Q6MG14 (NRM_RAT) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Nurim

Alternative name(s):
Nuclear envelope membrane protein
Nuclear rim protein

Gene names

Name:

Nrm

Organism

Rattus norvegicus (Rat) [Reference proteome]

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	262 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Subcellular location	Nucleus inner membrane; Multi-pass membrane protein By similarity.
Sequence similarities	Belongs to the nurim family.

Ontologies

Keywords
Cellular component	Membrane Nucleus
Domain	Transmembrane Transmembrane helix
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW nuclear envelope Inferred from sequence or structural similarity. Source: UniProtKB nuclear inner membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 262	262	Nurim		PRO_0000299400
Regions
	Topological domain	1 – 4	4	Nuclear Potential
	Transmembrane	5 – 28	24	Helical; Potential
	Topological domain	29 – 58	30	Perinuclear space Potential
	Transmembrane	59 – 80	22	Helical; Potential
	Topological domain	81 – 97	17	Nuclear Potential
	Transmembrane	98 – 114	17	Helical; Potential
	Topological domain	115 – 133	19	Perinuclear space Potential
	Transmembrane	134 – 164	31	Helical; Potential
	Topological domain	165 – 191	27	Nuclear Potential
	Transmembrane	192 – 210	19	Helical; Potential
	Topological domain	211 – 216	6	Perinuclear space Potential
	Transmembrane	217 – 234	18	Helical; Potential
	Topological domain	235 – 262	28	Nuclear Potential
	Compositional bias	67 – 72	6	Poly-Leu
	Compositional bias	139 – 253	115	Leu-rich

Sequences

	Sequence		Length	Mass (Da)
	Q6MG14 [UniParc]. Last modified July 5, 2004. Version 1. Checksum: FEAC40DA59359772	FASTA	262	29,382
	10 20 30 40 50 60 MAPALLLVPA ALASFVLAFG TGVEFVRFTS LRPLLGGIPE SGGPDARHGW LAALQDRSIL 70 80 90 100 110 120 ASLAWDLCLL LLFVVQHSLM ATEAVKAWTS RYFGVLQRSL YVACTALALQ LVMRYWEATP 130 140 150 160 170 180 RGPVLWEARA EPWATWVPLL CFVLHVVSWL LIFSILLVFD YAELMGLKQV YYHVLGLGEP 190 200 210 220 230 240 LSLKSPRALR LFSHLRHPVC VELLTVLWVV PTLGTDRLLL ALLFTLYLGL AHGLDQQDLR 250 260 YLRSQLQRKL QLLSRPQDGE AE

References

[1]	"The genomic sequence and comparative analysis of the rat major histocompatibility complex." Hurt P., Walter L., Sudbrak R., Klages S., Mueller I., Shiina T., Inoko H., Lehrach H., Guenther E., Reinhardt R., Himmelbauer H. Genome Res. 14:631-639(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Brown Norway.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BX883048 Genomic DNA. Translation: CAE84033.1.
IPI	IPI00417747.
RefSeq	NP_997673.1. NM_212508.2.
UniGene	Rn.38521.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	10116.ENSRNOP00000001085.
Proteomic databases
PaxDb	Q6MG14.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSRNOT00000001085; ENSRNOP00000001085; ENSRNOG00000000818.
GeneID	361791.
KEGG	rno:361791.
UCSC	RGD:1302966. rat.
Organism-specific databases
CTD	11270.
RGD	1302966. Nrm.
Phylogenomic databases
eggNOG	NOG87490.
GeneTree	ENSGT00390000008146.
HOGENOM	HOG000039993.
HOVERGEN	HBG102998.
InParanoid	Q6MG14.
OMA	HPLMLGF.
OrthoDB	EOG4HT8T2.
Gene expression databases
Genevestigator	Q6MG14.
Family and domain databases
ProtoNet	Search...
Other
NextBio	677619.

Entry information

Entry name

NRM_RAT

Accession

Primary (citable) accession number: Q6MG14

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 11, 2007
Last sequence update:	July 5, 2004
Last modified:	April 3, 2013
This is version 47 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program