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Q6MG72

- Q6MG72_RAT

UniProt

Q6MG72 - Q6MG72_RAT

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Protein
Submitted name: HLA-B associated transcript 8, rat orthologue
Gene
Ehmt2, Apom, Bat4, Bat8, C2, C4a, Cfb, Csnk2b, G7e, Hspa1a, Hspa1b, Hspa1l, Ly6g5c, Ly6g6c, Neu1, Ng35, Rps25-ps2, Stk19
Organism
Rattus norvegicus (Rat)
Status
Unreviewed - Annotation score: 4 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].SAAS annotations
S-adenosyl-L-methionine + histone L-lysine = S-adenosyl-L-homocysteine + histone N(6)-methyl-L-lysine.

GO - Molecular functioni

  1. histone methyltransferase activity (H3-K27 specific) Source: Ensembl
  2. histone methyltransferase activity (H3-K9 specific) Source: Ensembl
  3. zinc ion binding Source: InterPro
Complete GO annotation...

GO - Biological processi

  1. DNA methylation on cytosine within a CG sequence Source: Ensembl
  2. fertilization Source: Ensembl
  3. negative regulation of transcription from RNA polymerase II promoter Source: Ensembl
  4. organ growth Source: Ensembl
  5. peptidyl-lysine dimethylation Source: Ensembl
  6. regulation of DNA replication Source: Ensembl
  7. spermatid development Source: Ensembl
  8. synaptonemal complex assembly Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

MethyltransferaseUniRule annotationSAAS annotations, Transferase

Keywords - Ligandi

S-adenosyl-L-methionineSAAS annotations

Enzyme and pathway databases

ReactomeiREACT_194748. Senescence-Associated Secretory Phenotype (SASP).
REACT_206206. RNA Polymerase I Transcription Initiation.

Names & Taxonomyi

Protein namesi
Submitted name:
HLA-B associated transcript 8, rat orthologueImported
Submitted name:
Protein Ehmt2Imported
Gene namesi
Name:Ehmt2Imported
Synonyms:ApomImported, Bat4Imported, Bat8Imported, C2Imported, C4aImported, CfbImported, Csnk2bImported, G7eImported, Hspa1aImported, Hspa1bImported, Hspa1lImported, Ly6g5cImported, Ly6g6cImported, Neu1Imported, Ng35Imported, Rps25-ps2Imported, Stk19Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 20

Organism-specific databases

RGDi1302972. Ehmt2.

Subcellular locationi

Nucleus By similarity

GO - Cellular componenti

  1. chromosome Source: UniProtKB-KW
  2. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

ChromosomeSAAS annotations, NucleusSAAS annotations

PTM / Processingi

Proteomic databases

PaxDbiQ6MG72.

Expressioni

Gene expression databases

GenevestigatoriQ6MG72.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000042145.

Family & Domainsi

Sequence similaritiesi

Contains 1 SET domain.UniRule annotation
Contains 1 post-SET domain.UniRule annotation
Contains 1 pre-SET domain.
Contains 6 ANK repeats.UniRule annotation
Contains SET domain.SAAS annotations
Contains post-SET domain.SAAS annotations
Contains pre-SET domain.SAAS annotations

Keywords - Domaini

ANK repeatUniRule annotation, RepeatUniRule annotation

Phylogenomic databases

eggNOGiCOG0666.
GeneTreeiENSGT00750000117632.
HOGENOMiHOG000231216.
HOVERGENiHBG028394.
InParanoidiQ6MG72.
KOiK11420.
OMAiAQASWAP.
OrthoDBiEOG744T8D.
TreeFamiTF106443.

Family and domain databases

Gene3Di1.25.40.20. 1 hit.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR003616. Post-SET_dom.
IPR007728. Pre-SET_dom.
IPR003606. Pre-SET_Zn-bd_sub.
IPR001214. SET_dom.
[Graphical view]
PfamiPF12796. Ank_2. 3 hits.
PF05033. Pre-SET. 1 hit.
PF00856. SET. 1 hit.
[Graphical view]
PRINTSiPR01415. ANKYRIN.
SMARTiSM00248. ANK. 6 hits.
SM00508. PostSET. 1 hit.
SM00468. PreSET. 1 hit.
SM00317. SET. 1 hit.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 5 hits.
PS50867. PRE_SET. 1 hit.
PS50280. SET. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6MG72-1 [UniParc]FASTAAdd to Basket

« Hide

MRGLPRGRGL MRARGRGRAA PTGGRGRGRG GAHRGRGRPR SLLSLPRAQA     50
SWAPQLPAGL TGPPVPCLPS QGEAPAEMGA LLLEKEPRGA AERVHGSLGD 100
TSHSEETLPK ANPDSLEPTG PSSPASVTVT VGDEGADTPV GATPLIGEEP 150
ENLEGDGGRI LLGHATKSFP SSPSKGGACP SRAKMSMTGA GKSPPSVQSL 200
AMRLLSMPGA QGAATAGPEP PPATTAGQEG QPKVHRARKT MSKPSNGQPP 250
VPEKRPPEVQ HFRMSDDMHL GKVTSDVAKR RKLTSGSLSE DLGSAGGSGE 300
VILEKGEPRP LEEWETVVGD DFSLYYDAYS VDERVDSDSK SEVEALAEQL 350
SEEEEEEEEE EEEEEEEEEE EEEEEEDEES GNQSDRSGSS GRRKAKKKWR 400
KDSPWVKPSR KRRKREPPRA KEPRGVNGVG SSGPSEYMEV PLGSLELPSE 450
GTLSPNHAGV SNDTSSLETE RGFEELPLCS CRMEAPKIDR ISERAGHKCM 500
ATESVDGELL GCNAAILKRE TMRPSSRVAL MVLCEAHRAR MVKHHCCPGC 550
GYFCTAGTFL ECHPDFRVAH RFHKACVSQL NGMVFCPHCG EDASEAQEVT 600
IPRGDGGTPP VGTVAPAPPP LAHDAPGRAD TSQPSARMRG HGEPRRPPCD 650
PLADTIDSSG PSLTLPNGGC LSAVGLPPGP GREALEKALV IQESERRKKL 700
RFHPRQLYLS VKQGELQKVI LMLLDNLDPN FQSDQQSKRT PLHAAAQKGS 750
VEICHVLLQA GANINAVDKQ QRTPLMEAVV NNHLEVARYM VQLGGCVYSK 800
EEDGSTCLHH AAKIGNLEMV SLLLSTGQVD VNAQDSGGWT PIIWAAEHKH 850
IDVIRMLLTR GADVTLTDNE ENICLHWASF TGSAAIAEVL LNAQCDLHAV 900
NYHGDTPLHI AARESYHDCV LLFLSRGANP ELRNKEGDTA WDLTPERSDV 950
WFALQLNRKL RLGVGNRAVR TEKIICRDVA RGYENVPIPC VNGVDGEPCP 1000
EDYKYISENC ETSTMNIDRN ITHLQHCTCV DDCSSSNCLC GQLSIRCWYD 1050
KDGRLLQEFN KIEPPLIFEC NQACSCWRSC KNRVVQSGIK VRLQLYRTAK 1100
MGWGVRALQT IPQGTFICEY VGELISDAEA DVREDDSYLF DLDNKDGEVY 1150
CIDARYYGNI SRFINHLCDP NIIPVRVFML HQDLRFPRIA FFSSRDIRTG 1200
EELGFDYGDR FWDIKSKYFT CQCGSEKCKH SAEAIALEQS RLARLDPHPE 1250
LLPDLSSLPP INT 1263
Length:1,263
Mass (Da):138,100
Last modified:July 5, 2004 - v1
Checksum:i86C615F048069B8E
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AABR06099868 Genomic DNA. No translation available.
BX883045 Genomic DNA. Translation: CAE83974.1.
RefSeqiNP_997628.1. NM_212463.1.
UniGeneiRn.116518.

Genome annotation databases

EnsembliENSRNOT00000047370; ENSRNOP00000042145; ENSRNOG00000030630.
GeneIDi361798.
KEGGirno:361798.
UCSCiRGD:1302972. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AABR06099868 Genomic DNA. No translation available.
BX883045 Genomic DNA. Translation: CAE83974.1 .
RefSeqi NP_997628.1. NM_212463.1.
UniGenei Rn.116518.

3D structure databases

ModBasei Search...

Protein-protein interaction databases

STRINGi 10116.ENSRNOP00000042145.

Proteomic databases

PaxDbi Q6MG72.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000047370 ; ENSRNOP00000042145 ; ENSRNOG00000030630 .
GeneIDi 361798.
KEGGi rno:361798.
UCSCi RGD:1302972. rat.

Organism-specific databases

CTDi 10919.
RGDi 1302972. Ehmt2.

Phylogenomic databases

eggNOGi COG0666.
GeneTreei ENSGT00750000117632.
HOGENOMi HOG000231216.
HOVERGENi HBG028394.
InParanoidi Q6MG72.
KOi K11420.
OMAi AQASWAP.
OrthoDBi EOG744T8D.
TreeFami TF106443.

Enzyme and pathway databases

Reactomei REACT_194748. Senescence-Associated Secretory Phenotype (SASP).
REACT_206206. RNA Polymerase I Transcription Initiation.

Miscellaneous databases

NextBioi 677640.
PROi Q6MG72.

Gene expression databases

Genevestigatori Q6MG72.

Family and domain databases

Gene3Di 1.25.40.20. 1 hit.
InterProi IPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR003616. Post-SET_dom.
IPR007728. Pre-SET_dom.
IPR003606. Pre-SET_Zn-bd_sub.
IPR001214. SET_dom.
[Graphical view ]
Pfami PF12796. Ank_2. 3 hits.
PF05033. Pre-SET. 1 hit.
PF00856. SET. 1 hit.
[Graphical view ]
PRINTSi PR01415. ANKYRIN.
SMARTi SM00248. ANK. 6 hits.
SM00508. PostSET. 1 hit.
SM00468. PreSET. 1 hit.
SM00317. SET. 1 hit.
[Graphical view ]
SUPFAMi SSF48403. SSF48403. 1 hit.
PROSITEi PS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 5 hits.
PS50867. PRE_SET. 1 hit.
PS50280. SET. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: Brown NorwayImported.
  2. "The genomic sequence and comparative analysis of the rat major histocompatibility complex."
    Hurt P., Walter L., Sudbrak R., Klages S., Mueller I., Shiina T., Inoko H., Lehrach H., Guenther E., Reinhardt R., Himmelbauer H.
    Genome Res. 14:631-639(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: Brown NorwayImported.
  3. "Genome sequence of the Brown Norway rat yields insights into mammalian evolution."
    Rat Genome Sequencing Project Consortium
    Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., Morgan M.
    , Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., Collins F.S.
    Nature 428:493-521(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Brown NorwayImported.
  4. Ensembl
    Submitted (JUL-2011) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: Brown NorwayImported.

Entry informationi

Entry nameiQ6MG72_RAT
AccessioniPrimary (citable) accession number: Q6MG72
Secondary accession number(s): F1M7S8
Entry historyi
Integrated into UniProtKB/TrEMBL: July 5, 2004
Last sequence update: July 5, 2004
Last modified: September 3, 2014
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

External Data

Dasty 3

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