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Q6MDK7

- NADK_PARUW

UniProt

Q6MDK7 - NADK_PARUW

Protein

NAD kinase

Gene

nadK

Organism
Protochlamydia amoebophila (strain UWE25)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 61 (01 Oct 2014)
      Sequence version 1 (05 Jul 2004)
      Previous versions | rss
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    Functioni

    Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.UniRule annotation

    Catalytic activityi

    ATP + NAD+ = ADP + NADP+.UniRule annotation

    Cofactori

    Divalent metal ions.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei63 – 631Proton acceptorUniRule annotation
    Binding sitei68 – 681NADUniRule annotation
    Binding sitei163 – 1631NADUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi63 – 642NADUniRule annotation
    Nucleotide bindingi133 – 1342NADUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. metal ion binding Source: UniProtKB-HAMAP
    3. NAD+ kinase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. NAD metabolic process Source: InterPro
    2. NADP biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Ligandi

    ATP-binding, NAD, NADP, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciPAMO264201:GH0M-633-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    NAD kinaseUniRule annotation (EC:2.7.1.23UniRule annotation)
    Alternative name(s):
    ATP-dependent NAD kinaseUniRule annotation
    Gene namesi
    Name:nadKUniRule annotation
    Ordered Locus Names:pc0618
    OrganismiProtochlamydia amoebophila (strain UWE25)
    Taxonomic identifieri264201 [NCBI]
    Taxonomic lineageiBacteriaChlamydiaeChlamydialesParachlamydiaceaeCandidatus Protochlamydia
    ProteomesiUP000000529: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 279279NAD kinasePRO_0000229661Add
    BLAST

    Proteomic databases

    PRIDEiQ6MDK7.

    Interactioni

    Protein-protein interaction databases

    STRINGi264201.pc0618.

    Structurei

    3D structure databases

    ProteinModelPortaliQ6MDK7.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the NAD kinase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0061.
    HOGENOMiHOG000227222.
    KOiK00858.
    OMAiKLHWAGS.
    OrthoDBiEOG6PZXDR.

    Family and domain databases

    Gene3Di2.60.200.30. 1 hit.
    3.40.50.10330. 1 hit.
    HAMAPiMF_00361. NAD_kinase.
    InterProiIPR017438. ATP-NAD_kinase_dom_1.
    IPR016064. ATP-NAD_kinase_PpnK-typ.
    IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
    IPR002504. PolyP/ATP_NADK.
    [Graphical view]
    PANTHERiPTHR20275. PTHR20275. 1 hit.
    PfamiPF01513. NAD_kinase. 1 hit.
    [Graphical view]
    SUPFAMiSSF111331. SSF111331. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q6MDK7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MIALFPNESK DPSLKIAAEI CQFLISRNIE ITAEDKHAKQ LNVFPLSQVN    50
    VQHINFRISL GGDGTILRLI HKHPTIHAPL LGINLGSLGF LADIPLDGIF 100
    PSLEDLIKGR YRVQKRMMVE GSVLCKPSCF AVNEVVIHRA QNPCLIDLAI 150
    YVDGNYLNTF SADGMIISTP SGSTAYSLAA GGPILTPELK AFVLTPICPH 200
    TISNRPIVLM PEISIQVKYL SSYAPVEVSS DGISSFSLST NEIFHASISS 250
    QTFDLVCLER HDYFATLREK LGWQGKLKI 279
    Length:279
    Mass (Da):30,646
    Last modified:July 5, 2004 - v1
    Checksum:iF95C43591363B812
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BX908798 Genomic DNA. Translation: CAF23342.1.
    RefSeqiYP_007617.1. NC_005861.1.

    Genome annotation databases

    EnsemblBacteriaiCAF23342; CAF23342; pc0618.
    GeneIDi2780280.
    KEGGipcu:pc0618.
    PATRICi31996544. VBICanPro72727_0621.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BX908798 Genomic DNA. Translation: CAF23342.1 .
    RefSeqi YP_007617.1. NC_005861.1.

    3D structure databases

    ProteinModelPortali Q6MDK7.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 264201.pc0618.

    Proteomic databases

    PRIDEi Q6MDK7.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAF23342 ; CAF23342 ; pc0618 .
    GeneIDi 2780280.
    KEGGi pcu:pc0618.
    PATRICi 31996544. VBICanPro72727_0621.

    Phylogenomic databases

    eggNOGi COG0061.
    HOGENOMi HOG000227222.
    KOi K00858.
    OMAi KLHWAGS.
    OrthoDBi EOG6PZXDR.

    Enzyme and pathway databases

    BioCyci PAMO264201:GH0M-633-MONOMER.

    Family and domain databases

    Gene3Di 2.60.200.30. 1 hit.
    3.40.50.10330. 1 hit.
    HAMAPi MF_00361. NAD_kinase.
    InterProi IPR017438. ATP-NAD_kinase_dom_1.
    IPR016064. ATP-NAD_kinase_PpnK-typ.
    IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
    IPR002504. PolyP/ATP_NADK.
    [Graphical view ]
    PANTHERi PTHR20275. PTHR20275. 1 hit.
    Pfami PF01513. NAD_kinase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF111331. SSF111331. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: UWE25.

    Entry informationi

    Entry nameiNADK_PARUW
    AccessioniPrimary (citable) accession number: Q6MDK7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 4, 2006
    Last sequence update: July 5, 2004
    Last modified: October 1, 2014
    This is version 61 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3