ID   Q6MG72_RAT              Unreviewed;      1263 AA.
AC   Q6MG72; F1M7S8;
DT   05-JUL-2004, integrated into UniProtKB/TrEMBL.
DT   05-JUL-2004, sequence version 1.
DT   24-JAN-2024, entry version 166.
DE   SubName: Full=HLA-B associated transcript 8, rat orthologue {ECO:0000313|EMBL:CAE83974.1};
GN   Name=Ehmt2 {ECO:0000313|RGD:1302972};
GN   Synonyms=Apom {ECO:0000313|RGD:1302972}, Bat4
GN   {ECO:0000313|RGD:1302972}, Bat8 {ECO:0000313|EMBL:CAE83974.1}, C2
GN   {ECO:0000313|RGD:1302972}, C4a {ECO:0000313|RGD:1302972}, Cfb
GN   {ECO:0000313|RGD:1302972}, Csnk2b {ECO:0000313|RGD:1302972}, G7e
GN   {ECO:0000313|RGD:1302972}, Hspa1a {ECO:0000313|RGD:1302972}, Hspa1b
GN   {ECO:0000313|RGD:1302972}, Hspa1l {ECO:0000313|RGD:1302972}, Ly6g5c
GN   {ECO:0000313|RGD:1302972}, Ly6g6c {ECO:0000313|RGD:1302972}, Neu1
GN   {ECO:0000313|RGD:1302972}, Ng35 {ECO:0000313|RGD:1302972}, Rps25-ps2
GN   {ECO:0000313|RGD:1302972}, Stk19 {ECO:0000313|RGD:1302972};
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116 {ECO:0000313|EMBL:CAE83974.1};
RN   [1] {ECO:0000313|EMBL:CAE83974.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Brown Norway {ECO:0000313|EMBL:CAE83974.1};
RA   Boehm S., Borzym K., Gelling S., Gimmel V., Heitmann K., Kosiura A.,
RA   Lang N., Lehrack S., Thiel J., Sontag M., Hurt P., Himmelbauer H.,
RA   Sudbrak R., Reinhardt R.;
RL   Submitted (DEC-2003) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:CAE83974.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Brown Norway {ECO:0000313|EMBL:CAE83974.1};
RX   PubMed=15060004; DOI=10.1101/gr.1987704;
RA   Hurt P., Walter L., Sudbrak R., Klages S., Mueller I., Shiina T., Inoko H.,
RA   Lehrach H., Guenther E., Reinhardt R., Himmelbauer H.;
RT   "The genomic sequence and comparative analysis of the rat major
RT   histocompatibility complex.";
RL   Genome Res. 14:631-639(2004).
RN   [3] {ECO:0007829|PubMed:22673903}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=22673903;
RA   Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A., Lundby C.,
RA   Olsen J.V.;
RT   "Quantitative maps of protein phosphorylation sites across 14 different rat
RT   organs and tissues.";
RL   Nat. Commun. 3:876-876(2012).
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DR   EMBL; BX883045; CAE83974.1; -; Genomic_DNA.
DR   RefSeq; NP_997628.1; NM_212463.1.
DR   AlphaFoldDB; Q6MG72; -.
DR   SMR; Q6MG72; -.
DR   IntAct; Q6MG72; 1.
DR   STRING; 10116.ENSRNOP00000042145; -.
DR   iPTMnet; Q6MG72; -.
DR   PhosphoSitePlus; Q6MG72; -.
DR   PaxDb; 10116-ENSRNOP00000042145; -.
DR   GeneID; 361798; -.
DR   KEGG; rno:361798; -.
DR   UCSC; RGD:1302972; rat.
DR   AGR; RGD:1302972; -.
DR   CTD; 10919; -.
DR   RGD; 1302972; Ehmt2.
DR   VEuPathDB; HostDB:ENSRNOG00000030630; -.
DR   eggNOG; KOG1082; Eukaryota.
DR   HOGENOM; CLU_005790_0_0_1; -.
DR   InParanoid; Q6MG72; -.
DR   OrthoDB; 5481936at2759; -.
DR   Reactome; R-RNO-2559582; Senescence-Associated Secretory Phenotype (SASP).
DR   Reactome; R-RNO-3214841; PKMTs methylate histone lysines.
DR   Reactome; R-RNO-6804760; Regulation of TP53 Activity through Methylation.
DR   Reactome; R-RNO-73762; RNA Polymerase I Transcription Initiation.
DR   Reactome; R-RNO-8953750; Transcriptional Regulation by E2F6.
DR   PRO; PR:Q6MG72; -.
DR   Bgee; ENSRNOG00000030630; Expressed in frontal cortex and 19 other cell types or tissues.
DR   ExpressionAtlas; Q6MG72; baseline and differential.
DR   GO; GO:0000785; C:chromatin; ISO:RGD.
DR   GO; GO:0005634; C:nucleus; ISO:RGD.
DR   GO; GO:0070742; F:C2H2 zinc finger domain binding; ISO:RGD.
DR   GO; GO:0046976; F:histone H3K27 methyltransferase activity; ISO:RGD.
DR   GO; GO:0140759; F:histone H3K56 methyltransferase activity; ISO:RGD.
DR   GO; GO:0046974; F:histone H3K9 methyltransferase activity; ISO:RGD.
DR   GO; GO:0002039; F:p53 binding; ISO:RGD.
DR   GO; GO:1990841; F:promoter-specific chromatin binding; ISO:RGD.
DR   GO; GO:0016279; F:protein-lysine N-methyltransferase activity; ISO:RGD.
DR   GO; GO:0000977; F:RNA polymerase II transcription regulatory region sequence-specific DNA binding; ISO:RGD.
DR   GO; GO:0001222; F:transcription corepressor binding; ISO:RGD.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0048148; P:behavioral response to cocaine; ISO:RGD.
DR   GO; GO:0071314; P:cellular response to cocaine; ISO:RGD.
DR   GO; GO:0009267; P:cellular response to starvation; ISO:RGD.
DR   GO; GO:0071466; P:cellular response to xenobiotic stimulus; IDA:RGD.
DR   GO; GO:0006306; P:DNA methylation; ISO:RGD.
DR   GO; GO:0010424; P:DNA methylation on cytosine within a CG sequence; ISO:RGD.
DR   GO; GO:0009566; P:fertilization; ISO:RGD.
DR   GO; GO:0031507; P:heterochromatin formation; IMP:GO_Central.
DR   GO; GO:0007616; P:long-term memory; IMP:RGD.
DR   GO; GO:1902902; P:negative regulation of autophagosome assembly; ISO:RGD.
DR   GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; ISO:RGD.
DR   GO; GO:0048665; P:neuron fate specification; ISO:RGD.
DR   GO; GO:0048599; P:oocyte development; ISO:RGD.
DR   GO; GO:0035265; P:organ growth; ISO:RGD.
DR   GO; GO:0036166; P:phenotypic switching; ISO:RGD.
DR   GO; GO:0044030; P:regulation of DNA methylation; IDA:RGD.
DR   GO; GO:0006275; P:regulation of DNA replication; ISO:RGD.
DR   GO; GO:0031399; P:regulation of protein modification process; IMP:RGD.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; ISO:RGD.
DR   GO; GO:0045471; P:response to ethanol; IEP:RGD.
DR   GO; GO:0060992; P:response to fungicide; IEP:RGD.
DR   GO; GO:0031667; P:response to nutrient levels; IEP:RGD.
DR   GO; GO:0007286; P:spermatid development; ISO:RGD.
DR   GO; GO:0007130; P:synaptonemal complex assembly; ISO:RGD.
DR   CDD; cd20905; EHMT_ZBD; 1.
DR   CDD; cd10533; SET_EHMT2; 1.
DR   Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 1.
DR   Gene3D; 2.170.270.10; SET domain; 1.
DR   InterPro; IPR002110; Ankyrin_rpt.
DR   InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR   InterPro; IPR043550; EHMT1/EHMT2.
DR   InterPro; IPR047762; EHMT_CRR.
DR   InterPro; IPR007728; Pre-SET_dom.
DR   InterPro; IPR001214; SET_dom.
DR   InterPro; IPR046341; SET_dom_sf.
DR   InterPro; IPR038034; SET_EHMT2.
DR   PANTHER; PTHR46307; G9A, ISOFORM B; 1.
DR   PANTHER; PTHR46307:SF1; HISTONE-LYSINE N-METHYLTRANSFERASE EHMT2; 1.
DR   Pfam; PF00023; Ank; 1.
DR   Pfam; PF12796; Ank_2; 2.
DR   Pfam; PF21533; EHMT1-2_CRR; 1.
DR   Pfam; PF05033; Pre-SET; 1.
DR   Pfam; PF00856; SET; 1.
DR   PRINTS; PR01415; ANKYRIN.
DR   SMART; SM00248; ANK; 6.
DR   SMART; SM00468; PreSET; 1.
DR   SMART; SM00317; SET; 1.
DR   SUPFAM; SSF48403; Ankyrin repeat; 1.
DR   SUPFAM; SSF82199; SET domain; 1.
DR   PROSITE; PS50297; ANK_REP_REGION; 4.
DR   PROSITE; PS50088; ANK_REPEAT; 5.
DR   PROSITE; PS50867; PRE_SET; 1.
DR   PROSITE; PS50280; SET; 1.
PE   1: Evidence at protein level;
KW   Chromosome {ECO:0000256|ARBA:ARBA00022454}.
SQ   SEQUENCE   1263 AA;  138100 MW;  86C615F048069B8E CRC64;
     MRGLPRGRGL MRARGRGRAA PTGGRGRGRG GAHRGRGRPR SLLSLPRAQA SWAPQLPAGL
     TGPPVPCLPS QGEAPAEMGA LLLEKEPRGA AERVHGSLGD TSHSEETLPK ANPDSLEPTG
     PSSPASVTVT VGDEGADTPV GATPLIGEEP ENLEGDGGRI LLGHATKSFP SSPSKGGACP
     SRAKMSMTGA GKSPPSVQSL AMRLLSMPGA QGAATAGPEP PPATTAGQEG QPKVHRARKT
     MSKPSNGQPP VPEKRPPEVQ HFRMSDDMHL GKVTSDVAKR RKLTSGSLSE DLGSAGGSGE
     VILEKGEPRP LEEWETVVGD DFSLYYDAYS VDERVDSDSK SEVEALAEQL SEEEEEEEEE
     EEEEEEEEEE EEEEEEDEES GNQSDRSGSS GRRKAKKKWR KDSPWVKPSR KRRKREPPRA
     KEPRGVNGVG SSGPSEYMEV PLGSLELPSE GTLSPNHAGV SNDTSSLETE RGFEELPLCS
     CRMEAPKIDR ISERAGHKCM ATESVDGELL GCNAAILKRE TMRPSSRVAL MVLCEAHRAR
     MVKHHCCPGC GYFCTAGTFL ECHPDFRVAH RFHKACVSQL NGMVFCPHCG EDASEAQEVT
     IPRGDGGTPP VGTVAPAPPP LAHDAPGRAD TSQPSARMRG HGEPRRPPCD PLADTIDSSG
     PSLTLPNGGC LSAVGLPPGP GREALEKALV IQESERRKKL RFHPRQLYLS VKQGELQKVI
     LMLLDNLDPN FQSDQQSKRT PLHAAAQKGS VEICHVLLQA GANINAVDKQ QRTPLMEAVV
     NNHLEVARYM VQLGGCVYSK EEDGSTCLHH AAKIGNLEMV SLLLSTGQVD VNAQDSGGWT
     PIIWAAEHKH IDVIRMLLTR GADVTLTDNE ENICLHWASF TGSAAIAEVL LNAQCDLHAV
     NYHGDTPLHI AARESYHDCV LLFLSRGANP ELRNKEGDTA WDLTPERSDV WFALQLNRKL
     RLGVGNRAVR TEKIICRDVA RGYENVPIPC VNGVDGEPCP EDYKYISENC ETSTMNIDRN
     ITHLQHCTCV DDCSSSNCLC GQLSIRCWYD KDGRLLQEFN KIEPPLIFEC NQACSCWRSC
     KNRVVQSGIK VRLQLYRTAK MGWGVRALQT IPQGTFICEY VGELISDAEA DVREDDSYLF
     DLDNKDGEVY CIDARYYGNI SRFINHLCDP NIIPVRVFML HQDLRFPRIA FFSSRDIRTG
     EELGFDYGDR FWDIKSKYFT CQCGSEKCKH SAEAIALEQS RLARLDPHPE LLPDLSSLPP
     INT
//