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Q6MEJ2

- GCSPA_PARUW

UniProt

Q6MEJ2 - GCSPA_PARUW

Protein

Probable glycine dehydrogenase (decarboxylating) subunit 1

Gene

gcvPA

Organism
Protochlamydia amoebophila (strain UWE25)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 69 (01 Oct 2014)
      Sequence version 1 (05 Jul 2004)
      Previous versions | rss
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    Functioni

    The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

    Catalytic activityi

    Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

    GO - Molecular functioni

    1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
    2. pyridoxal phosphate binding Source: InterPro

    GO - Biological processi

    1. glycine catabolic process Source: InterPro
    2. nucleoside metabolic process Source: InterPro

    Keywords - Molecular functioni

    Oxidoreductase

    Enzyme and pathway databases

    BioCyciPAMO264201:GH0M-287-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable glycine dehydrogenase (decarboxylating) subunit 1UniRule annotation (EC:1.4.4.2UniRule annotation)
    Alternative name(s):
    Glycine cleavage system P-protein subunit 1UniRule annotation
    Glycine decarboxylase subunit 1UniRule annotation
    Glycine dehydrogenase (aminomethyl-transferring) subunit 1UniRule annotation
    Gene namesi
    Name:gcvPAUniRule annotation
    Ordered Locus Names:pc0283
    OrganismiProtochlamydia amoebophila (strain UWE25)
    Taxonomic identifieri264201 [NCBI]
    Taxonomic lineageiBacteriaChlamydiaeChlamydialesParachlamydiaceaeCandidatus Protochlamydia
    ProteomesiUP000000529: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 446446Probable glycine dehydrogenase (decarboxylating) subunit 1PRO_1000045673Add
    BLAST

    Interactioni

    Subunit structurei

    The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits.UniRule annotation

    Protein-protein interaction databases

    STRINGi264201.pc0283.

    Structurei

    3D structure databases

    ProteinModelPortaliQ6MEJ2.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the GcvP family. N-terminal subunit subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0403.
    HOGENOMiHOG000132025.
    KOiK00282.
    OMAiRLVGQTE.
    OrthoDBiEOG6XWV3B.

    Family and domain databases

    Gene3Di3.40.640.10. 1 hit.
    HAMAPiMF_00712. GcvPA.
    InterProiIPR023010. GcvPA.
    IPR020580. GDC-P_N.
    IPR020581. GDC_P.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    [Graphical view]
    PANTHERiPTHR11773. PTHR11773. 1 hit.
    PfamiPF02347. GDC-P. 1 hit.
    [Graphical view]
    PIRSFiPIRSF006815. GcvPA. 1 hit.
    SUPFAMiSSF53383. SSF53383. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q6MEJ2-1 [UniParc]FASTAAdd to Basket

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    MDFISNKTPQ IEAMLTEIGI QNVEELFKSI PSSLILQAPS VDDGLSEYEG    50
    IQLIESLAVR NTFPNLVSYL GAGAYEHHIP ALVGAVCSKS EFLTAYTPYQ 100
    AEASQGMLQI IFEFQSAICA LTGMDVANAS VYDGASACAE AILMSLRHHK 150
    TRRQILLSDS LHPHYKKVIE QYLKSQDCEL ITVPFLQEGT LDASFLKMYL 200
    NDQTAAILLQ SPNFFGCIED VQPITEMAKS QGALTILCAN PISYGLLSSA 250
    KELGVDIAVG DCQPFGLSLS FGGPYAGYMA CKQELMRQLP GRIVGETLDV 300
    QGSRGFVLTL QAREQHIRRE KATSNICTNQ ALAALASLVA MLWYGKEGVK 350
    ELALTNYQRA NYLKFHLGKI STINVWNQGA SFNEFVVDFK QDSNQVLEFF 400
    RLNGIEPGIE LKRYYPSLKT CLLIAVTETK NQIQLDQFIK VCKELF 446
    Length:446
    Mass (Da):49,350
    Last modified:July 5, 2004 - v1
    Checksum:i2C14E46369B97FDD
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BX908798 Genomic DNA. Translation: CAF23007.1.
    RefSeqiYP_007282.1. NC_005861.1.

    Genome annotation databases

    EnsemblBacteriaiCAF23007; CAF23007; pc0283.
    GeneIDi2780941.
    KEGGipcu:pc0283.
    PATRICi31995860. VBICanPro72727_0290.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BX908798 Genomic DNA. Translation: CAF23007.1 .
    RefSeqi YP_007282.1. NC_005861.1.

    3D structure databases

    ProteinModelPortali Q6MEJ2.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 264201.pc0283.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAF23007 ; CAF23007 ; pc0283 .
    GeneIDi 2780941.
    KEGGi pcu:pc0283.
    PATRICi 31995860. VBICanPro72727_0290.

    Phylogenomic databases

    eggNOGi COG0403.
    HOGENOMi HOG000132025.
    KOi K00282.
    OMAi RLVGQTE.
    OrthoDBi EOG6XWV3B.

    Enzyme and pathway databases

    BioCyci PAMO264201:GH0M-287-MONOMER.

    Family and domain databases

    Gene3Di 3.40.640.10. 1 hit.
    HAMAPi MF_00712. GcvPA.
    InterProi IPR023010. GcvPA.
    IPR020580. GDC-P_N.
    IPR020581. GDC_P.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    [Graphical view ]
    PANTHERi PTHR11773. PTHR11773. 1 hit.
    Pfami PF02347. GDC-P. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF006815. GcvPA. 1 hit.
    SUPFAMi SSF53383. SSF53383. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: UWE25.

    Entry informationi

    Entry nameiGCSPA_PARUW
    AccessioniPrimary (citable) accession number: Q6MEJ2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: July 5, 2004
    Last modified: October 1, 2014
    This is version 69 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3