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Protein

Protein G6b

Gene

G6b

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Inhibits platelet aggregation and activation by agonists such as ADP and collagen-related peptide. Appears to operate in a calcium-independent manner (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Ligandi

Heparin-binding

Enzyme and pathway databases

ReactomeiR-RNO-114604. GPVI-mediated activation cascade.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein G6b
Gene namesi
Name:G6b
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 20

Organism-specific databases

RGDi1303269. G6b.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini18 – 140123ExtracellularSequence analysisAdd
BLAST
Transmembranei141 – 16121HelicalSequence analysisAdd
BLAST
Topological domaini162 – 23271CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1717By similarityAdd
BLAST
Chaini18 – 232215Protein G6bPRO_0000021313Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi32 – 321N-linked (GlcNAc...)Sequence analysis
Glycosylationi112 – 1121N-linked (GlcNAc...)Sequence analysis
Modified residuei202 – 2021PhosphotyrosineBy similarity

Post-translational modificationi

N-glycosylated.
May be O-glycosylated.By similarity

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ6MG59.
PRIDEiQ6MG59.

Expressioni

Gene expression databases

ExpressionAtlasiQ6MG59. baseline.

Interactioni

Subunit structurei

Interacts with PTPN6 and PTPN11. Binds to heparin (By similarity).By similarity

Family & Domainsi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IYA7. Eukaryota.
ENOG41118MY. LUCA.
GeneTreeiENSGT00390000017793.
HOGENOMiHOG000043067.
HOVERGENiHBG080566.
InParanoidiQ6MG59.
OMAiPRFPACK.
OrthoDBiEOG7ZWD3V.
PhylomeDBiQ6MG59.
TreeFamiTF337394.

Family and domain databases

InterProiIPR028070. G6B.
[Graphical view]
PfamiPF15096. G6B. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6MG59-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALVLQLLPL LLSKVQGNPE VSLEGNPGDR VNLSCIGVSD PTRWAWAPSF
60 70 80 90 100
PACKGLSKGR RPILWASSSG TPTVLQHFSG RLRSLDTGIK RLELLLSAGD
110 120 130 140 150
SGTFFCKGRQ ENESRTVIQV LGDKAGCRPS GSTHGSEYSK VLIPLLGFGL
160 170 180 190 200
VLGLGALGLV WWRRSCVPPS HIAPVINAEP QRPLEQDSKI SGHLDQEPNL
210 220 230
HYADLDHSVL RRHRRMSALV PGDASTVYAV VV
Length:232
Mass (Da):25,083
Last modified:July 5, 2004 - v1
Checksum:i728345F61CFD085A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX883045 Genomic DNA. Translation: CAE83987.1.
RefSeqiNP_001003976.1. NM_001003976.1.
UniGeneiRn.142706.

Genome annotation databases

EnsembliENSRNOT00000037191; ENSRNOP00000033088; ENSRNOG00000026936.
GeneIDi406865.
KEGGirno:406865.
UCSCiRGD:1303269. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX883045 Genomic DNA. Translation: CAE83987.1.
RefSeqiNP_001003976.1. NM_001003976.1.
UniGeneiRn.142706.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PaxDbiQ6MG59.
PRIDEiQ6MG59.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000037191; ENSRNOP00000033088; ENSRNOG00000026936.
GeneIDi406865.
KEGGirno:406865.
UCSCiRGD:1303269. rat.

Organism-specific databases

CTDi106722.
RGDi1303269. G6b.

Phylogenomic databases

eggNOGiENOG410IYA7. Eukaryota.
ENOG41118MY. LUCA.
GeneTreeiENSGT00390000017793.
HOGENOMiHOG000043067.
HOVERGENiHBG080566.
InParanoidiQ6MG59.
OMAiPRFPACK.
OrthoDBiEOG7ZWD3V.
PhylomeDBiQ6MG59.
TreeFamiTF337394.

Enzyme and pathway databases

ReactomeiR-RNO-114604. GPVI-mediated activation cascade.

Miscellaneous databases

PROiQ6MG59.

Gene expression databases

ExpressionAtlasiQ6MG59. baseline.

Family and domain databases

InterProiIPR028070. G6B.
[Graphical view]
PfamiPF15096. G6B. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The genomic sequence and comparative analysis of the rat major histocompatibility complex."
    Hurt P., Walter L., Sudbrak R., Klages S., Mueller I., Shiina T., Inoko H., Lehrach H., Guenther E., Reinhardt R., Himmelbauer H.
    Genome Res. 14:631-639(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Brown Norway.

Entry informationi

Entry nameiG6B_RAT
AccessioniPrimary (citable) accession number: Q6MG59
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 21, 2005
Last sequence update: July 5, 2004
Last modified: July 6, 2016
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.