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Protein

N(G),N(G)-dimethylarginine dimethylaminohydrolase 2

Gene

Ddah2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Hydrolyzes N(G),N(G)-dimethyl-L-arginine (ADMA) and N(G)-monomethyl-L-arginine (MMA) which act as inhibitors of NOS. Has therefore a role in the regulation of nitric oxide generation (By similarity).By similarity

Catalytic activityi

N(omega),N(omega)-dimethyl-L-arginine + H2O = dimethylamine + L-citrulline.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei171Proton donorBy similarity1
Active sitei276NucleophileSequence analysis1

GO - Molecular functioni

  • amino acid binding Source: RGD
  • dimethylargininase activity Source: RGD

GO - Biological processi

Keywordsi

Molecular functionHydrolase

Enzyme and pathway databases

BRENDAi3.5.3.18 5301
ReactomeiR-RNO-203615 eNOS activation

Names & Taxonomyi

Protein namesi
Recommended name:
N(G),N(G)-dimethylarginine dimethylaminohydrolase 2 (EC:3.5.3.18)
Short name:
DDAH-2
Short name:
Dimethylarginine dimethylaminohydrolase 2
Alternative name(s):
DDAHII
Dimethylargininase-2
Gene namesi
Name:Ddah2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 20

Organism-specific databases

RGDi1302955 Ddah2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002707601 – 285N(G),N(G)-dimethylarginine dimethylaminohydrolase 2Add BLAST285

Proteomic databases

PaxDbiQ6MG60
PRIDEiQ6MG60

PTM databases

iPTMnetiQ6MG60
PhosphoSitePlusiQ6MG60
SwissPalmiQ6MG60

Expressioni

Gene expression databases

BgeeiENSRNOG00000000842
GenevisibleiQ6MG60 RN

Interactioni

Protein-protein interaction databases

BioGridi254630, 1 interactor
IntActiQ6MG60, 1 interactor
STRINGi10116.ENSRNOP00000001118

Structurei

3D structure databases

ProteinModelPortaliQ6MG60
SMRiQ6MG60
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the DDAH family.Curated

Phylogenomic databases

eggNOGiENOG410ISNS Eukaryota
ENOG4111YMV LUCA
GeneTreeiENSGT00390000009331
HOGENOMiHOG000161035
HOVERGENiHBG055937
InParanoidiQ6MG60
KOiK01482
OMAiCPYGRFT
PhylomeDBiQ6MG60
TreeFamiTF314737

Family and domain databases

InterProiView protein in InterPro
IPR033199 DDAH/AD
IPR033202 DDAH2
PANTHERiPTHR12737 PTHR12737, 1 hit
PTHR12737:SF16 PTHR12737:SF16, 1 hit

Sequencei

Sequence statusi: Complete.

Q6MG60-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGTPGEGLGR CSHALIRGVP ESLASGEGAG AGLPALDLAK AQREHGVLGG
60 70 80 90 100
KLRQRLGLQL LELPPEESLP LGPLLGDTAV IQGDTALITR PWSPARRPEV
110 120 130 140 150
DGVRKALQDL GLRIVEMGDE NATLDGTDVL FTGREFFVGL SKWTNHRGAE
160 170 180 190 200
IVADTFRDFA VSTVPVSGAS HLRGLCGMGG PRTVVAGSSE AAQKAVRAMA
210 220 230 240 250
ALTDHPYASL TLPDDAASDC LFLRPGLPGT TPFLLHRGGG DLPNSQEALQ
260 270 280
KLSDVTLVPV SCSELEKVGA GLSSLCLVLS TRPHC
Length:285
Mass (Da):29,688
Last modified:July 5, 2004 - v1
Checksum:iC28D60FF20CEAEFF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX883045 Genomic DNA Translation: CAE83986.1
BC086443 mRNA Translation: AAH86443.1
BC097930 mRNA Translation: AAH97930.1
RefSeqiNP_001159408.1, NM_001165936.1
NP_997697.1, NM_212532.2
UniGeneiRn.203056

Genome annotation databases

EnsembliENSRNOT00000001118; ENSRNOP00000001118; ENSRNOG00000000842
ENSRNOT00000083353; ENSRNOP00000068864; ENSRNOG00000000842
ENSRNOT00000088251; ENSRNOP00000069121; ENSRNOG00000000842
GeneIDi294239
KEGGirno:294239
UCSCiRGD:1302955 rat

Similar proteinsi

Entry informationi

Entry nameiDDAH2_RAT
AccessioniPrimary (citable) accession number: Q6MG60
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: July 5, 2004
Last modified: May 23, 2018
This is version 103 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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