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Protein

E3 ubiquitin-protein ligase PPP1R11

Gene

Ppp1r11

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Atypical E3 ubiquitin-protein ligase which ubiquitinates TLR2 at 'Lys-754' leading to its degradation by the proteasome. Plays a role in regulating inflammatory cytokine release and gram-positive bacterial clearance by functioning, in part, through the ubiquitination and degradation of TLR2. Inhibitor of protein phosphatase 1.By similarity

Catalytic activityi

S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N6-ubiquitinyl-[acceptor protein]-L-lysine.By similarity

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionProtein phosphatase inhibitor, Transferase
Biological processUbl conjugation pathway

Enzyme and pathway databases

UniPathwayiUPA00143

Names & Taxonomyi

Protein namesi
Recommended name:
E3 ubiquitin-protein ligase PPP1R11 (EC:2.3.2.27)
Alternative name(s):
Protein phosphatase 1 regulatory subunit 11
Gene namesi
Name:Ppp1r11
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 20

Organism-specific databases

RGDi1303163 Ppp1r11

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00002396232 – 127E3 ubiquitin-protein ligase PPP1R11Add BLAST126

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1
Modified residuei74PhosphoserineBy similarity1
Modified residuei75PhosphoserineBy similarity1
Modified residuei76PhosphothreonineBy similarity1
Modified residuei78PhosphoserineBy similarity1
Modified residuei110PhosphothreonineBy similarity1

Post-translational modificationi

Auto-ubiquitinated.By similarity

Keywords - PTMi

Acetylation, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbiQ6MFY6
PRIDEiQ6MFY6

PTM databases

iPTMnetiQ6MFY6
PhosphoSitePlusiQ6MFY6

Expressioni

Gene expression databases

BgeeiENSRNOG00000000780
GenevisibleiQ6MFY6 RN

Interactioni

Subunit structurei

Interacts with TLR2 and UBE2D2.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000001013

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni53 – 63Atypical RING finger domain 1By similarityAdd BLAST11
Regioni86 – 95Atypical RING finger domain 2By similarity10

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi101 – 124Pro-richAdd BLAST24

Phylogenomic databases

eggNOGiKOG4102 Eukaryota
ENOG41126IN LUCA
GeneTreeiENSGT00390000001153
HOGENOMiHOG000232107
HOVERGENiHBG080560
InParanoidiQ6MFY6
KOiK17553
OMAiVVWATET
OrthoDBiEOG091G152U

Family and domain databases

InterProiView protein in InterPro
IPR011107 PPI_Ypi1
PANTHERiPTHR20835 PTHR20835, 1 hit
PfamiView protein in Pfam
PF07491 PPI_Ypi1, 1 hit

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6MFY6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAEAGAGGLS ETVTETTVTV TTEPENRSLT IKLRKRKPEK KVEWSSDTVD
60 70 80 90 100
NEHMGRRSSK CCCIYEKPRA FGESSTESDE DEEEGCGHTH CVRGHRKGRR
110 120
PTTPGPTPTT PPQPPDPSQP PPGPMQH
Length:127
Mass (Da):13,936
Last modified:June 13, 2006 - v2
Checksum:iAB29CF553C6158A6
GO
Isoform 2 (identifier: Q6MFY6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     25-25: E → VRNAGRGA

Show »
Length:134
Mass (Da):14,589
Checksum:i7188A9F3B07068CC
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_01924725E → VRNAGRGA in isoform 2. Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX883051 Genomic DNA Translation: CAE84061.1
BC079252 mRNA Translation: AAH79252.1
RefSeqiNP_997707.2, NM_212542.3 [Q6MFY6-1]
UniGeneiRn.63970

Genome annotation databases

EnsembliENSRNOT00000001013; ENSRNOP00000001013; ENSRNOG00000000780 [Q6MFY6-1]
GeneIDi294207
KEGGirno:294207
UCSCiRGD:1303163 rat [Q6MFY6-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiPP1RB_RAT
AccessioniPrimary (citable) accession number: Q6MFY6
Secondary accession number(s): Q6AXZ8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 13, 2006
Last sequence update: June 13, 2006
Last modified: April 25, 2018
This is version 80 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health