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Q6MG48 (PRC2A_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 72. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Protein PRRC2A
Alternative name(s):
HLA-B-associated transcript 2
Proline-rich and coiled-coil-containing protein 2A
Gene names
Name:Prrc2a
Synonyms:Bat2
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length2161 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

May play a role in the regulation of pre-mRNA splicing By similarity.

Subcellular location

Cytoplasm By similarity. Nucleus By similarity.

Ontologies

Keywords
   Cellular componentCytoplasm
Nucleus
   DomainRepeat
   PTMAcetylation
Phosphoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

nucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 21612161Protein PRRC2A
PRO_0000064832

Regions

Repeat41 – 95551-1
Repeat98 – 154571-2
Repeat281 – 337571-3
Repeat337 – 429932-1
Repeat487 – 560742-2
Repeat1760 – 1815561-4
Repeat1920 – 1969503-1
Repeat1986 – 2035503-2
Repeat2061 – 2110503-3
Region41 – 181517754 X 57 AA type A repeats
Region337 – 5602242 X type B repeats
Region1920 – 21101913 X 50 AA type C repeats
Compositional bias404 – 41411Poly-Pro
Compositional bias465 – 4706Poly-Arg
Compositional bias471 – 4744Poly-Glu
Compositional bias657 – 67014Poly-Gln
Compositional bias697 – 7015Poly-Pro
Compositional bias827 – 8348Poly-Pro
Compositional bias909 – 9168Poly-Gly
Compositional bias917 – 9204Poly-Pro
Compositional bias959 – 9624Poly-Pro
Compositional bias1239 – 12446Poly-Arg
Compositional bias1297 – 13004Poly-Pro
Compositional bias1407 – 14104Poly-Gly
Compositional bias1413 – 14219Poly-Gly
Compositional bias1451 – 14577Poly-Pro

Amino acid modifications

Modified residue271N6-acetyllysine By similarity
Modified residue351N6-acetyllysine By similarity
Modified residue1661Phosphoserine By similarity
Modified residue3421Phosphoserine By similarity
Modified residue3501Phosphoserine By similarity
Modified residue3781Phosphoserine By similarity
Modified residue3811Phosphoserine By similarity
Modified residue4551Phosphoserine By similarity
Modified residue6091Phosphothreonine By similarity
Modified residue7601Phosphoserine By similarity
Modified residue7621Phosphoserine By similarity
Modified residue7651Phosphoserine By similarity
Modified residue8091Phosphoserine By similarity
Modified residue10001Phosphothreonine By similarity
Modified residue10071Phosphoserine By similarity
Modified residue10881Phosphoserine By similarity
Modified residue10921Phosphoserine By similarity
Modified residue10951Phosphoserine By similarity
Modified residue10971Phosphotyrosine By similarity
Modified residue11131Phosphoserine By similarity
Modified residue11501Phosphoserine By similarity
Modified residue11991N6-acetyllysine By similarity
Modified residue12221Phosphoserine By similarity
Modified residue13071Phosphoserine By similarity
Modified residue13541Phosphothreonine By similarity
Modified residue14061Phosphothreonine Ref.2
Modified residue21171Phosphoserine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q6MG48 [UniParc].

Last modified July 5, 2004. Version 1.
Checksum: 8843EDDB4443C6AD

FASTA2,161229,047
        10         20         30         40         50         60 
MSDRSGPTAK GKDGKKYSSL NLFDTYKGKS LEIQKPAVAP RHGLQSLGKV AIARRMPPPA 

        70         80         90        100        110        120 
NLPSLKAENK GNDPNVSLVP KDGTGWASKQ EQSDPKSSDA STAQPPESQP LPASQTPASN 

       130        140        150        160        170        180 
QPKRPPTAPE NTPSVPSGVK SWAQASVTHG AHGDGGRASS LLSRFSREEF PTLQAAGDQD 

       190        200        210        220        230        240 
KAAKERESAE QSSGPGPSLR PQNSTTWRDG GGRGPDELEG PDSKLHHGHD PRGGLQPSGP 

       250        260        270        280        290        300 
PQFPPYRGMM PPFMYPPYLP FPPPYGPQGP YRYPTPDGPS RFPRVAGPRG SGPPMRLVEP 

       310        320        330        340        350        360 
VGRPSILKED NLKEFDQLDQ ENDDGWAGAH EEVDYTEKLK FSDEEDGRDS DEEGAEGHKD 

       370        380        390        400        410        420 
SQSAAGEEPE TDGKKGTSPG SELPPPKTAW TENSRPSETE PAAPPIPKPP PPPPHRGPVG 

       430        440        450        460        470        480 
NWGPPGDYPD RGGPPCKPPA PEDEDEAWRQ RRKQSSSEIS LAVERARRRR EEEERRMQEE 

       490        500        510        520        530        540 
RRAACAEKLK RLDEKFGAPD KRLKAEPAAP PVTPPAPALP PVVPKETPTP PALPPTPTPT 

       550        560        570        580        590        600 
PEKDPEEPAH APPVQSAPTQ AGPPAPTPVS GGGTASSTSS GSFEASPAEP QLPSKEGPEP 

       610        620        630        640        650        660 
PEEVPAPTTP PAPKVEPKGD GVGPTRQPPS QGLGYPKYQK SLPPRFQRQQ QEQLLKQQQQ 

       670        680        690        700        710        720 
QQWQQQQQQQ GTAPPAPVPP SPPQPVTLGA VPAPQAPPPP PKALYPGALG RPPPMPPMNF 

       730        740        750        760        770        780 
DPRWMMIPPY VDPRLLQGRP PLDFYPPGVH PSGLVPRERS DSGGSSSEPF ERHAPPLLRE 

       790        800        810        820        830        840 
RGTPPVDPKL AWVGDVFTTT PTDPRPLTSP LRQAADEEEK SLRSETPPVP PPPPYLANYP 

       850        860        870        880        890        900 
GFPENGTPGP PISRFPLEES APPGPRPLPW PPGNDEAAKM QAPPPKKEPP KEEPAQLSGP 

       910        920        930        940        950        960 
EAGRKPARGV GGGGQGPPPP RRENRTETRW GPRPGSCRRG IPPEDPGVPP RRAGPIKKPP 

       970        980        990       1000       1010       1020 
PPVKADELPP KSLEPGDETP KAPKPDALKT AKGKVGPKET PAGGNLSPAP RLRRDYSYER 

      1030       1040       1050       1060       1070       1080 
VGPTSCRGRG RGEYFARGRG FRGTYGGRGR GARSREFRSY REFRGDDGRG GGSGGTNHPS 

      1090       1100       1110       1120       1130       1140 
APRGRTASET RSEGSEYEEI PKRRRQRGSE TGSETHESDL APSDKEAPPP KEGVLAQVPL 

      1150       1160       1170       1180       1190       1200 
APPQPGAPPS PAPARFSTAR GGRVFTPRGV PSRRGRGGGR PPPVCSGWSP PAKSLVPKKP 

      1210       1220       1230       1240       1250       1260 
PTGPLPPNKE PLKEKLISGP LSPMSRAGNM GVGMEDGERP RRRRHGRAQQ QDKPPRFRRL 

      1270       1280       1290       1300       1310       1320 
KQDRENAARG TDGKPPPLTL PASTPAPTET LATVAAPPPP RRTAAKSPDL SNQNSDQANE 

      1330       1340       1350       1360       1370       1380 
EWETASESSD FASERRGDKE TPPAALITSK AVGTPGGNSG GAGPGISTMS RGDLSQRAKD 

      1390       1400       1410       1420       1430       1440 
LSKRSFSSQR PGMDRQNRRP GAGGKTGGGG SSGGGGAGPG GRTGPGRGDK RSWPSPKNRS 

      1450       1460       1470       1480       1490       1500 
RPPEERPPGL PLPPPPPSSS AVFRLDQVIH SNPAGIQQAL AQLSSRQGNV TAPGGHPRPK 

      1510       1520       1530       1540       1550       1560 
PGPPQAPQGS SPRPPTHYDP PRASNAISSD PHFEEPGPMV RGVGGTPRDS AGVNPFPPKR 

      1570       1580       1590       1600       1610       1620 
RERPPRKPEL LQEETVPASH SSGFLGSKPE VPGPQEESRD SGTEALTPHI WNRLHTATSR 

      1630       1640       1650       1660       1670       1680 
KSYQPGSIEP WMEPLSPFED VAGTEMSQSD SGVDLSGGSQ VSSGPCSQRS SPDGGLKGSA 

      1690       1700       1710       1720       1730       1740 
EGPPRRPGGP SPLKAVPGES SSASEPSEPH RRRPPASHEG ERKELPREQP LPPGPIGTER 

      1750       1760       1770       1780       1790       1800 
SQRTDRGPEP GPLRPAHRAG SQVEFGTTNK DSDLCLVVGD TLKGEKELAA SATEAVPVSR 

      1810       1820       1830       1840       1850       1860 
DWELLPSASA SAEPQAKSLG SGQCGPEPSP SGQRLYPEVF YGSPGPPNSQ VSGGAPIDSQ 

      1870       1880       1890       1900       1910       1920 
LHPSSGGFRP GTPSVHQYRS QPLYLPPGPA PPSALLSGVA LKGQFLDFSA LQATELGKLP 

      1930       1940       1950       1960       1970       1980 
AGGVLYPPPS FLYSAAFCPS PLPDPPLLQV RQDLPSPSDF YSTPLQPGGQ SGFLPSGAPA 

      1990       2000       2010       2020       2030       2040 
QQMLLPVVDS QLPVVNFGSL PPAPPPAPPP LSLLPVGPAL QPPNLAVRPP PAPAARVLPS 

      2050       2060       2070       2080       2090       2100 
PARPFPASLG RAELHPVELK PFQDYRKLSS NLGGPGSSRA PPSGRSFSGL NSRLKAPPST 

      2110       2120       2130       2140       2150       2160 
YSGVFRTQRI DLYQQASPPD ALRWMPKPWE RTGPPSREGP PRRAEEPGPR GEKEPGLPPP 


R 

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References

[1]"The genomic sequence and comparative analysis of the rat major histocompatibility complex."
Hurt P., Walter L., Sudbrak R., Klages S., Mueller I., Shiina T., Inoko H., Lehrach H., Guenther E., Reinhardt R., Himmelbauer H.
Genome Res. 14:631-639(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Brown Norway.
[2]"Quantitative phosphoproteomics of vasopressin-sensitive renal cells: regulation of aquaporin-2 phosphorylation at two sites."
Hoffert J.D., Pisitkun T., Wang G., Shen R.-F., Knepper M.A.
Proc. Natl. Acad. Sci. U.S.A. 103:7159-7164(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-1406, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BX883046 Genomic DNA. Translation: CAE83998.1.
RefSeqNP_997627.1. NM_212462.2.
XP_006256114.1. XM_006256052.1.
UniGeneRn.34262.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10116.ENSRNOP00000001133.

PTM databases

PhosphoSiteQ6MG48.

Proteomic databases

PaxDbQ6MG48.
PRIDEQ6MG48.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSRNOT00000001133; ENSRNOP00000001133; ENSRNOG00000000852.
GeneID294250.
KEGGrno:294250.
UCSCRGD:1303025. rat.

Organism-specific databases

CTD7916.
RGD1303025. Prrc2a.

Phylogenomic databases

eggNOGNOG40021.
GeneTreeENSGT00530000063496.
HOVERGENHBG004820.
InParanoidQ6MG48.
OMADALRWMP.
OrthoDBEOG7DZ8J2.
PhylomeDBQ6MG48.

Gene expression databases

GenevestigatorQ6MG48.

Family and domain databases

InterProIPR009738. BAT2_N.
[Graphical view]
PfamPF07001. BAT2_N. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio637822.
PROQ6MG48.

Entry information

Entry namePRC2A_RAT
AccessionPrimary (citable) accession number: Q6MG48
Entry history
Integrated into UniProtKB/Swiss-Prot: August 16, 2005
Last sequence update: July 5, 2004
Last modified: April 16, 2014
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program