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Q6MD64

- IF2_PARUW

UniProt

Q6MD64 - IF2_PARUW

Protein

Translation initiation factor IF-2

Gene

infB

Organism
Protochlamydia amoebophila (strain UWE25)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 75 (01 Oct 2014)
      Sequence version 1 (05 Jul 2004)
      Previous versions | rss
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    Functioni

    One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.UniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi427 – 4348GTPUniRule annotation
    Nucleotide bindingi473 – 4775GTPUniRule annotation
    Nucleotide bindingi527 – 5304GTPUniRule annotation

    GO - Molecular functioni

    1. GTPase activity Source: UniProtKB-HAMAP
    2. GTP binding Source: UniProtKB-KW
    3. translation initiation factor activity Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Initiation factor

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    GTP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciPAMO264201:GH0M-779-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Translation initiation factor IF-2UniRule annotation
    Gene namesi
    Name:infBUniRule annotation
    Ordered Locus Names:pc0761
    OrganismiProtochlamydia amoebophila (strain UWE25)
    Taxonomic identifieri264201 [NCBI]
    Taxonomic lineageiBacteriaChlamydiaeChlamydialesParachlamydiaceaeCandidatus Protochlamydia
    ProteomesiUP000000529: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 920920Translation initiation factor IF-2PRO_0000228221Add
    BLAST

    Proteomic databases

    PRIDEiQ6MD64.

    Interactioni

    Protein-protein interaction databases

    STRINGi264201.pc0761.

    Structurei

    3D structure databases

    ProteinModelPortaliQ6MD64.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini418 – 585168tr-type GAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni427 – 4348G1By similarity
    Regioni452 – 4565G2By similarity
    Regioni473 – 4764G3By similarity
    Regioni527 – 5304G4By similarity
    Regioni563 – 5653G5By similarity

    Sequence similaritiesi

    Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0532.
    HOGENOMiHOG000076906.
    KOiK02519.
    OMAiDNRTGGY.
    OrthoDBiEOG67HJSV.

    Family and domain databases

    Gene3Di3.40.50.10050. 1 hit.
    3.40.50.300. 1 hit.
    HAMAPiMF_00100_B. IF_2_B.
    InterProiIPR000795. EF_GTP-bd_dom.
    IPR006847. IF2_N.
    IPR027417. P-loop_NTPase.
    IPR005225. Small_GTP-bd_dom.
    IPR000178. TF_IF2_bacterial-like.
    IPR015760. TIF_IF2.
    IPR023115. TIF_IF2_dom3.
    IPR009000. Transl_B-barrel.
    IPR004161. Transl_elong_EFTu/EF1A_2.
    [Graphical view]
    PANTHERiPTHR23115:SF41. PTHR23115:SF41. 1 hit.
    PfamiPF00009. GTP_EFTU. 1 hit.
    PF03144. GTP_EFTU_D2. 2 hits.
    PF11987. IF-2. 1 hit.
    PF04760. IF2_N. 1 hit.
    [Graphical view]
    SUPFAMiSSF50447. SSF50447. 2 hits.
    SSF52156. SSF52156. 1 hit.
    SSF52540. SSF52540. 1 hit.
    TIGRFAMsiTIGR00487. IF-2. 1 hit.
    TIGR00231. small_GTP. 1 hit.
    PROSITEiPS51722. G_TR_2. 1 hit.
    PS01176. IF2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q6MD64-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAKNLKLNIK NAQIAEAINL SGLKSKLAKK KEEESTQKSS AAKSTSKTTK    50
    TEVEELPKEE APRIRARSKS AFAEAPADQS SKEITEEIKT SQDEESISRE 100
    AAKVIEEKSR MKTSAEIRQE IFGEELSQAP SKDSSQELEF AEKIKTNETK 150
    PTTFIEPTIA SPAPAEPKSL VEDKTSITHV YQNQKRDIPI RESLPPQEKL 200
    GPTGKHMRDF IKPKPQPERV SRPLEANNSN QKEVSEANKE KLDKNKIKPK 250
    SKGFEEPKVL TADDDARKGL KSPKFKEFKD IKPARKPETR QFDARDRQGL 300
    RTSDEDQHWR KKKNKQRQNI QEDTTIRPTS LKVRLPISIK DLASEMKLKA 350
    SQLVGKLFLQ GIVVTLNDLL EDETTAQLLG QEFGCEITID TAEEKRIQIT 400
    DKSIREELQQ SPTDQLQLRP PVVAFMGHVD HGKTSLIDAI RKSNRAAGEA 450
    GAITQHIGAF RCHTTVGDIA ILDTPGHEAF SAMRARGADV TDIVVLVVAG 500
    DEGLRQQSIE AIQHARAANV IIVVAINKCD KPNFNPDNVY RQLAEQNLLP 550
    EPWGGQTITV NCSAVTGEGI PELLEMLALQ AEVLELRANP SMRARGTVLE 600
    SEMHKGLGSV ATILVQNGTL KRGDALVFGL LWGRVKTMHD EYGKELQEAG 650
    PSTPVEITGL SGLPEAGQEF IVVKNEKEAR EIANVRSEGA RQNTFMLQQK 700
    KKVSMENMLQ QASATGKKML NIVLRADVQG SLEALKVALL KIESDKADLN 750
    IIFNGVGEVS ESDVQLAAAS KAIVLGFHTQ IESHAEALVK QLGVQVRLHN 800
    IIYHAIDDIK VLMAGLLEKI AQETEKGKAI VKATFKSSQA GIIAGCQVIE 850
    GSIHRNNYVR LKRGQEVIWK GTISSLKRVK EDVREVQKGI ECGILLNNFT 900
    DILEGDIIEA YDITYISQEL 920
    Length:920
    Mass (Da):101,783
    Last modified:July 5, 2004 - v1
    Checksum:i67B581DDB0A94631
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BX908798 Genomic DNA. Translation: CAF23485.1.
    RefSeqiYP_007760.1. NC_005861.1.

    Genome annotation databases

    EnsemblBacteriaiCAF23485; CAF23485; pc0761.
    GeneIDi2781082.
    KEGGipcu:pc0761.
    PATRICi31996846. VBICanPro72727_0769.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BX908798 Genomic DNA. Translation: CAF23485.1 .
    RefSeqi YP_007760.1. NC_005861.1.

    3D structure databases

    ProteinModelPortali Q6MD64.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 264201.pc0761.

    Proteomic databases

    PRIDEi Q6MD64.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAF23485 ; CAF23485 ; pc0761 .
    GeneIDi 2781082.
    KEGGi pcu:pc0761.
    PATRICi 31996846. VBICanPro72727_0769.

    Phylogenomic databases

    eggNOGi COG0532.
    HOGENOMi HOG000076906.
    KOi K02519.
    OMAi DNRTGGY.
    OrthoDBi EOG67HJSV.

    Enzyme and pathway databases

    BioCyci PAMO264201:GH0M-779-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.10050. 1 hit.
    3.40.50.300. 1 hit.
    HAMAPi MF_00100_B. IF_2_B.
    InterProi IPR000795. EF_GTP-bd_dom.
    IPR006847. IF2_N.
    IPR027417. P-loop_NTPase.
    IPR005225. Small_GTP-bd_dom.
    IPR000178. TF_IF2_bacterial-like.
    IPR015760. TIF_IF2.
    IPR023115. TIF_IF2_dom3.
    IPR009000. Transl_B-barrel.
    IPR004161. Transl_elong_EFTu/EF1A_2.
    [Graphical view ]
    PANTHERi PTHR23115:SF41. PTHR23115:SF41. 1 hit.
    Pfami PF00009. GTP_EFTU. 1 hit.
    PF03144. GTP_EFTU_D2. 2 hits.
    PF11987. IF-2. 1 hit.
    PF04760. IF2_N. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50447. SSF50447. 2 hits.
    SSF52156. SSF52156. 1 hit.
    SSF52540. SSF52540. 1 hit.
    TIGRFAMsi TIGR00487. IF-2. 1 hit.
    TIGR00231. small_GTP. 1 hit.
    PROSITEi PS51722. G_TR_2. 1 hit.
    PS01176. IF2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: UWE25.

    Entry informationi

    Entry nameiIF2_PARUW
    AccessioniPrimary (citable) accession number: Q6MD64
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 21, 2006
    Last sequence update: July 5, 2004
    Last modified: October 1, 2014
    This is version 75 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3