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Protein

MutS protein homolog 5

Gene

Msh5

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Involved in meiotic recombination. Facilitate crossovers between homologs during meiosis (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi589 – 5968ATPSequence analysis

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Meiosis

Keywords - Ligandi

ATP-binding, DNA-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
MutS protein homolog 5
Gene namesi
Name:Msh5
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 20

Organism-specific databases

RGDi1303008. Msh5.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 831831MutS protein homolog 5PRO_0000115204Add
BLAST

Proteomic databases

PaxDbiQ6MG62.
PRIDEiQ6MG62.

PTM databases

iPTMnetiQ6MG62.

Expressioni

Gene expression databases

ExpressionAtlasiQ6MG62. baseline and differential.

Interactioni

Subunit structurei

Heterooligomer of MSH4 and MSH5. Interacts with HJURP (By similarity).By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000057489.

Structurei

3D structure databases

ProteinModelPortaliQ6MG62.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the DNA mismatch repair MutS family.Curated

Phylogenomic databases

eggNOGiKOG0221. Eukaryota.
COG0249. LUCA.
GeneTreeiENSGT00550000074977.
HOGENOMiHOG000006649.
HOVERGENiHBG001449.
InParanoidiQ6MG62.
KOiK08741.
OMAiLAFKKFV.
OrthoDBiEOG74XS60.
PhylomeDBiQ6MG62.
TreeFamiTF314549.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR011184. DNA_mismatch_repair_MutS.
IPR000432. DNA_mismatch_repair_MutS_C.
IPR007861. DNA_mismatch_repair_MutS_clamp.
IPR007696. DNA_mismatch_repair_MutS_core.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF05192. MutS_III. 1 hit.
PF05190. MutS_IV. 1 hit.
PF00488. MutS_V. 1 hit.
[Graphical view]
PIRSFiPIRSF005813. MSH2. 1 hit.
SMARTiSM00534. MUTSac. 1 hit.
SM00533. MUTSd. 1 hit.
[Graphical view]
SUPFAMiSSF48334. SSF48334. 1 hit.
SSF52540. SSF52540. 1 hit.
PROSITEiPS00486. DNA_MISMATCH_REPAIR_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6MG62-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAFRATPGRT PPGPGPGVPS ASFSSPQPAM AAPGGIEEED EEEPAEIHLC
60 70 80 90 100
VLWSSGYLGI AYYDTSDSTI HFMPDAPDHE SLKLLQRVLD EINPQSVVTS
110 120 130 140 150
AKQDEAMTQF LGKLASQEHR EPKRPEIILL PSVDFGPEIS KQRLLSGNYS
160 170 180 190 200
FISESMTATE KILFLSSIIP FDCVLTVRAL GGLLKFLSRR RVGVELEDYS
210 220 230 240 250
VGVPILGFKK FVLTHLVSID QDTYSVLQIF KSESHPSVYK VASGLKEGLS
260 270 280 290 300
LFGILNRCRC RWGQKLLRLW FTRPTRELRE LNSRLDVIEF FLMPQNLDMA
310 320 330 340 350
QMMHRLLSHI KNVPLILKRM KLSHTKVSDW QVLYKTVYSA LGLRDACRSL
360 370 380 390 400
PQSIQLFRDI TQEFSDDLHH IASLIGKVVD FEESLAENRF TVLPNIDPEI
410 420 430 440 450
DAKKRRLMGL PSFLTEVAQK ELENLDSCIP SCSVIYIPLI GFLLSIPRLS
460 470 480 490 500
FMVEASDFEI EGLDFMFLSE DKLHYRSART KELDALLGDL HCEIRDQEML
510 520 530 540 550
LMHQLQCQVL ARAPVLTRVL DLASRLDVLL ALASAARDYG YSRPHYSPCI
560 570 580 590 600
QGVRIKNGRH PLMELCARTF VPNSTDCGGD QGRVKVITGP NSSGKSIYLK
610 620 630 640 650
QVGLITFMAL VGSFVPAEEA EIGVIDAIFT RIHSCESISL GLSTFMIDLN
660 670 680 690 700
QVAKAVNNAT EHSLVLIDEF GKGTNSVDGL ALLTAVLRHW LALGPSCPHI
710 720 730 740 750
FVATNFLSLV QLQLLPQGPL VQYLTMETCE DGNDLVFFYQ LCHGVASASH
760 770 780 790 800
ASYTAAQAGL PDPLIARGKE VSDSIRSGKP VKPMHELVRR TQMENCQALV
810 820 830
DKFLKLDLED PSLDLDIFIS QEVLPAATTI L
Length:831
Mass (Da):92,452
Last modified:July 5, 2004 - v1
Checksum:i6C6AE6C02795321D
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti379 – 3791Missing in AAH83904 (PubMed:15489334).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX883045 Genomic DNA. Translation: CAE83984.1.
BC083904 mRNA. Translation: AAH83904.1.
RefSeqiNP_997701.2. NM_212536.2.
XP_006256119.1. XM_006256057.2.
XP_008770939.1. XM_008772717.1.
UniGeneiRn.44043.

Genome annotation databases

EnsembliENSRNOT00000091022; ENSRNOP00000074342; ENSRNOG00000000857.
GeneIDi294252.
KEGGirno:294252.
UCSCiRGD:1303008. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX883045 Genomic DNA. Translation: CAE83984.1.
BC083904 mRNA. Translation: AAH83904.1.
RefSeqiNP_997701.2. NM_212536.2.
XP_006256119.1. XM_006256057.2.
XP_008770939.1. XM_008772717.1.
UniGeneiRn.44043.

3D structure databases

ProteinModelPortaliQ6MG62.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000057489.

PTM databases

iPTMnetiQ6MG62.

Proteomic databases

PaxDbiQ6MG62.
PRIDEiQ6MG62.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000091022; ENSRNOP00000074342; ENSRNOG00000000857.
GeneIDi294252.
KEGGirno:294252.
UCSCiRGD:1303008. rat.

Organism-specific databases

CTDi4439.
RGDi1303008. Msh5.

Phylogenomic databases

eggNOGiKOG0221. Eukaryota.
COG0249. LUCA.
GeneTreeiENSGT00550000074977.
HOGENOMiHOG000006649.
HOVERGENiHBG001449.
InParanoidiQ6MG62.
KOiK08741.
OMAiLAFKKFV.
OrthoDBiEOG74XS60.
PhylomeDBiQ6MG62.
TreeFamiTF314549.

Miscellaneous databases

NextBioi637830.
PROiQ6MG62.

Gene expression databases

ExpressionAtlasiQ6MG62. baseline and differential.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR011184. DNA_mismatch_repair_MutS.
IPR000432. DNA_mismatch_repair_MutS_C.
IPR007861. DNA_mismatch_repair_MutS_clamp.
IPR007696. DNA_mismatch_repair_MutS_core.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF05192. MutS_III. 1 hit.
PF05190. MutS_IV. 1 hit.
PF00488. MutS_V. 1 hit.
[Graphical view]
PIRSFiPIRSF005813. MSH2. 1 hit.
SMARTiSM00534. MUTSac. 1 hit.
SM00533. MUTSd. 1 hit.
[Graphical view]
SUPFAMiSSF48334. SSF48334. 1 hit.
SSF52540. SSF52540. 1 hit.
PROSITEiPS00486. DNA_MISMATCH_REPAIR_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The genomic sequence and comparative analysis of the rat major histocompatibility complex."
    Hurt P., Walter L., Sudbrak R., Klages S., Mueller I., Shiina T., Inoko H., Lehrach H., Guenther E., Reinhardt R., Himmelbauer H.
    Genome Res. 14:631-639(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Brown Norway.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.

Entry informationi

Entry nameiMSH5_RAT
AccessioniPrimary (citable) accession number: Q6MG62
Secondary accession number(s): Q5XHZ5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 24, 2006
Last sequence update: July 5, 2004
Last modified: May 11, 2016
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.