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Protein

FK506-binding protein-like

Gene

Fkbpl

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May be involved in response to X-ray. Regulates p21 protein stability by binding to Hsp90 and p21.By similarity

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-RNO-8852276 The role of GTSE1 in G2/M progression after G2 checkpoint

Names & Taxonomyi

Protein namesi
Recommended name:
FK506-binding protein-like
Alternative name(s):
WAF-1/CIP1 stabilizing protein 39
Short name:
WISp39
Gene namesi
Name:Fkbpl
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi

Organism-specific databases

RGDi1303227 Fkbpl

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002898801 – 347FK506-binding protein-likeAdd BLAST347

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei3PhosphothreonineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ6MG81
PRIDEiQ6MG81

Expressioni

Gene expression databases

BgeeiENSRNOG00000000432
GenevisibleiQ6MG81 RN

Interactioni

Subunit structurei

Forms a ternary complex with CDKN1A/p21 and HSP90AB1/Hsp90.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000000494

Structurei

3D structure databases

ProteinModelPortaliQ6MG81
SMRiQ6MG81
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati208 – 241TPR 1Add BLAST34
Repeati250 – 283TPR 2Add BLAST34
Repeati284 – 317TPR 3Add BLAST34

Keywords - Domaini

Repeat, TPR repeat

Phylogenomic databases

eggNOGiKOG1124 Eukaryota
COG0457 LUCA
GeneTreeiENSGT00760000119159
HOGENOMiHOG000272638
HOVERGENiHBG099465
InParanoidiQ6MG81
KOiK20097
OMAiLESMCQG
OrthoDBiEOG091G0G4G
PhylomeDBiQ6MG81
TreeFamiTF105297

Family and domain databases

Gene3Di1.25.40.10, 1 hit
InterProiView protein in InterPro
IPR023566 PPIase_FKBP
IPR013026 TPR-contain_dom
IPR011990 TPR-like_helical_dom_sf
IPR001440 TPR_1
IPR019734 TPR_repeat
PANTHERiPTHR43811 PTHR43811, 1 hit
PfamiView protein in Pfam
PF00515 TPR_1, 1 hit
SMARTiView protein in SMART
SM00028 TPR, 3 hits
SUPFAMiSSF48452 SSF48452, 1 hit
PROSITEiView protein in PROSITE
PS50005 TPR, 2 hits
PS50293 TPR_REGION, 1 hit

Sequencei

Sequence statusi: Complete.

Q6MG81-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
METSLISPMK ENNTAQPQQR EENTQQNLNA AVPIKQQSPG LLPEALEVGV
60 70 80 90 100
KPDPASQILA TQEIENPVAG FEGDSDKFHI STDEMAEHLQ ASDLWYCPDG
110 120 130 140 150
SFVKKIIVHG HGLDKPKLGS KCRVLALGFP FGSGMPEGWT ELTIGTGQWR
160 170 180 190 200
EKTWGELTEK CLESMRQGEE AKIHLPGSST PLAKLRLDSF TNGRDSWELE
210 220 230 240 250
AVEKEALAKE EHRRGTELFR AGNPQGAARC YGRALRLLLT LPPPGPPERT
260 270 280 290 300
ILHANLAACQ LLLGHPQLAA QSCDRVLERE PGHLKALYRR GVAQAALGDL
310 320 330 340
DKATADLKKV LAVDPKNRAA KEELGKVVIQ GKIQDAGLAR GLRKMFS
Length:347
Mass (Da):37,960
Last modified:July 5, 2004 - v1
Checksum:iFC519CC9F6774C29
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX883044 Genomic DNA Translation: CAE83965.1
BC086532 mRNA Translation: AAH86532.1
RefSeqiNP_001002818.1, NM_001002818.2
UniGeneiRn.54367

Genome annotation databases

EnsembliENSRNOT00000000494; ENSRNOP00000000494; ENSRNOG00000000432
GeneIDi406168
KEGGirno:406168
UCSCiRGD:1303227 rat

Entry informationi

Entry nameiFKBPL_RAT
AccessioniPrimary (citable) accession number: Q6MG81
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: July 5, 2004
Last modified: May 23, 2018
This is version 101 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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