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Protein
Submitted name:

Neuraminidase 1

Gene

Neu1

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-RNO-1660662. Glycosphingolipid metabolism.
R-RNO-4085001. Sialic acid metabolism.
R-RNO-6798695. Neutrophil degranulation.

Names & Taxonomyi

Protein namesi
Submitted name:
Neuraminidase 1Imported
Submitted name:
Neuraminidase 1, isoform CRA_bImported
Submitted name:
Sialidase 1 (Lysosomal sialidase)Imported
Submitted name:
Sialidase-1Imported
Gene namesi
Name:Neu1Imported
Synonyms:ApomImported, Bat4Imported, C2Imported, C4aImported, CfbImported, Csnk2bImported, G7eImported, Hspa1aImported, Hspa1bImported, Hspa1lImported, Ly6g5cImported, Ly6g6cImported, Ng35Imported, Rps25-ps2Imported, Stk19Imported
ORF Names:rCG_38385Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 20

Organism-specific databases

RGDi3163. Neu1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 39Sequence analysisAdd BLAST39
ChainiPRO_500878262640 – 409Sequence analysisAdd BLAST370

Expressioni

Gene expression databases

BgeeiENSRNOG00000032942.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000050614.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini82 – 372SialidasesInterPro annotationAdd BLAST291

Keywords - Domaini

SignalSequence analysis

Phylogenomic databases

eggNOGiENOG410IE33. Eukaryota.
COG4409. LUCA.
GeneTreeiENSGT00720000108878.
HOVERGENiHBG057314.
KOiK01186.
OMAiRNQYTES.
OrthoDBiEOG091G0HAW.

Family and domain databases

Gene3Di2.120.10.10. 1 hit.
InterProiIPR026856. Sialidase_fam.
IPR011040. Sialidases.
[Graphical view]
PANTHERiPTHR10628. PTHR10628. 1 hit.
PfamiPF13088. BNR_2. 1 hit.
[Graphical view]
SUPFAMiSSF50939. SSF50939. 1 hit.

Sequencei

Sequence statusi: Complete.

Q6MG70-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVGAEPSRPP GPPSYWTGRR GQGLAAIFLL LVSAAGSEAR TEDDFSLVQP
60 70 80 90 100
LVTMEQLLWV SGKQIGSVDT FRIPLITATP RGTLLAFAEA RKKSASDEGA
110 120 130 140 150
KFIAMRRSTD QGSTWSSTAF IVDDGEASDG LNLGAVVNDV DTGVVFLIYT
160 170 180 190 200
LCAHKVNCQV ASTMLVWSKD DGVSWSPPRN LSVDIGTEMF APGPGSGIQK
210 220 230 240 250
QREPWKGRLI VCGHGTLERD GVFCLLSDDH GASWHYGTGV SGIPFGQPKH
260 270 280 290 300
DHDFNPDECQ PYELPDGSVI INARNQNNYH CRCRIVLRSY DACDTLRPRD
310 320 330 340 350
VTFDPELVDP VVAAGALATS SGIVFFSNPA HPEYRVNLTL RWSFSNGTSW
360 370 380 390 400
QKERVQLWPG PSGYSSLTAL ENSTDGKKQP PQLFVLYEKG LNRYTESISM

VKISVYGTL
Length:409
Mass (Da):44,635
Last modified:July 5, 2004 - v1
Checksum:iE562FA1E0A1C91BC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR07044392 Genomic DNA. No translation available.
BC100639 mRNA. Translation: AAI00640.1.
BX883045 Genomic DNA. Translation: CAE83976.1.
CH474121 Genomic DNA. Translation: EDL83469.1.
RefSeqiNP_113710.2. NM_031522.3.
UniGeneiRn.128560.

Genome annotation databases

EnsembliENSRNOT00000049344; ENSRNOP00000050614; ENSRNOG00000032942.
GeneIDi24591.
KEGGirno:24591.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR07044392 Genomic DNA. No translation available.
BC100639 mRNA. Translation: AAI00640.1.
BX883045 Genomic DNA. Translation: CAE83976.1.
CH474121 Genomic DNA. Translation: EDL83469.1.
RefSeqiNP_113710.2. NM_031522.3.
UniGeneiRn.128560.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000050614.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000049344; ENSRNOP00000050614; ENSRNOG00000032942.
GeneIDi24591.
KEGGirno:24591.

Organism-specific databases

CTDi4758.
RGDi3163. Neu1.

Phylogenomic databases

eggNOGiENOG410IE33. Eukaryota.
COG4409. LUCA.
GeneTreeiENSGT00720000108878.
HOVERGENiHBG057314.
KOiK01186.
OMAiRNQYTES.
OrthoDBiEOG091G0HAW.

Enzyme and pathway databases

ReactomeiR-RNO-1660662. Glycosphingolipid metabolism.
R-RNO-4085001. Sialic acid metabolism.
R-RNO-6798695. Neutrophil degranulation.

Gene expression databases

BgeeiENSRNOG00000032942.

Family and domain databases

Gene3Di2.120.10.10. 1 hit.
InterProiIPR026856. Sialidase_fam.
IPR011040. Sialidases.
[Graphical view]
PANTHERiPTHR10628. PTHR10628. 1 hit.
PfamiPF13088. BNR_2. 1 hit.
[Graphical view]
SUPFAMiSSF50939. SSF50939. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiQ6MG70_RAT
AccessioniPrimary (citable) accession number: Q6MG70
Secondary accession number(s): D3ZB63
Entry historyi
Integrated into UniProtKB/TrEMBL: July 5, 2004
Last sequence update: July 5, 2004
Last modified: November 30, 2016
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.