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Protein

Protein phosphatase 1 regulatory subunit 11

Gene

Ppp1r11

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Inhibitor of protein phosphatase 1.By similarity

GO - Molecular functioni

  • protein phosphatase inhibitor activity Source: RGD

GO - Biological processi

  • negative regulation of catalytic activity Source: GOC
Complete GO annotation...

Keywords - Molecular functioni

Protein phosphatase inhibitor

Names & Taxonomyi

Protein namesi
Recommended name:
Protein phosphatase 1 regulatory subunit 11
Gene namesi
Name:Ppp1r11
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 20

Organism-specific databases

RGDi1303163. Ppp1r11.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 127126Protein phosphatase 1 regulatory subunit 11PRO_0000239623Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanineBy similarity
Modified residuei74 – 741PhosphoserineBy similarity
Modified residuei75 – 751PhosphoserineBy similarity
Modified residuei76 – 761PhosphothreonineBy similarity
Modified residuei78 – 781PhosphoserineBy similarity
Modified residuei110 – 1101PhosphothreonineBy similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiQ6MFY6.
PRIDEiQ6MFY6.

PTM databases

iPTMnetiQ6MFY6.
PhosphoSiteiQ6MFY6.

Expressioni

Gene expression databases

GenevisibleiQ6MFY6. RN.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000001013.

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi101 – 12424Pro-richAdd
BLAST

Phylogenomic databases

eggNOGiKOG4102. Eukaryota.
ENOG41126IN. LUCA.
GeneTreeiENSGT00390000001153.
HOGENOMiHOG000232107.
HOVERGENiHBG080560.
InParanoidiQ6MFY6.
KOiK17553.
OMAiRRVIFHE.
OrthoDBiEOG73Z2WZ.

Family and domain databases

InterProiIPR011107. PPI_Ypi1.
[Graphical view]
PANTHERiPTHR20835. PTHR20835. 1 hit.
PfamiPF07491. PPI_Ypi1. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6MFY6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAEAGAGGLS ETVTETTVTV TTEPENRSLT IKLRKRKPEK KVEWSSDTVD
60 70 80 90 100
NEHMGRRSSK CCCIYEKPRA FGESSTESDE DEEEGCGHTH CVRGHRKGRR
110 120
PTTPGPTPTT PPQPPDPSQP PPGPMQH
Length:127
Mass (Da):13,936
Last modified:June 13, 2006 - v2
Checksum:iAB29CF553C6158A6
GO
Isoform 2 (identifier: Q6MFY6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     25-25: E → VRNAGRGA

Show »
Length:134
Mass (Da):14,589
Checksum:i7188A9F3B07068CC
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei25 – 251E → VRNAGRGA in isoform 2. CuratedVSP_019247

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX883051 Genomic DNA. Translation: CAE84061.1.
BC079252 mRNA. Translation: AAH79252.1.
RefSeqiNP_997707.2. NM_212542.3. [Q6MFY6-1]
UniGeneiRn.63970.

Genome annotation databases

EnsembliENSRNOT00000001013; ENSRNOP00000001013; ENSRNOG00000000780. [Q6MFY6-1]
GeneIDi294207.
KEGGirno:294207.
UCSCiRGD:1303163. rat. [Q6MFY6-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX883051 Genomic DNA. Translation: CAE84061.1.
BC079252 mRNA. Translation: AAH79252.1.
RefSeqiNP_997707.2. NM_212542.3. [Q6MFY6-1]
UniGeneiRn.63970.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000001013.

PTM databases

iPTMnetiQ6MFY6.
PhosphoSiteiQ6MFY6.

Proteomic databases

PaxDbiQ6MFY6.
PRIDEiQ6MFY6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000001013; ENSRNOP00000001013; ENSRNOG00000000780. [Q6MFY6-1]
GeneIDi294207.
KEGGirno:294207.
UCSCiRGD:1303163. rat. [Q6MFY6-1]

Organism-specific databases

CTDi6992.
RGDi1303163. Ppp1r11.

Phylogenomic databases

eggNOGiKOG4102. Eukaryota.
ENOG41126IN. LUCA.
GeneTreeiENSGT00390000001153.
HOGENOMiHOG000232107.
HOVERGENiHBG080560.
InParanoidiQ6MFY6.
KOiK17553.
OMAiRRVIFHE.
OrthoDBiEOG73Z2WZ.

Miscellaneous databases

PROiQ6MFY6.

Gene expression databases

GenevisibleiQ6MFY6. RN.

Family and domain databases

InterProiIPR011107. PPI_Ypi1.
[Graphical view]
PANTHERiPTHR20835. PTHR20835. 1 hit.
PfamiPF07491. PPI_Ypi1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The genomic sequence and comparative analysis of the rat major histocompatibility complex."
    Hurt P., Walter L., Sudbrak R., Klages S., Mueller I., Shiina T., Inoko H., Lehrach H., Guenther E., Reinhardt R., Himmelbauer H.
    Genome Res. 14:631-639(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], ALTERNATIVE SPLICING (ISOFORM 2).
    Strain: Brown Norway.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Testis.

Entry informationi

Entry nameiPP1RB_RAT
AccessioniPrimary (citable) accession number: Q6MFY6
Secondary accession number(s): Q6AXZ8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 13, 2006
Last sequence update: June 13, 2006
Last modified: June 8, 2016
This is version 69 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.