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Protein

MutS protein homolog 5

Gene

Msh5

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Involved in DNA mismatch repair and meiotic recombination processes. Facilitates crossovers between homologs during meiosis (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi589 – 596ATPSequence analysis8

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processDNA damage, DNA repair, Meiosis
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
MutS protein homolog 5
Gene namesi
Name:Msh5
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 20

Organism-specific databases

RGDi1303008 Msh5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001152041 – 831MutS protein homolog 5Add BLAST831

Proteomic databases

PaxDbiQ6MG62
PRIDEiQ6MG62

PTM databases

iPTMnetiQ6MG62
PhosphoSitePlusiQ6MG62

Expressioni

Gene expression databases

BgeeiENSRNOG00000000857
ExpressionAtlasiQ6MG62 baseline and differential

Interactioni

Subunit structurei

Heterooligomer of MSH4 and MSH5. Interacts with HJURP (By similarity).By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000057489

Structurei

3D structure databases

ProteinModelPortaliQ6MG62
SMRiQ6MG62
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the DNA mismatch repair MutS family.Curated

Phylogenomic databases

eggNOGiKOG0221 Eukaryota
COG0249 LUCA
GeneTreeiENSGT00550000074977
HOGENOMiHOG000006649
HOVERGENiHBG001449
InParanoidiQ6MG62
KOiK08741
OMAiNDLVFFY
PhylomeDBiQ6MG62
TreeFamiTF314549

Family and domain databases

InterProiView protein in InterPro
IPR011184 DNA_mismatch_repair_Msh2
IPR000432 DNA_mismatch_repair_MutS_C
IPR007861 DNA_mismatch_repair_MutS_clamp
IPR007696 DNA_mismatch_repair_MutS_core
IPR036187 DNA_mismatch_repair_MutS_sf
IPR027417 P-loop_NTPase
PfamiView protein in Pfam
PF05192 MutS_III, 1 hit
PF05190 MutS_IV, 1 hit
PF00488 MutS_V, 1 hit
PIRSFiPIRSF005813 MSH2, 1 hit
SMARTiView protein in SMART
SM00534 MUTSac, 1 hit
SM00533 MUTSd, 1 hit
SUPFAMiSSF48334 SSF48334, 1 hit
SSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS00486 DNA_MISMATCH_REPAIR_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q6MG62-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAFRATPGRT PPGPGPGVPS ASFSSPQPAM AAPGGIEEED EEEPAEIHLC
60 70 80 90 100
VLWSSGYLGI AYYDTSDSTI HFMPDAPDHE SLKLLQRVLD EINPQSVVTS
110 120 130 140 150
AKQDEAMTQF LGKLASQEHR EPKRPEIILL PSVDFGPEIS KQRLLSGNYS
160 170 180 190 200
FISESMTATE KILFLSSIIP FDCVLTVRAL GGLLKFLSRR RVGVELEDYS
210 220 230 240 250
VGVPILGFKK FVLTHLVSID QDTYSVLQIF KSESHPSVYK VASGLKEGLS
260 270 280 290 300
LFGILNRCRC RWGQKLLRLW FTRPTRELRE LNSRLDVIEF FLMPQNLDMA
310 320 330 340 350
QMMHRLLSHI KNVPLILKRM KLSHTKVSDW QVLYKTVYSA LGLRDACRSL
360 370 380 390 400
PQSIQLFRDI TQEFSDDLHH IASLIGKVVD FEESLAENRF TVLPNIDPEI
410 420 430 440 450
DAKKRRLMGL PSFLTEVAQK ELENLDSCIP SCSVIYIPLI GFLLSIPRLS
460 470 480 490 500
FMVEASDFEI EGLDFMFLSE DKLHYRSART KELDALLGDL HCEIRDQEML
510 520 530 540 550
LMHQLQCQVL ARAPVLTRVL DLASRLDVLL ALASAARDYG YSRPHYSPCI
560 570 580 590 600
QGVRIKNGRH PLMELCARTF VPNSTDCGGD QGRVKVITGP NSSGKSIYLK
610 620 630 640 650
QVGLITFMAL VGSFVPAEEA EIGVIDAIFT RIHSCESISL GLSTFMIDLN
660 670 680 690 700
QVAKAVNNAT EHSLVLIDEF GKGTNSVDGL ALLTAVLRHW LALGPSCPHI
710 720 730 740 750
FVATNFLSLV QLQLLPQGPL VQYLTMETCE DGNDLVFFYQ LCHGVASASH
760 770 780 790 800
ASYTAAQAGL PDPLIARGKE VSDSIRSGKP VKPMHELVRR TQMENCQALV
810 820 830
DKFLKLDLED PSLDLDIFIS QEVLPAATTI L
Length:831
Mass (Da):92,452
Last modified:July 5, 2004 - v1
Checksum:i6C6AE6C02795321D
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti379Missing in AAH83904 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX883045 Genomic DNA Translation: CAE83984.1
BC083904 mRNA Translation: AAH83904.1
RefSeqiNP_997701.2, NM_212536.2
XP_017457063.1, XM_017601574.1
UniGeneiRn.44043

Genome annotation databases

EnsembliENSRNOT00000091022; ENSRNOP00000074342; ENSRNOG00000000857
GeneIDi294252
KEGGirno:294252
UCSCiRGD:1303008 rat

Similar proteinsi

Entry informationi

Entry nameiMSH5_RAT
AccessioniPrimary (citable) accession number: Q6MG62
Secondary accession number(s): Q5XHZ5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 24, 2006
Last sequence update: July 5, 2004
Last modified: May 23, 2018
This is version 101 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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