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Q6MG89 (Q6MG89_RAT) Unreviewed, UniProtKB/TrEMBL

Last modified April 16, 2014. Version 85. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein names

Notch homolog 4, isoform CRA_b EMBL EDL83377.1

Protein Notch4 Ensembl ENSRNOP00000000513
Gene names
Name:Notch4 RGD 1303282 Ensembl ENSRNOP00000000513 EMBL CAE83957.1
Synonyms:Ager RGD 69258, Btnl6 RGD 1588460, Cyp21a1-ps RGD 1303332, Ng5 RGD 1359348, Rnf5 RGD 1588458, Stk19-ps RGD 1588459, Tnx RGD 1594402
ORF Names:rCG_38227 EMBL EDL83377.1
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length1961 AA.
Sequence statusComplete.
Protein existencePredicted

General annotation (Comments)

Sequence similarities

Contains 5 ANK repeats. RuleBase RU003321

Sequences

Sequence LengthMass (Da)Tools
Q6MG89 [UniParc].

Last modified July 5, 2004. Version 1.
Checksum: 5B1034E29EE07A3C

FASTA1,961206,076
        10         20         30         40         50         60 
MQRQWLLLLL LPLSFPVILT RELLCGGSPE PCANGGTCLR LSQGQGTCQC APGFLGETCQ 

        70         80         90        100        110        120 
FPDPCWDTQL CENGGSCQAL LPTAPSSHSP TSPLTPHFSC TCPSGFTGDR CQSPLEELCP 

       130        140        150        160        170        180 
PSFCSNGGHC SVQVSGRPQC SCEPGWTGEQ CQLRDFCSAN PCANGGVCLA TYPQIQCRCP 

       190        200        210        220        230        240 
TGFEGHICER DVNECFLEPG PCPRGTSCHN TLGSFQCLCP VGQEGPQCKL RKGACLPGTC 

       250        260        270        280        290        300 
LNGGTCQLVP EGDTTFHLCL CPPGFTGLNC EMNPDDCVRN QCQNGATCQD GLGTYTCLCP 

       310        320        330        340        350        360 
KTWKGWDCSE DIDECEAQGP PRCRNGGTCQ NSAGGFHCVC VSGWGGEGCD ENLDDCAAAT 

       370        380        390        400        410        420 
CALGSTCIDR VGSFSCLCPP GRTGLLCHLE DMCLRQPCHV NAQCSTNPLT GSTLCICQPG 

       430        440        450        460        470        480 
YSGPTCHQDL DECQMAQQGP SPCEHGGSCI NTPGSFNCLC LPGYTGSRCE ADHNECLSQP 

       490        500        510        520        530        540 
CHPGSTCLDL LATFQCLCPP GLEGRLCEVE INECASNPCL NQAACHDQLN GFLCLCLPGF 

       550        560        570        580        590        600 
TGARCEKDMD ECSSAPCANG GHCQDQPGAF HCECLPGFEG PRCETEADEC RSDPCPVGAS 

       610        620        630        640        650        660 
CLDLPGAFLC LCRPGFTGQL CEVPLCSPIL CQPGQQCQDQ EHRAPCLCPD GSPGCVPAED 

       670        680        690        700        710        720 
DCPCHHGHCQ RSLCVCNEGW TGPECETELG GCLSTPCAHG GTCHPQPSGY NCSCLAGYTG 

       730        740        750        760        770        780 
LTCSEEITAC HSGPCLNGGS CSIHPEGYSC TCPPSHTGPH CQTAVDHCAS ASCLNGGTCM 

       790        800        810        820        830        840 
SKPGTFFCHC ATGFQGLHCE KKIHPSCADN PCRNKATCQD TPRGARCLCS PGYTGSSCQT 

       850        860        870        880        890        900 
LIDLCARKPC PHTARCLQSG PSFHCLCHQG WTGSLCDLPL SCQAAAMSQG VEISNLCQNG 

       910        920        930        940        950        960 
GLCIDTGSSY FCRCPPGFEG KLCQDTVNPC TSKPCLHGAT CVPQPNGYVC QCAPGYEGQN 

       970        980        990       1000       1010       1020 
CSKVHDACQS GPCHNHGTCT PRPGGFHCAC PPGFVGLRCE GDVDECLDRP CHPSGTASCH 

      1030       1040       1050       1060       1070       1080 
SLANAFYCQC LPGHTGQRCE VEMDLCQSQP CSNGGSCEVT TGPPPGFTCR CPEGFEGPTC 

      1090       1100       1110       1120       1130       1140 
SRKAPACGNH HCHNGGLCLP SPKPGSPPLC ACLSGFGGPD CLTPPAPPGC GPPSPCMHNG 

      1150       1160       1170       1180       1190       1200 
SCTETPGLGN PGFQCTCPPD SPGPRCQRPG ANGCEGRGGD GACDAGCSGP GGDWDGGDCS 

      1210       1220       1230       1240       1250       1260 
LGVPDPWKGC PPHSQCWLLF RDGRCHPQCD SEECLFDGYD CEIPPTCTPA YDQYCRDHFH 

      1270       1280       1290       1300       1310       1320 
NGHCEKGCNN AQCGWDGGDC RPEGDDSEGG PSLALLVVLS PPALDQQLLA LARVLSLTLR 

      1330       1340       1350       1360       1370       1380 
VGLWVRKDSE GRNMVFPYPG TRAKEELSGT RDSSSWERQA PHTQTPGKET ESLGAGFVVV 

      1390       1400       1410       1420       1430       1440 
MGVDLSRCGP EHPASRCPRD SGLLLRFLAA MAAVGALEPL LPGPLLAAHP QAGTGSPATR 

      1450       1460       1470       1480       1490       1500 
LPWPILCSPV VGVLLLALGA LLVLQLIRRR RREHGALWLP PGFIRRPQTQ QAPHRRRPPL 

      1510       1520       1530       1540       1550       1560 
GEDNIGLKAL KPEAEVDEDG VVMCSGPEEG EAEKTASASR CQLWPLRSGC EGLPQAVMLT 

      1570       1580       1590       1600       1610       1620 
PPQECESELP DSDTCGPDGV TPLMSAVFCG GVQSTTVQRL GLGNPEPWEP LLDRGACPQA 

      1630       1640       1650       1660       1670       1680 
HTVGTGETPL HLAARFSRPT AARRLLEAGA NPNQPDRAGR TPLHTAVAAD AREVCQLLLA 

      1690       1700       1710       1720       1730       1740 
SRQTAVDART DDGTTPLMLA ARLAVEDLVE ELIAARADVG ARDKRGKTAL HWAAAVNNAR 

      1750       1760       1770       1780       1790       1800 
AARCLLQTGA DKDAQDSREQ TPLFLAAREG AVEVAQLLLE IGAARGLRDQ AGLAPADVAR 

      1810       1820       1830       1840       1850       1860 
QRSHWDLLTL LEGAGPITQE ARSHARNTPG GGAAPRCRTL SAGARPRGGG ACLQARTWSV 

      1870       1880       1890       1900       1910       1920 
DLGARRGAVY ARCRSRSGGS GGPSMRGRRL SADSRGRRGA RVSQDDWPRD WVALEACGSA 

      1930       1940       1950       1960 
CSAPIPPPSL TPSPERGSPQ VSWGLPVHQE VPLNSGGRNQ N 

« Hide

References

« Hide 'large scale' references
[1]Boehm S., Borzym K., Gelling S., Gimmel V., Heitmann K., Kosiura A., Lang N., Lehrack S., Thiel J., Sontag M., Hurt P., Himmelbauer H., Sudbrak R., Reinhardt R.
Submitted (DEC-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
Strain: Brown Norway EMBL CAE83957.1.
[2]"The genomic sequence and comparative analysis of the rat major histocompatibility complex."
Hurt P., Walter L., Sudbrak R., Klages S., Mueller I., Shiina T., Inoko H., Lehrach H., Guenther E., Reinhardt R., Himmelbauer H.
Genome Res. 14:631-639(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: Brown Norway EMBL CAE83957.1.
[3]"Genome sequence of the Brown Norway rat yields insights into mammalian evolution."
Rat Genome Sequencing Project Consortium
Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., Morgan M. expand/collapse author list , Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., Collins F.S.
Nature 428:493-521(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Brown Norway Ensembl ENSRNOP00000000513.
[4]"Gene and alternative splicing annotation with AIR."
Florea L., Di Francesco V., Miller J., Turner R., Yao A., Harris M., Walenz B., Mobarry C., Merkulov G.V., Charlab R., Dew I., Deng Z., Istrail S., Li P., Sutton G.
Genome Res. 15:54-66(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: BN EMBL EDL83377.1.
[5]Mural R.J., Li P.W., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S.H., Dew I., Evans C.A., Ferriera S., Flanigan M., Fosler C., Glodek A., Gu Z., Holt R.A., Jennings D., Kraft C.L., Lu F. expand/collapse author list , Nguyen T., Nusskern D.R., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Wang Z., Woodage T., Zheng X.H., Zhong F.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
Strain: BN EMBL EDL83377.1.
[6]Ensembl
Submitted (FEB-2012) to UniProtKB
Cited for: IDENTIFICATION.
Strain: Brown Norway Ensembl ENSRNOP00000000513.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AABR06099863 Genomic DNA. No translation available.
BX883044 Genomic DNA. Translation: CAE83957.1.
CH474121 Genomic DNA. Translation: EDL83377.1.
RefSeqNP_001002827.1. NM_001002827.1.
UniGeneRn.12967.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10116.ENSRNOP00000000513.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSRNOT00000000513; ENSRNOP00000000513; ENSRNOG00000000442.
GeneID406162.
KEGGrno:406162.
UCSCRGD:1303282. rat.

Organism-specific databases

CTD4855.
RGD1303282. Notch4.

Phylogenomic databases

eggNOGCOG0666.
GeneTreeENSGT00730000110611.
HOGENOMHOG000234369.
HOVERGENHBG052650.
InParanoidQ6MG89.
KOK02599.
OMAEGHACEH.
OrthoDBEOG7992RD.
TreeFamTF351641.

Gene expression databases

GenevestigatorQ6MG89.

Family and domain databases

Gene3D1.25.40.20. 1 hit.
InterProIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR000742. EG-like_dom.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR018097. EGF_Ca-bd_CS.
IPR003645. Fol_N.
IPR009030. Growth_fac_rcpt_N_dom.
IPR008297. Notch.
IPR022355. Notch_4.
IPR000800. Notch_dom.
IPR011656. Notch_NODP_dom.
[Graphical view]
PfamPF12796. Ank_2. 2 hits.
PF00008. EGF. 14 hits.
PF07645. EGF_CA. 3 hits.
PF12661. hEGF. 3 hits.
PF07684. NODP. 1 hit.
PF00066. Notch. 3 hits.
[Graphical view]
PIRSFPIRSF002279. Notch. 1 hit.
PRINTSPR01452. LNOTCHREPEAT.
PR01987. NOTCH4.
SMARTSM00248. ANK. 5 hits.
SM00181. EGF. 15 hits.
SM00179. EGF_CA. 12 hits.
SM00274. FOLN. 6 hits.
SM00004. NL. 3 hits.
[Graphical view]
SUPFAMSSF48403. SSF48403. 1 hit.
SSF57184. SSF57184. 3 hits.
SSF90193. SSF90193. 2 hits.
PROSITEPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 5 hits.
PS00010. ASX_HYDROXYL. 10 hits.
PS00022. EGF_1. 28 hits.
PS01186. EGF_2. 21 hits.
PS50026. EGF_3. 27 hits.
PS01187. EGF_CA. 9 hits.
PS50258. LNR. 3 hits.
[Graphical view]
ProtoNetSearch...

Other

NextBio696070.
PROQ6MG89.

Entry information

Entry nameQ6MG89_RAT
AccessionPrimary (citable) accession number: Q6MG89
Entry history
Integrated into UniProtKB/TrEMBL: July 5, 2004
Last sequence update: July 5, 2004
Last modified: April 16, 2014
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)