Q6MG89 (Q6MG89_RAT) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Notch homolog 4, [Drosophila] EMBL CAE83957.1

Submitted name:
Notch homolog 4, isoform CRA_b EMBL EDL83377.1
Submitted name:
Protein Notch4 Ensembl ENSRNOP00000000513

Gene names

Name:	Notch4 RGD 1303282 Ensembl ENSRNOP00000000513 EMBL CAE83957.1
Synonyms:	Ager RGD 69258, Btnl6 RGD 1588460, Cyp21a1-ps RGD 1303332, Ng5 RGD 1359348, Rnf5 RGD 1588458, Stk19-ps RGD 1588459, Tnx RGD 1594402
ORF Names:	rCG_38227 EMBL EDL83377.1

Organism

Rattus norvegicus (Rat) [Reference proteome]

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	1961 AA.
Sequence status	Complete.
Protein existence	Predicted

Ontologies

Keywords
Domain	ANK repeat RuleBase RU003321 EGF-like domain SAAS SAAS001881 RuleBase RU000459 Repeat RuleBase RU003536
PTM	Disulfide bond SAAS SAAS001881
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	Notch signaling pathway Inferred from electronic annotation. Source: InterPro endothelial cell morphogenesis Inferred from direct assay PubMed 10964583. Source: RGD mammary gland development Inferred from electronic annotation. Source: Compara regulation of developmental process Inferred from electronic annotation. Source: InterPro
Cellular_component	cell surface Inferred from electronic annotation. Source: Compara integral to membrane Inferred from electronic annotation. Source: InterPro
Molecular_function	calcium ion binding Inferred from electronic annotation. Source: InterPro receptor activity Traceable author statement PubMed 10964583. Source: RGD
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q6MG89 [UniParc]. Last modified July 5, 2004. Version 1. Checksum: 5B1034E29EE07A3C	FASTA	1,961	206,076
	10 20 30 40 50 60 MQRQWLLLLL LPLSFPVILT RELLCGGSPE PCANGGTCLR LSQGQGTCQC APGFLGETCQ 70 80 90 100 110 120 FPDPCWDTQL CENGGSCQAL LPTAPSSHSP TSPLTPHFSC TCPSGFTGDR CQSPLEELCP 130 140 150 160 170 180 PSFCSNGGHC SVQVSGRPQC SCEPGWTGEQ CQLRDFCSAN PCANGGVCLA TYPQIQCRCP 190 200 210 220 230 240 TGFEGHICER DVNECFLEPG PCPRGTSCHN TLGSFQCLCP VGQEGPQCKL RKGACLPGTC 250 260 270 280 290 300 LNGGTCQLVP EGDTTFHLCL CPPGFTGLNC EMNPDDCVRN QCQNGATCQD GLGTYTCLCP 310 320 330 340 350 360 KTWKGWDCSE DIDECEAQGP PRCRNGGTCQ NSAGGFHCVC VSGWGGEGCD ENLDDCAAAT 370 380 390 400 410 420 CALGSTCIDR VGSFSCLCPP GRTGLLCHLE DMCLRQPCHV NAQCSTNPLT GSTLCICQPG 430 440 450 460 470 480 YSGPTCHQDL DECQMAQQGP SPCEHGGSCI NTPGSFNCLC LPGYTGSRCE ADHNECLSQP 490 500 510 520 530 540 CHPGSTCLDL LATFQCLCPP GLEGRLCEVE INECASNPCL NQAACHDQLN GFLCLCLPGF 550 560 570 580 590 600 TGARCEKDMD ECSSAPCANG GHCQDQPGAF HCECLPGFEG PRCETEADEC RSDPCPVGAS 610 620 630 640 650 660 CLDLPGAFLC LCRPGFTGQL CEVPLCSPIL CQPGQQCQDQ EHRAPCLCPD GSPGCVPAED 670 680 690 700 710 720 DCPCHHGHCQ RSLCVCNEGW TGPECETELG GCLSTPCAHG GTCHPQPSGY NCSCLAGYTG 730 740 750 760 770 780 LTCSEEITAC HSGPCLNGGS CSIHPEGYSC TCPPSHTGPH CQTAVDHCAS ASCLNGGTCM 790 800 810 820 830 840 SKPGTFFCHC ATGFQGLHCE KKIHPSCADN PCRNKATCQD TPRGARCLCS PGYTGSSCQT 850 860 870 880 890 900 LIDLCARKPC PHTARCLQSG PSFHCLCHQG WTGSLCDLPL SCQAAAMSQG VEISNLCQNG 910 920 930 940 950 960 GLCIDTGSSY FCRCPPGFEG KLCQDTVNPC TSKPCLHGAT CVPQPNGYVC QCAPGYEGQN 970 980 990 1000 1010 1020 CSKVHDACQS GPCHNHGTCT PRPGGFHCAC PPGFVGLRCE GDVDECLDRP CHPSGTASCH 1030 1040 1050 1060 1070 1080 SLANAFYCQC LPGHTGQRCE VEMDLCQSQP CSNGGSCEVT TGPPPGFTCR CPEGFEGPTC 1090 1100 1110 1120 1130 1140 SRKAPACGNH HCHNGGLCLP SPKPGSPPLC ACLSGFGGPD CLTPPAPPGC GPPSPCMHNG 1150 1160 1170 1180 1190 1200 SCTETPGLGN PGFQCTCPPD SPGPRCQRPG ANGCEGRGGD GACDAGCSGP GGDWDGGDCS 1210 1220 1230 1240 1250 1260 LGVPDPWKGC PPHSQCWLLF RDGRCHPQCD SEECLFDGYD CEIPPTCTPA YDQYCRDHFH 1270 1280 1290 1300 1310 1320 NGHCEKGCNN AQCGWDGGDC RPEGDDSEGG PSLALLVVLS PPALDQQLLA LARVLSLTLR 1330 1340 1350 1360 1370 1380 VGLWVRKDSE GRNMVFPYPG TRAKEELSGT RDSSSWERQA PHTQTPGKET ESLGAGFVVV 1390 1400 1410 1420 1430 1440 MGVDLSRCGP EHPASRCPRD SGLLLRFLAA MAAVGALEPL LPGPLLAAHP QAGTGSPATR 1450 1460 1470 1480 1490 1500 LPWPILCSPV VGVLLLALGA LLVLQLIRRR RREHGALWLP PGFIRRPQTQ QAPHRRRPPL 1510 1520 1530 1540 1550 1560 GEDNIGLKAL KPEAEVDEDG VVMCSGPEEG EAEKTASASR CQLWPLRSGC EGLPQAVMLT 1570 1580 1590 1600 1610 1620 PPQECESELP DSDTCGPDGV TPLMSAVFCG GVQSTTVQRL GLGNPEPWEP LLDRGACPQA 1630 1640 1650 1660 1670 1680 HTVGTGETPL HLAARFSRPT AARRLLEAGA NPNQPDRAGR TPLHTAVAAD AREVCQLLLA 1690 1700 1710 1720 1730 1740 SRQTAVDART DDGTTPLMLA ARLAVEDLVE ELIAARADVG ARDKRGKTAL HWAAAVNNAR 1750 1760 1770 1780 1790 1800 AARCLLQTGA DKDAQDSREQ TPLFLAAREG AVEVAQLLLE IGAARGLRDQ AGLAPADVAR 1810 1820 1830 1840 1850 1860 QRSHWDLLTL LEGAGPITQE ARSHARNTPG GGAAPRCRTL SAGARPRGGG ACLQARTWSV 1870 1880 1890 1900 1910 1920 DLGARRGAVY ARCRSRSGGS GGPSMRGRRL SADSRGRRGA RVSQDDWPRD WVALEACGSA 1930 1940 1950 1960 CSAPIPPPSL TPSPERGSPQ VSWGLPVHQE VPLNSGGRNQ N

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	Boehm S., Borzym K., Gelling S., Gimmel V., Heitmann K., Kosiura A., Lang N., Lehrack S., Thiel J., Sontag M., Hurt P., Himmelbauer H., Sudbrak R., Reinhardt R. Submitted (DEC-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Strain: Brown Norway EMBL CAE83957.1.
[2]	"The genomic sequence and comparative analysis of the rat major histocompatibility complex." Hurt P., Walter L., Sudbrak R., Klages S., Mueller I., Shiina T., Inoko H., Lehrach H., Guenther E., Reinhardt R., Himmelbauer H. Genome Res. 14:631-639(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: Brown Norway EMBL CAE83957.1.
[3]	"Genome sequence of the Brown Norway rat yields insights into mammalian evolution." Rat Genome Sequencing Project Consortium Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., Morgan M. , Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., Collins F.S. Nature 428:493-521(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Brown Norway Ensembl ENSRNOP00000000513.
[4]	"Gene and alternative splicing annotation with AIR." Florea L., Di Francesco V., Miller J., Turner R., Yao A., Harris M., Walenz B., Mobarry C., Merkulov G.V., Charlab R., Dew I., Deng Z., Istrail S., Li P., Sutton G. Genome Res. 15:54-66(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: BN EMBL EDL83377.1.
[5]	Mural R.J., Li P.W., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S.H., Dew I., Evans C.A., Ferriera S., Flanigan M., Fosler C., Glodek A., Gu Z., Holt R.A., Jennings D., Kraft C.L., Lu F. , Nguyen T., Nusskern D.R., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Wang Z., Woodage T., Zheng X.H., Zhong F. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Strain: BN EMBL EDL83377.1.
[6]	Ensembl Submitted (FEB-2012) to UniProtKB Cited for: IDENTIFICATION. Strain: Brown Norway Ensembl ENSRNOP00000000513.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AABR06099863 Genomic DNA. No translation available. BX883044 Genomic DNA. Translation: CAE83957.1. CH474121 Genomic DNA. Translation: EDL83377.1.
IPI	IPI00215401.
RefSeq	NP_001002827.1. NM_001002827.1.
UniGene	Rn.12967.
3D structure databases
SMR	Q6MG89. Positions 429-544, 1606-1812.
ModBase	Search...
Protein-protein interaction databases
STRING	10116.ENSRNOP00000000513.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSRNOT00000000513; ENSRNOP00000000513; ENSRNOG00000000442.
GeneID	406162.
KEGG	rno:406162.
UCSC	RGD:1303282. rat.
Organism-specific databases
CTD	4855.
RGD	1303282. Notch4.
Phylogenomic databases
eggNOG	COG0666.
GeneTree	ENSGT00690000101660.
HOGENOM	HOG000234369.
HOVERGEN	HBG052650.
InParanoid	Q6MG89.
KO	K02599.
OMA	ACPQAHT.
OrthoDB	EOG437RD0.
Gene expression databases
Genevestigator	Q6MG89.
Family and domain databases
Gene3D	1.25.40.20. 1 hit.
InterPro	IPR002110. Ankyrin_rpt. IPR020683. Ankyrin_rpt-contain_dom. IPR000742. EG-like_dom. IPR001881. EGF-like_Ca-bd. IPR013032. EGF-like_CS. IPR000152. EGF-type_Asp/Asn_hydroxyl_site. IPR018097. EGF_Ca-bd_CS. IPR003645. Fol_N. IPR008297. Notch. IPR022355. Notch_4. IPR000800. Notch_dom. IPR011656. Notch_NODP_dom. [Graphical view]
Pfam	PF12796. Ank_2. 2 hits. PF00008. EGF. 14 hits. PF07645. EGF_CA. 3 hits. PF12661. hEGF. 3 hits. PF07684. NODP. 1 hit. PF00066. Notch. 3 hits. [Graphical view]
PIRSF	PIRSF002279. Notch. 1 hit.
PRINTS	PR01452. LNOTCHREPEAT. PR01987. NOTCH4.
SMART	SM00248. ANK. 5 hits. SM00181. EGF. 15 hits. SM00179. EGF_CA. 12 hits. SM00274. FOLN. 6 hits. SM00004. NL. 3 hits. [Graphical view]
SUPFAM	SSF48403. ANK. 1 hit. SSF90193. Notch_region. 2 hits.
PROSITE	PS50297. ANK_REP_REGION. 1 hit. PS50088. ANK_REPEAT. 5 hits. PS00010. ASX_HYDROXYL. 10 hits. PS00022. EGF_1. 28 hits. PS01186. EGF_2. 21 hits. PS50026. EGF_3. 27 hits. PS01187. EGF_CA. 9 hits. PS50258. LNR. 3 hits. [Graphical view]
ProtoNet	Search...
Other
NextBio	696070.

Entry information

Entry name

Q6MG89_RAT

Accession

Primary (citable) accession number: Q6MG89

Entry history

Integrated into UniProtKB/TrEMBL:	July 5, 2004
Last sequence update:	July 5, 2004
Last modified:	May 29, 2013
This is version 78 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)