ID   A6KT88_RAT              Unreviewed;       160 AA.
AC   A6KT88; Q6MG18;
DT   28-JUN-2023, integrated into UniProtKB/TrEMBL.
DT   28-JUN-2023, sequence version 1.
DT   27-MAR-2024, entry version 5.
DE   SubName: Full=Immediate early response 3 {ECO:0000313|EMBL:CAE84029.1, ECO:0000313|Ensembl:ENSRNOP00000001099.3};
GN   Name=Ier3 {ECO:0000313|EMBL:CAE84029.1,
GN   ECO:0000313|Ensembl:ENSRNOP00000001099.3, ECO:0000313|RGD:1303321};
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116 {ECO:0000313|EMBL:CAE84029.1};
RN   [1] {ECO:0000313|EMBL:CAE84029.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Brown Norway {ECO:0000313|EMBL:CAE84029.1};
RA   Boehm S., Borzym K., Gelling S., Gimmel V., Heitmann K., Kosiura A.,
RA   Lang N., Lehrack S., Thiel J., Sontag M., Hurt P., Himmelbauer H.,
RA   Sudbrak R., Reinhardt R.;
RL   Submitted (DEC-2003) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:CAE84029.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Brown Norway {ECO:0000313|EMBL:CAE84029.1};
RA   Shiina T., Inoko H.;
RL   Submitted (DEC-2003) to the EMBL/GenBank/DDBJ databases.
RN   [3] {ECO:0000313|EMBL:CAE84029.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Brown Norway {ECO:0000313|EMBL:CAE84029.1};
RX   PubMed=15060004; DOI=10.1101/gr.1987704;
RA   Hurt P., Walter L., Sudbrak R., Klages S., Mueller I., Shiina T., Inoko H.,
RA   Lehrach H., Guenther E., Reinhardt R., Himmelbauer H.;
RT   "The genomic sequence and comparative analysis of the rat major
RT   histocompatibility complex.";
RL   Genome Res. 14:631-639(2004).
RN   [4] {ECO:0000313|Ensembl:ENSRNOP00000001099.3, ECO:0000313|Proteomes:UP000002494}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000001099.3,
RC   ECO:0000313|Proteomes:UP000002494};
RX   PubMed=15057822; DOI=10.1038/nature02426;
RG   Rat Genome Sequencing Project Consortium;
RA   Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J.,
RA   Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G.,
RA   Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G.,
RA   Morgan M., Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G.,
RA   Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S.,
RA   Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T.,
RA   Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D.,
RA   Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L.,
RA   Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D.,
RA   Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M.,
RA   Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C.,
RA   Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J.,
RA   Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H.,
RA   Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X.,
RA   Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q.,
RA   Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P.,
RA   Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A.,
RA   Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C.,
RA   Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J.,
RA   Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J.,
RA   Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F.,
RA   Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A.,
RA   Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A.,
RA   Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J.,
RA   Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E.,
RA   Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M.,
RA   Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C.,
RA   Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L.,
RA   Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W.,
RA   Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y.,
RA   Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V.,
RA   Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M.,
RA   Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S.,
RA   Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B.,
RA   Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R.,
RA   Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J.,
RA   Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D.,
RA   Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S.,
RA   Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S.,
RA   Mockrin S., Collins F.S.;
RT   "Genome sequence of the Brown Norway rat yields insights into mammalian
RT   evolution.";
RL   Nature 428:493-521(2004).
RN   [5] {ECO:0000313|Ensembl:ENSRNOP00000001099.3}
RP   IDENTIFICATION.
RC   STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000001099.3};
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; BX883048; CAE84029.1; -; Genomic_DNA.
DR   RefSeq; NP_997670.1; NM_212505.2.
DR   STRING; 10116.ENSRNOP00000001099; -.
DR   PaxDb; 10116-ENSRNOP00000001099; -.
DR   Ensembl; ENSRNOT00000001099.7; ENSRNOP00000001099.3; ENSRNOG00000000827.7.
DR   GeneID; 294235; -.
DR   KEGG; rno:294235; -.
DR   UCSC; RGD:1303321; rat.
DR   AGR; RGD:1303321; -.
DR   CTD; 8870; -.
DR   RGD; 1303321; Ier3.
DR   eggNOG; ENOG502S3QE; Eukaryota.
DR   GeneTree; ENSGT00390000003213; -.
DR   OMA; VIFCQIL; -.
DR   OrthoDB; 4597358at2759; -.
DR   TreeFam; TF338252; -.
DR   Reactome; R-RNO-6811558; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling.
DR   Proteomes; UP000002494; Chromosome 20.
DR   Bgee; ENSRNOG00000000827; Expressed in stomach and 19 other cell types or tissues.
DR   GO; GO:0005739; C:mitochondrion; IEA:GOC.
DR   GO; GO:0005634; C:nucleus; ISO:RGD.
DR   GO; GO:0006974; P:DNA damage response; ISO:RGD.
DR   GO; GO:0006096; P:glycolytic process; ISO:RGD.
DR   GO; GO:0008630; P:intrinsic apoptotic signaling pathway in response to DNA damage; ISO:RGD.
DR   GO; GO:0007095; P:mitotic G2 DNA damage checkpoint signaling; ISO:RGD.
DR   GO; GO:0045820; P:negative regulation of glycolytic process; ISO:RGD.
DR   GO; GO:0050728; P:negative regulation of inflammatory response; ISO:RGD.
DR   GO; GO:1901029; P:negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway; ISO:RGD.
DR   GO; GO:0003085; P:negative regulation of systemic arterial blood pressure; ISO:RGD.
DR   GO; GO:0045732; P:positive regulation of protein catabolic process; ISO:RGD.
DR   GO; GO:0006282; P:regulation of DNA repair; ISO:RGD.
DR   GO; GO:0046822; P:regulation of nucleocytoplasmic transport; ISO:RGD.
DR   GO; GO:2000377; P:regulation of reactive oxygen species metabolic process; ISO:RGD.
DR   GO; GO:0001562; P:response to protozoan; ISO:RGD.
DR   InterPro; IPR024829; IEX-1.
DR   PANTHER; PTHR16915; IMMEDIATE EARLY RESPONSE 3; 1.
DR   PANTHER; PTHR16915:SF0; RADIATION-INDUCIBLE IMMEDIATE-EARLY GENE IEX-1; 1.
DR   PRINTS; PR02100; GENEIEX1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000002494}.
FT   REGION          1..33
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   160 AA;  17605 MW;  69867C812D6FA93C CRC64;
     MCHSRNHLHT MTGLRAPAPA PSTSPELRRG SGPEIFTFDP LPERAVASAV RPNTSRGHRK
     RSRRVLYPRV VRRQLPTEEP NIAKRILFLL LAIIFCQILM AEEGVSQALA PEDATSAISP
     EPISVPITAP PVLEPLNLTS ESSDYALDLK AFLQQHPAAF
//