Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

E3 ubiquitin-protein ligase TRIM39

Gene

Trim39

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

E3 ubiquitin-protein ligase. May facilitate apoptosis by inhibiting APC/C-Cdh1-mediated poly-ubiquitination and subsequent proteasome-mediated degradation of the pro-apoptotic protein MOAP1 (By similarity).By similarity

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri29 – 7042RING-typePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri102 – 14342B box-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Apoptosis, Ubl conjugation pathway

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-RNO-983168. Antigen processing: Ubiquitination & Proteasome degradation.
UniPathwayiUPA00143.

Names & Taxonomyi

Protein namesi
Recommended name:
E3 ubiquitin-protein ligase TRIM39 (EC:6.3.2.-)
Alternative name(s):
RING finger protein 23
Tripartite motif-containing protein 39
Gene namesi
Name:Trim39
Synonyms:Rnf23
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 20

Organism-specific databases

RGDi1303115. Trim39.

Subcellular locationi

  • Cytoplasmcytosol By similarity
  • Mitochondrion By similarity

  • Note: Found predominantly in the cytosol. Partial shift from the cytosol to the mitochondria when colocalized with MOAP1 (By similarity).By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 488488E3 ubiquitin-protein ligase TRIM39PRO_0000056259Add
BLAST

Post-translational modificationi

Autoubiquitinated.By similarity

Keywords - PTMi

Ubl conjugation

Proteomic databases

PaxDbiQ6MFZ5.

Expressioni

Gene expression databases

ExpressionAtlasiQ6MFZ5. baseline and differential.
GenevisibleiQ6MFZ5. RN.

Interactioni

Subunit structurei

Interacts with MOAP1.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000001021.

Structurei

3D structure databases

ProteinModelPortaliQ6MFZ5.
SMRiQ6MFZ5. Positions 13-69, 106-143, 307-483.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini289 – 484196B30.2/SPRYPROSITE-ProRule annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili181 – 25070Sequence analysisAdd
BLAST

Sequence similaritiesi

Belongs to the TRIM/RBCC family.Curated
Contains 1 B box-type zinc finger.PROSITE-ProRule annotation
Contains 1 B30.2/SPRY domain.PROSITE-ProRule annotation
Contains 1 RING-type zinc finger.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri29 – 7042RING-typePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri102 – 14342B box-typePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Coiled coil, Zinc-finger

Phylogenomic databases

eggNOGiENOG410ITFV. Eukaryota.
ENOG410YDPJ. LUCA.
GeneTreeiENSGT00760000118893.
HOGENOMiHOG000234133.
HOVERGENiHBG001357.
InParanoidiQ6MFZ5.
KOiK12015.
OMAiVECRRQQ.
OrthoDBiEOG7MPRDJ.
PhylomeDBiQ6MFZ5.
TreeFamiTF342569.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
4.10.45.10. 1 hit.
InterProiIPR001870. B30.2/SPRY.
IPR003879. Butyrophylin.
IPR013320. ConA-like_dom.
IPR006574. PRY.
IPR003877. SPRY_dom.
IPR000315. Znf_B-box.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
IPR017907. Znf_RING_CS.
[Graphical view]
PfamiPF13765. PRY. 1 hit.
PF00622. SPRY. 1 hit.
PF00643. zf-B_box. 1 hit.
[Graphical view]
PRINTSiPR01407. BUTYPHLNCDUF.
SMARTiSM00336. BBOX. 1 hit.
SM00589. PRY. 1 hit.
SM00184. RING. 1 hit.
SM00449. SPRY. 1 hit.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 1 hit.
PROSITEiPS50188. B302_SPRY. 1 hit.
PS50119. ZF_BBOX. 1 hit.
PS00518. ZF_RING_1. 1 hit.
PS50089. ZF_RING_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6MFZ5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAETSLLEAG ASAASTAAAL ENLQVEASCS VCLEYLKEPV IIECGHNFCK
60 70 80 90 100
ACITRWWEDL ERDFPCPVCR KTSRYRSLRP NRQLGSMVEI AKQLQTVKRK
110 120 130 140 150
IRDESLCSQH HEPLSLFCYE DQEAVCLICA ISHTHRAHTV VPMDDATQEY
160 170 180 190 200
KEKLQKCLEP LEQKLQEITC CKASEERKPG ELKRLVESRR QQILKEFEEL
210 220 230 240 250
HRRLDEEQQT LLSRLEEEEQ DILQRLRENA AHLGDRRRDL AHLAAEVEGK
260 270 280 290 300
CLQSGFEMLK DVKSTLEKCE KVKTMEVTSV SIELEKNFSH FPRQYFALRK
310 320 330 340 350
ILKQLIADVT LDPETAHPNL VLSEDRKSVK FVETRLRDLP DTPQRFTFYP
360 370 380 390 400
CVLATEGFTS GRHYWEVEVG DKTHWAVGVC RDSVSRKGEL TPLPETGYWR
410 420 430 440 450
VRLWNGDKYA ATTTPFTPLH IKVKPKRVGI FLDYEAGTLS FYNVTDRSHI
460 470 480
YTFTDTFTEK LWPLFYPGIR AGRKNAAPLT IRPPTDWE
Length:488
Mass (Da):56,394
Last modified:July 5, 2004 - v1
Checksum:i576A9FACB54B5F72
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX883050 Genomic DNA. Translation: CAE84052.1.
RefSeqiNP_998727.1. NM_213562.1.
UniGeneiRn.229996.

Genome annotation databases

EnsembliENSRNOT00000001021; ENSRNOP00000001021; ENSRNOG00000000785.
GeneIDi309591.
KEGGirno:309591.
UCSCiRGD:1303115. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX883050 Genomic DNA. Translation: CAE84052.1.
RefSeqiNP_998727.1. NM_213562.1.
UniGeneiRn.229996.

3D structure databases

ProteinModelPortaliQ6MFZ5.
SMRiQ6MFZ5. Positions 13-69, 106-143, 307-483.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000001021.

Proteomic databases

PaxDbiQ6MFZ5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000001021; ENSRNOP00000001021; ENSRNOG00000000785.
GeneIDi309591.
KEGGirno:309591.
UCSCiRGD:1303115. rat.

Organism-specific databases

CTDi56658.
RGDi1303115. Trim39.

Phylogenomic databases

eggNOGiENOG410ITFV. Eukaryota.
ENOG410YDPJ. LUCA.
GeneTreeiENSGT00760000118893.
HOGENOMiHOG000234133.
HOVERGENiHBG001357.
InParanoidiQ6MFZ5.
KOiK12015.
OMAiVECRRQQ.
OrthoDBiEOG7MPRDJ.
PhylomeDBiQ6MFZ5.
TreeFamiTF342569.

Enzyme and pathway databases

UniPathwayiUPA00143.
ReactomeiR-RNO-983168. Antigen processing: Ubiquitination & Proteasome degradation.

Miscellaneous databases

NextBioi661022.
PROiQ6MFZ5.

Gene expression databases

ExpressionAtlasiQ6MFZ5. baseline and differential.
GenevisibleiQ6MFZ5. RN.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
4.10.45.10. 1 hit.
InterProiIPR001870. B30.2/SPRY.
IPR003879. Butyrophylin.
IPR013320. ConA-like_dom.
IPR006574. PRY.
IPR003877. SPRY_dom.
IPR000315. Znf_B-box.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
IPR017907. Znf_RING_CS.
[Graphical view]
PfamiPF13765. PRY. 1 hit.
PF00622. SPRY. 1 hit.
PF00643. zf-B_box. 1 hit.
[Graphical view]
PRINTSiPR01407. BUTYPHLNCDUF.
SMARTiSM00336. BBOX. 1 hit.
SM00589. PRY. 1 hit.
SM00184. RING. 1 hit.
SM00449. SPRY. 1 hit.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 1 hit.
PROSITEiPS50188. B302_SPRY. 1 hit.
PS50119. ZF_BBOX. 1 hit.
PS00518. ZF_RING_1. 1 hit.
PS50089. ZF_RING_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The genomic sequence and comparative analysis of the rat major histocompatibility complex."
    Hurt P., Walter L., Sudbrak R., Klages S., Mueller I., Shiina T., Inoko H., Lehrach H., Guenther E., Reinhardt R., Himmelbauer H.
    Genome Res. 14:631-639(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Brown Norway.

Entry informationi

Entry nameiTRI39_RAT
AccessioniPrimary (citable) accession number: Q6MFZ5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 7, 2004
Last sequence update: July 5, 2004
Last modified: May 11, 2016
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.