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Q6MCT5

- Q6MCT5_PARUW

UniProt

Q6MCT5 - Q6MCT5_PARUW

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Protein

Riboflavin biosynthesis protein RibBA

Gene

ribA

Organism
Protochlamydia amoebophila (strain UWE25)
Status
Unreviewed - Annotation score: 4 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate.UniRule annotationSAAS annotation
Catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate.UniRule annotationSAAS annotation

Catalytic activityi

D-ribulose 5-phosphate = formate + L-3,4-dihydroxybutan-2-one 4-phosphate.UniRule annotation
GTP + 3 H2O = formate + 2,5-diamino-6-hydroxy-4-(5-phospho-D-ribosylamino)pyrimidine + diphosphate.UniRule annotation

Cofactori

Protein has several cofactor binding sites:
  • Note: Binds 1 zinc ion per subunit.UniRule annotation
  • Note: Binds 2 divalent metal cations per subunit. Magnesium or manganese.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi28 – 281Magnesium or manganese 1UniRule annotation
Metal bindingi28 – 281Magnesium or manganese 2UniRule annotation
Binding sitei32 – 321D-ribulose 5-phosphateUniRule annotation
Sitei127 – 1271Essential for DHBP synthase activityUniRule annotation
Metal bindingi144 – 1441Magnesium or manganese 2UniRule annotation
Binding sitei165 – 1651D-ribulose 5-phosphateUniRule annotation
Sitei165 – 1651Essential for DHBP synthase activityUniRule annotation
Metal bindingi258 – 2581Zinc; catalyticUniRule annotation
Metal bindingi269 – 2691Zinc; catalyticUniRule annotation
Metal bindingi271 – 2711Zinc; catalyticUniRule annotation
Binding sitei274 – 2741GTPUniRule annotation
Binding sitei319 – 3191GTPUniRule annotation
Active sitei331 – 3311Proton acceptor; for GTP cyclohydrolase activityUniRule annotation
Active sitei333 – 3331Nucleophile; for GTP cyclohydrolase activityUniRule annotation
Binding sitei354 – 3541GTPUniRule annotation
Binding sitei359 – 3591GTPUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi253 – 2575GTPUniRule annotation
Nucleotide bindingi297 – 2993GTPUniRule annotation

GO - Molecular functioni

  1. 3,4-dihydroxy-2-butanone-4-phosphate synthase activity Source: UniProtKB-HAMAP
  2. GTP binding Source: UniProtKB-KW
  3. GTP cyclohydrolase II activity Source: UniProtKB-HAMAP
  4. magnesium ion binding Source: UniProtKB-HAMAP
  5. manganese ion binding Source: UniProtKB-HAMAP
  6. zinc ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. riboflavin biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

HydrolaseUniRule annotationImported, LyaseUniRule annotation

Keywords - Biological processi

Riboflavin biosynthesisUniRule annotationSAAS annotation

Keywords - Ligandi

GTP-bindingUniRule annotationSAAS annotation, MagnesiumUniRule annotation, ManganeseUniRule annotation, Metal-bindingUniRule annotationSAAS annotation, Nucleotide-binding, ZincUniRule annotation

Enzyme and pathway databases

BioCyciPAMO264201:GH0M-914-MONOMER.
UniPathwayiUPA00275; UER00399.
UPA00275; UER00400.

Names & Taxonomyi

Protein namesi
Recommended name:
Riboflavin biosynthesis protein RibBAUniRule annotationSAAS annotation
Gene namesi
Name:ribAImported
Synonyms:ribBAUniRule annotation
Ordered Locus Names:pc0890Imported
OrganismiProtochlamydia amoebophila (strain UWE25)Imported
Taxonomic identifieri264201 [NCBI]
Taxonomic lineageiBacteriaChlamydiaeChlamydialesParachlamydiaceaeCandidatus Protochlamydia
ProteomesiUP000000529: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi264201.pc0890.

Structurei

3D structure databases

ProteinModelPortaliQ6MCT5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 202202DHBP synthaseUniRule annotationAdd
BLAST
Regioni27 – 282D-ribulose 5-phosphate bindingUniRule annotation
Regioni141 – 1455D-ribulose 5-phosphate bindingUniRule annotation
Regioni203 – 412210GTP cyclohydrolase IIUniRule annotationAdd
BLAST

Sequence similaritiesi

In the C-terminal section; belongs to the GTP cyclohydrolase II family.UniRule annotation
In the N-terminal section; belongs to the DHBP synthase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0108.
HOGENOMiHOG000115440.
KOiK14652.
OMAiGKGLICM.
OrthoDBiEOG679TK8.

Family and domain databases

Gene3Di3.90.870.10. 1 hit.
HAMAPiMF_00179. RibA.
MF_00180. RibB.
MF_01283. RibBA.
InterProiIPR017945. DHBP_synth_RibB-like_a/b_dom.
IPR000422. DHBP_synthase_RibB.
IPR000926. GTP_CycHdrlaseII_RibA.
IPR016299. Riboflavin_synth_RibBA.
[Graphical view]
PfamiPF00926. DHBP_synthase. 1 hit.
PF00925. GTP_cyclohydro2. 1 hit.
[Graphical view]
PIRSFiPIRSF001259. RibA. 1 hit.
SUPFAMiSSF55821. SSF55821. 1 hit.
TIGRFAMsiTIGR00505. ribA. 1 hit.
TIGR00506. ribB. 1 hit.

Sequencei

Sequence statusi: Complete.

Q6MCT5-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKTYRLEDAL LALKEGKFVI VVDDENRENE GDLILAAEKA HPSSLGFMIR
60 70 80 90 100
HTTGIICLAM KGQRLDELKL PPMVTDNTDR KQTAFTVSVD YLHQGVTTGV
110 120 130 140 150
SAEDRTKTIL SLIHPHTKPE DLGRPGHIFP LRYKEGGVLK RAGHTEAAVD
160 170 180 190 200
LTNLAKLYPA GILAELINED GSMMRLPELE KFSDLHQIPI ITIAELIRFR
210 220 230 240 250
RRHEKLVSCF SQSPIPTPFG DFNAYVYESQ LDGIQHIALV KGEIKNQKNI
260 270 280 290 300
LVRMHSECLT GDVFGSKRCD CGSQLKLAME KIEQEGRGVI IYLRGHEGRG
310 320 330 340 350
IGIGHKLKAY NLQDQGKDTL EANLELGFPI DSREYGIGAQ ILVDLGLSTI
360 370 380 390 400
RLMTNNLAKY NGLAGYDLEI TERVPLPVCV TKENKHYLQT KKDKLGHLID
410
LSEDKLEIHH ST
Length:412
Mass (Da):46,075
Last modified:July 5, 2004 - v1
Checksum:i5D48E399C35CF8B0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX908798 Genomic DNA. Translation: CAF23614.1.
RefSeqiYP_007889.1. NC_005861.1.

Genome annotation databases

EnsemblBacteriaiCAF23614; CAF23614; pc0890.
GeneIDi2780041.
KEGGipcu:pc0890.
PATRICi31997129. VBICanPro72727_0904.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX908798 Genomic DNA. Translation: CAF23614.1 .
RefSeqi YP_007889.1. NC_005861.1.

3D structure databases

ProteinModelPortali Q6MCT5.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 264201.pc0890.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAF23614 ; CAF23614 ; pc0890 .
GeneIDi 2780041.
KEGGi pcu:pc0890.
PATRICi 31997129. VBICanPro72727_0904.

Phylogenomic databases

eggNOGi COG0108.
HOGENOMi HOG000115440.
KOi K14652.
OMAi GKGLICM.
OrthoDBi EOG679TK8.

Enzyme and pathway databases

UniPathwayi UPA00275 ; UER00399 .
UPA00275 ; UER00400 .
BioCyci PAMO264201:GH0M-914-MONOMER.

Family and domain databases

Gene3Di 3.90.870.10. 1 hit.
HAMAPi MF_00179. RibA.
MF_00180. RibB.
MF_01283. RibBA.
InterProi IPR017945. DHBP_synth_RibB-like_a/b_dom.
IPR000422. DHBP_synthase_RibB.
IPR000926. GTP_CycHdrlaseII_RibA.
IPR016299. Riboflavin_synth_RibBA.
[Graphical view ]
Pfami PF00926. DHBP_synthase. 1 hit.
PF00925. GTP_cyclohydro2. 1 hit.
[Graphical view ]
PIRSFi PIRSF001259. RibA. 1 hit.
SUPFAMi SSF55821. SSF55821. 1 hit.
TIGRFAMsi TIGR00505. ribA. 1 hit.
TIGR00506. ribB. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: UWE25Imported.

Entry informationi

Entry nameiQ6MCT5_PARUW
AccessioniPrimary (citable) accession number: Q6MCT5
Entry historyi
Integrated into UniProtKB/TrEMBL: July 5, 2004
Last sequence update: July 5, 2004
Last modified: November 26, 2014
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Multifunctional enzymeUniRule annotation, Reference proteomeImported

External Data

Dasty 3