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Q6MG48

- PRC2A_RAT

UniProt

Q6MG48 - PRC2A_RAT

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Protein

Protein PRRC2A

Gene
Prrc2a, Bat2
Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

May play a role in the regulation of pre-mRNA splicing By similarity.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein PRRC2A
Alternative name(s):
HLA-B-associated transcript 2
Proline-rich and coiled-coil-containing protein 2A
Gene namesi
Name:Prrc2a
Synonyms:Bat2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 20

Organism-specific databases

RGDi1303025. Prrc2a.

Subcellular locationi

Cytoplasm By similarity. Nucleus By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
  2. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 21612161Protein PRRC2APRO_0000064832Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei27 – 271N6-acetyllysine By similarity
Modified residuei35 – 351N6-acetyllysine By similarity
Modified residuei166 – 1661Phosphoserine By similarity
Modified residuei342 – 3421Phosphoserine By similarity
Modified residuei350 – 3501Phosphoserine By similarity
Modified residuei378 – 3781Phosphoserine By similarity
Modified residuei381 – 3811Phosphoserine By similarity
Modified residuei455 – 4551Phosphoserine By similarity
Modified residuei609 – 6091Phosphothreonine By similarity
Modified residuei760 – 7601Phosphoserine By similarity
Modified residuei762 – 7621Phosphoserine By similarity
Modified residuei765 – 7651Phosphoserine By similarity
Modified residuei809 – 8091Phosphoserine By similarity
Modified residuei1000 – 10001Phosphothreonine By similarity
Modified residuei1007 – 10071Phosphoserine By similarity
Modified residuei1088 – 10881Phosphoserine By similarity
Modified residuei1092 – 10921Phosphoserine By similarity
Modified residuei1095 – 10951Phosphoserine By similarity
Modified residuei1097 – 10971Phosphotyrosine By similarity
Modified residuei1113 – 11131Phosphoserine By similarity
Modified residuei1150 – 11501Phosphoserine By similarity
Modified residuei1199 – 11991N6-acetyllysine By similarity
Modified residuei1222 – 12221Phosphoserine By similarity
Modified residuei1307 – 13071Phosphoserine By similarity
Modified residuei1354 – 13541Phosphothreonine By similarity
Modified residuei1406 – 14061Phosphothreonine1 Publication
Modified residuei2117 – 21171Phosphoserine By similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiQ6MG48.
PRIDEiQ6MG48.

PTM databases

PhosphoSiteiQ6MG48.

Expressioni

Gene expression databases

GenevestigatoriQ6MG48.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000001133.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati41 – 95551-1Add
BLAST
Repeati98 – 154571-2Add
BLAST
Repeati281 – 337571-3Add
BLAST
Repeati337 – 429932-1Add
BLAST
Repeati487 – 560742-2Add
BLAST
Repeati1760 – 1815561-4Add
BLAST
Repeati1920 – 1969503-1Add
BLAST
Repeati1986 – 2035503-2Add
BLAST
Repeati2061 – 2110503-3Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni41 – 181517754 X 57 AA type A repeatsAdd
BLAST
Regioni337 – 5602242 X type B repeatsAdd
BLAST
Regioni1920 – 21101913 X 50 AA type C repeatsAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi404 – 41411Poly-ProAdd
BLAST
Compositional biasi465 – 4706Poly-Arg
Compositional biasi471 – 4744Poly-Glu
Compositional biasi657 – 67014Poly-GlnAdd
BLAST
Compositional biasi697 – 7015Poly-Pro
Compositional biasi827 – 8348Poly-Pro
Compositional biasi909 – 9168Poly-Gly
Compositional biasi917 – 9204Poly-Pro
Compositional biasi959 – 9624Poly-Pro
Compositional biasi1239 – 12446Poly-Arg
Compositional biasi1297 – 13004Poly-Pro
Compositional biasi1407 – 14104Poly-Gly
Compositional biasi1413 – 14219Poly-Gly
Compositional biasi1451 – 14577Poly-Pro

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiNOG40021.
GeneTreeiENSGT00530000063496.
HOVERGENiHBG004820.
InParanoidiQ6MG48.
OMAiDALRWMP.
OrthoDBiEOG7DZ8J2.
PhylomeDBiQ6MG48.

Family and domain databases

InterProiIPR009738. BAT2_N.
[Graphical view]
PfamiPF07001. BAT2_N. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6MG48-1 [UniParc]FASTAAdd to Basket

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MSDRSGPTAK GKDGKKYSSL NLFDTYKGKS LEIQKPAVAP RHGLQSLGKV     50
AIARRMPPPA NLPSLKAENK GNDPNVSLVP KDGTGWASKQ EQSDPKSSDA 100
STAQPPESQP LPASQTPASN QPKRPPTAPE NTPSVPSGVK SWAQASVTHG 150
AHGDGGRASS LLSRFSREEF PTLQAAGDQD KAAKERESAE QSSGPGPSLR 200
PQNSTTWRDG GGRGPDELEG PDSKLHHGHD PRGGLQPSGP PQFPPYRGMM 250
PPFMYPPYLP FPPPYGPQGP YRYPTPDGPS RFPRVAGPRG SGPPMRLVEP 300
VGRPSILKED NLKEFDQLDQ ENDDGWAGAH EEVDYTEKLK FSDEEDGRDS 350
DEEGAEGHKD SQSAAGEEPE TDGKKGTSPG SELPPPKTAW TENSRPSETE 400
PAAPPIPKPP PPPPHRGPVG NWGPPGDYPD RGGPPCKPPA PEDEDEAWRQ 450
RRKQSSSEIS LAVERARRRR EEEERRMQEE RRAACAEKLK RLDEKFGAPD 500
KRLKAEPAAP PVTPPAPALP PVVPKETPTP PALPPTPTPT PEKDPEEPAH 550
APPVQSAPTQ AGPPAPTPVS GGGTASSTSS GSFEASPAEP QLPSKEGPEP 600
PEEVPAPTTP PAPKVEPKGD GVGPTRQPPS QGLGYPKYQK SLPPRFQRQQ 650
QEQLLKQQQQ QQWQQQQQQQ GTAPPAPVPP SPPQPVTLGA VPAPQAPPPP 700
PKALYPGALG RPPPMPPMNF DPRWMMIPPY VDPRLLQGRP PLDFYPPGVH 750
PSGLVPRERS DSGGSSSEPF ERHAPPLLRE RGTPPVDPKL AWVGDVFTTT 800
PTDPRPLTSP LRQAADEEEK SLRSETPPVP PPPPYLANYP GFPENGTPGP 850
PISRFPLEES APPGPRPLPW PPGNDEAAKM QAPPPKKEPP KEEPAQLSGP 900
EAGRKPARGV GGGGQGPPPP RRENRTETRW GPRPGSCRRG IPPEDPGVPP 950
RRAGPIKKPP PPVKADELPP KSLEPGDETP KAPKPDALKT AKGKVGPKET 1000
PAGGNLSPAP RLRRDYSYER VGPTSCRGRG RGEYFARGRG FRGTYGGRGR 1050
GARSREFRSY REFRGDDGRG GGSGGTNHPS APRGRTASET RSEGSEYEEI 1100
PKRRRQRGSE TGSETHESDL APSDKEAPPP KEGVLAQVPL APPQPGAPPS 1150
PAPARFSTAR GGRVFTPRGV PSRRGRGGGR PPPVCSGWSP PAKSLVPKKP 1200
PTGPLPPNKE PLKEKLISGP LSPMSRAGNM GVGMEDGERP RRRRHGRAQQ 1250
QDKPPRFRRL KQDRENAARG TDGKPPPLTL PASTPAPTET LATVAAPPPP 1300
RRTAAKSPDL SNQNSDQANE EWETASESSD FASERRGDKE TPPAALITSK 1350
AVGTPGGNSG GAGPGISTMS RGDLSQRAKD LSKRSFSSQR PGMDRQNRRP 1400
GAGGKTGGGG SSGGGGAGPG GRTGPGRGDK RSWPSPKNRS RPPEERPPGL 1450
PLPPPPPSSS AVFRLDQVIH SNPAGIQQAL AQLSSRQGNV TAPGGHPRPK 1500
PGPPQAPQGS SPRPPTHYDP PRASNAISSD PHFEEPGPMV RGVGGTPRDS 1550
AGVNPFPPKR RERPPRKPEL LQEETVPASH SSGFLGSKPE VPGPQEESRD 1600
SGTEALTPHI WNRLHTATSR KSYQPGSIEP WMEPLSPFED VAGTEMSQSD 1650
SGVDLSGGSQ VSSGPCSQRS SPDGGLKGSA EGPPRRPGGP SPLKAVPGES 1700
SSASEPSEPH RRRPPASHEG ERKELPREQP LPPGPIGTER SQRTDRGPEP 1750
GPLRPAHRAG SQVEFGTTNK DSDLCLVVGD TLKGEKELAA SATEAVPVSR 1800
DWELLPSASA SAEPQAKSLG SGQCGPEPSP SGQRLYPEVF YGSPGPPNSQ 1850
VSGGAPIDSQ LHPSSGGFRP GTPSVHQYRS QPLYLPPGPA PPSALLSGVA 1900
LKGQFLDFSA LQATELGKLP AGGVLYPPPS FLYSAAFCPS PLPDPPLLQV 1950
RQDLPSPSDF YSTPLQPGGQ SGFLPSGAPA QQMLLPVVDS QLPVVNFGSL 2000
PPAPPPAPPP LSLLPVGPAL QPPNLAVRPP PAPAARVLPS PARPFPASLG 2050
RAELHPVELK PFQDYRKLSS NLGGPGSSRA PPSGRSFSGL NSRLKAPPST 2100
YSGVFRTQRI DLYQQASPPD ALRWMPKPWE RTGPPSREGP PRRAEEPGPR 2150
GEKEPGLPPP R 2161
Length:2,161
Mass (Da):229,047
Last modified:July 5, 2004 - v1
Checksum:i8843EDDB4443C6AD
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BX883046 Genomic DNA. Translation: CAE83998.1.
RefSeqiNP_997627.1. NM_212462.2.
XP_006256114.1. XM_006256052.1.
UniGeneiRn.34262.

Genome annotation databases

EnsembliENSRNOT00000001133; ENSRNOP00000001133; ENSRNOG00000000852.
GeneIDi294250.
KEGGirno:294250.
UCSCiRGD:1303025. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BX883046 Genomic DNA. Translation: CAE83998.1 .
RefSeqi NP_997627.1. NM_212462.2.
XP_006256114.1. XM_006256052.1.
UniGenei Rn.34262.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10116.ENSRNOP00000001133.

PTM databases

PhosphoSitei Q6MG48.

Proteomic databases

PaxDbi Q6MG48.
PRIDEi Q6MG48.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000001133 ; ENSRNOP00000001133 ; ENSRNOG00000000852 .
GeneIDi 294250.
KEGGi rno:294250.
UCSCi RGD:1303025. rat.

Organism-specific databases

CTDi 7916.
RGDi 1303025. Prrc2a.

Phylogenomic databases

eggNOGi NOG40021.
GeneTreei ENSGT00530000063496.
HOVERGENi HBG004820.
InParanoidi Q6MG48.
OMAi DALRWMP.
OrthoDBi EOG7DZ8J2.
PhylomeDBi Q6MG48.

Miscellaneous databases

NextBioi 637822.
PROi Q6MG48.

Gene expression databases

Genevestigatori Q6MG48.

Family and domain databases

InterProi IPR009738. BAT2_N.
[Graphical view ]
Pfami PF07001. BAT2_N. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The genomic sequence and comparative analysis of the rat major histocompatibility complex."
    Hurt P., Walter L., Sudbrak R., Klages S., Mueller I., Shiina T., Inoko H., Lehrach H., Guenther E., Reinhardt R., Himmelbauer H.
    Genome Res. 14:631-639(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Brown Norway.
  2. "Quantitative phosphoproteomics of vasopressin-sensitive renal cells: regulation of aquaporin-2 phosphorylation at two sites."
    Hoffert J.D., Pisitkun T., Wang G., Shen R.-F., Knepper M.A.
    Proc. Natl. Acad. Sci. U.S.A. 103:7159-7164(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-1406, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiPRC2A_RAT
AccessioniPrimary (citable) accession number: Q6MG48
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 16, 2005
Last sequence update: July 5, 2004
Last modified: April 16, 2014
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

External Data

Dasty 3

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