Q6MG72 (Q6MG72_RAT) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
HLA-B associated transcript 8, rat orthologue EMBL CAE83974.1

Submitted name:
Protein Ehmt2 Ensembl ENSRNOP00000042145

Gene names

Name:	Ehmt2 Ensembl ENSRNOP00000042145 RGD 1302972
Synonyms:	Apom RGD 620773, Bat4 RGD 1303304, Bat8 EMBL CAE83974.1, C2 RGD 2231, C4a RGD 620005, Cfb RGD 2204, Csnk2b RGD 619978, G7e RGD 1591982, Hspa1a RGD 2840, Hspa1b RGD 1593284, Hspa1l RGD 1595925, Ly6g5c RGD 735180, Ly6g6c RGD 1302999, Neu1 RGD 3163, Ng35 RGD 1302958, Rps25-ps2 RGD 1594424, Stk19 RGD 1359601

Organism

Rattus norvegicus (Rat) [Reference proteome] EMBL CAE83974.1

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	1263 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone]. SAAS SAAS007728 S-adenosyl-L-methionine + histone L-lysine = S-adenosyl-L-homocysteine + histone N(6)-methyl-L-lysine. RuleBase RU004542
Subcellular location	Nucleus By similarity RuleBase RU004542.
Sequence similarities	Contains 1 SET domain. SAAS SAAS007728 RuleBase RU004538 Contains 1 post-SET domain. SAAS SAAS001214 RuleBase RU004541 Contains 1 pre-SET domain. SAAS SAAS007728 RuleBase RU004542

Ontologies

Keywords
Cellular component	Chromosome SAAS SAAS007728 Nucleus SAAS SAAS007728 RuleBase RU004542
Domain	ANK repeat RuleBase RU003321 Repeat RuleBase RU003536
Molecular function	Methyltransferase SAAS SAAS007728 RuleBase RU004541 Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	DNA methylation on cytosine within a CG sequence Inferred from electronic annotation. Source: Compara fertilization Inferred from electronic annotation. Source: Compara negative regulation of transcription from RNA polymerase II promoter Inferred from electronic annotation. Source: Compara organ growth Inferred from electronic annotation. Source: Compara pachytene Inferred from electronic annotation. Source: Compara peptidyl-lysine dimethylation Inferred from electronic annotation. Source: Compara regulation of DNA replication Inferred from electronic annotation. Source: Compara spermatid development Inferred from electronic annotation. Source: Compara synaptonemal complex assembly Inferred from electronic annotation. Source: Compara
Cellular_component	chromosome Inferred from electronic annotation. Source: UniProtKB-KW nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	histone methyltransferase activity (H3-K27 specific) Inferred from electronic annotation. Source: Compara histone methyltransferase activity (H3-K9 specific) Inferred from electronic annotation. Source: Compara zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q6MG72 [UniParc]. Last modified July 5, 2004. Version 1. Checksum: 86C615F048069B8E	FASTA	1,263	138,100
	10 20 30 40 50 60 MRGLPRGRGL MRARGRGRAA PTGGRGRGRG GAHRGRGRPR SLLSLPRAQA SWAPQLPAGL 70 80 90 100 110 120 TGPPVPCLPS QGEAPAEMGA LLLEKEPRGA AERVHGSLGD TSHSEETLPK ANPDSLEPTG 130 140 150 160 170 180 PSSPASVTVT VGDEGADTPV GATPLIGEEP ENLEGDGGRI LLGHATKSFP SSPSKGGACP 190 200 210 220 230 240 SRAKMSMTGA GKSPPSVQSL AMRLLSMPGA QGAATAGPEP PPATTAGQEG QPKVHRARKT 250 260 270 280 290 300 MSKPSNGQPP VPEKRPPEVQ HFRMSDDMHL GKVTSDVAKR RKLTSGSLSE DLGSAGGSGE 310 320 330 340 350 360 VILEKGEPRP LEEWETVVGD DFSLYYDAYS VDERVDSDSK SEVEALAEQL SEEEEEEEEE 370 380 390 400 410 420 EEEEEEEEEE EEEEEEDEES GNQSDRSGSS GRRKAKKKWR KDSPWVKPSR KRRKREPPRA 430 440 450 460 470 480 KEPRGVNGVG SSGPSEYMEV PLGSLELPSE GTLSPNHAGV SNDTSSLETE RGFEELPLCS 490 500 510 520 530 540 CRMEAPKIDR ISERAGHKCM ATESVDGELL GCNAAILKRE TMRPSSRVAL MVLCEAHRAR 550 560 570 580 590 600 MVKHHCCPGC GYFCTAGTFL ECHPDFRVAH RFHKACVSQL NGMVFCPHCG EDASEAQEVT 610 620 630 640 650 660 IPRGDGGTPP VGTVAPAPPP LAHDAPGRAD TSQPSARMRG HGEPRRPPCD PLADTIDSSG 670 680 690 700 710 720 PSLTLPNGGC LSAVGLPPGP GREALEKALV IQESERRKKL RFHPRQLYLS VKQGELQKVI 730 740 750 760 770 780 LMLLDNLDPN FQSDQQSKRT PLHAAAQKGS VEICHVLLQA GANINAVDKQ QRTPLMEAVV 790 800 810 820 830 840 NNHLEVARYM VQLGGCVYSK EEDGSTCLHH AAKIGNLEMV SLLLSTGQVD VNAQDSGGWT 850 860 870 880 890 900 PIIWAAEHKH IDVIRMLLTR GADVTLTDNE ENICLHWASF TGSAAIAEVL LNAQCDLHAV 910 920 930 940 950 960 NYHGDTPLHI AARESYHDCV LLFLSRGANP ELRNKEGDTA WDLTPERSDV WFALQLNRKL 970 980 990 1000 1010 1020 RLGVGNRAVR TEKIICRDVA RGYENVPIPC VNGVDGEPCP EDYKYISENC ETSTMNIDRN 1030 1040 1050 1060 1070 1080 ITHLQHCTCV DDCSSSNCLC GQLSIRCWYD KDGRLLQEFN KIEPPLIFEC NQACSCWRSC 1090 1100 1110 1120 1130 1140 KNRVVQSGIK VRLQLYRTAK MGWGVRALQT IPQGTFICEY VGELISDAEA DVREDDSYLF 1150 1160 1170 1180 1190 1200 DLDNKDGEVY CIDARYYGNI SRFINHLCDP NIIPVRVFML HQDLRFPRIA FFSSRDIRTG 1210 1220 1230 1240 1250 1260 EELGFDYGDR FWDIKSKYFT CQCGSEKCKH SAEAIALEQS RLARLDPHPE LLPDLSSLPP INT

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	Boehm S., Borzym K., Gelling S., Gimmel V., Heitmann K., Kosiura A., Lang N., Lehrack S., Thiel J., Sontag M., Hurt P., Himmelbauer H., Sudbrak R., Reinhardt R. Submitted (DEC-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Strain: Brown Norway EMBL CAE83974.1.
[2]	"The genomic sequence and comparative analysis of the rat major histocompatibility complex." Hurt P., Walter L., Sudbrak R., Klages S., Mueller I., Shiina T., Inoko H., Lehrach H., Guenther E., Reinhardt R., Himmelbauer H. Genome Res. 14:631-639(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: Brown Norway EMBL CAE83974.1.
[3]	"Genome sequence of the Brown Norway rat yields insights into mammalian evolution." Rat Genome Sequencing Project Consortium Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., Morgan M. , Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., Collins F.S. Nature 428:493-521(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Brown Norway Ensembl ENSRNOP00000042145.
[4]	Ensembl Submitted (JUL-2011) to UniProtKB Cited for: IDENTIFICATION. Strain: Brown Norway Ensembl ENSRNOP00000042145.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AABR06099868 Genomic DNA. No translation available. BX883045 Genomic DNA. Translation: CAE83974.1.
IPI	IPI00417731.
RefSeq	NP_997628.1. NM_212463.1.
UniGene	Rn.116518.
3D structure databases
ProteinModelPortal	Q6MG72.
SMR	Q6MG72. Positions 735-961, 975-1245.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q6MG72. 1 interaction.
Proteomic databases
PaxDb	Q6MG72.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSRNOT00000047370; ENSRNOP00000042145; ENSRNOG00000030630.
GeneID	361798.
KEGG	rno:361798.
UCSC	RGD:1302972. rat.
Organism-specific databases
CTD	10919.
RGD	1302972. Ehmt2.
Phylogenomic databases
eggNOG	COG0666.
GeneTree	ENSGT00690000101898.
HOGENOM	HOG000231216.
HOVERGEN	HBG028394.
InParanoid	Q6MG72.
KO	K11420.
OrthoDB	EOG4KSPJ5.
Gene expression databases
Genevestigator	Q6MG72.
Family and domain databases
Gene3D	1.25.40.20. 1 hit.
InterPro	IPR002110. Ankyrin_rpt. IPR020683. Ankyrin_rpt-contain_dom. IPR003616. Post-SET_dom. IPR007728. Pre-SET_dom. IPR003606. Pre-SET_Zn-bd_sub. IPR001214. SET_dom. [Graphical view]
Pfam	PF12796. Ank_2. 3 hits. PF05033. Pre-SET. 1 hit. PF00856. SET. 1 hit. [Graphical view]
PRINTS	PR01415. ANKYRIN.
SMART	SM00248. ANK. 6 hits. SM00508. PostSET. 1 hit. SM00468. PreSET. 1 hit. SM00317. SET. 1 hit. [Graphical view]
SUPFAM	SSF48403. ANK. 1 hit.
PROSITE	PS50297. ANK_REP_REGION. 1 hit. PS50088. ANK_REPEAT. 5 hits. PS50867. PRE_SET. 1 hit. PS50280. SET. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	35582351.

Entry information

Entry name

Q6MG72_RAT

Accession

Primary (citable) accession number: Q6MG72
Secondary accession number(s): F1M7S8

Entry history

Integrated into UniProtKB/TrEMBL:	July 5, 2004
Last sequence update:	July 5, 2004
Last modified:	May 1, 2013
This is version 78 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)