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Q6MG48

- PRC2A_RAT

UniProt

Q6MG48 - PRC2A_RAT

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Protein

Protein PRRC2A

Gene

Prrc2a

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

May play a role in the regulation of pre-mRNA splicing.By similarity

GO - Molecular functioni

  1. poly(A) RNA binding Source: Ensembl
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Protein PRRC2A
Alternative name(s):
HLA-B-associated transcript 2
Proline-rich and coiled-coil-containing protein 2A
Gene namesi
Name:Prrc2a
Synonyms:Bat2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 20

Organism-specific databases

RGDi1303025. Prrc2a.

Subcellular locationi

Cytoplasm By similarity. Nucleus By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
  2. extracellular vesicular exosome Source: Ensembl
  3. nucleus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 21612161Protein PRRC2APRO_0000064832Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei27 – 271N6-acetyllysineBy similarity
Modified residuei35 – 351N6-acetyllysineBy similarity
Modified residuei166 – 1661PhosphoserineBy similarity
Modified residuei342 – 3421PhosphoserineBy similarity
Modified residuei350 – 3501PhosphoserineBy similarity
Modified residuei378 – 3781PhosphoserineBy similarity
Modified residuei381 – 3811PhosphoserineBy similarity
Modified residuei455 – 4551PhosphoserineBy similarity
Modified residuei609 – 6091PhosphothreonineBy similarity
Modified residuei760 – 7601PhosphoserineBy similarity
Modified residuei762 – 7621PhosphoserineBy similarity
Modified residuei765 – 7651PhosphoserineBy similarity
Modified residuei809 – 8091PhosphoserineBy similarity
Modified residuei1000 – 10001PhosphothreonineBy similarity
Modified residuei1007 – 10071PhosphoserineBy similarity
Modified residuei1088 – 10881PhosphoserineBy similarity
Modified residuei1092 – 10921PhosphoserineBy similarity
Modified residuei1095 – 10951PhosphoserineBy similarity
Modified residuei1097 – 10971PhosphotyrosineBy similarity
Modified residuei1113 – 11131PhosphoserineBy similarity
Modified residuei1150 – 11501PhosphoserineBy similarity
Modified residuei1199 – 11991N6-acetyllysineBy similarity
Modified residuei1222 – 12221PhosphoserineBy similarity
Modified residuei1307 – 13071PhosphoserineBy similarity
Modified residuei1354 – 13541PhosphothreonineBy similarity
Modified residuei1406 – 14061Phosphothreonine1 Publication
Modified residuei2117 – 21171PhosphoserineBy similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiQ6MG48.
PRIDEiQ6MG48.

PTM databases

PhosphoSiteiQ6MG48.

Expressioni

Gene expression databases

GenevestigatoriQ6MG48.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000001133.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati41 – 95551-1Add
BLAST
Repeati98 – 154571-2Add
BLAST
Repeati281 – 337571-3Add
BLAST
Repeati337 – 429932-1Add
BLAST
Repeati487 – 560742-2Add
BLAST
Repeati1760 – 1815561-4Add
BLAST
Repeati1920 – 1969503-1Add
BLAST
Repeati1986 – 2035503-2Add
BLAST
Repeati2061 – 2110503-3Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni41 – 181517754 X 57 AA type A repeatsAdd
BLAST
Regioni337 – 5602242 X type B repeatsAdd
BLAST
Regioni1920 – 21101913 X 50 AA type C repeatsAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi404 – 41411Poly-ProAdd
BLAST
Compositional biasi465 – 4706Poly-Arg
Compositional biasi471 – 4744Poly-Glu
Compositional biasi657 – 67014Poly-GlnAdd
BLAST
Compositional biasi697 – 7015Poly-Pro
Compositional biasi827 – 8348Poly-Pro
Compositional biasi909 – 9168Poly-Gly
Compositional biasi917 – 9204Poly-Pro
Compositional biasi959 – 9624Poly-Pro
Compositional biasi1239 – 12446Poly-Arg
Compositional biasi1297 – 13004Poly-Pro
Compositional biasi1407 – 14104Poly-Gly
Compositional biasi1413 – 14219Poly-Gly
Compositional biasi1451 – 14577Poly-Pro

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiNOG40021.
GeneTreeiENSGT00530000063496.
HOVERGENiHBG004820.
InParanoidiQ6MG48.
OMAiDALRWMP.
OrthoDBiEOG7DZ8J2.
PhylomeDBiQ6MG48.

Family and domain databases

InterProiIPR009738. BAT2_N.
[Graphical view]
PfamiPF07001. BAT2_N. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6MG48-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSDRSGPTAK GKDGKKYSSL NLFDTYKGKS LEIQKPAVAP RHGLQSLGKV
60 70 80 90 100
AIARRMPPPA NLPSLKAENK GNDPNVSLVP KDGTGWASKQ EQSDPKSSDA
110 120 130 140 150
STAQPPESQP LPASQTPASN QPKRPPTAPE NTPSVPSGVK SWAQASVTHG
160 170 180 190 200
AHGDGGRASS LLSRFSREEF PTLQAAGDQD KAAKERESAE QSSGPGPSLR
210 220 230 240 250
PQNSTTWRDG GGRGPDELEG PDSKLHHGHD PRGGLQPSGP PQFPPYRGMM
260 270 280 290 300
PPFMYPPYLP FPPPYGPQGP YRYPTPDGPS RFPRVAGPRG SGPPMRLVEP
310 320 330 340 350
VGRPSILKED NLKEFDQLDQ ENDDGWAGAH EEVDYTEKLK FSDEEDGRDS
360 370 380 390 400
DEEGAEGHKD SQSAAGEEPE TDGKKGTSPG SELPPPKTAW TENSRPSETE
410 420 430 440 450
PAAPPIPKPP PPPPHRGPVG NWGPPGDYPD RGGPPCKPPA PEDEDEAWRQ
460 470 480 490 500
RRKQSSSEIS LAVERARRRR EEEERRMQEE RRAACAEKLK RLDEKFGAPD
510 520 530 540 550
KRLKAEPAAP PVTPPAPALP PVVPKETPTP PALPPTPTPT PEKDPEEPAH
560 570 580 590 600
APPVQSAPTQ AGPPAPTPVS GGGTASSTSS GSFEASPAEP QLPSKEGPEP
610 620 630 640 650
PEEVPAPTTP PAPKVEPKGD GVGPTRQPPS QGLGYPKYQK SLPPRFQRQQ
660 670 680 690 700
QEQLLKQQQQ QQWQQQQQQQ GTAPPAPVPP SPPQPVTLGA VPAPQAPPPP
710 720 730 740 750
PKALYPGALG RPPPMPPMNF DPRWMMIPPY VDPRLLQGRP PLDFYPPGVH
760 770 780 790 800
PSGLVPRERS DSGGSSSEPF ERHAPPLLRE RGTPPVDPKL AWVGDVFTTT
810 820 830 840 850
PTDPRPLTSP LRQAADEEEK SLRSETPPVP PPPPYLANYP GFPENGTPGP
860 870 880 890 900
PISRFPLEES APPGPRPLPW PPGNDEAAKM QAPPPKKEPP KEEPAQLSGP
910 920 930 940 950
EAGRKPARGV GGGGQGPPPP RRENRTETRW GPRPGSCRRG IPPEDPGVPP
960 970 980 990 1000
RRAGPIKKPP PPVKADELPP KSLEPGDETP KAPKPDALKT AKGKVGPKET
1010 1020 1030 1040 1050
PAGGNLSPAP RLRRDYSYER VGPTSCRGRG RGEYFARGRG FRGTYGGRGR
1060 1070 1080 1090 1100
GARSREFRSY REFRGDDGRG GGSGGTNHPS APRGRTASET RSEGSEYEEI
1110 1120 1130 1140 1150
PKRRRQRGSE TGSETHESDL APSDKEAPPP KEGVLAQVPL APPQPGAPPS
1160 1170 1180 1190 1200
PAPARFSTAR GGRVFTPRGV PSRRGRGGGR PPPVCSGWSP PAKSLVPKKP
1210 1220 1230 1240 1250
PTGPLPPNKE PLKEKLISGP LSPMSRAGNM GVGMEDGERP RRRRHGRAQQ
1260 1270 1280 1290 1300
QDKPPRFRRL KQDRENAARG TDGKPPPLTL PASTPAPTET LATVAAPPPP
1310 1320 1330 1340 1350
RRTAAKSPDL SNQNSDQANE EWETASESSD FASERRGDKE TPPAALITSK
1360 1370 1380 1390 1400
AVGTPGGNSG GAGPGISTMS RGDLSQRAKD LSKRSFSSQR PGMDRQNRRP
1410 1420 1430 1440 1450
GAGGKTGGGG SSGGGGAGPG GRTGPGRGDK RSWPSPKNRS RPPEERPPGL
1460 1470 1480 1490 1500
PLPPPPPSSS AVFRLDQVIH SNPAGIQQAL AQLSSRQGNV TAPGGHPRPK
1510 1520 1530 1540 1550
PGPPQAPQGS SPRPPTHYDP PRASNAISSD PHFEEPGPMV RGVGGTPRDS
1560 1570 1580 1590 1600
AGVNPFPPKR RERPPRKPEL LQEETVPASH SSGFLGSKPE VPGPQEESRD
1610 1620 1630 1640 1650
SGTEALTPHI WNRLHTATSR KSYQPGSIEP WMEPLSPFED VAGTEMSQSD
1660 1670 1680 1690 1700
SGVDLSGGSQ VSSGPCSQRS SPDGGLKGSA EGPPRRPGGP SPLKAVPGES
1710 1720 1730 1740 1750
SSASEPSEPH RRRPPASHEG ERKELPREQP LPPGPIGTER SQRTDRGPEP
1760 1770 1780 1790 1800
GPLRPAHRAG SQVEFGTTNK DSDLCLVVGD TLKGEKELAA SATEAVPVSR
1810 1820 1830 1840 1850
DWELLPSASA SAEPQAKSLG SGQCGPEPSP SGQRLYPEVF YGSPGPPNSQ
1860 1870 1880 1890 1900
VSGGAPIDSQ LHPSSGGFRP GTPSVHQYRS QPLYLPPGPA PPSALLSGVA
1910 1920 1930 1940 1950
LKGQFLDFSA LQATELGKLP AGGVLYPPPS FLYSAAFCPS PLPDPPLLQV
1960 1970 1980 1990 2000
RQDLPSPSDF YSTPLQPGGQ SGFLPSGAPA QQMLLPVVDS QLPVVNFGSL
2010 2020 2030 2040 2050
PPAPPPAPPP LSLLPVGPAL QPPNLAVRPP PAPAARVLPS PARPFPASLG
2060 2070 2080 2090 2100
RAELHPVELK PFQDYRKLSS NLGGPGSSRA PPSGRSFSGL NSRLKAPPST
2110 2120 2130 2140 2150
YSGVFRTQRI DLYQQASPPD ALRWMPKPWE RTGPPSREGP PRRAEEPGPR
2160
GEKEPGLPPP R
Length:2,161
Mass (Da):229,047
Last modified:July 5, 2004 - v1
Checksum:i8843EDDB4443C6AD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX883046 Genomic DNA. Translation: CAE83998.1.
RefSeqiNP_997627.1. NM_212462.2.
XP_006256114.1. XM_006256052.2.
UniGeneiRn.34262.

Genome annotation databases

EnsembliENSRNOT00000001133; ENSRNOP00000001133; ENSRNOG00000000852.
GeneIDi294250.
KEGGirno:294250.
UCSCiRGD:1303025. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX883046 Genomic DNA. Translation: CAE83998.1 .
RefSeqi NP_997627.1. NM_212462.2.
XP_006256114.1. XM_006256052.2.
UniGenei Rn.34262.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10116.ENSRNOP00000001133.

PTM databases

PhosphoSitei Q6MG48.

Proteomic databases

PaxDbi Q6MG48.
PRIDEi Q6MG48.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000001133 ; ENSRNOP00000001133 ; ENSRNOG00000000852 .
GeneIDi 294250.
KEGGi rno:294250.
UCSCi RGD:1303025. rat.

Organism-specific databases

CTDi 7916.
RGDi 1303025. Prrc2a.

Phylogenomic databases

eggNOGi NOG40021.
GeneTreei ENSGT00530000063496.
HOVERGENi HBG004820.
InParanoidi Q6MG48.
OMAi DALRWMP.
OrthoDBi EOG7DZ8J2.
PhylomeDBi Q6MG48.

Miscellaneous databases

NextBioi 637822.
PROi Q6MG48.

Gene expression databases

Genevestigatori Q6MG48.

Family and domain databases

InterProi IPR009738. BAT2_N.
[Graphical view ]
Pfami PF07001. BAT2_N. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The genomic sequence and comparative analysis of the rat major histocompatibility complex."
    Hurt P., Walter L., Sudbrak R., Klages S., Mueller I., Shiina T., Inoko H., Lehrach H., Guenther E., Reinhardt R., Himmelbauer H.
    Genome Res. 14:631-639(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Brown Norway.
  2. "Quantitative phosphoproteomics of vasopressin-sensitive renal cells: regulation of aquaporin-2 phosphorylation at two sites."
    Hoffert J.D., Pisitkun T., Wang G., Shen R.-F., Knepper M.A.
    Proc. Natl. Acad. Sci. U.S.A. 103:7159-7164(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-1406, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiPRC2A_RAT
AccessioniPrimary (citable) accession number: Q6MG48
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 16, 2005
Last sequence update: July 5, 2004
Last modified: October 29, 2014
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

External Data

Dasty 3