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Protein
Submitted name:

Advanced glycosylation end product-specific receptor

Gene

Ager

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionReceptorImported

Enzyme and pathway databases

ReactomeiR-RNO-1810476 RIP-mediated NFkB activation via ZBP1
R-RNO-3134963 DEx/H-box helicases activate type I IFN and inflammatory cytokines production
R-RNO-445989 TAK1 activates NFkB by phosphorylation and activation of IKKs complex
R-RNO-879415 Advanced glycosylation endproduct receptor signaling
R-RNO-933542 TRAF6 mediated NF-kB activation

Names & Taxonomyi

Protein namesi
Submitted name:
Advanced glycosylation end product-specific receptorImported
Submitted name:
Advanced glycosylation end product-specific receptor, isoform CRA_aImported
Gene namesi
Name:AgerImported
Synonyms:Btnl6Imported, Cyp21a1-psImported, Ng5Imported, Rnf5Imported, Stk19-psImported, TnxImported
ORF Names:rCG_38231Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi

Organism-specific databases

RGDi69258 Ager

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei339 – 361HelicalSequence analysisAdd BLAST23

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
ChainiPRO_501431053123 – 402Sequence analysisAdd BLAST380

Keywords - PTMi

Disulfide bondSAAS annotation

Expressioni

Gene expression databases

BgeeiENSRNOG00000000439
ExpressionAtlasiQ6MG86 baseline and differential

Interactioni

GO - Molecular functioni

Structurei

3D structure databases

SMRiQ6MG86
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 109Ig-likeInterPro annotationAdd BLAST108
Domaini123 – 219Ig-likeInterPro annotationAdd BLAST97
Domaini233 – 315Ig-likeInterPro annotationAdd BLAST83

Keywords - Domaini

Immunoglobulin domainSAAS annotation, RepeatSAAS annotation, SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiENOG410IVT2 Eukaryota
ENOG4111C4I LUCA
GeneTreeiENSGT00890000139566
HOVERGENiHBG004350
KOiK19722
OMAiPNKVGTC
OrthoDBiEOG091G0BCY
TreeFamiTF337155

Family and domain databases

Gene3Di2.60.40.10, 3 hits
InterProiView protein in InterPro
IPR013162 CD80_C2-set
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003006 Ig/MHC_CS
IPR003599 Ig_sub
IPR003598 Ig_sub2
PfamiView protein in Pfam
PF08205 C2-set_2, 1 hit
PF13895 Ig_2, 1 hit
SMARTiView protein in SMART
SM00409 IG, 2 hits
SM00408 IGc2, 2 hits
SUPFAMiSSF48726 SSF48726, 3 hits
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 3 hits
PS00290 IG_MHC, 1 hit

Sequencei

Sequence statusi: Complete.

Q6MG86-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPTGTVARAW VLVLALWGAV AGGQNITARI GEPLMLSCKG APKKPTQKLE
60 70 80 90 100
WKLNTGRTEA WKVLSPQGDP WDSVARILPN GSLLLPAIGI VDEGTFRCRA
110 120 130 140 150
TNRLGKEVKS NYRVRVYQIP GKPEIVNPAS ELTANVPNKV GTCVSEGSYP
160 170 180 190 200
AGTLSWHLDG KPLIPDGKGT VVKEETRRHP ETGLFTLRSE LTVTPAQGGT
210 220 230 240 250
TPTYSCSFSL GLPRHRPLNT APIQPRVREP LPPEGIQLLV EPEGGTVAPG
260 270 280 290 300
GTVTLTCAIS AQPPPQIHWI KDGTPLPLAP SPVLLLPEVG HEDEGIYSCV
310 320 330 340 350
ATHPSHGPQE SPPVNIRVTE TGDEGQAAGS VDGSGLGTLA LALGILGGLG
360 370 380 390 400
IAALLIGAIL WRKRQPRLEE RKAPESQEDE EERAELNQSE EAEMPENGAG

GP
Length:402
Mass (Da):42,645
Last modified:July 5, 2004 - v1
Checksum:iCEA49453C05E1CA1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR07044388 Genomic DNA No translation available.
BC084697 mRNA Translation: AAH84697.1
BX883044 Genomic DNA Translation: CAE83960.1
CH474121 Genomic DNA Translation: EDL83392.1
RefSeqiNP_445788.2, NM_053336.2
UniGeneiRn.9829

Genome annotation databases

EnsembliENSRNOT00000000508; ENSRNOP00000000508; ENSRNOG00000000439
GeneIDi81722
KEGGirno:81722

Entry informationi

Entry nameiQ6MG86_RAT
AccessioniPrimary (citable) accession number: Q6MG86
Entry historyiIntegrated into UniProtKB/TrEMBL: July 5, 2004
Last sequence update: July 5, 2004
Last modified: May 23, 2018
This is version 140 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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