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Protein

FK506-binding protein-like

Gene

Fkbpl

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in response to X-ray. Regulates p21 protein stability by binding to Hsp90 and p21.By similarity

Names & Taxonomyi

Protein namesi
Recommended name:
FK506-binding protein-like
Alternative name(s):
WAF-1/CIP1 stabilizing protein 39
Short name:
WISp39
Gene namesi
Name:Fkbpl
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 20

Organism-specific databases

RGDi1303227. Fkbpl.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 347347FK506-binding protein-likePRO_0000289880Add
BLAST

Proteomic databases

PaxDbiQ6MG81.
PRIDEiQ6MG81.

Expressioni

Gene expression databases

GenevisibleiQ6MG81. RN.

Interactioni

Subunit structurei

Forms a ternary complex with CDKN1A/p21 and HSP90AB1/Hsp90.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000000494.

Structurei

3D structure databases

ProteinModelPortaliQ6MG81.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati208 – 24134TPR 1Add
BLAST
Repeati250 – 28334TPR 2Add
BLAST
Repeati284 – 31734TPR 3Add
BLAST

Sequence similaritiesi

Contains 3 TPR repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, TPR repeat

Phylogenomic databases

eggNOGiKOG1124. Eukaryota.
COG0457. LUCA.
GeneTreeiENSGT00680000100108.
HOGENOMiHOG000272638.
HOVERGENiHBG099465.
InParanoidiQ6MG81.
OMAiDSWELEA.
OrthoDBiEOG7HTHHD.
PhylomeDBiQ6MG81.
TreeFamiTF105297.

Family and domain databases

Gene3Di1.25.40.10. 1 hit.
InterProiIPR023566. PPIase_FKBP.
IPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical_dom.
IPR001440. TPR_1.
IPR019734. TPR_repeat.
[Graphical view]
PANTHERiPTHR10516. PTHR10516. 2 hits.
PfamiPF00515. TPR_1. 1 hit.
[Graphical view]
SMARTiSM00028. TPR. 3 hits.
[Graphical view]
SUPFAMiSSF48452. SSF48452. 1 hit.
PROSITEiPS50005. TPR. 2 hits.
PS50293. TPR_REGION. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6MG81-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
METSLISPMK ENNTAQPQQR EENTQQNLNA AVPIKQQSPG LLPEALEVGV
60 70 80 90 100
KPDPASQILA TQEIENPVAG FEGDSDKFHI STDEMAEHLQ ASDLWYCPDG
110 120 130 140 150
SFVKKIIVHG HGLDKPKLGS KCRVLALGFP FGSGMPEGWT ELTIGTGQWR
160 170 180 190 200
EKTWGELTEK CLESMRQGEE AKIHLPGSST PLAKLRLDSF TNGRDSWELE
210 220 230 240 250
AVEKEALAKE EHRRGTELFR AGNPQGAARC YGRALRLLLT LPPPGPPERT
260 270 280 290 300
ILHANLAACQ LLLGHPQLAA QSCDRVLERE PGHLKALYRR GVAQAALGDL
310 320 330 340
DKATADLKKV LAVDPKNRAA KEELGKVVIQ GKIQDAGLAR GLRKMFS
Length:347
Mass (Da):37,960
Last modified:July 5, 2004 - v1
Checksum:iFC519CC9F6774C29
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX883044 Genomic DNA. Translation: CAE83965.1.
BC086532 mRNA. Translation: AAH86532.1.
RefSeqiNP_001002818.1. NM_001002818.2.
UniGeneiRn.54367.

Genome annotation databases

EnsembliENSRNOT00000000494; ENSRNOP00000000494; ENSRNOG00000000432.
GeneIDi406168.
KEGGirno:406168.
UCSCiRGD:1303227. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX883044 Genomic DNA. Translation: CAE83965.1.
BC086532 mRNA. Translation: AAH86532.1.
RefSeqiNP_001002818.1. NM_001002818.2.
UniGeneiRn.54367.

3D structure databases

ProteinModelPortaliQ6MG81.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000000494.

Proteomic databases

PaxDbiQ6MG81.
PRIDEiQ6MG81.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000000494; ENSRNOP00000000494; ENSRNOG00000000432.
GeneIDi406168.
KEGGirno:406168.
UCSCiRGD:1303227. rat.

Organism-specific databases

CTDi63943.
RGDi1303227. Fkbpl.

Phylogenomic databases

eggNOGiKOG1124. Eukaryota.
COG0457. LUCA.
GeneTreeiENSGT00680000100108.
HOGENOMiHOG000272638.
HOVERGENiHBG099465.
InParanoidiQ6MG81.
OMAiDSWELEA.
OrthoDBiEOG7HTHHD.
PhylomeDBiQ6MG81.
TreeFamiTF105297.

Miscellaneous databases

NextBioi696090.
PROiQ6MG81.

Gene expression databases

GenevisibleiQ6MG81. RN.

Family and domain databases

Gene3Di1.25.40.10. 1 hit.
InterProiIPR023566. PPIase_FKBP.
IPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical_dom.
IPR001440. TPR_1.
IPR019734. TPR_repeat.
[Graphical view]
PANTHERiPTHR10516. PTHR10516. 2 hits.
PfamiPF00515. TPR_1. 1 hit.
[Graphical view]
SMARTiSM00028. TPR. 3 hits.
[Graphical view]
SUPFAMiSSF48452. SSF48452. 1 hit.
PROSITEiPS50005. TPR. 2 hits.
PS50293. TPR_REGION. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The genomic sequence and comparative analysis of the rat major histocompatibility complex."
    Hurt P., Walter L., Sudbrak R., Klages S., Mueller I., Shiina T., Inoko H., Lehrach H., Guenther E., Reinhardt R., Himmelbauer H.
    Genome Res. 14:631-639(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Brown Norway.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Ovary.

Entry informationi

Entry nameiFKBPL_RAT
AccessioniPrimary (citable) accession number: Q6MG81
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: July 5, 2004
Last modified: May 11, 2016
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.