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Q6MEN1

- SYE_PARUW

UniProt

Q6MEN1 - SYE_PARUW

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Protein

Glutamate--tRNA ligase

Gene
gltX, pc0244
Organism
Protochlamydia amoebophila (strain UWE25)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) By similarity.UniRule annotation

Catalytic activityi

ATP + L-glutamate + tRNA(Glu) = AMP + diphosphate + L-glutamyl-tRNA(Glu).UniRule annotation

Cofactori

Binds 1 zinc ion per subunit By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi106 – 1061Zinc By similarity
Metal bindingi108 – 1081Zinc By similarity
Metal bindingi133 – 1331Zinc By similarity
Metal bindingi135 – 1351Zinc By similarity
Binding sitei253 – 2531ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. glutamate-tRNA ligase activity Source: UniProtKB-HAMAP
  3. metal ion binding Source: UniProtKB-KW
  4. tRNA binding Source: InterPro

GO - Biological processi

  1. glutamyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Metal-binding, Nucleotide-binding, Zinc

Enzyme and pathway databases

BioCyciPAMO264201:GH0M-248-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate--tRNA ligase (EC:6.1.1.17)
Alternative name(s):
Glutamyl-tRNA synthetase
Short name:
GluRS
Gene namesi
Name:gltX
Ordered Locus Names:pc0244
OrganismiProtochlamydia amoebophila (strain UWE25)
Taxonomic identifieri264201 [NCBI]
Taxonomic lineageiBacteriaChlamydiaeChlamydialesParachlamydiaceaeCandidatus Protochlamydia
ProteomesiUP000000529: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 502502Glutamate--tRNA ligaseUniRule annotationPRO_0000119618Add
BLAST

Proteomic databases

PRIDEiQ6MEN1.

Interactioni

Subunit structurei

Monomer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi264201.pc0244.

Structurei

3D structure databases

ProteinModelPortaliQ6MEN1.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi9 – 1911"HIGH" regionUniRule annotationAdd
BLAST
Motifi250 – 2545"KMSKS" regionUniRule annotation

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0008.
HOGENOMiHOG000252720.
KOiK01885.
OMAiVTGQTHG.
OrthoDBiEOG6DRPF7.

Family and domain databases

Gene3Di1.10.10.350. 1 hit.
1.10.1160.10. 1 hit.
3.40.50.620. 2 hits.
HAMAPiMF_00022_B. Glu_tRNA_synth_B.
InterProiIPR008925. aa-tRNA-synth_I_codon-bd.
IPR020751. aa-tRNA-synth_I_codon-bd_sub2.
IPR001412. aa-tRNA-synth_I_CS.
IPR004527. Glu-tRNA-ligase_bac/mito.
IPR000924. Glu/Gln-tRNA-synth.
IPR020061. Glu/Gln-tRNA-synth_Ib_a-bdl.
IPR020058. Glu/Gln-tRNA-synth_Ib_cat-dom.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PANTHERiPTHR10119. PTHR10119. 1 hit.
PfamiPF00749. tRNA-synt_1c. 1 hit.
[Graphical view]
PRINTSiPR00987. TRNASYNTHGLU.
SUPFAMiSSF48163. SSF48163. 1 hit.
TIGRFAMsiTIGR00464. gltX_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6MEN1-1 [UniParc]FASTAAdd to Basket

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MSVRVRIAPS PTGDPHVGTA YMALFNMIFA RHYNGTFILR IEDTDRARSR    50
PEYEENIYSA LKWANIQWDE GPDIGGAYGP YRQSERFDIY KQYAEELLSK 100
GKAYKCFCTA AELDEMRELS AKQGGRQGYD RRCRHLTPDE IIEREQAELS 150
YVIRLKVPLN GECVYEDAIK KRMTFPWADI DDQVLLKSDG FPTYHLANVV 200
DDYLMKISHV IRGDEWMSST PKHILLYESF GWTPPTFLHM PLLLGKDGKK 250
LSKRKNPTSI FFYRDSGYLS EAFINFLTLM GYSMTGDQEI YSLDDIIREF 300
DYKRIGVSGA IFDVQKLDWV NQQYLIKNIP VEQLWDRIKE WSFNDEFMQR 350
LMPLCHSRIK TFGDFMDLFN FLFINHLHYN DAIFVVKDLS KEQICYLIQS 400
LIWRLDELEN WNGTGVNQAS REIAEIFGVN HKKIVMPILF ASLMSKTQGP 450
PLFDSVNLLG KDRTRARLLK AMEYLGGISN KKMASLKKAW QEKSGQPLMI 500
KD 502
Length:502
Mass (Da):58,420
Last modified:July 5, 2004 - v1
Checksum:i1903CD607A03A1A2
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BX908798 Genomic DNA. Translation: CAF22968.1.
RefSeqiYP_007243.1. NC_005861.1.

Genome annotation databases

EnsemblBacteriaiCAF22968; CAF22968; pc0244.
GeneIDi2781428.
KEGGipcu:pc0244.
PATRICi31995772. VBICanPro72727_0246.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BX908798 Genomic DNA. Translation: CAF22968.1 .
RefSeqi YP_007243.1. NC_005861.1.

3D structure databases

ProteinModelPortali Q6MEN1.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 264201.pc0244.

Proteomic databases

PRIDEi Q6MEN1.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAF22968 ; CAF22968 ; pc0244 .
GeneIDi 2781428.
KEGGi pcu:pc0244.
PATRICi 31995772. VBICanPro72727_0246.

Phylogenomic databases

eggNOGi COG0008.
HOGENOMi HOG000252720.
KOi K01885.
OMAi VTGQTHG.
OrthoDBi EOG6DRPF7.

Enzyme and pathway databases

BioCyci PAMO264201:GH0M-248-MONOMER.

Family and domain databases

Gene3Di 1.10.10.350. 1 hit.
1.10.1160.10. 1 hit.
3.40.50.620. 2 hits.
HAMAPi MF_00022_B. Glu_tRNA_synth_B.
InterProi IPR008925. aa-tRNA-synth_I_codon-bd.
IPR020751. aa-tRNA-synth_I_codon-bd_sub2.
IPR001412. aa-tRNA-synth_I_CS.
IPR004527. Glu-tRNA-ligase_bac/mito.
IPR000924. Glu/Gln-tRNA-synth.
IPR020061. Glu/Gln-tRNA-synth_Ib_a-bdl.
IPR020058. Glu/Gln-tRNA-synth_Ib_cat-dom.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view ]
PANTHERi PTHR10119. PTHR10119. 1 hit.
Pfami PF00749. tRNA-synt_1c. 1 hit.
[Graphical view ]
PRINTSi PR00987. TRNASYNTHGLU.
SUPFAMi SSF48163. SSF48163. 1 hit.
TIGRFAMsi TIGR00464. gltX_bact. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: UWE25.

Entry informationi

Entry nameiSYE_PARUW
AccessioniPrimary (citable) accession number: Q6MEN1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 7, 2005
Last sequence update: July 5, 2004
Last modified: May 14, 2014
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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