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Protein

E3 ubiquitin-protein ligase TRIM39

Gene

Trim39

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

E3 ubiquitin-protein ligase. May facilitate apoptosis by inhibiting APC/C-Cdh1-mediated poly-ubiquitination and subsequent proteasome-mediated degradation of the pro-apoptotic protein MOAP1.By similarity

Catalytic activityi

S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N6-ubiquitinyl-[acceptor protein]-L-lysine.

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri29 – 70RING-typePROSITE-ProRule annotationAdd BLAST42
Zinc fingeri102 – 143B box-typePROSITE-ProRule annotationAdd BLAST42

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase
Biological processApoptosis, Ubl conjugation pathway
LigandMetal-binding, Zinc

Enzyme and pathway databases

UniPathwayiUPA00143.

Names & Taxonomyi

Protein namesi
Recommended name:
E3 ubiquitin-protein ligase TRIM39 (EC:2.3.2.27)
Alternative name(s):
RING finger protein 23
RING-type E3 ubiquitin transferase TRIM39Curated
Tripartite motif-containing protein 39
Gene namesi
Name:Trim39
Synonyms:Rnf23
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 20

Organism-specific databases

RGDi1303115. Trim39.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000562591 – 488E3 ubiquitin-protein ligase TRIM39Add BLAST488

Post-translational modificationi

Autoubiquitinated.By similarity

Keywords - PTMi

Ubl conjugation

Proteomic databases

PaxDbiQ6MFZ5.

Expressioni

Gene expression databases

BgeeiENSRNOG00000000785.
ExpressionAtlasiQ6MFZ5. baseline and differential.
GenevisibleiQ6MFZ5. RN.

Interactioni

Subunit structurei

Interacts with MOAP1.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000001021.

Structurei

3D structure databases

ProteinModelPortaliQ6MFZ5.
SMRiQ6MFZ5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini289 – 484B30.2/SPRYPROSITE-ProRule annotationAdd BLAST196

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili181 – 250Sequence analysisAdd BLAST70

Sequence similaritiesi

Belongs to the TRIM/RBCC family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri29 – 70RING-typePROSITE-ProRule annotationAdd BLAST42
Zinc fingeri102 – 143B box-typePROSITE-ProRule annotationAdd BLAST42

Keywords - Domaini

Coiled coil, Zinc-finger

Phylogenomic databases

eggNOGiENOG410ITFV. Eukaryota.
ENOG410YDPJ. LUCA.
GeneTreeiENSGT00760000118893.
HOGENOMiHOG000234133.
HOVERGENiHBG001357.
InParanoidiQ6MFZ5.
KOiK12015.
PhylomeDBiQ6MFZ5.
TreeFamiTF342569.

Family and domain databases

CDDicd00021. BBOX. 1 hit.
cd13745. SPRY_PRY_TRIM39. 1 hit.
Gene3Di3.30.40.10. 1 hit.
InterProiView protein in InterPro
IPR001870. B30.2/SPRY.
IPR003879. Butyrophylin_SPRY.
IPR013320. ConA-like_dom_sf.
IPR006574. PRY.
IPR035033. PRY/SPRY_TRIM39.
IPR003877. SPRY_dom.
IPR000315. Znf_B-box.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
IPR017907. Znf_RING_CS.
PfamiView protein in Pfam
PF13765. PRY. 1 hit.
PF00622. SPRY. 1 hit.
PF00643. zf-B_box. 1 hit.
PRINTSiPR01407. BUTYPHLNCDUF.
SMARTiView protein in SMART
SM00336. BBOX. 1 hit.
SM00589. PRY. 1 hit.
SM00184. RING. 1 hit.
SM00449. SPRY. 1 hit.
SUPFAMiSSF49899. SSF49899. 1 hit.
PROSITEiView protein in PROSITE
PS50188. B302_SPRY. 1 hit.
PS50119. ZF_BBOX. 1 hit.
PS00518. ZF_RING_1. 1 hit.
PS50089. ZF_RING_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q6MFZ5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAETSLLEAG ASAASTAAAL ENLQVEASCS VCLEYLKEPV IIECGHNFCK
60 70 80 90 100
ACITRWWEDL ERDFPCPVCR KTSRYRSLRP NRQLGSMVEI AKQLQTVKRK
110 120 130 140 150
IRDESLCSQH HEPLSLFCYE DQEAVCLICA ISHTHRAHTV VPMDDATQEY
160 170 180 190 200
KEKLQKCLEP LEQKLQEITC CKASEERKPG ELKRLVESRR QQILKEFEEL
210 220 230 240 250
HRRLDEEQQT LLSRLEEEEQ DILQRLRENA AHLGDRRRDL AHLAAEVEGK
260 270 280 290 300
CLQSGFEMLK DVKSTLEKCE KVKTMEVTSV SIELEKNFSH FPRQYFALRK
310 320 330 340 350
ILKQLIADVT LDPETAHPNL VLSEDRKSVK FVETRLRDLP DTPQRFTFYP
360 370 380 390 400
CVLATEGFTS GRHYWEVEVG DKTHWAVGVC RDSVSRKGEL TPLPETGYWR
410 420 430 440 450
VRLWNGDKYA ATTTPFTPLH IKVKPKRVGI FLDYEAGTLS FYNVTDRSHI
460 470 480
YTFTDTFTEK LWPLFYPGIR AGRKNAAPLT IRPPTDWE
Length:488
Mass (Da):56,394
Last modified:July 5, 2004 - v1
Checksum:i576A9FACB54B5F72
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX883050 Genomic DNA. Translation: CAE84052.1.
RefSeqiNP_998727.1. NM_213562.1.
UniGeneiRn.229996.

Genome annotation databases

EnsembliENSRNOT00000001021; ENSRNOP00000001021; ENSRNOG00000000785.
GeneIDi309591.
KEGGirno:309591.
UCSCiRGD:1303115. rat.

Similar proteinsi

Entry informationi

Entry nameiTRI39_RAT
AccessioniPrimary (citable) accession number: Q6MFZ5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 7, 2004
Last sequence update: July 5, 2004
Last modified: November 22, 2017
This is version 106 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families