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Protein
Submitted name:

Euchromatic histone lysine methyltransferase 2

Gene

Ehmt2

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

  • behavioral response to cocaine Source: Ensembl
  • cellular response to cocaine Source: Ensembl
  • cellular response to drug Source: RGD
  • DNA methylation on cytosine within a CG sequence Source: Ensembl
  • fertilization Source: Ensembl
  • long-term memory Source: RGD
  • negative regulation of autophagosome assembly Source: Ensembl
  • negative regulation of transcription by RNA polymerase II Source: Ensembl
  • neuron fate specification Source: Ensembl
  • organ growth Source: Ensembl
  • phenotypic switching Source: Ensembl
  • regulation of DNA methylation Source: RGD
  • regulation of DNA replication Source: Ensembl
  • regulation of histone H3-K4 methylation Source: RGD
  • regulation of histone H3-K9 methylation Source: RGD
  • response to ethanol Source: RGD
  • response to fungicide Source: RGD
  • response to nutrient levels Source: RGD
  • spermatid development Source: Ensembl
  • synaptonemal complex assembly Source: Ensembl

Enzyme and pathway databases

ReactomeiR-RNO-2559582 Senescence-Associated Secretory Phenotype (SASP)
R-RNO-3214841 PKMTs methylate histone lysines
R-RNO-6804760 Regulation of TP53 Activity through Methylation
R-RNO-73762 RNA Polymerase I Transcription Initiation
R-RNO-8953750 Transcriptional Regulation by E2F6

Names & Taxonomyi

Protein namesi
Submitted name:
Euchromatic histone lysine methyltransferase 2Imported
Submitted name:
HLA-B associated transcript 8, rat orthologueImported
Gene namesi
Name:Ehmt2Imported
Synonyms:ApomImported, Bat4Imported, Bat8Imported, C2Imported, C4aImported, CfbImported, Csnk2bImported, G7eImported, Hspa1aImported, Hspa1bImported, Hspa1lImported, Ly6g5cImported, Ly6g6cImported, Neu1Imported, Ng35Imported, Rps25-ps2Imported, Stk19Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 20

Organism-specific databases

RGDi1302972 Ehmt2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

ChromosomeSAAS annotation, NucleusSAAS annotation

PTM / Processingi

Proteomic databases

PRIDEiQ6MG72

Expressioni

Gene expression databases

BgeeiENSRNOG00000030630
ExpressionAtlasiQ6MG72 baseline and differential

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

IntActiQ6MG72, 1 interactor
STRINGi10116.ENSRNOP00000042145

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini707 – 940ANK_REP_REGIONInterPro annotationAdd BLAST234
Repeati737 – 769ANKPROSITE-ProRule annotationAdd BLAST33
Repeati770 – 802ANKPROSITE-ProRule annotationAdd BLAST33
Repeati803 – 827ANKPROSITE-ProRule annotationAdd BLAST25
Repeati837 – 869ANKPROSITE-ProRule annotationAdd BLAST33
Repeati903 – 935ANKPROSITE-ProRule annotationAdd BLAST33
Domaini1025 – 1088Pre-SETInterPro annotationAdd BLAST64
Domaini1091 – 1208SETInterPro annotationAdd BLAST118

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili336 – 383Sequence analysisAdd BLAST48

Keywords - Domaini

ANK repeatPROSITE-ProRule annotation, Coiled coilSequence analysis

Phylogenomic databases

eggNOGiKOG1082 Eukaryota
COG0666 LUCA
COG2940 LUCA
GeneTreeiENSGT00780000121845
HOGENOMiHOG000231216
HOVERGENiHBG028394
KOiK11420
OMAiRTEKIIC
OrthoDBiEOG091G00U6
TreeFamiTF106443

Family and domain databases

CDDicd00204 ANK, 2 hits
Gene3Di1.25.40.20, 1 hit
InterProiView protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
IPR038034 EHMT2
IPR007728 Pre-SET_dom
IPR001214 SET_dom
PANTHERiPTHR22884:SF361 PTHR22884:SF361, 1 hit
PfamiView protein in Pfam
PF12796 Ank_2, 3 hits
PF05033 Pre-SET, 1 hit
PF00856 SET, 1 hit
PRINTSiPR01415 ANKYRIN
SMARTiView protein in SMART
SM00248 ANK, 6 hits
SM00468 PreSET, 1 hit
SM00317 SET, 1 hit
SUPFAMiSSF48403 SSF48403, 1 hit
PROSITEiView protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 5 hits
PS50867 PRE_SET, 1 hit
PS50280 SET, 1 hit

Sequencei

Sequence statusi: Complete.

Q6MG72-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRGLPRGRGL MRARGRGRAA PTGGRGRGRG GAHRGRGRPR SLLSLPRAQA
60 70 80 90 100
SWAPQLPAGL TGPPVPCLPS QGEAPAEMGA LLLEKEPRGA AERVHGSLGD
110 120 130 140 150
TSHSEETLPK ANPDSLEPTG PSSPASVTVT VGDEGADTPV GATPLIGEEP
160 170 180 190 200
ENLEGDGGRI LLGHATKSFP SSPSKGGACP SRAKMSMTGA GKSPPSVQSL
210 220 230 240 250
AMRLLSMPGA QGAATAGPEP PPATTAGQEG QPKVHRARKT MSKPSNGQPP
260 270 280 290 300
VPEKRPPEVQ HFRMSDDMHL GKVTSDVAKR RKLTSGSLSE DLGSAGGSGE
310 320 330 340 350
VILEKGEPRP LEEWETVVGD DFSLYYDAYS VDERVDSDSK SEVEALAEQL
360 370 380 390 400
SEEEEEEEEE EEEEEEEEEE EEEEEEDEES GNQSDRSGSS GRRKAKKKWR
410 420 430 440 450
KDSPWVKPSR KRRKREPPRA KEPRGVNGVG SSGPSEYMEV PLGSLELPSE
460 470 480 490 500
GTLSPNHAGV SNDTSSLETE RGFEELPLCS CRMEAPKIDR ISERAGHKCM
510 520 530 540 550
ATESVDGELL GCNAAILKRE TMRPSSRVAL MVLCEAHRAR MVKHHCCPGC
560 570 580 590 600
GYFCTAGTFL ECHPDFRVAH RFHKACVSQL NGMVFCPHCG EDASEAQEVT
610 620 630 640 650
IPRGDGGTPP VGTVAPAPPP LAHDAPGRAD TSQPSARMRG HGEPRRPPCD
660 670 680 690 700
PLADTIDSSG PSLTLPNGGC LSAVGLPPGP GREALEKALV IQESERRKKL
710 720 730 740 750
RFHPRQLYLS VKQGELQKVI LMLLDNLDPN FQSDQQSKRT PLHAAAQKGS
760 770 780 790 800
VEICHVLLQA GANINAVDKQ QRTPLMEAVV NNHLEVARYM VQLGGCVYSK
810 820 830 840 850
EEDGSTCLHH AAKIGNLEMV SLLLSTGQVD VNAQDSGGWT PIIWAAEHKH
860 870 880 890 900
IDVIRMLLTR GADVTLTDNE ENICLHWASF TGSAAIAEVL LNAQCDLHAV
910 920 930 940 950
NYHGDTPLHI AARESYHDCV LLFLSRGANP ELRNKEGDTA WDLTPERSDV
960 970 980 990 1000
WFALQLNRKL RLGVGNRAVR TEKIICRDVA RGYENVPIPC VNGVDGEPCP
1010 1020 1030 1040 1050
EDYKYISENC ETSTMNIDRN ITHLQHCTCV DDCSSSNCLC GQLSIRCWYD
1060 1070 1080 1090 1100
KDGRLLQEFN KIEPPLIFEC NQACSCWRSC KNRVVQSGIK VRLQLYRTAK
1110 1120 1130 1140 1150
MGWGVRALQT IPQGTFICEY VGELISDAEA DVREDDSYLF DLDNKDGEVY
1160 1170 1180 1190 1200
CIDARYYGNI SRFINHLCDP NIIPVRVFML HQDLRFPRIA FFSSRDIRTG
1210 1220 1230 1240 1250
EELGFDYGDR FWDIKSKYFT CQCGSEKCKH SAEAIALEQS RLARLDPHPE
1260
LLPDLSSLPP INT
Length:1,263
Mass (Da):138,100
Last modified:July 5, 2004 - v1
Checksum:i86C615F048069B8E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR07044392 Genomic DNA No translation available.
BX883045 Genomic DNA Translation: CAE83974.1
RefSeqiNP_997628.1, NM_212463.1
UniGeneiRn.116518

Genome annotation databases

EnsembliENSRNOT00000047370; ENSRNOP00000042145; ENSRNOG00000030630
GeneIDi361798
KEGGirno:361798
UCSCiRGD:1302972 rat

Similar proteinsi

Entry informationi

Entry nameiQ6MG72_RAT
AccessioniPrimary (citable) accession number: Q6MG72
Secondary accession number(s): F1M7S8
Entry historyiIntegrated into UniProtKB/TrEMBL: July 5, 2004
Last sequence update: July 5, 2004
Last modified: May 23, 2018
This is version 133 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

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