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Q6MG72 (Q6MG72_RAT) Unreviewed, UniProtKB/TrEMBL

Last modified April 16, 2014. Version 87. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein names

Protein Ehmt2 Ensembl ENSRNOP00000042145
Gene names
Name:Ehmt2 Ensembl ENSRNOP00000042145 RGD 1302972
Synonyms:Apom RGD 620773, Bat4 RGD 1303304, Bat8 EMBL CAE83974.1, C2 RGD 2231, C4a RGD 620005, Cfb RGD 2204, Csnk2b RGD 619978, G7e RGD 1591982, Hspa1a RGD 2840, Hspa1b RGD 1593284, Hspa1l RGD 1595925, Ly6g5c RGD 735180, Ly6g6c RGD 1302999, Neu1 RGD 3163, Ng35 RGD 1302958, Rps25-ps2 RGD 1594424, Stk19 RGD 1359601
OrganismRattus norvegicus (Rat) [Reference proteome] EMBL CAE83974.1
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length1263 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone]. SAAS SAAS001214 RuleBase RU004542

S-adenosyl-L-methionine + histone L-lysine = S-adenosyl-L-homocysteine + histone N(6)-methyl-L-lysine.

Subcellular location

Nucleus By similarity RuleBase RU004542.

Sequence similarities

Contains 1 SET domain. RuleBase RU004538

Contains 1 post-SET domain. RuleBase RU004541

Contains 1 pre-SET domain. RuleBase RU004542

Contains 6 ANK repeats. RuleBase RU003321

Contains SET domain. SAAS SAAS001214

Contains post-SET domain. SAAS SAAS001214

Contains pre-SET domain. SAAS SAAS001214

Ontologies

Keywords
   Cellular componentChromosome SAAS SAAS007728
Nucleus SAAS SAAS001214 RuleBase RU004542
   DomainANK repeat RuleBase RU003321
Repeat RuleBase RU003536
   LigandS-adenosyl-L-methionine SAAS SAAS001214
   Molecular functionMethyltransferase SAAS SAAS001214 RuleBase RU004541
Transferase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processDNA methylation on cytosine within a CG sequence

Inferred from electronic annotation. Source: Ensembl

fertilization

Inferred from electronic annotation. Source: Ensembl

negative regulation of transcription from RNA polymerase II promoter

Inferred from electronic annotation. Source: Ensembl

organ growth

Inferred from electronic annotation. Source: Ensembl

peptidyl-lysine dimethylation

Inferred from electronic annotation. Source: Ensembl

regulation of DNA replication

Inferred from electronic annotation. Source: Ensembl

spermatid development

Inferred from electronic annotation. Source: Ensembl

synaptonemal complex assembly

Inferred from electronic annotation. Source: Ensembl

   Cellular_componentchromosome

Inferred from electronic annotation. Source: UniProtKB-KW

nucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionhistone methyltransferase activity (H3-K27 specific)

Inferred from electronic annotation. Source: Ensembl

histone methyltransferase activity (H3-K9 specific)

Inferred from electronic annotation. Source: Ensembl

zinc ion binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequences

Sequence LengthMass (Da)Tools
Q6MG72 [UniParc].

Last modified July 5, 2004. Version 1.
Checksum: 86C615F048069B8E

FASTA1,263138,100
        10         20         30         40         50         60 
MRGLPRGRGL MRARGRGRAA PTGGRGRGRG GAHRGRGRPR SLLSLPRAQA SWAPQLPAGL 

        70         80         90        100        110        120 
TGPPVPCLPS QGEAPAEMGA LLLEKEPRGA AERVHGSLGD TSHSEETLPK ANPDSLEPTG 

       130        140        150        160        170        180 
PSSPASVTVT VGDEGADTPV GATPLIGEEP ENLEGDGGRI LLGHATKSFP SSPSKGGACP 

       190        200        210        220        230        240 
SRAKMSMTGA GKSPPSVQSL AMRLLSMPGA QGAATAGPEP PPATTAGQEG QPKVHRARKT 

       250        260        270        280        290        300 
MSKPSNGQPP VPEKRPPEVQ HFRMSDDMHL GKVTSDVAKR RKLTSGSLSE DLGSAGGSGE 

       310        320        330        340        350        360 
VILEKGEPRP LEEWETVVGD DFSLYYDAYS VDERVDSDSK SEVEALAEQL SEEEEEEEEE 

       370        380        390        400        410        420 
EEEEEEEEEE EEEEEEDEES GNQSDRSGSS GRRKAKKKWR KDSPWVKPSR KRRKREPPRA 

       430        440        450        460        470        480 
KEPRGVNGVG SSGPSEYMEV PLGSLELPSE GTLSPNHAGV SNDTSSLETE RGFEELPLCS 

       490        500        510        520        530        540 
CRMEAPKIDR ISERAGHKCM ATESVDGELL GCNAAILKRE TMRPSSRVAL MVLCEAHRAR 

       550        560        570        580        590        600 
MVKHHCCPGC GYFCTAGTFL ECHPDFRVAH RFHKACVSQL NGMVFCPHCG EDASEAQEVT 

       610        620        630        640        650        660 
IPRGDGGTPP VGTVAPAPPP LAHDAPGRAD TSQPSARMRG HGEPRRPPCD PLADTIDSSG 

       670        680        690        700        710        720 
PSLTLPNGGC LSAVGLPPGP GREALEKALV IQESERRKKL RFHPRQLYLS VKQGELQKVI 

       730        740        750        760        770        780 
LMLLDNLDPN FQSDQQSKRT PLHAAAQKGS VEICHVLLQA GANINAVDKQ QRTPLMEAVV 

       790        800        810        820        830        840 
NNHLEVARYM VQLGGCVYSK EEDGSTCLHH AAKIGNLEMV SLLLSTGQVD VNAQDSGGWT 

       850        860        870        880        890        900 
PIIWAAEHKH IDVIRMLLTR GADVTLTDNE ENICLHWASF TGSAAIAEVL LNAQCDLHAV 

       910        920        930        940        950        960 
NYHGDTPLHI AARESYHDCV LLFLSRGANP ELRNKEGDTA WDLTPERSDV WFALQLNRKL 

       970        980        990       1000       1010       1020 
RLGVGNRAVR TEKIICRDVA RGYENVPIPC VNGVDGEPCP EDYKYISENC ETSTMNIDRN 

      1030       1040       1050       1060       1070       1080 
ITHLQHCTCV DDCSSSNCLC GQLSIRCWYD KDGRLLQEFN KIEPPLIFEC NQACSCWRSC 

      1090       1100       1110       1120       1130       1140 
KNRVVQSGIK VRLQLYRTAK MGWGVRALQT IPQGTFICEY VGELISDAEA DVREDDSYLF 

      1150       1160       1170       1180       1190       1200 
DLDNKDGEVY CIDARYYGNI SRFINHLCDP NIIPVRVFML HQDLRFPRIA FFSSRDIRTG 

      1210       1220       1230       1240       1250       1260 
EELGFDYGDR FWDIKSKYFT CQCGSEKCKH SAEAIALEQS RLARLDPHPE LLPDLSSLPP 


INT 

« Hide

References

« Hide 'large scale' references
[1]Boehm S., Borzym K., Gelling S., Gimmel V., Heitmann K., Kosiura A., Lang N., Lehrack S., Thiel J., Sontag M., Hurt P., Himmelbauer H., Sudbrak R., Reinhardt R.
Submitted (DEC-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
Strain: Brown Norway EMBL CAE83974.1.
[2]"The genomic sequence and comparative analysis of the rat major histocompatibility complex."
Hurt P., Walter L., Sudbrak R., Klages S., Mueller I., Shiina T., Inoko H., Lehrach H., Guenther E., Reinhardt R., Himmelbauer H.
Genome Res. 14:631-639(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: Brown Norway EMBL CAE83974.1.
[3]"Genome sequence of the Brown Norway rat yields insights into mammalian evolution."
Rat Genome Sequencing Project Consortium
Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., Morgan M. expand/collapse author list , Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., Collins F.S.
Nature 428:493-521(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Brown Norway Ensembl ENSRNOP00000042145.
[4]Ensembl
Submitted (JUL-2011) to UniProtKB
Cited for: IDENTIFICATION.
Strain: Brown Norway Ensembl ENSRNOP00000042145.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AABR06099868 Genomic DNA. No translation available.
BX883045 Genomic DNA. Translation: CAE83974.1.
RefSeqNP_997628.1. NM_212463.1.
UniGeneRn.116518.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10116.ENSRNOP00000042145.

Proteomic databases

PaxDbQ6MG72.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSRNOT00000047370; ENSRNOP00000042145; ENSRNOG00000030630.
GeneID361798.
KEGGrno:361798.
UCSCRGD:1302972. rat.

Organism-specific databases

CTD10919.
RGD1302972. Ehmt2.

Phylogenomic databases

eggNOGCOG0666.
GeneTreeENSGT00750000117632.
HOGENOMHOG000231216.
HOVERGENHBG028394.
InParanoidQ6MG72.
KOK11420.
OMAHGGRILL.
OrthoDBEOG744T8D.
TreeFamTF106443.

Gene expression databases

GenevestigatorQ6MG72.

Family and domain databases

Gene3D1.25.40.20. 1 hit.
InterProIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR003616. Post-SET_dom.
IPR007728. Pre-SET_dom.
IPR003606. Pre-SET_Zn-bd_sub.
IPR001214. SET_dom.
[Graphical view]
PfamPF12796. Ank_2. 3 hits.
PF05033. Pre-SET. 1 hit.
PF00856. SET. 1 hit.
[Graphical view]
PRINTSPR01415. ANKYRIN.
SMARTSM00248. ANK. 6 hits.
SM00508. PostSET. 1 hit.
SM00468. PreSET. 1 hit.
SM00317. SET. 1 hit.
[Graphical view]
SUPFAMSSF48403. SSF48403. 1 hit.
PROSITEPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 5 hits.
PS50867. PRE_SET. 1 hit.
PS50280. SET. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio677640.
PROQ6MG72.

Entry information

Entry nameQ6MG72_RAT
AccessionPrimary (citable) accession number: Q6MG72
Secondary accession number(s): F1M7S8
Entry history
Integrated into UniProtKB/TrEMBL: July 5, 2004
Last sequence update: July 5, 2004
Last modified: April 16, 2014
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)