Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Guanine nucleotide-binding protein-like 1

Gene

Gnl1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Possible regulatory or functional link with the histocompatibility cluster.By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi225 – 2284GTPSequence analysis
Nucleotide bindingi367 – 3748GTPSequence analysis
Nucleotide bindingi411 – 4155GTPSequence analysis

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Guanine nucleotide-binding protein-like 1
Gene namesi
Name:Gnl1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 20

Organism-specific databases

RGDi1303051. Gnl1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 607607Guanine nucleotide-binding protein-like 1PRO_0000295691Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei32 – 321PhosphoserineBy similarity
Modified residuei33 – 331PhosphoserineBy similarity
Modified residuei34 – 341PhosphoserineBy similarity
Modified residuei48 – 481PhosphothreonineCombined sources
Modified residuei50 – 501PhosphothreonineCombined sources
Modified residuei51 – 511PhosphoserineCombined sources
Modified residuei68 – 681PhosphoserineBy similarity
Modified residuei324 – 3241PhosphoserineCombined sources
Modified residuei561 – 5611PhosphoserineBy similarity
Modified residuei562 – 5621PhosphoserineBy similarity
Modified residuei563 – 5631PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ6MG06.
PRIDEiQ6MG06.

PTM databases

iPTMnetiQ6MG06.
PhosphoSiteiQ6MG06.

Expressioni

Gene expression databases

ExpressionAtlasiQ6MG06. baseline and differential.
GenevisibleiQ6MG06. RN.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000045697.

Structurei

3D structure databases

ProteinModelPortaliQ6MG06.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini178 – 418241CP-type GPROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi551 – 60757Asp/Glu-rich (highly acidic)Add
BLAST

Domaini

In contrast to other GTP-binding proteins, this family is characterized by a circular permutation of the GTPase motifs described by a G4-G1-G3 pattern.

Sequence similaritiesi

Belongs to the TRAFAC class YlqF/YawG GTPase family.PROSITE-ProRule annotation
Contains 1 CP-type G (guanine nucleotide-binding) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG1424. Eukaryota.
COG1161. LUCA.
GeneTreeiENSGT00530000063453.
HOGENOMiHOG000007598.
HOVERGENiHBG005865.
InParanoidiQ6MG06.
OMAiKYLRSTQ.
OrthoDBiEOG7RRF6P.
PhylomeDBiQ6MG06.
TreeFamiTF324569.

Family and domain databases

Gene3Di3.40.50.300. 3 hits.
InterProiIPR030378. G_CP_dom.
IPR006073. GTP_binding_domain.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01926. MMR_HSR1. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
PROSITEiPS51721. G_CP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6MG06-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPRKKPFSVK QKKKQLQDKR ERKRGLQDGL RSSSNSRSGS RERREEQTDT
60 70 80 90 100
SDGESVTHHI RRLNQQPSQG LGPRGYDPNR YRLHFERDSR EEVERRKRAA
110 120 130 140 150
REQVLQPVSA EMLELDIQEV YQPGSVLDFP RRPPWSYEMS KEQLMSQEER
160 170 180 190 200
SFQEYLGKIH GAYTSEKLSY FEHNLETWRQ LWRVLEMSDI VLLITDIRHP
210 220 230 240 250
VVNFPPALYE YVTGELGLAL VLVLNKVDLA PPALVVAWKH YFHQHYPQLH
260 270 280 290 300
IVLFTSFPRD TRTPQEPGSV LKKSRRRGRG WTRALGPEQL LRACEAITVG
310 320 330 340 350
KVDLSSWREK IARDVAGASW GNVSGEEEEE EDGPAVLVEQ QTDSAMEPTG
360 370 380 390 400
PSRERYKDGV VTIGCVGFPN VGKSSLINGL VGRKVVSVSR TPGHTRYFQT
410 420 430 440 450
YFLTPSVKLC DCPGLIFPSL LPRQLQVLAG IYPIAQIQEP YTSVGYLACR
460 470 480 490 500
IPVQALLHLR HPEAEDPSAE HPWCAWDVCE AWAEKRGYKT AKAARNDVYR
510 520 530 540 550
AANSLLRLAV DGRLSLCFHP PGYSEQRGTW ESHAETAELV LSQGRVGPAG
560 570 580 590 600
DEEEEEEEEL SSSCEEEGEE DRDADEEGEG DEDTPTSDTG SCLAARNPYA

LLGEGEC
Length:607
Mass (Da):68,707
Last modified:July 5, 2004 - v1
Checksum:iB384481372E3F92D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX883048 Genomic DNA. Translation: CAE84041.1.
BC129081 mRNA. Translation: AAI29082.1.
RefSeqiNP_997665.1. NM_212500.3.
UniGeneiRn.35325.

Genome annotation databases

EnsembliENSRNOT00000050373; ENSRNOP00000045697; ENSRNOG00000000798.
GeneIDi309593.
KEGGirno:309593.
UCSCiRGD:1303051. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX883048 Genomic DNA. Translation: CAE84041.1.
BC129081 mRNA. Translation: AAI29082.1.
RefSeqiNP_997665.1. NM_212500.3.
UniGeneiRn.35325.

3D structure databases

ProteinModelPortaliQ6MG06.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000045697.

PTM databases

iPTMnetiQ6MG06.
PhosphoSiteiQ6MG06.

Proteomic databases

PaxDbiQ6MG06.
PRIDEiQ6MG06.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000050373; ENSRNOP00000045697; ENSRNOG00000000798.
GeneIDi309593.
KEGGirno:309593.
UCSCiRGD:1303051. rat.

Organism-specific databases

CTDi2794.
RGDi1303051. Gnl1.

Phylogenomic databases

eggNOGiKOG1424. Eukaryota.
COG1161. LUCA.
GeneTreeiENSGT00530000063453.
HOGENOMiHOG000007598.
HOVERGENiHBG005865.
InParanoidiQ6MG06.
OMAiKYLRSTQ.
OrthoDBiEOG7RRF6P.
PhylomeDBiQ6MG06.
TreeFamiTF324569.

Miscellaneous databases

PROiQ6MG06.

Gene expression databases

ExpressionAtlasiQ6MG06. baseline and differential.
GenevisibleiQ6MG06. RN.

Family and domain databases

Gene3Di3.40.50.300. 3 hits.
InterProiIPR030378. G_CP_dom.
IPR006073. GTP_binding_domain.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01926. MMR_HSR1. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
PROSITEiPS51721. G_CP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The genomic sequence and comparative analysis of the rat major histocompatibility complex."
    Hurt P., Walter L., Sudbrak R., Klages S., Mueller I., Shiina T., Inoko H., Lehrach H., Guenther E., Reinhardt R., Himmelbauer H.
    Genome Res. 14:631-639(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Brown Norway.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Placenta.
  3. "Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues."
    Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A., Lundby C., Olsen J.V.
    Nat. Commun. 3:876-876(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-48; THR-50; SER-51 AND SER-324, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiGNL1_RAT
AccessioniPrimary (citable) accession number: Q6MG06
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 24, 2007
Last sequence update: July 5, 2004
Last modified: July 6, 2016
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.