Q6MCW1 (SURE_PARUW) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
5'-nucleotidase surE
EC=3.1.3.5

Alternative name(s):
Nucleoside 5'-monophosphate phosphohydrolase

Gene names

Name:	surE
Ordered Locus Names:	pc0864

Organism

Protochlamydia amoebophila (strain UWE25) [Complete proteome] [HAMAP]

Taxonomic identifier

264201 [NCBI]

Taxonomic lineage

Bacteria › Chlamydiae › Chlamydiales › Parachlamydiaceae › Candidatus Protochlamydia

Protein attributes

Sequence length	261 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates By similarity. HAMAP MF_00060
Catalytic activity	A 5'-ribonucleotide + H2O = a ribonucleoside + phosphate. HAMAP MF_00060
Cofactor	Binds 1 divalent metal cation per subunit By similarity.
Subcellular location	Cytoplasm Potential HAMAP MF_00060.
Sequence similarities	Belongs to the surE nucleotidase family.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	Metal-binding Nucleotide-binding
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	5'-nucleotidase activity Inferred from electronic annotation. Source: EC metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW nucleotide binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 261	261	5'-nucleotidase surE HAMAP MF_00060		PRO_0000235631
Sites
	Metal binding	12	1	Divalent metal cation By similarity
	Metal binding	13	1	Divalent metal cation By similarity
	Metal binding	43	1	Divalent metal cation By similarity
	Metal binding	100	1	Divalent metal cation By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q6MCW1 [UniParc]. Last modified July 5, 2004. Version 1. Checksum: 048C575B4314E5FD	FASTA	261	29,165
	10 20 30 40 50 60 MSSKPLILVT NDDGVHAKGI RHLWQSIQDL ADLIIVAPQQ EQSAVSLSIT VRRPLHIEKV 70 80 90 100 110 120 DWLNAQADVW SVNGTPADCV KLALNVVLPK RPQLIVSGIN RGTNAGRNIF YSGTVAAIME 130 140 150 160 170 180 GVMQGIPGIA FSYGDYFNPS YHLIESFIPG IVNYALQNAM QEGTFLNVNF PKTEHGPIKG 190 200 210 220 230 240 IRLTTQGKEY WAENPEKRQH PAEQNSYYWL GSKLAEYDER EDSDIFLLRK GFATVVPLHI 250 260 GDLTNHSHLL KEKLAFETFV N

References

[1]

"Illuminating the evolutionary history of chlamydiae." Horn M., Collingro A., Schmitz-Esser S., Beier C.L., Purkhold U., Fartmann B., Brandt P., Nyakatura G.J., Droege M., Frishman D., Rattei T., Mewes H.-W., Wagner M. Science 304:728-730(2004) [PubMed: 15073324] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: UWE25.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BX908798 Genomic DNA. Translation: CAF23588.1.
RefSeq	YP_007863.1. NC_005861.1.
3D structure databases
ProteinModelPortal	Q6MCW1.
ModBase	Search...
Protein-protein interaction databases
STRING	Q6MCW1.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	2781128.
GenomeReviews	Gene locus pc0864 in contig BX908798_GR.
KEGG	pcu:pc0864.
NMPDR	fig|264201.1.peg.864.
PATRIC	31997074. VBICanPro72727_0877.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0496.
HOGENOM	HBG600532.
OMA	DCVKMGI.
PhylomeDB	Q6MCW1.
ProtClustDB	CLSK2762275.
Enzyme and pathway databases
BioCyc	CPRO264201:PC0864-MONOMER.
Family and domain databases
HAMAP	MF_00060. SurE. [Tree]
InterPro	IPR002828. SurE-like_Pase/nucleotidase. [Graphical view]
Gene3D	G3DSA:3.40.1210.10. SurE-like_Pase/nucleotidase. 1 hit.
KO	K03787.
Pfam	PF01975. SurE. 1 hit. [Graphical view]
SUPFAM	SSF64167. SurE-like_Pase/nucleotidase. 1 hit.
TIGRFAMs	TIGR00087. SurE. 1 hit.
ProtoNet	Search...

Entry information

Entry name

SURE_PARUW

Accession

Primary (citable) accession number: Q6MCW1

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 16, 2006
Last sequence update:	July 5, 2004
Last modified:	January 25, 2012
This is version 45 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program