Q6ME04 (UPPP_PARUW) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Undecaprenyl-diphosphatase
EC=3.6.1.27

Alternative name(s):
Bacitracin resistance protein
Undecaprenyl pyrophosphate phosphatase

Gene names

Name:	uppP
Synonyms:	bacA, upk
Ordered Locus Names:	pc0471

Organism

Protochlamydia amoebophila (strain UWE25) [Complete proteome] [HAMAP]

Taxonomic identifier

264201 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Chlamydiae/Verrucomicrobia group › Chlamydiae › Chlamydiia › Chlamydiales › Parachlamydiaceae › Candidatus Protochlamydia › Candidatus Protochlamydia amoebophila

Protein attributes

Sequence length	257 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin By similarity. HAMAP-Rule MF_01006
Catalytic activity	Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate. HAMAP-Rule MF_01006
Subcellular location	Cell inner membrane; Multi-pass membrane protein By similarity HAMAP-Rule MF_01006.
Miscellaneous	Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available. HAMAP-Rule MF_01006
Sequence similarities	Belongs to the UppP family.

Ontologies

Keywords
Biological process	Antibiotic resistance Cell shape Cell wall biogenesis/degradation Peptidoglycan synthesis
Cellular component	Cell inner membrane Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	dephosphorylation Inferred from electronic annotation. Source: InterPro peptidoglycan biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW regulation of cell shape Inferred from electronic annotation. Source: UniProtKB-KW response to antibiotic Inferred from electronic annotation. Source: HAMAP
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	undecaprenyl-diphosphatase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 257	257	Undecaprenyl-diphosphatase HAMAP-Rule MF_01006		PRO_0000151173
Regions
	Transmembrane	42 – 62	21	Helical; Potential
	Transmembrane	76 – 96	21	Helical; Potential
	Transmembrane	103 – 123	21	Helical; Potential
	Transmembrane	136 – 156	21	Helical; Potential
	Transmembrane	172 – 192	21	Helical; Potential
	Transmembrane	209 – 229	21	Helical; Potential
	Transmembrane	237 – 257	21	Helical; Potential

Sequences

	Sequence		Length	Mass (Da)
	Q6ME04 [UniParc]. Last modified July 5, 2004. Version 1. Checksum: 45E6EEE6374CDBC1	FASTA	257	29,031
	10 20 30 40 50 60 MTIWEAFFLG LIQGVTEFLP ISSSGHLELA QYFLGFEKLQ SYVLFNLICH LGTLGSILYM 70 80 90 100 110 120 FLPQIKQSLI TERNHIFHII LGTLPLFPLV LILKPIKATF DQPQYLGLCF LFSAALLFSG 130 140 150 160 170 180 VYFRLQMQKK HSLRDCLTIG LFQAVAVLPG ISRSGATISA ARLLGWDKQD AIQFSFLLAI 190 200 210 220 230 240 PAILGGTFLE IWQFLKLPAS EIPPIEIGQF LTGFITSFMI GCASLWAVIQ MMTQDKWVYF 250 AWYCLFIGIA TTLYFQM

References

[1]

"Illuminating the evolutionary history of chlamydiae." Horn M., Collingro A., Schmitz-Esser S., Beier C.L., Purkhold U., Fartmann B., Brandt P., Nyakatura G.J., Droege M., Frishman D., Rattei T., Mewes H.-W., Wagner M. Science 304:728-730(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: UWE25.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BX908798 Genomic DNA. Translation: CAF23195.1.
RefSeq	YP_007470.1. NC_005861.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	264201.pc0471.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	CAF23195; CAF23195; pc0471.
GeneID	2780731.
KEGG	pcu:pc0471.
PATRIC	31996240. VBICanPro72727_0473.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG1968.
HOGENOM	HOG000218357.
KO	K06153.
OMA	ITERNHI.
ProtClustDB	CLSK2762180.
Enzyme and pathway databases
BioCyc	PAMO264201:GH0M-482-MONOMER.
Family and domain databases
HAMAP	MF_01006. Undec_diphosphatase.
InterPro	IPR003824. Bacitracin-R_BacA. [Graphical view]
Pfam	PF02673. BacA. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

UPPP_PARUW

Accession

Primary (citable) accession number: Q6ME04

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 19, 2004
Last sequence update:	July 5, 2004
Last modified:	May 29, 2013
This is version 59 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program