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Protein

ATP-binding cassette sub-family F member 1

Gene

Abcf1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Required for efficient Cap- and IRES-mediated mRNA translation initiation. Not involved in the ribosome biogenesis (By similarity).By similarity1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi330 – 337ATP 1PROSITE-ProRule annotation8
Nucleotide bindingi652 – 659ATP 2PROSITE-ProRule annotation8

GO - Molecular functioni

GO - Biological processi

  • positive regulation of translation Source: UniProtKB
  • translation Source: RGD
  • translational initiation Source: UniProtKB

Keywordsi

Molecular functionActivator
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-RNO-382556 ABC-family proteins mediated transport

Names & Taxonomyi

Protein namesi
Recommended name:
ATP-binding cassette sub-family F member 1
Alternative name(s):
ATP-binding cassette 50
Gene namesi
Name:Abcf1
Synonyms:Abc50
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 20

Organism-specific databases

RGDi620286 Abcf1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000933221 – 839ATP-binding cassette sub-family F member 1Add BLAST839

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei22PhosphoserineBy similarity1
Modified residuei105PhosphoserineBy similarity1
Modified residuei109PhosphoserineCombined sources1
Modified residuei140PhosphoserineCombined sources1
Modified residuei195PhosphothreonineCombined sources1
Modified residuei197PhosphoserineCombined sources1
Modified residuei227PhosphoserineCombined sources1
Modified residuei589PhosphoserineBy similarity1

Post-translational modificationi

Phosphorylated at phosphoserine and phosphothreonine. Phosphorylation on Ser-109 and Ser-140 by CK2; inhibits association of EIF2 with ribosomes (By similarity).By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ6MG08
PRIDEiQ6MG08

PTM databases

iPTMnetiQ6MG08
PhosphoSitePlusiQ6MG08

Expressioni

Gene expression databases

BgeeiENSRNOG00000000799
GenevisibleiQ6MG08 RN

Interactioni

Subunit structurei

Interacts (via N-terminus) with EIF2S1; the interaction is independent of its phosphorylated status. Associates (via both ABC transporter domains) with the ribosomes (By similarity).By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000001049

Structurei

3D structure databases

ProteinModelPortaliQ6MG08
SMRiQ6MG08
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini298 – 542ABC transporter 1PROSITE-ProRule annotationAdd BLAST245
Domaini619 – 834ABC transporter 2PROSITE-ProRule annotationAdd BLAST216

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi85 – 93Poly-Asp9
Compositional biasi139 – 149Poly-GluAdd BLAST11

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0066 Eukaryota
COG0488 LUCA
GeneTreeiENSGT00630000089843
HOGENOMiHOG000271637
HOVERGENiHBG050440
InParanoidiQ6MG08
KOiK06184
OMAiKEYTVRF
OrthoDBiEOG091G031N
PhylomeDBiQ6MG08

Family and domain databases

InterProiView protein in InterPro
IPR003593 AAA+_ATPase
IPR032781 ABC_tran_Xtn
IPR003439 ABC_transporter-like
IPR017871 ABC_transporter_CS
IPR027417 P-loop_NTPase
PfamiView protein in Pfam
PF00005 ABC_tran, 2 hits
PF12848 ABC_tran_Xtn, 1 hit
SMARTiView protein in SMART
SM00382 AAA, 2 hits
SUPFAMiSSF52540 SSF52540, 3 hits
PROSITEiView protein in PROSITE
PS00211 ABC_TRANSPORTER_1, 2 hits
PS50893 ABC_TRANSPORTER_2, 2 hits

Sequencei

Sequence statusi: Complete.

Q6MG08-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPKGPKQQPP EPEWIGDGEG TSPADKVVKK GKKDKKTKKT FFEELAVEDK
60 70 80 90 100
QAGEEEKLQK EKEQQQQQQQ QKKKRDTRKG RRKKDVDDDD DGDERVLMER
110 120 130 140 150
LKQLSVPASD EEDEVPVPVP RGRKKAKGGN VFEALIQDES EEEKEEEEEK
160 170 180 190 200
PVLKPAKPEK NRINKAVAEE PPGLRNKKGK EEKSKGKAKN KPSATDSEGE
210 220 230 240 250
DDEDMTKEKE PPRPGKDKDK KGAEQGSEEE KEEKEGEVKA NDPYAHLSKK
260 270 280 290 300
EKKKLKKQMD YERQVESLKA ANAAENDFSV SQAEVSSRQA MLENASDIKL
310 320 330 340 350
EKFSISAHGK ELFVNADLYI VAGRRYGLVG PNGKGKTTLL KHIANRALSI
360 370 380 390 400
PPNIDVLLCE QEVVADETPA VQAVLRADTK RLRLLEEEKR LQGQLEQGDD
410 420 430 440 450
TAAEKLEKVY EELRATGAAA AEAKARRILA GLGFDPEMQN RPTQKFSGGW
460 470 480 490 500
RMRVSLARAL FMEPTLLMLD EPTNHLDLNA VIWLNNYLQG WRKTLLIVSH
510 520 530 540 550
DQGFLDDVCT DIIHLDTQRL HYYRGNYMTF KKMYQQKQKE LLKQYEKQEK
560 570 580 590 600
KLKELKAGGK STKQAEKQTK EVLTRKQQKC RRKNQDEESQ DPPELLKRPR
610 620 630 640 650
EYTVRFTFPD PPPLSPPVLG LHGVTFGYEG QKPLFKNLDF GIDMDSRICI
660 670 680 690 700
VGPNGVGKST LLLLLTGKLT PTNGEMRKNH RLKIGFFNQQ YAEQLHMEET
710 720 730 740 750
PTEYLQRGFN LPYQDARKCL GRFGLESHAH TIQICKLSGG QKARVVFAEL
760 770 780 790 800
ACREPDVLIL DEPTNNLDIE SIDALGEAIN EYKGAVIVVS HDARLITETN
810 820 830
CQLWVVEEQS VSQIDGDFDD YKREVLEALG EVMVNRPRD
Length:839
Mass (Da):95,252
Last modified:July 5, 2004 - v1
Checksum:i0EB651DD0B3F5B24
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti201D → DK in AAG23960 (PubMed:10931828).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX883048 Genomic DNA Translation: CAE84039.1
AF293383 mRNA Translation: AAG23960.1
RefSeqiNP_001103353.1, NM_001109883.2
UniGeneiRn.14350

Genome annotation databases

EnsembliENSRNOT00000001049; ENSRNOP00000001049; ENSRNOG00000000799
GeneIDi85493
KEGGirno:85493
UCSCiRGD:620286 rat

Similar proteinsi

Entry informationi

Entry nameiABCF1_RAT
AccessioniPrimary (citable) accession number: Q6MG08
Secondary accession number(s): Q9ERQ2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 7, 2004
Last sequence update: July 5, 2004
Last modified: May 23, 2018
This is version 99 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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