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Q6MD64 (IF2_PARUW) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 72. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Translation initiation factor IF-2
Gene names
Name:infB
Ordered Locus Names:pc0761
OrganismProtochlamydia amoebophila (strain UWE25) [Complete proteome] [HAMAP]
Taxonomic identifier264201 [NCBI]
Taxonomic lineageBacteriaChlamydiaeChlamydialesParachlamydiaceaeCandidatus Protochlamydia

Protein attributes

Sequence length920 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex By similarity. HAMAP-Rule MF_00100

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00100.

Sequence similarities

Belongs to the IF-2 family.

Ontologies

Keywords
   Biological processProtein biosynthesis
   Cellular componentCytoplasm
   LigandGTP-binding
Nucleotide-binding
   Molecular functionInitiation factor
   Technical termComplete proteome
Gene Ontology (GO)
   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionGTP binding

Inferred from electronic annotation. Source: UniProtKB-KW

GTPase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

translation initiation factor activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 920920Translation initiation factor IF-2 HAMAP-Rule MF_00100
PRO_0000228221

Regions

Nucleotide binding427 – 4348GTP By similarity
Nucleotide binding473 – 4775GTP By similarity
Nucleotide binding527 – 5304GTP By similarity
Region421 – 569149G-domain HAMAP-Rule MF_00100

Sequences

Sequence LengthMass (Da)Tools
Q6MD64 [UniParc].

Last modified July 5, 2004. Version 1.
Checksum: 67B581DDB0A94631

FASTA920101,783
        10         20         30         40         50         60 
MAKNLKLNIK NAQIAEAINL SGLKSKLAKK KEEESTQKSS AAKSTSKTTK TEVEELPKEE 

        70         80         90        100        110        120 
APRIRARSKS AFAEAPADQS SKEITEEIKT SQDEESISRE AAKVIEEKSR MKTSAEIRQE 

       130        140        150        160        170        180 
IFGEELSQAP SKDSSQELEF AEKIKTNETK PTTFIEPTIA SPAPAEPKSL VEDKTSITHV 

       190        200        210        220        230        240 
YQNQKRDIPI RESLPPQEKL GPTGKHMRDF IKPKPQPERV SRPLEANNSN QKEVSEANKE 

       250        260        270        280        290        300 
KLDKNKIKPK SKGFEEPKVL TADDDARKGL KSPKFKEFKD IKPARKPETR QFDARDRQGL 

       310        320        330        340        350        360 
RTSDEDQHWR KKKNKQRQNI QEDTTIRPTS LKVRLPISIK DLASEMKLKA SQLVGKLFLQ 

       370        380        390        400        410        420 
GIVVTLNDLL EDETTAQLLG QEFGCEITID TAEEKRIQIT DKSIREELQQ SPTDQLQLRP 

       430        440        450        460        470        480 
PVVAFMGHVD HGKTSLIDAI RKSNRAAGEA GAITQHIGAF RCHTTVGDIA ILDTPGHEAF 

       490        500        510        520        530        540 
SAMRARGADV TDIVVLVVAG DEGLRQQSIE AIQHARAANV IIVVAINKCD KPNFNPDNVY 

       550        560        570        580        590        600 
RQLAEQNLLP EPWGGQTITV NCSAVTGEGI PELLEMLALQ AEVLELRANP SMRARGTVLE 

       610        620        630        640        650        660 
SEMHKGLGSV ATILVQNGTL KRGDALVFGL LWGRVKTMHD EYGKELQEAG PSTPVEITGL 

       670        680        690        700        710        720 
SGLPEAGQEF IVVKNEKEAR EIANVRSEGA RQNTFMLQQK KKVSMENMLQ QASATGKKML 

       730        740        750        760        770        780 
NIVLRADVQG SLEALKVALL KIESDKADLN IIFNGVGEVS ESDVQLAAAS KAIVLGFHTQ 

       790        800        810        820        830        840 
IESHAEALVK QLGVQVRLHN IIYHAIDDIK VLMAGLLEKI AQETEKGKAI VKATFKSSQA 

       850        860        870        880        890        900 
GIIAGCQVIE GSIHRNNYVR LKRGQEVIWK GTISSLKRVK EDVREVQKGI ECGILLNNFT 

       910        920 
DILEGDIIEA YDITYISQEL 

« Hide

References

[1]"Illuminating the evolutionary history of chlamydiae."
Horn M., Collingro A., Schmitz-Esser S., Beier C.L., Purkhold U., Fartmann B., Brandt P., Nyakatura G.J., Droege M., Frishman D., Rattei T., Mewes H.-W., Wagner M.
Science 304:728-730(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: UWE25.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BX908798 Genomic DNA. Translation: CAF23485.1.
RefSeqYP_007760.1. NC_005861.1.

3D structure databases

ProteinModelPortalQ6MD64.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING264201.pc0761.

Proteomic databases

PRIDEQ6MD64.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAF23485; CAF23485; pc0761.
GeneID2781082.
KEGGpcu:pc0761.
PATRIC31996846. VBICanPro72727_0769.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0532.
HOGENOMHOG000076906.
KOK02519.
OMARTGGYSQ.
OrthoDBEOG67HJSV.
ProtClustDBPRK05306.

Enzyme and pathway databases

BioCycPAMO264201:GH0M-779-MONOMER.

Family and domain databases

Gene3D3.40.50.10050. 1 hit.
3.40.50.300. 1 hit.
HAMAPMF_00100_B. IF_2_B.
InterProIPR000795. EF_GTP-bd_dom.
IPR006847. IF2_N.
IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR000178. TF_IF2_bacterial-like.
IPR015760. TIF_IF2.
IPR023115. TIF_IF2_dom3.
IPR009000. Transl_B-barrel.
IPR004161. Transl_elong_EFTu/EF1A_2.
[Graphical view]
PANTHERPTHR23115:SF41. PTHR23115:SF41. 1 hit.
PfamPF00009. GTP_EFTU. 1 hit.
PF03144. GTP_EFTU_D2. 2 hits.
PF11987. IF-2. 1 hit.
PF04760. IF2_N. 1 hit.
[Graphical view]
SUPFAMSSF50447. SSF50447. 2 hits.
SSF52156. SSF52156. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsTIGR00487. IF-2. 1 hit.
TIGR00231. small_GTP. 1 hit.
PROSITEPS01176. IF2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameIF2_PARUW
AccessionPrimary (citable) accession number: Q6MD64
Entry history
Integrated into UniProtKB/Swiss-Prot: March 21, 2006
Last sequence update: July 5, 2004
Last modified: April 16, 2014
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Translation initiation factors

List of translation initiation factor entries