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Protein

Chloride intracellular channel protein 1

Gene

Clic1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Can insert into membranes and form chloride ion channels. Channel activity depends on the pH. Membrane insertion seems to be redox-regulated and may occur only under oxydizing conditions (By similarity).By similarity

GO - Molecular functioni

  • cadherin binding Source: Ensembl
  • voltage-gated chloride channel activity Source: RGD

GO - Biological processi

Keywordsi

Molecular functionChloride channel, Ion channel, Voltage-gated channel
Biological processIon transport, Transport
LigandChloride

Names & Taxonomyi

Protein namesi
Recommended name:
Chloride intracellular channel protein 1By similarityImported
Gene namesi
Name:Clic1Imported
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 20

Organism-specific databases

RGDi1303043. Clic1.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei26 – 46Helical; Note=After insertion into the membraneSequence analysisAdd BLAST21

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00003651032 – 241Chloride intracellular channel protein 1By similarityAdd BLAST240

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanine1 Publication1
Modified residuei13N6-acetyllysineBy similarity1
Disulfide bondi24 ↔ 59By similarity
Modified residuei119N6-acetyllysineBy similarity1
Modified residuei121PhosphoserineBy similarity1
Modified residuei131N6-acetyllysineBy similarity1
Modified residuei156PhosphoserineBy similarity1
Modified residuei211PhosphoserineBy similarity1
Modified residuei233PhosphotyrosineBy similarity1

Keywords - PTMi

Acetylation, Disulfide bond, Phosphoprotein

Proteomic databases

PaxDbiQ6MG61.
PRIDEiQ6MG61.

PTM databases

iPTMnetiQ6MG61.
PhosphoSitePlusiQ6MG61.

Expressioni

Gene expression databases

BgeeiENSRNOG00000029682.
GenevisibleiQ6MG61. RN.

Interactioni

Subunit structurei

Monomer. Homodimer (in vitro). Interacts with TRAPPC2. Dimerization requires a conformation change that leads to the exposure of a large hydrophobic surface. In vivo, this may lead to membrane insertion (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000060240.

Structurei

3D structure databases

ProteinModelPortaliQ6MG61.
SMRiQ6MG61.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini93 – 233GST C-terminalSequence analysisAdd BLAST141

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni2 – 90Required for insertion into the membraneBy similarityAdd BLAST89

Domaini

Members of this family may change from a globular, soluble state to a state where the N-terminal domain is inserted into the membrane and functions as chloride channel. A conformation change of the N-terminal domain is thought to expose hydrophobic surfaces that trigger membrane insertion (By similarity).By similarity

Sequence similaritiesi

Belongs to the chloride channel CLIC family.Sequence analysis

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410INGZ. Eukaryota.
ENOG410ZZZX. LUCA.
GeneTreeiENSGT00550000074477.
HOGENOMiHOG000231548.
HOVERGENiHBG050994.
InParanoidiQ6MG61.
KOiK05021.
OMAiLWRYLNA.
OrthoDBiEOG091G0IHT.
PhylomeDBiQ6MG61.
TreeFamiTF315438.

Family and domain databases

InterProiView protein in InterPro
IPR002946. CLIC.
IPR030259. CLIC-1.
IPR010987. Glutathione-S-Trfase_C-like.
IPR036282. Glutathione-S-Trfase_C_sf.
IPR004045. Glutathione_S-Trfase_N.
IPR036249. Thioredoxin-like_sf.
PANTHERiPTHR43920:SF2. PTHR43920:SF2. 1 hit.
PfamiView protein in Pfam
PF13409. GST_N_2. 1 hit.
PRINTSiPR01263. INTCLCHANNEL.
SUPFAMiSSF47616. SSF47616. 1 hit.
SSF52833. SSF52833. 1 hit.
TIGRFAMsiTIGR00862. O-ClC. 1 hit.
PROSITEiView protein in PROSITE
PS50405. GST_CTER. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6MG61-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAEEQPQVEL FVKAGSDGAK IGNCPFSQRL FMVLWLKGVT FNVTTVDTKR
60 70 80 90 100
RTETVQKLCP GGQLPFLLYG TEVHTDTNKI EEFLEAVLCP PRYPKLAALN
110 120 130 140 150
PESNTSGLDI FAKFSAYIKN SNPALNDNLE KGLLKALKVL DNYLTSPLPE
160 170 180 190 200
EVDETSAEDE GISQRKFLDG NELTLADCNL LPKLHIVQVV CKKYRGFTIP
210 220 230 240
EAFRGVHRYL SNAYAREEFA STCPDDEEIE LAYEQVARAL K
Length:241
Mass (Da):26,981
Last modified:July 5, 2004 - v1
Checksum:i1774F7190D44B01C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX883045 Genomic DNA. Translation: CAE83985.1.
CH474121 Genomic DNA. Translation: EDL83493.1.
BC099823 mRNA. Translation: AAH99823.1.
RefSeqiNP_001002807.1. NM_001002807.2.
UniGeneiRn.203139.

Genome annotation databases

EnsembliENSRNOT00000068435; ENSRNOP00000060240; ENSRNOG00000029682.
GeneIDi406864.
KEGGirno:406864.
UCSCiRGD:1303043. rat.

Similar proteinsi

Entry informationi

Entry nameiCLIC1_RAT
AccessioniPrimary (citable) accession number: Q6MG61
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 3, 2009
Last sequence update: July 5, 2004
Last modified: October 25, 2017
This is version 115 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families