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Q6MG72

- Q6MG72_RAT

UniProt

Q6MG72 - Q6MG72_RAT

Protein
Submitted name:

HLA-B associated transcript 8, rat orthologue

Gene

Ehmt2

Organism
Rattus norvegicus (Rat)
Status
Unreviewed - Annotation score: 4 out of 5- Protein predictedi
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    • History
      Entry version 92 (01 Oct 2014)
      Sequence version 1 (05 Jul 2004)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].SAAS annotation
    S-adenosyl-L-methionine + histone L-lysine = S-adenosyl-L-homocysteine + histone N(6)-methyl-L-lysine.

    GO - Molecular functioni

    1. histone methyltransferase activity (H3-K27 specific) Source: Ensembl
    2. histone methyltransferase activity (H3-K9 specific) Source: Ensembl
    3. zinc ion binding Source: InterPro

    GO - Biological processi

    1. DNA methylation on cytosine within a CG sequence Source: Ensembl
    2. fertilization Source: Ensembl
    3. negative regulation of transcription from RNA polymerase II promoter Source: Ensembl
    4. organ growth Source: Ensembl
    5. peptidyl-lysine dimethylation Source: Ensembl
    6. regulation of DNA replication Source: Ensembl
    7. spermatid development Source: Ensembl
    8. synaptonemal complex assembly Source: Ensembl

    Keywords - Molecular functioni

    MethyltransferaseUniRule annotationSAAS annotation, Transferase

    Keywords - Ligandi

    S-adenosyl-L-methionineSAAS annotation

    Enzyme and pathway databases

    ReactomeiREACT_194748. Senescence-Associated Secretory Phenotype (SASP).
    REACT_206206. RNA Polymerase I Transcription Initiation.

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    HLA-B associated transcript 8, rat orthologueImported
    Submitted name:
    Protein Ehmt2Imported
    Gene namesi
    Name:Ehmt2Imported
    Synonyms:ApomImported, Bat4Imported, Bat8Imported, C2Imported, C4aImported, CfbImported, Csnk2bImported, G7eImported, Hspa1aImported, Hspa1bImported, Hspa1lImported, Ly6g5cImported, Ly6g6cImported, Neu1Imported, Ng35Imported, Rps25-ps2Imported, Stk19Imported
    OrganismiRattus norvegicus (Rat)Imported
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 20

    Organism-specific databases

    RGDi1302972. Ehmt2.

    Subcellular locationi

    Nucleus UniRule annotation
    Nucleus By similarity

    GO - Cellular componenti

    1. chromosome Source: UniProtKB-KW
    2. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    ChromosomeSAAS annotation, NucleusUniRule annotationSAAS annotation

    PTM / Processingi

    Proteomic databases

    PaxDbiQ6MG72.

    Expressioni

    Gene expression databases

    GenevestigatoriQ6MG72.

    Interactioni

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000042145.

    Family & Domainsi

    Sequence similaritiesi

    Contains 1 SET domain.UniRule annotation
    Contains 1 post-SET domain.UniRule annotation
    Contains 1 pre-SET domain.UniRule annotation
    Contains 6 ANK repeats.UniRule annotation
    Contains SET domain.SAAS annotation
    Contains post-SET domain.SAAS annotation
    Contains pre-SET domain.SAAS annotation

    Keywords - Domaini

    ANK repeatUniRule annotation, RepeatUniRule annotation

    Phylogenomic databases

    eggNOGiCOG0666.
    GeneTreeiENSGT00750000117632.
    HOGENOMiHOG000231216.
    HOVERGENiHBG028394.
    InParanoidiQ6MG72.
    KOiK11420.
    OMAiAQASWAP.
    OrthoDBiEOG744T8D.
    TreeFamiTF106443.

    Family and domain databases

    Gene3Di1.25.40.20. 1 hit.
    InterProiIPR002110. Ankyrin_rpt.
    IPR020683. Ankyrin_rpt-contain_dom.
    IPR003616. Post-SET_dom.
    IPR007728. Pre-SET_dom.
    IPR003606. Pre-SET_Zn-bd_sub.
    IPR001214. SET_dom.
    [Graphical view]
    PfamiPF12796. Ank_2. 3 hits.
    PF05033. Pre-SET. 1 hit.
    PF00856. SET. 1 hit.
    [Graphical view]
    PRINTSiPR01415. ANKYRIN.
    SMARTiSM00248. ANK. 6 hits.
    SM00508. PostSET. 1 hit.
    SM00468. PreSET. 1 hit.
    SM00317. SET. 1 hit.
    [Graphical view]
    SUPFAMiSSF48403. SSF48403. 1 hit.
    PROSITEiPS50297. ANK_REP_REGION. 1 hit.
    PS50088. ANK_REPEAT. 5 hits.
    PS50867. PRE_SET. 1 hit.
    PS50280. SET. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q6MG72-1 [UniParc]FASTAAdd to Basket

    « Hide

    MRGLPRGRGL MRARGRGRAA PTGGRGRGRG GAHRGRGRPR SLLSLPRAQA     50
    SWAPQLPAGL TGPPVPCLPS QGEAPAEMGA LLLEKEPRGA AERVHGSLGD 100
    TSHSEETLPK ANPDSLEPTG PSSPASVTVT VGDEGADTPV GATPLIGEEP 150
    ENLEGDGGRI LLGHATKSFP SSPSKGGACP SRAKMSMTGA GKSPPSVQSL 200
    AMRLLSMPGA QGAATAGPEP PPATTAGQEG QPKVHRARKT MSKPSNGQPP 250
    VPEKRPPEVQ HFRMSDDMHL GKVTSDVAKR RKLTSGSLSE DLGSAGGSGE 300
    VILEKGEPRP LEEWETVVGD DFSLYYDAYS VDERVDSDSK SEVEALAEQL 350
    SEEEEEEEEE EEEEEEEEEE EEEEEEDEES GNQSDRSGSS GRRKAKKKWR 400
    KDSPWVKPSR KRRKREPPRA KEPRGVNGVG SSGPSEYMEV PLGSLELPSE 450
    GTLSPNHAGV SNDTSSLETE RGFEELPLCS CRMEAPKIDR ISERAGHKCM 500
    ATESVDGELL GCNAAILKRE TMRPSSRVAL MVLCEAHRAR MVKHHCCPGC 550
    GYFCTAGTFL ECHPDFRVAH RFHKACVSQL NGMVFCPHCG EDASEAQEVT 600
    IPRGDGGTPP VGTVAPAPPP LAHDAPGRAD TSQPSARMRG HGEPRRPPCD 650
    PLADTIDSSG PSLTLPNGGC LSAVGLPPGP GREALEKALV IQESERRKKL 700
    RFHPRQLYLS VKQGELQKVI LMLLDNLDPN FQSDQQSKRT PLHAAAQKGS 750
    VEICHVLLQA GANINAVDKQ QRTPLMEAVV NNHLEVARYM VQLGGCVYSK 800
    EEDGSTCLHH AAKIGNLEMV SLLLSTGQVD VNAQDSGGWT PIIWAAEHKH 850
    IDVIRMLLTR GADVTLTDNE ENICLHWASF TGSAAIAEVL LNAQCDLHAV 900
    NYHGDTPLHI AARESYHDCV LLFLSRGANP ELRNKEGDTA WDLTPERSDV 950
    WFALQLNRKL RLGVGNRAVR TEKIICRDVA RGYENVPIPC VNGVDGEPCP 1000
    EDYKYISENC ETSTMNIDRN ITHLQHCTCV DDCSSSNCLC GQLSIRCWYD 1050
    KDGRLLQEFN KIEPPLIFEC NQACSCWRSC KNRVVQSGIK VRLQLYRTAK 1100
    MGWGVRALQT IPQGTFICEY VGELISDAEA DVREDDSYLF DLDNKDGEVY 1150
    CIDARYYGNI SRFINHLCDP NIIPVRVFML HQDLRFPRIA FFSSRDIRTG 1200
    EELGFDYGDR FWDIKSKYFT CQCGSEKCKH SAEAIALEQS RLARLDPHPE 1250
    LLPDLSSLPP INT 1263
    Length:1,263
    Mass (Da):138,100
    Last modified:July 5, 2004 - v1
    Checksum:i86C615F048069B8E
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AABR06099868 Genomic DNA. No translation available.
    BX883045 Genomic DNA. Translation: CAE83974.1.
    RefSeqiNP_997628.1. NM_212463.1.
    UniGeneiRn.116518.

    Genome annotation databases

    EnsembliENSRNOT00000047370; ENSRNOP00000042145; ENSRNOG00000030630.
    GeneIDi361798.
    KEGGirno:361798.
    UCSCiRGD:1302972. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AABR06099868 Genomic DNA. No translation available.
    BX883045 Genomic DNA. Translation: CAE83974.1 .
    RefSeqi NP_997628.1. NM_212463.1.
    UniGenei Rn.116518.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10116.ENSRNOP00000042145.

    Proteomic databases

    PaxDbi Q6MG72.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000047370 ; ENSRNOP00000042145 ; ENSRNOG00000030630 .
    GeneIDi 361798.
    KEGGi rno:361798.
    UCSCi RGD:1302972. rat.

    Organism-specific databases

    CTDi 10919.
    RGDi 1302972. Ehmt2.

    Phylogenomic databases

    eggNOGi COG0666.
    GeneTreei ENSGT00750000117632.
    HOGENOMi HOG000231216.
    HOVERGENi HBG028394.
    InParanoidi Q6MG72.
    KOi K11420.
    OMAi AQASWAP.
    OrthoDBi EOG744T8D.
    TreeFami TF106443.

    Enzyme and pathway databases

    Reactomei REACT_194748. Senescence-Associated Secretory Phenotype (SASP).
    REACT_206206. RNA Polymerase I Transcription Initiation.

    Miscellaneous databases

    NextBioi 677640.
    PROi Q6MG72.

    Gene expression databases

    Genevestigatori Q6MG72.

    Family and domain databases

    Gene3Di 1.25.40.20. 1 hit.
    InterProi IPR002110. Ankyrin_rpt.
    IPR020683. Ankyrin_rpt-contain_dom.
    IPR003616. Post-SET_dom.
    IPR007728. Pre-SET_dom.
    IPR003606. Pre-SET_Zn-bd_sub.
    IPR001214. SET_dom.
    [Graphical view ]
    Pfami PF12796. Ank_2. 3 hits.
    PF05033. Pre-SET. 1 hit.
    PF00856. SET. 1 hit.
    [Graphical view ]
    PRINTSi PR01415. ANKYRIN.
    SMARTi SM00248. ANK. 6 hits.
    SM00508. PostSET. 1 hit.
    SM00468. PreSET. 1 hit.
    SM00317. SET. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48403. SSF48403. 1 hit.
    PROSITEi PS50297. ANK_REP_REGION. 1 hit.
    PS50088. ANK_REPEAT. 5 hits.
    PS50867. PRE_SET. 1 hit.
    PS50280. SET. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: Brown NorwayImported.
    2. "The genomic sequence and comparative analysis of the rat major histocompatibility complex."
      Hurt P., Walter L., Sudbrak R., Klages S., Mueller I., Shiina T., Inoko H., Lehrach H., Guenther E., Reinhardt R., Himmelbauer H.
      Genome Res. 14:631-639(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: Brown NorwayImported.
    3. "Genome sequence of the Brown Norway rat yields insights into mammalian evolution."
      Rat Genome Sequencing Project Consortium
      Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., Morgan M.
      , Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., Collins F.S.
      Nature 428:493-521(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Brown NorwayImported.
    4. Ensembl
      Submitted (JUL-2011) to UniProtKB
      Cited for: IDENTIFICATION.
      Strain: Brown NorwayImported.

    Entry informationi

    Entry nameiQ6MG72_RAT
    AccessioniPrimary (citable) accession number: Q6MG72
    Secondary accession number(s): F1M7S8
    Entry historyi
    Integrated into UniProtKB/TrEMBL: July 5, 2004
    Last sequence update: July 5, 2004
    Last modified: October 1, 2014
    This is version 92 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3