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Q6MG48

- PRC2A_RAT

UniProt

Q6MG48 - PRC2A_RAT

Protein

Protein PRRC2A

Gene

Prrc2a

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 73 (01 Oct 2014)
      Sequence version 1 (05 Jul 2004)
      Previous versions | rss
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    Functioni

    May play a role in the regulation of pre-mRNA splicing.By similarity

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein PRRC2A
    Alternative name(s):
    HLA-B-associated transcript 2
    Proline-rich and coiled-coil-containing protein 2A
    Gene namesi
    Name:Prrc2a
    Synonyms:Bat2
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 20

    Organism-specific databases

    RGDi1303025. Prrc2a.

    Subcellular locationi

    Cytoplasm By similarity. Nucleus By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell
    2. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm, Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 21612161Protein PRRC2APRO_0000064832Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei27 – 271N6-acetyllysineBy similarity
    Modified residuei35 – 351N6-acetyllysineBy similarity
    Modified residuei166 – 1661PhosphoserineBy similarity
    Modified residuei342 – 3421PhosphoserineBy similarity
    Modified residuei350 – 3501PhosphoserineBy similarity
    Modified residuei378 – 3781PhosphoserineBy similarity
    Modified residuei381 – 3811PhosphoserineBy similarity
    Modified residuei455 – 4551PhosphoserineBy similarity
    Modified residuei609 – 6091PhosphothreonineBy similarity
    Modified residuei760 – 7601PhosphoserineBy similarity
    Modified residuei762 – 7621PhosphoserineBy similarity
    Modified residuei765 – 7651PhosphoserineBy similarity
    Modified residuei809 – 8091PhosphoserineBy similarity
    Modified residuei1000 – 10001PhosphothreonineBy similarity
    Modified residuei1007 – 10071PhosphoserineBy similarity
    Modified residuei1088 – 10881PhosphoserineBy similarity
    Modified residuei1092 – 10921PhosphoserineBy similarity
    Modified residuei1095 – 10951PhosphoserineBy similarity
    Modified residuei1097 – 10971PhosphotyrosineBy similarity
    Modified residuei1113 – 11131PhosphoserineBy similarity
    Modified residuei1150 – 11501PhosphoserineBy similarity
    Modified residuei1199 – 11991N6-acetyllysineBy similarity
    Modified residuei1222 – 12221PhosphoserineBy similarity
    Modified residuei1307 – 13071PhosphoserineBy similarity
    Modified residuei1354 – 13541PhosphothreonineBy similarity
    Modified residuei1406 – 14061Phosphothreonine1 Publication
    Modified residuei2117 – 21171PhosphoserineBy similarity

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    PaxDbiQ6MG48.
    PRIDEiQ6MG48.

    PTM databases

    PhosphoSiteiQ6MG48.

    Expressioni

    Gene expression databases

    GenevestigatoriQ6MG48.

    Interactioni

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000001133.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati41 – 95551-1Add
    BLAST
    Repeati98 – 154571-2Add
    BLAST
    Repeati281 – 337571-3Add
    BLAST
    Repeati337 – 429932-1Add
    BLAST
    Repeati487 – 560742-2Add
    BLAST
    Repeati1760 – 1815561-4Add
    BLAST
    Repeati1920 – 1969503-1Add
    BLAST
    Repeati1986 – 2035503-2Add
    BLAST
    Repeati2061 – 2110503-3Add
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni41 – 181517754 X 57 AA type A repeatsAdd
    BLAST
    Regioni337 – 5602242 X type B repeatsAdd
    BLAST
    Regioni1920 – 21101913 X 50 AA type C repeatsAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi404 – 41411Poly-ProAdd
    BLAST
    Compositional biasi465 – 4706Poly-Arg
    Compositional biasi471 – 4744Poly-Glu
    Compositional biasi657 – 67014Poly-GlnAdd
    BLAST
    Compositional biasi697 – 7015Poly-Pro
    Compositional biasi827 – 8348Poly-Pro
    Compositional biasi909 – 9168Poly-Gly
    Compositional biasi917 – 9204Poly-Pro
    Compositional biasi959 – 9624Poly-Pro
    Compositional biasi1239 – 12446Poly-Arg
    Compositional biasi1297 – 13004Poly-Pro
    Compositional biasi1407 – 14104Poly-Gly
    Compositional biasi1413 – 14219Poly-Gly
    Compositional biasi1451 – 14577Poly-Pro

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    eggNOGiNOG40021.
    GeneTreeiENSGT00530000063496.
    HOVERGENiHBG004820.
    InParanoidiQ6MG48.
    OMAiDALRWMP.
    OrthoDBiEOG7DZ8J2.
    PhylomeDBiQ6MG48.

    Family and domain databases

    InterProiIPR009738. BAT2_N.
    [Graphical view]
    PfamiPF07001. BAT2_N. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q6MG48-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSDRSGPTAK GKDGKKYSSL NLFDTYKGKS LEIQKPAVAP RHGLQSLGKV     50
    AIARRMPPPA NLPSLKAENK GNDPNVSLVP KDGTGWASKQ EQSDPKSSDA 100
    STAQPPESQP LPASQTPASN QPKRPPTAPE NTPSVPSGVK SWAQASVTHG 150
    AHGDGGRASS LLSRFSREEF PTLQAAGDQD KAAKERESAE QSSGPGPSLR 200
    PQNSTTWRDG GGRGPDELEG PDSKLHHGHD PRGGLQPSGP PQFPPYRGMM 250
    PPFMYPPYLP FPPPYGPQGP YRYPTPDGPS RFPRVAGPRG SGPPMRLVEP 300
    VGRPSILKED NLKEFDQLDQ ENDDGWAGAH EEVDYTEKLK FSDEEDGRDS 350
    DEEGAEGHKD SQSAAGEEPE TDGKKGTSPG SELPPPKTAW TENSRPSETE 400
    PAAPPIPKPP PPPPHRGPVG NWGPPGDYPD RGGPPCKPPA PEDEDEAWRQ 450
    RRKQSSSEIS LAVERARRRR EEEERRMQEE RRAACAEKLK RLDEKFGAPD 500
    KRLKAEPAAP PVTPPAPALP PVVPKETPTP PALPPTPTPT PEKDPEEPAH 550
    APPVQSAPTQ AGPPAPTPVS GGGTASSTSS GSFEASPAEP QLPSKEGPEP 600
    PEEVPAPTTP PAPKVEPKGD GVGPTRQPPS QGLGYPKYQK SLPPRFQRQQ 650
    QEQLLKQQQQ QQWQQQQQQQ GTAPPAPVPP SPPQPVTLGA VPAPQAPPPP 700
    PKALYPGALG RPPPMPPMNF DPRWMMIPPY VDPRLLQGRP PLDFYPPGVH 750
    PSGLVPRERS DSGGSSSEPF ERHAPPLLRE RGTPPVDPKL AWVGDVFTTT 800
    PTDPRPLTSP LRQAADEEEK SLRSETPPVP PPPPYLANYP GFPENGTPGP 850
    PISRFPLEES APPGPRPLPW PPGNDEAAKM QAPPPKKEPP KEEPAQLSGP 900
    EAGRKPARGV GGGGQGPPPP RRENRTETRW GPRPGSCRRG IPPEDPGVPP 950
    RRAGPIKKPP PPVKADELPP KSLEPGDETP KAPKPDALKT AKGKVGPKET 1000
    PAGGNLSPAP RLRRDYSYER VGPTSCRGRG RGEYFARGRG FRGTYGGRGR 1050
    GARSREFRSY REFRGDDGRG GGSGGTNHPS APRGRTASET RSEGSEYEEI 1100
    PKRRRQRGSE TGSETHESDL APSDKEAPPP KEGVLAQVPL APPQPGAPPS 1150
    PAPARFSTAR GGRVFTPRGV PSRRGRGGGR PPPVCSGWSP PAKSLVPKKP 1200
    PTGPLPPNKE PLKEKLISGP LSPMSRAGNM GVGMEDGERP RRRRHGRAQQ 1250
    QDKPPRFRRL KQDRENAARG TDGKPPPLTL PASTPAPTET LATVAAPPPP 1300
    RRTAAKSPDL SNQNSDQANE EWETASESSD FASERRGDKE TPPAALITSK 1350
    AVGTPGGNSG GAGPGISTMS RGDLSQRAKD LSKRSFSSQR PGMDRQNRRP 1400
    GAGGKTGGGG SSGGGGAGPG GRTGPGRGDK RSWPSPKNRS RPPEERPPGL 1450
    PLPPPPPSSS AVFRLDQVIH SNPAGIQQAL AQLSSRQGNV TAPGGHPRPK 1500
    PGPPQAPQGS SPRPPTHYDP PRASNAISSD PHFEEPGPMV RGVGGTPRDS 1550
    AGVNPFPPKR RERPPRKPEL LQEETVPASH SSGFLGSKPE VPGPQEESRD 1600
    SGTEALTPHI WNRLHTATSR KSYQPGSIEP WMEPLSPFED VAGTEMSQSD 1650
    SGVDLSGGSQ VSSGPCSQRS SPDGGLKGSA EGPPRRPGGP SPLKAVPGES 1700
    SSASEPSEPH RRRPPASHEG ERKELPREQP LPPGPIGTER SQRTDRGPEP 1750
    GPLRPAHRAG SQVEFGTTNK DSDLCLVVGD TLKGEKELAA SATEAVPVSR 1800
    DWELLPSASA SAEPQAKSLG SGQCGPEPSP SGQRLYPEVF YGSPGPPNSQ 1850
    VSGGAPIDSQ LHPSSGGFRP GTPSVHQYRS QPLYLPPGPA PPSALLSGVA 1900
    LKGQFLDFSA LQATELGKLP AGGVLYPPPS FLYSAAFCPS PLPDPPLLQV 1950
    RQDLPSPSDF YSTPLQPGGQ SGFLPSGAPA QQMLLPVVDS QLPVVNFGSL 2000
    PPAPPPAPPP LSLLPVGPAL QPPNLAVRPP PAPAARVLPS PARPFPASLG 2050
    RAELHPVELK PFQDYRKLSS NLGGPGSSRA PPSGRSFSGL NSRLKAPPST 2100
    YSGVFRTQRI DLYQQASPPD ALRWMPKPWE RTGPPSREGP PRRAEEPGPR 2150
    GEKEPGLPPP R 2161
    Length:2,161
    Mass (Da):229,047
    Last modified:July 5, 2004 - v1
    Checksum:i8843EDDB4443C6AD
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BX883046 Genomic DNA. Translation: CAE83998.1.
    RefSeqiNP_997627.1. NM_212462.2.
    XP_006256114.1. XM_006256052.1.
    UniGeneiRn.34262.

    Genome annotation databases

    EnsembliENSRNOT00000001133; ENSRNOP00000001133; ENSRNOG00000000852.
    GeneIDi294250.
    KEGGirno:294250.
    UCSCiRGD:1303025. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BX883046 Genomic DNA. Translation: CAE83998.1 .
    RefSeqi NP_997627.1. NM_212462.2.
    XP_006256114.1. XM_006256052.1.
    UniGenei Rn.34262.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10116.ENSRNOP00000001133.

    PTM databases

    PhosphoSitei Q6MG48.

    Proteomic databases

    PaxDbi Q6MG48.
    PRIDEi Q6MG48.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000001133 ; ENSRNOP00000001133 ; ENSRNOG00000000852 .
    GeneIDi 294250.
    KEGGi rno:294250.
    UCSCi RGD:1303025. rat.

    Organism-specific databases

    CTDi 7916.
    RGDi 1303025. Prrc2a.

    Phylogenomic databases

    eggNOGi NOG40021.
    GeneTreei ENSGT00530000063496.
    HOVERGENi HBG004820.
    InParanoidi Q6MG48.
    OMAi DALRWMP.
    OrthoDBi EOG7DZ8J2.
    PhylomeDBi Q6MG48.

    Miscellaneous databases

    NextBioi 637822.
    PROi Q6MG48.

    Gene expression databases

    Genevestigatori Q6MG48.

    Family and domain databases

    InterProi IPR009738. BAT2_N.
    [Graphical view ]
    Pfami PF07001. BAT2_N. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The genomic sequence and comparative analysis of the rat major histocompatibility complex."
      Hurt P., Walter L., Sudbrak R., Klages S., Mueller I., Shiina T., Inoko H., Lehrach H., Guenther E., Reinhardt R., Himmelbauer H.
      Genome Res. 14:631-639(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Brown Norway.
    2. "Quantitative phosphoproteomics of vasopressin-sensitive renal cells: regulation of aquaporin-2 phosphorylation at two sites."
      Hoffert J.D., Pisitkun T., Wang G., Shen R.-F., Knepper M.A.
      Proc. Natl. Acad. Sci. U.S.A. 103:7159-7164(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-1406, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiPRC2A_RAT
    AccessioniPrimary (citable) accession number: Q6MG48
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 16, 2005
    Last sequence update: July 5, 2004
    Last modified: October 1, 2014
    This is version 73 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    External Data

    Dasty 3