Reviewed, UniProtKB/Swiss-Prot Q6MEA7 (NDK2_PARUW)

Names and origin

Protein names

Recommended name:
    Nucleoside diphosphate kinase 2
      Short name=NDK 2
      Short name=NDP kinase 2
    EC=2.7.4.6
Alternative name(s):
    Nucleoside-2-P kinase 2

Gene names

Name:	ndk2
Ordered Locus Names:	pc0368

Organism

Protochlamydia amoebophila (strain UWE25) [Complete proteome] [HAMAP]

Taxonomic identifier

264201 [NCBI]

Taxonomic lineage

Bacteria › Chlamydiae › Chlamydiales › Parachlamydiaceae › Candidatus Protochlamydia

Protein attributes

Sequence length	143 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. HAMAP MF_00451
Catalytic activity	ATP + nucleoside diphosphate = ADP + nucleoside triphosphate. HAMAP MF_00451
Cofactor	Magnesium By similarity.
Subunit structure	Homotetramer By similarity.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the NDK family.

Ontologies

Keywords
Biological process	Nucleotide metabolism
Cellular component	Cytoplasm
Ligand	ATP-binding Magnesium Metal-binding Nucleotide-binding
Molecular function	Kinase Transferase
PTM	Phosphoprotein
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	CTP biosynthetic process Inferred from electronic annotation. Source: HAMAP GTP biosynthetic process Inferred from electronic annotation. Source: HAMAP UTP biosynthetic process Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: HAMAP magnesium ion binding Inferred from electronic annotation. Source: UniProtKB-KW nucleoside diphosphate kinase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 143	143	Nucleoside diphosphate kinase 2 HAMAP MF_00451		PRO_0000226567
Sites
	Active site	117	1	Pros-phosphohistidine intermediate By similarity
	Binding site	11	1	ATP By similarity
	Binding site	59	1	ATP By similarity
	Binding site	87	1	ATP By similarity
	Binding site	93	1	ATP By similarity
	Binding site	104	1	ATP By similarity
	Binding site	114	1	ATP By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q6MEA7-1 [UniParc]. Last modified July 5, 2004. Version 1. Checksum: EC4E76DDBF032ECA	FASTA	143	15,815
	10 20 30 40 50 60 MTLERTLSII KPDAVGNNHI GEIIARFEKA GLRIVAAKMK QLDRKDAEGF YAVHKGRPFF 70 80 90 100 110 120 EDLVGFMTTG PVMIMVLEGE NAINKNREIM GATDPKKAAP GTIRADFAQT IDENAVHGSD 130 140 AAETAKTEIE YFFKSQDVCA RKR

References

[1]

"Illuminating the evolutionary history of chlamydiae." Horn M., Collingro A., Schmitz-Esser S., Beier C.L., Purkhold U., Fartmann B., Brandt P., Nyakatura G.J., Droege M., Frishman D., Rattei T., Mewes H.-W., Wagner M. Science 304:728-730(2004) [PubMed: 15073324] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	BX908798 Genomic DNA. Translation: CAF23092.1.
RefSeq	YP_007367.1.
3D structure databases
HSSP	HSSP built from PDB template 1K44 based on UniProtKB P71904.
ModBase	Search...
Protein-protein interaction databases
STRING	Q6MEA7.
Genome annotation databases
GeneID	2780636.
GenomeReviews	Gene locus pc0368 in contig BX908798_GR.
KEGG	pcu:pc0368.
NMPDR	fig|264201.1.peg.368.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q6MEA7.
OMA	GKEFYER.
Enzyme and pathway databases
BioCyc	CPRO264201:PC0368-MON.
Family and domain databases
HAMAP	MF_00451. [Tree]
InterPro	IPR001564. Nuc_diP_kinase_core. [Graphical view]
Gene3D	G3DSA:3.30.70.141. NDK. 1 hit.
PANTHER	PTHR11349. Nuc_diP_kinase_core. 1 hit.
Pfam	PF00334. NDK. 1 hit. [Graphical view]
PRINTS	PR01243. NUCDPKINASE.
ProDom	PD001018. NDK. 1 hit. [Graphical view] [Entries sharing at least one domain]
SMART	SM00562. NDK. 1 hit. [Graphical view]
PROSITE	PS00469. NDP_KINASES. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

NDK2_PARUW

Accession

Primary (citable) accession number: Q6MEA7

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 7, 2006
Last sequence update:	July 5, 2004
Last modified:	November 3, 2009
This is version 40 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)