
KEGGirno:406162.
UCSCiRGD:1303282. rat.

Organism-specific databases

CTDi4855.
RGDi1303282. Notch4.

Phylogenomic databases

eggNOGiCOG0666.
GeneTreeiENSGT00760000118786.
HOGENOMiHOG000234369.
HOVERGENiHBG052650.
InParanoidiQ6MG89.
KOiK02599.
OMAiPSCGLHH.
OrthoDBiEOG7992RD.
PhylomeDBiQ6MG89.
TreeFamiTF351641.

Enzyme and pathway databases

ReactomeiREACT_274348. Notch-HLH transcription pathway.
REACT_295660. Pre-NOTCH Processing in the Endoplasmic Reticulum.
REACT_296822. Pre-NOTCH Processing in Golgi.
REACT_321246. Signaling by NOTCH4.

Miscellaneous databases

NextBioi696070.
PROiQ6MG89.

Gene expression databases

GenevestigatoriQ6MG89.

Family and domain databases

Gene3Di1.25.40.20. 1 hit.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR000742. EG-like_dom.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR018097. EGF_Ca-bd_CS.
IPR003645. Fol_N.
IPR009030. Growth_fac_rcpt_N_dom.
IPR022355. Notch_4.
IPR000800. Notch_dom.
IPR011656. Notch_NODP_dom.
[Graphical view]
PfamiPF12796. Ank_2. 2 hits.
PF00008. EGF. 14 hits.
PF07645. EGF_CA. 3 hits.
PF12661. hEGF. 3 hits.
PF07684. NODP. 1 hit.
PF00066. Notch. 3 hits.
[Graphical view]
PRINTSiPR01452. LNOTCHREPEAT.
PR01987. NOTCH4.
SMARTiSM00248. ANK. 5 hits.
SM00181. EGF. 15 hits.
SM00179. EGF_CA. 12 hits.
SM00274. FOLN. 6 hits.
SM00004. NL. 3 hits.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
SSF57184. SSF57184. 3 hits.
SSF90193. SSF90193. 2 hits.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 5 hits.
PS00010. ASX_HYDROXYL. 10 hits.
PS00022. EGF_1. 28 hits.
PS01186. EGF_2. 21 hits.
PS50026. EGF_3. 27 hits.
PS01187. EGF_CA. 9 hits.
PS50258. LNR. 3 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: Brown NorwayImported.
  2. "The genomic sequence and comparative analysis of the rat major histocompatibility complex."
    Hurt P., Walter L., Sudbrak R., Klages S., Mueller I., Shiina T., Inoko H., Lehrach H., Guenther E., Reinhardt R., Himmelbauer H.
    Genome Res. 14:631-639(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: Brown NorwayImported.
  3. "Genome sequence of the Brown Norway rat yields insights into mammalian evolution."
    Rat Genome Sequencing Project Consortium
    Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., Morgan M.
    , Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., Collins F.S.
    Nature 428:493-521(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Brown NorwayImported.
  4. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: BNImported.
  5. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: BNImported.
  6. Ensembl
    Submitted (JAN-2012) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: Brown NorwayImported.

Entry informationi

Entry nameiQ6MG89_RAT
AccessioniPrimary (citable) accession number: Q6MG89
Entry historyi
Integrated into UniProtKB/TrEMBL: July 5, 2004
Last sequence update: July 5, 2004
Last modified: April 1, 2015
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.