Reviewed, UniProtKB/Swiss-Prot Q6MEJ2 (GCSPA_PARUW)

Names and origin

Protein names

Recommended name:
    Probable glycine dehydrogenase [decarboxylating] subunit 1
    EC=1.4.4.2
Alternative name(s):
    Glycine decarboxylase subunit 1
    Glycine cleavage system P-protein subunit 1

Gene names

Name:	gcvPA
Ordered Locus Names:	pc0283

Organism

Protochlamydia amoebophila (strain UWE25) [Complete proteome] [HAMAP]

Taxonomic identifier

264201 [NCBI]

Taxonomic lineage

Bacteria › Chlamydiae › Chlamydiales › Parachlamydiaceae › Candidatus Protochlamydia

Protein attributes

Sequence length	446 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein By similarity.
Catalytic activity	Glycine + H-protein-lipoyllysine = H-protein-S-aminomethyldihydrolipoyllysine + CO2. HAMAP MF_00712
Subunit structure	The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is an heterodimer of two subunits By similarity.
Sequence similarities	Belongs to the gcvP family. N-terminal subunit subfamily.

Ontologies

Keywords
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	glycine decarboxylation via glycine cleavage system Inferred from electronic annotation. Source: HAMAP oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	glycine dehydrogenase (decarboxylating) activity Inferred from electronic annotation. Source: EC pyridoxal phosphate binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 446	446	Probable glycine dehydrogenase [decarboxylating] subunit 1 HAMAP MF_00712		PRO_1000045673

Sequences

	Sequence		Length	Mass (Da)
	Q6MEJ2-1 [UniParc]. Last modified July 5, 2004. Version 1. Checksum: 2C14E46369B97FDD	FASTA	446	49,350
	10 20 30 40 50 60 MDFISNKTPQ IEAMLTEIGI QNVEELFKSI PSSLILQAPS VDDGLSEYEG IQLIESLAVR 70 80 90 100 110 120 NTFPNLVSYL GAGAYEHHIP ALVGAVCSKS EFLTAYTPYQ AEASQGMLQI IFEFQSAICA 130 140 150 160 170 180 LTGMDVANAS VYDGASACAE AILMSLRHHK TRRQILLSDS LHPHYKKVIE QYLKSQDCEL 190 200 210 220 230 240 ITVPFLQEGT LDASFLKMYL NDQTAAILLQ SPNFFGCIED VQPITEMAKS QGALTILCAN 250 260 270 280 290 300 PISYGLLSSA KELGVDIAVG DCQPFGLSLS FGGPYAGYMA CKQELMRQLP GRIVGETLDV 310 320 330 340 350 360 QGSRGFVLTL QAREQHIRRE KATSNICTNQ ALAALASLVA MLWYGKEGVK ELALTNYQRA 370 380 390 400 410 420 NYLKFHLGKI STINVWNQGA SFNEFVVDFK QDSNQVLEFF RLNGIEPGIE LKRYYPSLKT 430 440 CLLIAVTETK NQIQLDQFIK VCKELF

References

[1]

"Illuminating the evolutionary history of chlamydiae." Horn M., Collingro A., Schmitz-Esser S., Beier C.L., Purkhold U., Fartmann B., Brandt P., Nyakatura G.J., Droege M., Frishman D., Rattei T., Mewes H.-W., Wagner M. Science 304:728-730(2004) [PubMed: 15073324] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	BX908798 Genomic DNA. Translation: CAF23007.1.
RefSeq	YP_007282.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	2780941.
GenomeReviews	Gene locus pc0283 in contig BX908798_GR.
KEGG	pcu:pc0283.
NMPDR	fig|264201.1.peg.283.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q6MEJ2.
OMA	Q6MEJ2. VANASMY.
Enzyme and pathway databases
BioCyc	CPRO264201:PC0283-MON.
Family and domain databases
HAMAP	MF_00712. [Tree]
InterPro	IPR003437. GDC-P. IPR015421. PyrdxlP-dep_Trfase_major_sub1. [Graphical view]
Gene3D	G3DSA:3.40.640.10. PyrdxlP-dep_Trfase_major_sub1. 1 hit.
PANTHER	PTHR11773. GDC-P. 1 hit.
Pfam	PF02347. GDC-P. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

GCSPA_PARUW

Accession

Primary (citable) accession number: Q6MEJ2

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	July 5, 2004
Last modified:	June 16, 2009
This is version 32 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)