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Q6MG89

- Q6MG89_RAT

UniProt

Q6MG89 - Q6MG89_RAT

Protein
Submitted name:

Notch homolog 4, [Drosophila]

Gene

Notch4

Organism
Rattus norvegicus (Rat)
Status
Unreviewed - Annotation score: 3 out of 5- Protein predictedi
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    • History
      Entry version 89 (01 Oct 2014)
      Sequence version 1 (05 Jul 2004)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. calcium ion binding Source: InterPro
    2. receptor activity Source: RGD

    GO - Biological processi

    1. endothelial cell differentiation Source: RGD
    2. endothelial cell morphogenesis Source: RGD
    3. mammary gland development Source: Ensembl
    4. Notch signaling pathway Source: InterPro
    5. regulation of developmental process Source: InterPro

    Enzyme and pathway databases

    ReactomeiREACT_194281. Signaling by NOTCH4.
    REACT_198789. Pre-NOTCH Processing in Golgi.
    REACT_198791. Pre-NOTCH Processing in the Endoplasmic Reticulum.

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Notch homolog 4, [Drosophila]Imported
    Submitted name:
    Notch homolog 4, isoform CRA_bImported
    Submitted name:
    Protein Notch4Imported
    Gene namesi
    Name:Notch4Imported
    Synonyms:AgerImported, Btnl6Imported, Cyp21a1-psImported, Ng5Imported, Rnf5Imported, Stk19-psImported, TnxImported
    ORF Names:rCG_38227Imported
    OrganismiRattus norvegicus (Rat)Imported
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 20

    Organism-specific databases

    RGDi1303282. Notch4.

    Subcellular locationi

    GO - Cellular componenti

    1. cell surface Source: Ensembl
    2. integral component of membrane Source: InterPro

    PTM / Processingi

    Keywords - PTMi

    Disulfide bondSAAS annotation

    Expressioni

    Gene expression databases

    GenevestigatoriQ6MG89.

    Interactioni

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000000513.

    Family & Domainsi

    Sequence similaritiesi

    Contains 5 ANK repeats.UniRule annotation

    Keywords - Domaini

    ANK repeatUniRule annotation, EGF-like domainUniRule annotationSAAS annotation, RepeatUniRule annotationSAAS annotation

    Phylogenomic databases

    eggNOGiCOG0666.
    GeneTreeiENSGT00730000110611.
    HOGENOMiHOG000234369.
    HOVERGENiHBG052650.
    InParanoidiQ6MG89.
    KOiK02599.
    OMAiEGHACEH.
    OrthoDBiEOG7992RD.
    TreeFamiTF351641.

    Family and domain databases

    Gene3Di1.25.40.20. 1 hit.
    InterProiIPR002110. Ankyrin_rpt.
    IPR020683. Ankyrin_rpt-contain_dom.
    IPR000742. EG-like_dom.
    IPR001881. EGF-like_Ca-bd_dom.
    IPR013032. EGF-like_CS.
    IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
    IPR018097. EGF_Ca-bd_CS.
    IPR003645. Fol_N.
    IPR009030. Growth_fac_rcpt_N_dom.
    IPR008297. Notch.
    IPR022355. Notch_4.
    IPR000800. Notch_dom.
    IPR011656. Notch_NODP_dom.
    [Graphical view]
    PfamiPF12796. Ank_2. 2 hits.
    PF00008. EGF. 14 hits.
    PF07645. EGF_CA. 3 hits.
    PF12661. hEGF. 3 hits.
    PF07684. NODP. 1 hit.
    PF00066. Notch. 3 hits.
    [Graphical view]
    PIRSFiPIRSF002279. Notch. 1 hit.
    PRINTSiPR01452. LNOTCHREPEAT.
    PR01987. NOTCH4.
    SMARTiSM00248. ANK. 5 hits.
    SM00181. EGF. 15 hits.
    SM00179. EGF_CA. 12 hits.
    SM00274. FOLN. 6 hits.
    SM00004. NL. 3 hits.
    [Graphical view]
    SUPFAMiSSF48403. SSF48403. 1 hit.
    SSF57184. SSF57184. 3 hits.
    SSF90193. SSF90193. 2 hits.
    PROSITEiPS50297. ANK_REP_REGION. 1 hit.
    PS50088. ANK_REPEAT. 5 hits.
    PS00010. ASX_HYDROXYL. 10 hits.
    PS00022. EGF_1. 28 hits.
    PS01186. EGF_2. 21 hits.
    PS50026. EGF_3. 27 hits.
    PS01187. EGF_CA. 9 hits.
    PS50258. LNR. 3 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q6MG89-1 [UniParc]FASTAAdd to Basket

    « Hide

    MQRQWLLLLL LPLSFPVILT RELLCGGSPE PCANGGTCLR LSQGQGTCQC     50
    APGFLGETCQ FPDPCWDTQL CENGGSCQAL LPTAPSSHSP TSPLTPHFSC 100
    TCPSGFTGDR CQSPLEELCP PSFCSNGGHC SVQVSGRPQC SCEPGWTGEQ 150
    CQLRDFCSAN PCANGGVCLA TYPQIQCRCP TGFEGHICER DVNECFLEPG 200
    PCPRGTSCHN TLGSFQCLCP VGQEGPQCKL RKGACLPGTC LNGGTCQLVP 250
    EGDTTFHLCL CPPGFTGLNC EMNPDDCVRN QCQNGATCQD GLGTYTCLCP 300
    KTWKGWDCSE DIDECEAQGP PRCRNGGTCQ NSAGGFHCVC VSGWGGEGCD 350
    ENLDDCAAAT CALGSTCIDR VGSFSCLCPP GRTGLLCHLE DMCLRQPCHV 400
    NAQCSTNPLT GSTLCICQPG YSGPTCHQDL DECQMAQQGP SPCEHGGSCI 450
    NTPGSFNCLC LPGYTGSRCE ADHNECLSQP CHPGSTCLDL LATFQCLCPP 500
    GLEGRLCEVE INECASNPCL NQAACHDQLN GFLCLCLPGF TGARCEKDMD 550
    ECSSAPCANG GHCQDQPGAF HCECLPGFEG PRCETEADEC RSDPCPVGAS 600
    CLDLPGAFLC LCRPGFTGQL CEVPLCSPIL CQPGQQCQDQ EHRAPCLCPD 650
    GSPGCVPAED DCPCHHGHCQ RSLCVCNEGW TGPECETELG GCLSTPCAHG 700
    GTCHPQPSGY NCSCLAGYTG LTCSEEITAC HSGPCLNGGS CSIHPEGYSC 750
    TCPPSHTGPH CQTAVDHCAS ASCLNGGTCM SKPGTFFCHC ATGFQGLHCE 800
    KKIHPSCADN PCRNKATCQD TPRGARCLCS PGYTGSSCQT LIDLCARKPC 850
    PHTARCLQSG PSFHCLCHQG WTGSLCDLPL SCQAAAMSQG VEISNLCQNG 900
    GLCIDTGSSY FCRCPPGFEG KLCQDTVNPC TSKPCLHGAT CVPQPNGYVC 950
    QCAPGYEGQN CSKVHDACQS GPCHNHGTCT PRPGGFHCAC PPGFVGLRCE 1000
    GDVDECLDRP CHPSGTASCH SLANAFYCQC LPGHTGQRCE VEMDLCQSQP 1050
    CSNGGSCEVT TGPPPGFTCR CPEGFEGPTC SRKAPACGNH HCHNGGLCLP 1100
    SPKPGSPPLC ACLSGFGGPD CLTPPAPPGC GPPSPCMHNG SCTETPGLGN 1150
    PGFQCTCPPD SPGPRCQRPG ANGCEGRGGD GACDAGCSGP GGDWDGGDCS 1200
    LGVPDPWKGC PPHSQCWLLF RDGRCHPQCD SEECLFDGYD CEIPPTCTPA 1250
    YDQYCRDHFH NGHCEKGCNN AQCGWDGGDC RPEGDDSEGG PSLALLVVLS 1300
    PPALDQQLLA LARVLSLTLR VGLWVRKDSE GRNMVFPYPG TRAKEELSGT 1350
    RDSSSWERQA PHTQTPGKET ESLGAGFVVV MGVDLSRCGP EHPASRCPRD 1400
    SGLLLRFLAA MAAVGALEPL LPGPLLAAHP QAGTGSPATR LPWPILCSPV 1450
    VGVLLLALGA LLVLQLIRRR RREHGALWLP PGFIRRPQTQ QAPHRRRPPL 1500
    GEDNIGLKAL KPEAEVDEDG VVMCSGPEEG EAEKTASASR CQLWPLRSGC 1550
    EGLPQAVMLT PPQECESELP DSDTCGPDGV TPLMSAVFCG GVQSTTVQRL 1600
    GLGNPEPWEP LLDRGACPQA HTVGTGETPL HLAARFSRPT AARRLLEAGA 1650
    NPNQPDRAGR TPLHTAVAAD AREVCQLLLA SRQTAVDART DDGTTPLMLA 1700
    ARLAVEDLVE ELIAARADVG ARDKRGKTAL HWAAAVNNAR AARCLLQTGA 1750
    DKDAQDSREQ TPLFLAAREG AVEVAQLLLE IGAARGLRDQ AGLAPADVAR 1800
    QRSHWDLLTL LEGAGPITQE ARSHARNTPG GGAAPRCRTL SAGARPRGGG 1850
    ACLQARTWSV DLGARRGAVY ARCRSRSGGS GGPSMRGRRL SADSRGRRGA 1900
    RVSQDDWPRD WVALEACGSA CSAPIPPPSL TPSPERGSPQ VSWGLPVHQE 1950
    VPLNSGGRNQ N 1961
    Length:1,961
    Mass (Da):206,076
    Last modified:July 5, 2004 - v1
    Checksum:i5B1034E29EE07A3C
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AABR06099863 Genomic DNA. No translation available.
    BX883044 Genomic DNA. Translation: CAE83957.1.
    CH474121 Genomic DNA. Translation: EDL83377.1.
    RefSeqiNP_001002827.1. NM_001002827.1.
    UniGeneiRn.12967.

    Genome annotation databases

    EnsembliENSRNOT00000000513; ENSRNOP00000000513; ENSRNOG00000000442.
    GeneIDi406162.
    KEGGirno:406162.
    UCSCiRGD:1303282. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AABR06099863 Genomic DNA. No translation available.
    BX883044 Genomic DNA. Translation: CAE83957.1 .
    CH474121 Genomic DNA. Translation: EDL83377.1 .
    RefSeqi NP_001002827.1. NM_001002827.1.
    UniGenei Rn.12967.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10116.ENSRNOP00000000513.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000000513 ; ENSRNOP00000000513 ; ENSRNOG00000000442 .
    GeneIDi 406162.
    KEGGi rno:406162.
    UCSCi RGD:1303282. rat.

    Organism-specific databases

    CTDi 4855.
    RGDi 1303282. Notch4.

    Phylogenomic databases

    eggNOGi COG0666.
    GeneTreei ENSGT00730000110611.
    HOGENOMi HOG000234369.
    HOVERGENi HBG052650.
    InParanoidi Q6MG89.
    KOi K02599.
    OMAi EGHACEH.
    OrthoDBi EOG7992RD.
    TreeFami TF351641.

    Enzyme and pathway databases

    Reactomei REACT_194281. Signaling by NOTCH4.
    REACT_198789. Pre-NOTCH Processing in Golgi.
    REACT_198791. Pre-NOTCH Processing in the Endoplasmic Reticulum.

    Miscellaneous databases

    NextBioi 696070.
    PROi Q6MG89.

    Gene expression databases

    Genevestigatori Q6MG89.

    Family and domain databases

    Gene3Di 1.25.40.20. 1 hit.
    InterProi IPR002110. Ankyrin_rpt.
    IPR020683. Ankyrin_rpt-contain_dom.
    IPR000742. EG-like_dom.
    IPR001881. EGF-like_Ca-bd_dom.
    IPR013032. EGF-like_CS.
    IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
    IPR018097. EGF_Ca-bd_CS.
    IPR003645. Fol_N.
    IPR009030. Growth_fac_rcpt_N_dom.
    IPR008297. Notch.
    IPR022355. Notch_4.
    IPR000800. Notch_dom.
    IPR011656. Notch_NODP_dom.
    [Graphical view ]
    Pfami PF12796. Ank_2. 2 hits.
    PF00008. EGF. 14 hits.
    PF07645. EGF_CA. 3 hits.
    PF12661. hEGF. 3 hits.
    PF07684. NODP. 1 hit.
    PF00066. Notch. 3 hits.
    [Graphical view ]
    PIRSFi PIRSF002279. Notch. 1 hit.
    PRINTSi PR01452. LNOTCHREPEAT.
    PR01987. NOTCH4.
    SMARTi SM00248. ANK. 5 hits.
    SM00181. EGF. 15 hits.
    SM00179. EGF_CA. 12 hits.
    SM00274. FOLN. 6 hits.
    SM00004. NL. 3 hits.
    [Graphical view ]
    SUPFAMi SSF48403. SSF48403. 1 hit.
    SSF57184. SSF57184. 3 hits.
    SSF90193. SSF90193. 2 hits.
    PROSITEi PS50297. ANK_REP_REGION. 1 hit.
    PS50088. ANK_REPEAT. 5 hits.
    PS00010. ASX_HYDROXYL. 10 hits.
    PS00022. EGF_1. 28 hits.
    PS01186. EGF_2. 21 hits.
    PS50026. EGF_3. 27 hits.
    PS01187. EGF_CA. 9 hits.
    PS50258. LNR. 3 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: Brown NorwayImported.
    2. "The genomic sequence and comparative analysis of the rat major histocompatibility complex."
      Hurt P., Walter L., Sudbrak R., Klages S., Mueller I., Shiina T., Inoko H., Lehrach H., Guenther E., Reinhardt R., Himmelbauer H.
      Genome Res. 14:631-639(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: Brown NorwayImported.
    3. "Genome sequence of the Brown Norway rat yields insights into mammalian evolution."
      Rat Genome Sequencing Project Consortium
      Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., Morgan M.
      , Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., Collins F.S.
      Nature 428:493-521(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Brown NorwayImported.
    4. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: BNImported.
    5. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: BNImported.
    6. Ensembl
      Submitted (FEB-2012) to UniProtKB
      Cited for: IDENTIFICATION.
      Strain: Brown NorwayImported.

    Entry informationi

    Entry nameiQ6MG89_RAT
    AccessioniPrimary (citable) accession number: Q6MG89
    Entry historyi
    Integrated into UniProtKB/TrEMBL: July 5, 2004
    Last sequence update: July 5, 2004
    Last modified: October 1, 2014
    This is version 89 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3