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Q6MEJ2

- GCSPA_PARUW

UniProt

Q6MEJ2 - GCSPA_PARUW

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Protein
Probable glycine dehydrogenase (decarboxylating) subunit 1
Gene
gcvPA, pc0283
Organism
Protochlamydia amoebophila (strain UWE25)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein By similarity.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

GO - Molecular functioni

  1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. glycine catabolic process Source: InterPro
  2. nucleoside metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Enzyme and pathway databases

BioCyciPAMO264201:GH0M-287-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable glycine dehydrogenase (decarboxylating) subunit 1 (EC:1.4.4.2)
Alternative name(s):
Glycine cleavage system P-protein subunit 1
Glycine decarboxylase subunit 1
Glycine dehydrogenase (aminomethyl-transferring) subunit 1
Gene namesi
Name:gcvPA
Ordered Locus Names:pc0283
OrganismiProtochlamydia amoebophila (strain UWE25)
Taxonomic identifieri264201 [NCBI]
Taxonomic lineageiBacteriaChlamydiaeChlamydialesParachlamydiaceaeCandidatus Protochlamydia
ProteomesiUP000000529: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 446446Probable glycine dehydrogenase (decarboxylating) subunit 1UniRule annotation
PRO_1000045673Add
BLAST

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits By similarity.

Protein-protein interaction databases

STRINGi264201.pc0283.

Structurei

3D structure databases

ProteinModelPortaliQ6MEJ2.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0403.
HOGENOMiHOG000132025.
KOiK00282.
OMAiRLVGQTE.
OrthoDBiEOG6XWV3B.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
HAMAPiMF_00712. GcvPA.
InterProiIPR023010. GcvPA.
IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF02347. GDC-P. 1 hit.
[Graphical view]
PIRSFiPIRSF006815. GcvPA. 1 hit.
SUPFAMiSSF53383. SSF53383. 1 hit.

Sequencei

Sequence statusi: Complete.

Q6MEJ2-1 [UniParc]FASTAAdd to Basket

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MDFISNKTPQ IEAMLTEIGI QNVEELFKSI PSSLILQAPS VDDGLSEYEG    50
IQLIESLAVR NTFPNLVSYL GAGAYEHHIP ALVGAVCSKS EFLTAYTPYQ 100
AEASQGMLQI IFEFQSAICA LTGMDVANAS VYDGASACAE AILMSLRHHK 150
TRRQILLSDS LHPHYKKVIE QYLKSQDCEL ITVPFLQEGT LDASFLKMYL 200
NDQTAAILLQ SPNFFGCIED VQPITEMAKS QGALTILCAN PISYGLLSSA 250
KELGVDIAVG DCQPFGLSLS FGGPYAGYMA CKQELMRQLP GRIVGETLDV 300
QGSRGFVLTL QAREQHIRRE KATSNICTNQ ALAALASLVA MLWYGKEGVK 350
ELALTNYQRA NYLKFHLGKI STINVWNQGA SFNEFVVDFK QDSNQVLEFF 400
RLNGIEPGIE LKRYYPSLKT CLLIAVTETK NQIQLDQFIK VCKELF 446
Length:446
Mass (Da):49,350
Last modified:July 5, 2004 - v1
Checksum:i2C14E46369B97FDD
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BX908798 Genomic DNA. Translation: CAF23007.1.
RefSeqiYP_007282.1. NC_005861.1.

Genome annotation databases

EnsemblBacteriaiCAF23007; CAF23007; pc0283.
GeneIDi2780941.
KEGGipcu:pc0283.
PATRICi31995860. VBICanPro72727_0290.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BX908798 Genomic DNA. Translation: CAF23007.1 .
RefSeqi YP_007282.1. NC_005861.1.

3D structure databases

ProteinModelPortali Q6MEJ2.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 264201.pc0283.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAF23007 ; CAF23007 ; pc0283 .
GeneIDi 2780941.
KEGGi pcu:pc0283.
PATRICi 31995860. VBICanPro72727_0290.

Phylogenomic databases

eggNOGi COG0403.
HOGENOMi HOG000132025.
KOi K00282.
OMAi RLVGQTE.
OrthoDBi EOG6XWV3B.

Enzyme and pathway databases

BioCyci PAMO264201:GH0M-287-MONOMER.

Family and domain databases

Gene3Di 3.40.640.10. 1 hit.
HAMAPi MF_00712. GcvPA.
InterProi IPR023010. GcvPA.
IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view ]
PANTHERi PTHR11773. PTHR11773. 1 hit.
Pfami PF02347. GDC-P. 1 hit.
[Graphical view ]
PIRSFi PIRSF006815. GcvPA. 1 hit.
SUPFAMi SSF53383. SSF53383. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: UWE25.

Entry informationi

Entry nameiGCSPA_PARUW
AccessioniPrimary (citable) accession number: Q6MEJ2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: July 5, 2004
Last modified: September 3, 2014
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi