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Q6MD44 (G6PI_PARUW) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 63. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Glucose-6-phosphate isomerase

Short name=GPI
EC=5.3.1.9
Alternative name(s):
Phosphoglucose isomerase
Short name=PGI
Phosphohexose isomerase
Short name=PHI
Gene names
Name:pgi
Ordered Locus Names:pc0781
OrganismProtochlamydia amoebophila (strain UWE25) [Complete proteome] [HAMAP]
Taxonomic identifier264201 [NCBI]
Taxonomic lineageBacteriaChlamydiaeChlamydialesParachlamydiaceaeCandidatus Protochlamydia

Protein attributes

Sequence length537 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

D-glucose 6-phosphate = D-fructose 6-phosphate. HAMAP-Rule MF_00473

Pathway

Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 2/4. HAMAP-Rule MF_00473

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00473.

Sequence similarities

Belongs to the GPI family.

Ontologies

Keywords
   Biological processGluconeogenesis
Glycolysis
   Cellular componentCytoplasm
   Molecular functionIsomerase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processgluconeogenesis

Inferred from electronic annotation. Source: UniProtKB-HAMAP

glycolysis

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionglucose-6-phosphate isomerase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 537537Glucose-6-phosphate isomerase HAMAP-Rule MF_00473
PRO_0000180699

Sites

Active site3551Proton donor By similarity
Active site3861 By similarity
Active site5011 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q6MD44 [UniParc].

Last modified July 5, 2004. Version 1.
Checksum: 669C8A71457FFCA9

FASTA53760,649
        10         20         30         40         50         60 
MEFRMSKTSP SHFFNYSASK KLQELAKHPL DLTKELTPER VTQYVAEAGG FKLLYGTERV 

        70         80         90        100        110        120 
TNDVLAALKQ LSEESHALDK MNRMQDGEVM NFIERFPSEN RPALHTATRD LFDYPRTAKK 

       130        140        150        160        170        180 
AQEAAQLAKA ELEKLRQFLE KNDQNYHFTD LVTVAIGGSD LGPRAHYHAL EHLLKPGHHV 

       190        200        210        220        230        240 
HFISNVDPDD VAGVFRKIPD LKRTLVAVVS KSGTTLETAT NEELVREKFR QAGLDPKKHF 

       250        260        270        280        290        300 
VSITMPGTPM DNQEQYLKTF YMWDWIGGRY STTSMCGALM LSFAFGINTF WEFLKGAHEM 

       310        320        330        340        350        360 
DRIALETNLN KNLPLLAALL GIWNRNFLDY PTVALIPYSQ ALLRYTAHIQ QVDMESNGKH 

       370        380        390        400        410        420 
IDQQGIMTNF HTGPIIWGEP GTNSQHSFFQ LIHQGTATVP VSIIAFKENL YGEDLEFQGT 

       430        440        450        460        470        480 
TSQEKLLSNL FAQSLALATG QISENPNKTF LGNRPTNILL AKKLTPYTLG ALLSFFENKV 

       490        500        510        520        530 
AFQGFIWGIN SFDQEGVQLG KVLANRLINE FANQRKKTKP SSFAIGEAYL KHLDHFS 

« Hide

References

[1]"Illuminating the evolutionary history of chlamydiae."
Horn M., Collingro A., Schmitz-Esser S., Beier C.L., Purkhold U., Fartmann B., Brandt P., Nyakatura G.J., Droege M., Frishman D., Rattei T., Mewes H.-W., Wagner M.
Science 304:728-730(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: UWE25.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BX908798 Genomic DNA. Translation: CAF23505.1.
RefSeqYP_007780.1. NC_005861.1.

3D structure databases

ProteinModelPortalQ6MD44.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING264201.pc0781.

Proteomic databases

PRIDEQ6MD44.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAF23505; CAF23505; pc0781.
GeneID2779784.
KEGGpcu:pc0781.
PATRIC31996890. VBICanPro72727_0789.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0166.
HOGENOMHOG000261370.
KOK01810.
OMAEWTELED.
OrthoDBEOG64R61J.
ProtClustDBPRK14095.

Enzyme and pathway databases

BioCycPAMO264201:GH0M-801-MONOMER.
UniPathwayUPA00109; UER00181.

Family and domain databases

Gene3D1.10.1390.10. 1 hit.
HAMAPMF_00473. G6P_isomerase.
InterProIPR001672. G6P_Isomerase.
IPR023096. G6P_Isomerase_C.
IPR018189. Phosphoglucose_isomerase_CS.
[Graphical view]
PANTHERPTHR11469. PTHR11469. 1 hit.
PfamPF00342. PGI. 1 hit.
[Graphical view]
PRINTSPR00662. G6PISOMERASE.
PROSITEPS00174. P_GLUCOSE_ISOMERASE_2. 1 hit.
PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameG6PI_PARUW
AccessionPrimary (citable) accession number: Q6MD44
Entry history
Integrated into UniProtKB/Swiss-Prot: March 29, 2005
Last sequence update: July 5, 2004
Last modified: February 19, 2014
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways