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Protein

Translation initiation factor IF-2

Gene

infB

Organism
Protochlamydia amoebophila (strain UWE25)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.UniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi427 – 4348GTPUniRule annotation
Nucleotide bindingi473 – 4775GTPUniRule annotation
Nucleotide bindingi527 – 5304GTPUniRule annotation

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Initiation factor

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciPAMO264201:GH0M-779-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Translation initiation factor IF-2UniRule annotation
Gene namesi
Name:infBUniRule annotation
Ordered Locus Names:pc0761
OrganismiProtochlamydia amoebophila (strain UWE25)
Taxonomic identifieri264201 [NCBI]
Taxonomic lineageiBacteriaChlamydiaeChlamydialesParachlamydiaceaeCandidatus Protochlamydia
ProteomesiUP000000529 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 920920Translation initiation factor IF-2PRO_0000228221Add
BLAST

Proteomic databases

PRIDEiQ6MD64.

Interactioni

Protein-protein interaction databases

STRINGi264201.pc0761.

Structurei

3D structure databases

ProteinModelPortaliQ6MD64.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini418 – 585168tr-type GAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni427 – 4348G1By similarity
Regioni452 – 4565G2By similarity
Regioni473 – 4764G3By similarity
Regioni527 – 5304G4By similarity
Regioni563 – 5653G5By similarity

Sequence similaritiesi

Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG0532.
HOGENOMiHOG000076906.
KOiK02519.
OMAiDNRTGGY.
OrthoDBiEOG67HJSV.

Family and domain databases

Gene3Di3.40.50.10050. 1 hit.
3.40.50.300. 1 hit.
HAMAPiMF_00100_B. IF_2_B.
InterProiIPR006847. IF2_N.
IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR000795. TF_GTP-bd_dom.
IPR000178. TF_IF2_bacterial-like.
IPR015760. TIF_IF2.
IPR023115. TIF_IF2_dom3.
IPR009000. Transl_B-barrel.
IPR004161. Transl_elong_EFTu/EF1A_2.
[Graphical view]
PANTHERiPTHR23115:SF41. PTHR23115:SF41. 1 hit.
PfamiPF03144. GTP_EFTU_D2. 2 hits.
PF11987. IF-2. 1 hit.
PF04760. IF2_N. 1 hit.
[Graphical view]
SUPFAMiSSF50447. SSF50447. 2 hits.
SSF52156. SSF52156. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00487. IF-2. 1 hit.
TIGR00231. small_GTP. 1 hit.
PROSITEiPS51722. G_TR_2. 1 hit.
PS01176. IF2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6MD64-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAKNLKLNIK NAQIAEAINL SGLKSKLAKK KEEESTQKSS AAKSTSKTTK
60 70 80 90 100
TEVEELPKEE APRIRARSKS AFAEAPADQS SKEITEEIKT SQDEESISRE
110 120 130 140 150
AAKVIEEKSR MKTSAEIRQE IFGEELSQAP SKDSSQELEF AEKIKTNETK
160 170 180 190 200
PTTFIEPTIA SPAPAEPKSL VEDKTSITHV YQNQKRDIPI RESLPPQEKL
210 220 230 240 250
GPTGKHMRDF IKPKPQPERV SRPLEANNSN QKEVSEANKE KLDKNKIKPK
260 270 280 290 300
SKGFEEPKVL TADDDARKGL KSPKFKEFKD IKPARKPETR QFDARDRQGL
310 320 330 340 350
RTSDEDQHWR KKKNKQRQNI QEDTTIRPTS LKVRLPISIK DLASEMKLKA
360 370 380 390 400
SQLVGKLFLQ GIVVTLNDLL EDETTAQLLG QEFGCEITID TAEEKRIQIT
410 420 430 440 450
DKSIREELQQ SPTDQLQLRP PVVAFMGHVD HGKTSLIDAI RKSNRAAGEA
460 470 480 490 500
GAITQHIGAF RCHTTVGDIA ILDTPGHEAF SAMRARGADV TDIVVLVVAG
510 520 530 540 550
DEGLRQQSIE AIQHARAANV IIVVAINKCD KPNFNPDNVY RQLAEQNLLP
560 570 580 590 600
EPWGGQTITV NCSAVTGEGI PELLEMLALQ AEVLELRANP SMRARGTVLE
610 620 630 640 650
SEMHKGLGSV ATILVQNGTL KRGDALVFGL LWGRVKTMHD EYGKELQEAG
660 670 680 690 700
PSTPVEITGL SGLPEAGQEF IVVKNEKEAR EIANVRSEGA RQNTFMLQQK
710 720 730 740 750
KKVSMENMLQ QASATGKKML NIVLRADVQG SLEALKVALL KIESDKADLN
760 770 780 790 800
IIFNGVGEVS ESDVQLAAAS KAIVLGFHTQ IESHAEALVK QLGVQVRLHN
810 820 830 840 850
IIYHAIDDIK VLMAGLLEKI AQETEKGKAI VKATFKSSQA GIIAGCQVIE
860 870 880 890 900
GSIHRNNYVR LKRGQEVIWK GTISSLKRVK EDVREVQKGI ECGILLNNFT
910 920
DILEGDIIEA YDITYISQEL
Length:920
Mass (Da):101,783
Last modified:July 5, 2004 - v1
Checksum:i67B581DDB0A94631
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX908798 Genomic DNA. Translation: CAF23485.1.
RefSeqiWP_011175311.1. NC_005861.1.

Genome annotation databases

EnsemblBacteriaiCAF23485; CAF23485; pc0761.
KEGGipcu:pc0761.
PATRICi31996846. VBICanPro72727_0769.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX908798 Genomic DNA. Translation: CAF23485.1.
RefSeqiWP_011175311.1. NC_005861.1.

3D structure databases

ProteinModelPortaliQ6MD64.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi264201.pc0761.

Proteomic databases

PRIDEiQ6MD64.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAF23485; CAF23485; pc0761.
KEGGipcu:pc0761.
PATRICi31996846. VBICanPro72727_0769.

Phylogenomic databases

eggNOGiCOG0532.
HOGENOMiHOG000076906.
KOiK02519.
OMAiDNRTGGY.
OrthoDBiEOG67HJSV.

Enzyme and pathway databases

BioCyciPAMO264201:GH0M-779-MONOMER.

Family and domain databases

Gene3Di3.40.50.10050. 1 hit.
3.40.50.300. 1 hit.
HAMAPiMF_00100_B. IF_2_B.
InterProiIPR006847. IF2_N.
IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR000795. TF_GTP-bd_dom.
IPR000178. TF_IF2_bacterial-like.
IPR015760. TIF_IF2.
IPR023115. TIF_IF2_dom3.
IPR009000. Transl_B-barrel.
IPR004161. Transl_elong_EFTu/EF1A_2.
[Graphical view]
PANTHERiPTHR23115:SF41. PTHR23115:SF41. 1 hit.
PfamiPF03144. GTP_EFTU_D2. 2 hits.
PF11987. IF-2. 1 hit.
PF04760. IF2_N. 1 hit.
[Graphical view]
SUPFAMiSSF50447. SSF50447. 2 hits.
SSF52156. SSF52156. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00487. IF-2. 1 hit.
TIGR00231. small_GTP. 1 hit.
PROSITEiPS51722. G_TR_2. 1 hit.
PS01176. IF2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: UWE25.

Entry informationi

Entry nameiIF2_PARUW
AccessioniPrimary (citable) accession number: Q6MD64
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 21, 2006
Last sequence update: July 5, 2004
Last modified: July 22, 2015
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.