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Protein

Protein PRRC2A

Gene

Prrc2a

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May play a role in the regulation of pre-mRNA splicing.By similarity

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Protein PRRC2A
Alternative name(s):
HLA-B-associated transcript 2
Proline-rich and coiled-coil-containing protein 2A
Gene namesi
Name:Prrc2a
Synonyms:Bat2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 20

Organism-specific databases

RGDi1303025. Prrc2a.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000648321 – 2161Protein PRRC2AAdd BLAST2161

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei18PhosphoserineBy similarity1
Modified residuei19PhosphoserineBy similarity1
Modified residuei27N6-acetyllysineBy similarity1
Modified residuei30PhosphoserineBy similarity1
Modified residuei35N6-acetyllysineBy similarity1
Modified residuei146PhosphoserineBy similarity1
Modified residuei166PhosphoserineBy similarity1
Modified residuei204PhosphoserineBy similarity1
Modified residuei272Asymmetric dimethylarginineBy similarity1
Modified residuei296Omega-N-methylarginineBy similarity1
Modified residuei342PhosphoserineCombined sources1
Modified residuei350PhosphoserineCombined sources1
Modified residuei363PhosphoserineBy similarity1
Modified residuei378PhosphoserineBy similarity1
Modified residuei381PhosphoserineBy similarity1
Modified residuei455PhosphoserineBy similarity1
Modified residuei609PhosphothreonineBy similarity1
Modified residuei760PhosphoserineBy similarity1
Modified residuei762PhosphoserineCombined sources1
Modified residuei765PhosphoserineCombined sources1
Modified residuei808PhosphothreonineBy similarity1
Modified residuei809PhosphoserineCombined sources1
Modified residuei908Omega-N-methylarginineBy similarity1
Modified residuei936PhosphoserineBy similarity1
Modified residuei1000PhosphothreonineBy similarity1
Modified residuei1007PhosphoserineCombined sources1
Modified residuei1069Omega-N-methylarginineBy similarity1
Modified residuei1086PhosphothreonineBy similarity1
Modified residuei1088PhosphoserineCombined sources1
Modified residuei1092PhosphoserineBy similarity1
Modified residuei1095PhosphoserineBy similarity1
Modified residuei1097PhosphotyrosineBy similarity1
Modified residuei1109PhosphoserineBy similarity1
Modified residuei1113PhosphoserineCombined sources1
Modified residuei1123PhosphoserineBy similarity1
Modified residuei1150PhosphoserineCombined sources1
Modified residuei1199N6-acetyllysineBy similarity1
Modified residuei1222PhosphoserineCombined sources1
Modified residuei1307PhosphoserineBy similarity1
Modified residuei1311PhosphoserineBy similarity1
Modified residuei1324PhosphothreonineBy similarity1
Modified residuei1326PhosphoserineBy similarity1
Modified residuei1329PhosphoserineBy similarity1
Modified residuei1348PhosphothreonineBy similarity1
Modified residuei1354PhosphothreonineBy similarity1
Modified residuei1385PhosphoserineBy similarity1
Modified residuei1387PhosphoserineBy similarity1
Modified residuei1406PhosphothreonineCombined sources1
Modified residuei1761PhosphoserineCombined sources1
Modified residuei2040PhosphoserineBy similarity1
Modified residuei2086PhosphoserineBy similarity1
Modified residuei2117PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Methylation, Phosphoprotein

Proteomic databases

PaxDbiQ6MG48.
PRIDEiQ6MG48.

PTM databases

iPTMnetiQ6MG48.
PhosphoSitePlusiQ6MG48.

Expressioni

Gene expression databases

BgeeiENSRNOG00000000852.
ExpressionAtlasiQ6MG48. baseline and differential.
GenevisibleiQ6MG48. RN.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000001133.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati41 – 951-1Add BLAST55
Repeati98 – 1541-2Add BLAST57
Repeati281 – 3371-3Add BLAST57
Repeati337 – 4292-1Add BLAST93
Repeati487 – 5602-2Add BLAST74
Repeati1760 – 18151-4Add BLAST56
Repeati1920 – 19693-1Add BLAST50
Repeati1986 – 20353-2Add BLAST50
Repeati2061 – 21103-3Add BLAST50

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni41 – 18154 X 57 AA type A repeatsAdd BLAST1775
Regioni337 – 5602 X type B repeatsAdd BLAST224
Regioni1920 – 21103 X 50 AA type C repeatsAdd BLAST191

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi404 – 414Poly-ProAdd BLAST11
Compositional biasi465 – 470Poly-Arg6
Compositional biasi471 – 474Poly-Glu4
Compositional biasi657 – 670Poly-GlnAdd BLAST14
Compositional biasi697 – 701Poly-Pro5
Compositional biasi827 – 834Poly-Pro8
Compositional biasi909 – 916Poly-Gly8
Compositional biasi917 – 920Poly-Pro4
Compositional biasi959 – 962Poly-Pro4
Compositional biasi1239 – 1244Poly-Arg6
Compositional biasi1297 – 1300Poly-Pro4
Compositional biasi1407 – 1410Poly-Gly4
Compositional biasi1413 – 1421Poly-Gly9
Compositional biasi1451 – 1457Poly-Pro7

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG4817. Eukaryota.
ENOG410XQRI. LUCA.
GeneTreeiENSGT00530000063496.
HOVERGENiHBG004820.
InParanoidiQ6MG48.
OrthoDBiEOG091G02WC.
PhylomeDBiQ6MG48.

Family and domain databases

InterProiIPR009738. BAT2_N.
IPR033184. PRRC2.
[Graphical view]
PANTHERiPTHR14038. PTHR14038. 1 hit.
PfamiPF07001. BAT2_N. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6MG48-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSDRSGPTAK GKDGKKYSSL NLFDTYKGKS LEIQKPAVAP RHGLQSLGKV
60 70 80 90 100
AIARRMPPPA NLPSLKAENK GNDPNVSLVP KDGTGWASKQ EQSDPKSSDA
110 120 130 140 150
STAQPPESQP LPASQTPASN QPKRPPTAPE NTPSVPSGVK SWAQASVTHG
160 170 180 190 200
AHGDGGRASS LLSRFSREEF PTLQAAGDQD KAAKERESAE QSSGPGPSLR
210 220 230 240 250
PQNSTTWRDG GGRGPDELEG PDSKLHHGHD PRGGLQPSGP PQFPPYRGMM
260 270 280 290 300
PPFMYPPYLP FPPPYGPQGP YRYPTPDGPS RFPRVAGPRG SGPPMRLVEP
310 320 330 340 350
VGRPSILKED NLKEFDQLDQ ENDDGWAGAH EEVDYTEKLK FSDEEDGRDS
360 370 380 390 400
DEEGAEGHKD SQSAAGEEPE TDGKKGTSPG SELPPPKTAW TENSRPSETE
410 420 430 440 450
PAAPPIPKPP PPPPHRGPVG NWGPPGDYPD RGGPPCKPPA PEDEDEAWRQ
460 470 480 490 500
RRKQSSSEIS LAVERARRRR EEEERRMQEE RRAACAEKLK RLDEKFGAPD
510 520 530 540 550
KRLKAEPAAP PVTPPAPALP PVVPKETPTP PALPPTPTPT PEKDPEEPAH
560 570 580 590 600
APPVQSAPTQ AGPPAPTPVS GGGTASSTSS GSFEASPAEP QLPSKEGPEP
610 620 630 640 650
PEEVPAPTTP PAPKVEPKGD GVGPTRQPPS QGLGYPKYQK SLPPRFQRQQ
660 670 680 690 700
QEQLLKQQQQ QQWQQQQQQQ GTAPPAPVPP SPPQPVTLGA VPAPQAPPPP
710 720 730 740 750
PKALYPGALG RPPPMPPMNF DPRWMMIPPY VDPRLLQGRP PLDFYPPGVH
760 770 780 790 800
PSGLVPRERS DSGGSSSEPF ERHAPPLLRE RGTPPVDPKL AWVGDVFTTT
810 820 830 840 850
PTDPRPLTSP LRQAADEEEK SLRSETPPVP PPPPYLANYP GFPENGTPGP
860 870 880 890 900
PISRFPLEES APPGPRPLPW PPGNDEAAKM QAPPPKKEPP KEEPAQLSGP
910 920 930 940 950
EAGRKPARGV GGGGQGPPPP RRENRTETRW GPRPGSCRRG IPPEDPGVPP
960 970 980 990 1000
RRAGPIKKPP PPVKADELPP KSLEPGDETP KAPKPDALKT AKGKVGPKET
1010 1020 1030 1040 1050
PAGGNLSPAP RLRRDYSYER VGPTSCRGRG RGEYFARGRG FRGTYGGRGR
1060 1070 1080 1090 1100
GARSREFRSY REFRGDDGRG GGSGGTNHPS APRGRTASET RSEGSEYEEI
1110 1120 1130 1140 1150
PKRRRQRGSE TGSETHESDL APSDKEAPPP KEGVLAQVPL APPQPGAPPS
1160 1170 1180 1190 1200
PAPARFSTAR GGRVFTPRGV PSRRGRGGGR PPPVCSGWSP PAKSLVPKKP
1210 1220 1230 1240 1250
PTGPLPPNKE PLKEKLISGP LSPMSRAGNM GVGMEDGERP RRRRHGRAQQ
1260 1270 1280 1290 1300
QDKPPRFRRL KQDRENAARG TDGKPPPLTL PASTPAPTET LATVAAPPPP
1310 1320 1330 1340 1350
RRTAAKSPDL SNQNSDQANE EWETASESSD FASERRGDKE TPPAALITSK
1360 1370 1380 1390 1400
AVGTPGGNSG GAGPGISTMS RGDLSQRAKD LSKRSFSSQR PGMDRQNRRP
1410 1420 1430 1440 1450
GAGGKTGGGG SSGGGGAGPG GRTGPGRGDK RSWPSPKNRS RPPEERPPGL
1460 1470 1480 1490 1500
PLPPPPPSSS AVFRLDQVIH SNPAGIQQAL AQLSSRQGNV TAPGGHPRPK
1510 1520 1530 1540 1550
PGPPQAPQGS SPRPPTHYDP PRASNAISSD PHFEEPGPMV RGVGGTPRDS
1560 1570 1580 1590 1600
AGVNPFPPKR RERPPRKPEL LQEETVPASH SSGFLGSKPE VPGPQEESRD
1610 1620 1630 1640 1650
SGTEALTPHI WNRLHTATSR KSYQPGSIEP WMEPLSPFED VAGTEMSQSD
1660 1670 1680 1690 1700
SGVDLSGGSQ VSSGPCSQRS SPDGGLKGSA EGPPRRPGGP SPLKAVPGES
1710 1720 1730 1740 1750
SSASEPSEPH RRRPPASHEG ERKELPREQP LPPGPIGTER SQRTDRGPEP
1760 1770 1780 1790 1800
GPLRPAHRAG SQVEFGTTNK DSDLCLVVGD TLKGEKELAA SATEAVPVSR
1810 1820 1830 1840 1850
DWELLPSASA SAEPQAKSLG SGQCGPEPSP SGQRLYPEVF YGSPGPPNSQ
1860 1870 1880 1890 1900
VSGGAPIDSQ LHPSSGGFRP GTPSVHQYRS QPLYLPPGPA PPSALLSGVA
1910 1920 1930 1940 1950
LKGQFLDFSA LQATELGKLP AGGVLYPPPS FLYSAAFCPS PLPDPPLLQV
1960 1970 1980 1990 2000
RQDLPSPSDF YSTPLQPGGQ SGFLPSGAPA QQMLLPVVDS QLPVVNFGSL
2010 2020 2030 2040 2050
PPAPPPAPPP LSLLPVGPAL QPPNLAVRPP PAPAARVLPS PARPFPASLG
2060 2070 2080 2090 2100
RAELHPVELK PFQDYRKLSS NLGGPGSSRA PPSGRSFSGL NSRLKAPPST
2110 2120 2130 2140 2150
YSGVFRTQRI DLYQQASPPD ALRWMPKPWE RTGPPSREGP PRRAEEPGPR
2160
GEKEPGLPPP R
Length:2,161
Mass (Da):229,047
Last modified:July 5, 2004 - v1
Checksum:i8843EDDB4443C6AD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX883046 Genomic DNA. Translation: CAE83998.1.
RefSeqiNP_997627.1. NM_212462.2.
XP_006256114.1. XM_006256052.3.
UniGeneiRn.34262.

Genome annotation databases

EnsembliENSRNOT00000001133; ENSRNOP00000001133; ENSRNOG00000000852.
GeneIDi294250.
KEGGirno:294250.
UCSCiRGD:1303025. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX883046 Genomic DNA. Translation: CAE83998.1.
RefSeqiNP_997627.1. NM_212462.2.
XP_006256114.1. XM_006256052.3.
UniGeneiRn.34262.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000001133.

PTM databases

iPTMnetiQ6MG48.
PhosphoSitePlusiQ6MG48.

Proteomic databases

PaxDbiQ6MG48.
PRIDEiQ6MG48.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000001133; ENSRNOP00000001133; ENSRNOG00000000852.
GeneIDi294250.
KEGGirno:294250.
UCSCiRGD:1303025. rat.

Organism-specific databases

CTDi7916.
RGDi1303025. Prrc2a.

Phylogenomic databases

eggNOGiKOG4817. Eukaryota.
ENOG410XQRI. LUCA.
GeneTreeiENSGT00530000063496.
HOVERGENiHBG004820.
InParanoidiQ6MG48.
OrthoDBiEOG091G02WC.
PhylomeDBiQ6MG48.

Miscellaneous databases

PROiQ6MG48.

Gene expression databases

BgeeiENSRNOG00000000852.
ExpressionAtlasiQ6MG48. baseline and differential.
GenevisibleiQ6MG48. RN.

Family and domain databases

InterProiIPR009738. BAT2_N.
IPR033184. PRRC2.
[Graphical view]
PANTHERiPTHR14038. PTHR14038. 1 hit.
PfamiPF07001. BAT2_N. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPRC2A_RAT
AccessioniPrimary (citable) accession number: Q6MG48
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 16, 2005
Last sequence update: July 5, 2004
Last modified: November 30, 2016
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.