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Q6MF52 (AROB_PARUW) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 51. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
3-dehydroquinate synthase
EC=4.2.3.4
Gene names
Name:aroB
Ordered Locus Names:pc0073
OrganismProtochlamydia amoebophila (strain UWE25) [Complete proteome] [HAMAP]
Taxonomic identifier264201 [NCBI]
Taxonomic lineageBacteria › Chlamydiae › Chlamydiales › Parachlamydiaceae › Candidatus Protochlamydia

Protein attributes

Sequence length352 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

3-deoxy-D-arabino-hept-2-ulosonate 7-phosphate = 3-dehydroquinate + phosphate. HAMAP MF_00110

Cofactor

Divalent metal cations By similarity. HAMAP MF_00110

NAD By similarity. HAMAP MF_00110

Pathway

Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 2/7. HAMAP MF_00110

Subunit structure

Monomer By similarity. HAMAP MF_00110

Subcellular location

Cytoplasm Probable HAMAP MF_00110.

Sequence similarities

Belongs to the dehydroquinate synthase family.

Ontologies

Keywords
   Biological processAmino-acid biosynthesis
Aromatic amino acid biosynthesis
   Cellular componentCytoplasm
   LigandNAD
   Molecular functionLyase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processaromatic amino acid family biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular function3-dehydroquinate synthase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 3523523-dehydroquinate synthase HAMAP MF_00110
PRO_0000231105

Sequences

Sequence LengthMass (Da)Tools
Q6MF52 [UniParc].

Last modified July 5, 2004. Version 1.
Checksum: 29D1243413F13324

FASTA35239,939
        10         20         30         40         50         60 
MLNSSNYVIQ SHCLDDLKYY LESLSYSKVV IITHPQLWVM YEQKITEQLF KLSWNFSVLL 

        70         80         90        100        110        120 
IPEGETSKSL KQTTRCWRHF IKHQLDRYSL VVALGGGVIC DLAGFVASCY MRGIDTIYLP 

       130        140        150        160        170        180 
TTLLAMVDAS IGGKTGINTS KSKNIIGSFH LPKKILIDPF TLKTLSKKHY QAGFAEIIKY 

       190        200        210        220        230        240 
GMIASPSLFE FLENSWSLIE QRDEGLLEII IQQSCAIKKK YVEADFKDLG IRAQLNYGHT 

       250        260        270        280        290        300 
FGHVIEMMSR YQYLHGEAVS IGMSCAAYLS CQMGLTTQET MQRQDALCQQ AQLPIHLPHF 

       310        320        330        340        350 
PLTRFTYLMA KDKKGRNGSI NLILPEKVGK VTQIFDVDPH LIKNTLSTKM TK

« Hide

References

[1]"Illuminating the evolutionary history of chlamydiae."
Horn M., Collingro A., Schmitz-Esser S., Beier C.L., Purkhold U., Fartmann B., Brandt P., Nyakatura G.J., Droege M., Frishman D., Rattei T., Mewes H.-W., Wagner M.
Science 304:728-730(2004) [PubMed: 15073324] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: UWE25.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		BX908798 Genomic DNA. Translation: CAF22797.1.
RefSeqYP_007072.1. NC_005861.1.

3D structure databases

ProteinModelPortalQ6MF52.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ6MF52.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID2779772.
GenomeReviewsGene locus pc0073 in contig BX908798_GR.
KEGGpcu:pc0073.
NMPDRfig|264201.1.peg.73.
PATRIC31995434. VBICanPro72727_0079.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0337.
HOGENOMHBG632303.
OMAVMALEMS.
PhylomeDBQ6MF52.

Enzyme and pathway databases

BioCycCPRO264201:PC0073-MONOMER.

Family and domain databases

HAMAPMF_00110. DHQ_synthase.
[Tree]
InterProIPR016037. DHQ_synth_AroB.
[Graphical view]
KOK01735.
PANTHERPTHR21090:SF1. DHQ_synth_AroB. 1 hit.
PIRSFPIRSF001455. DHQ_synth. 1 hit.
TIGRFAMsTIGR01357. AroB. 1 hit.
ProtoNetSearch...

Entry information

Entry nameAROB_PARUW
AccessionPrimary (citable) accession number: Q6MF52
Entry history
Integrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: July 5, 2004
Last modified: January 25, 2012
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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