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Protein
Submitted name:

Immediate early response 3

Gene

Ier3

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: Annotation score: 4 out of 5-Protein predictedi

Functioni

GO - Biological processi

  1. intrinsic apoptotic signaling pathway in response to DNA damage Source: Ensembl
  2. mitotic G2 DNA damage checkpoint Source: Ensembl
  3. negative regulation of glycolytic process Source: Ensembl
  4. negative regulation of inflammatory response Source: Ensembl
  5. negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway Source: Ensembl
  6. negative regulation of systemic arterial blood pressure Source: Ensembl
  7. positive regulation of protein catabolic process Source: Ensembl
  8. regulation of DNA repair Source: Ensembl
  9. regulation of nucleocytoplasmic transport Source: Ensembl
  10. regulation of reactive oxygen species metabolic process Source: Ensembl
  11. response to protozoan Source: Ensembl
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
Immediate early response 3Imported
Submitted name:
Immediate early response 3, isoform CRA_aImported
Submitted name:
Protein Ier3Imported
Gene namesi
Name:Ier3Imported
Synonyms:2310ex4-5Imported, 2331ex4-5Imported, 2361ex4-5Imported, Flot1Imported, Gnl1Imported, Kiaa1949Imported, Rpl41-psImported, Rps2-ps1Imported, Rps2-ps2Imported, RT1-O2Imported, RT1-O3Imported, RT1-S2Imported, RT1-S3Imported, RT1-T24-1Imported, RT1-T24-2Imported, Tubb5Imported
ORF Names:rCG_41772Imported
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494 Componenti: Chromosome 20

Organism-specific databases

RGDi1303321. Ier3.

Subcellular locationi

GO - Cellular componenti

  1. nucleus Source: Ensembl
Complete GO annotation...

Expressioni

Gene expression databases

GenevestigatoriQ6MG18.

Family & Domainsi

Phylogenomic databases

GeneTreeiENSGT00390000003213.
HOVERGENiHBG000172.
InParanoidiQ6MG18.
OMAiMCHSRSS.
OrthoDBiEOG7Q5HG8.
PhylomeDBiQ6MG18.
TreeFamiTF338252.

Family and domain databases

InterProiIPR024829. IEX-1.
[Graphical view]
PANTHERiPTHR16915. PTHR16915. 1 hit.
PRINTSiPR02100. GENEIEX1.

Sequencei

Sequence statusi: Complete.

Q6MG18-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MCHSRNHLHT MTGLRAPAPA PSTSPELRRG SGPEIFTFDP LPERAVASAV
60 70 80 90 100
RPNTSRGHRK RSRRVLYPRV VRRQLPTEEP NIAKRILFLL LAIIFCQILM
110 120 130 140 150
AEEGVSQALA PEDATSAISP EPISVPITAP PVLEPLNLTS ESSDYALDLK
160
AFLQQHPAAF
Length:160
Mass (Da):17,605
Last modified:July 5, 2004 - v1
Checksum:i69867C812D6FA93C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR06099824 Genomic DNA. No translation available.
BX883048 Genomic DNA. Translation: CAE84029.1.
CH474118 Genomic DNA. Translation: EDL86742.1.
CH474118 Genomic DNA. Translation: EDL86743.1.
RefSeqiNP_997670.1. NM_212505.2.
UniGeneiRn.23638.

Genome annotation databases

EnsembliENSRNOT00000001099; ENSRNOP00000001099; ENSRNOG00000000827.
GeneIDi294235.
KEGGirno:294235.
UCSCiRGD:1303321. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR06099824 Genomic DNA. No translation available.
BX883048 Genomic DNA. Translation: CAE84029.1.
CH474118 Genomic DNA. Translation: EDL86742.1.
CH474118 Genomic DNA. Translation: EDL86743.1.
RefSeqiNP_997670.1. NM_212505.2.
UniGeneiRn.23638.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000001099; ENSRNOP00000001099; ENSRNOG00000000827.
GeneIDi294235.
KEGGirno:294235.
UCSCiRGD:1303321. rat.

Organism-specific databases

CTDi8870.
RGDi1303321. Ier3.

Phylogenomic databases

GeneTreeiENSGT00390000003213.
HOVERGENiHBG000172.
InParanoidiQ6MG18.
OMAiMCHSRSS.
OrthoDBiEOG7Q5HG8.
PhylomeDBiQ6MG18.
TreeFamiTF338252.

Miscellaneous databases

NextBioi637803.
PROiQ6MG18.

Gene expression databases

GenevestigatoriQ6MG18.

Family and domain databases

InterProiIPR024829. IEX-1.
[Graphical view]
PANTHERiPTHR16915. PTHR16915. 1 hit.
PRINTSiPR02100. GENEIEX1.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Shiina T., Inoko H.
    Submitted (NOV-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: Brown NorwayImported.
  2. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: Brown NorwayImported.
  3. "The genomic sequence and comparative analysis of the rat major histocompatibility complex."
    Hurt P., Walter L., Sudbrak R., Klages S., Mueller I., Shiina T., Inoko H., Lehrach H., Guenther E., Reinhardt R., Himmelbauer H.
    Genome Res. 14:631-639(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: Brown NorwayImported.
  4. "Genome sequence of the Brown Norway rat yields insights into mammalian evolution."
    Rat Genome Sequencing Project Consortium
    Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., Morgan M.
    , Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., Collins F.S.
    Nature 428:493-521(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Brown NorwayImported.
  5. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: BNImported.
  6. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: BNImported.
  7. Ensembl
    Submitted (JAN-2012) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: Brown NorwayImported.

Entry informationi

Entry nameiQ6MG18_RAT
AccessioniPrimary (citable) accession number: Q6MG18
Entry historyi
Integrated into UniProtKB/TrEMBL: July 5, 2004
Last sequence update: July 5, 2004
Last modified: April 1, 2015
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.