Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q6MCT5

- Q6MCT5_PARUW

UniProt

Q6MCT5 - Q6MCT5_PARUW

Protein

Riboflavin biosynthesis protein RibBA

Gene

ribA

Organism
Protochlamydia amoebophila (strain UWE25)
Status
Unreviewed - Annotation score: 4 out of 5- Protein inferred from homologyi
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 71 (01 Oct 2014)
      Sequence version 1 (05 Jul 2004)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate.UniRule annotationSAAS annotation
    Catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate.UniRule annotationSAAS annotation

    Catalytic activityi

    D-ribulose 5-phosphate = formate + L-3,4-dihydroxybutan-2-one 4-phosphate.UniRule annotation
    GTP + 3 H2O = formate + 2,5-diamino-6-hydroxy-4-(5-phospho-D-ribosylamino)pyrimidine + diphosphate.UniRule annotationSAAS annotation

    Cofactori

    Binds 1 zinc ion per subunit.UniRule annotationSAAS annotation
    Binds 2 divalent metal cations per subunit. Magnesium or manganese.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi28 – 281Magnesium or manganese 1UniRule annotation
    Metal bindingi28 – 281Magnesium or manganese 2UniRule annotation
    Binding sitei32 – 321D-ribulose 5-phosphateUniRule annotation
    Sitei127 – 1271Essential for DHBP synthase activityUniRule annotation
    Metal bindingi144 – 1441Magnesium or manganese 2UniRule annotation
    Binding sitei165 – 1651D-ribulose 5-phosphateUniRule annotation
    Sitei165 – 1651Essential for DHBP synthase activityUniRule annotation
    Metal bindingi258 – 2581Zinc; catalyticUniRule annotation
    Metal bindingi269 – 2691Zinc; catalyticUniRule annotation
    Metal bindingi271 – 2711Zinc; catalyticUniRule annotation
    Binding sitei274 – 2741GTPUniRule annotation
    Binding sitei319 – 3191GTPUniRule annotation
    Active sitei331 – 3311Proton acceptor; for GTP cyclohydrolase activityUniRule annotation
    Active sitei333 – 3331Nucleophile; for GTP cyclohydrolase activityUniRule annotation
    Binding sitei354 – 3541GTPUniRule annotation
    Binding sitei359 – 3591GTPUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi253 – 2575GTPUniRule annotation
    Nucleotide bindingi297 – 2993GTPUniRule annotation

    GO - Molecular functioni

    1. 3,4-dihydroxy-2-butanone-4-phosphate synthase activity Source: UniProtKB-HAMAP
    2. GTP binding Source: UniProtKB-KW
    3. GTP cyclohydrolase II activity Source: UniProtKB-HAMAP
    4. magnesium ion binding Source: UniProtKB-HAMAP
    5. manganese ion binding Source: UniProtKB-HAMAP
    6. zinc ion binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. riboflavin biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    HydrolaseUniRule annotationImported, LyaseUniRule annotation

    Keywords - Biological processi

    Riboflavin biosynthesisUniRule annotationSAAS annotation

    Keywords - Ligandi

    GTP-bindingUniRule annotationSAAS annotation, MagnesiumUniRule annotation, ManganeseUniRule annotation, Metal-bindingUniRule annotationSAAS annotation, Nucleotide-binding, ZincUniRule annotationSAAS annotation

    Enzyme and pathway databases

    BioCyciPAMO264201:GH0M-914-MONOMER.
    UniPathwayiUPA00275; UER00399.
    UPA00275; UER00400.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Riboflavin biosynthesis protein RibBAUniRule annotation
    Gene namesi
    Name:ribAImported
    Synonyms:ribBAUniRule annotation
    Ordered Locus Names:pc0890Imported
    OrganismiProtochlamydia amoebophila (strain UWE25)Imported
    Taxonomic identifieri264201 [NCBI]
    Taxonomic lineageiBacteriaChlamydiaeChlamydialesParachlamydiaceaeCandidatus Protochlamydia
    ProteomesiUP000000529: Chromosome

    Interactioni

    Protein-protein interaction databases

    STRINGi264201.pc0890.

    Structurei

    3D structure databases

    ProteinModelPortaliQ6MCT5.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni1 – 202202DHBP synthaseUniRule annotationAdd
    BLAST
    Regioni27 – 282D-ribulose 5-phosphate bindingUniRule annotation
    Regioni141 – 1455D-ribulose 5-phosphate bindingUniRule annotation
    Regioni203 – 412210GTP cyclohydrolase IIUniRule annotationAdd
    BLAST

    Sequence similaritiesi

    In the C-terminal section; belongs to the GTP cyclohydrolase II family.UniRule annotation
    In the N-terminal section; belongs to the DHBP synthase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0108.
    HOGENOMiHOG000115440.
    KOiK14652.
    OMAiGKGLICM.
    OrthoDBiEOG679TK8.

    Family and domain databases

    Gene3Di3.90.870.10. 1 hit.
    HAMAPiMF_00179. RibA.
    MF_00180. RibB.
    MF_01283. RibBA.
    InterProiIPR017945. DHBP_synth_RibB-like_a/b_dom.
    IPR000422. DHBP_synthase_RibB.
    IPR000926. GTP_CycHdrlaseII_RibA.
    IPR016299. Riboflavin_synth_RibBA.
    [Graphical view]
    PfamiPF00926. DHBP_synthase. 1 hit.
    PF00925. GTP_cyclohydro2. 1 hit.
    [Graphical view]
    PIRSFiPIRSF001259. RibA. 1 hit.
    SUPFAMiSSF55821. SSF55821. 1 hit.
    TIGRFAMsiTIGR00505. ribA. 1 hit.
    TIGR00506. ribB. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q6MCT5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKTYRLEDAL LALKEGKFVI VVDDENRENE GDLILAAEKA HPSSLGFMIR    50
    HTTGIICLAM KGQRLDELKL PPMVTDNTDR KQTAFTVSVD YLHQGVTTGV 100
    SAEDRTKTIL SLIHPHTKPE DLGRPGHIFP LRYKEGGVLK RAGHTEAAVD 150
    LTNLAKLYPA GILAELINED GSMMRLPELE KFSDLHQIPI ITIAELIRFR 200
    RRHEKLVSCF SQSPIPTPFG DFNAYVYESQ LDGIQHIALV KGEIKNQKNI 250
    LVRMHSECLT GDVFGSKRCD CGSQLKLAME KIEQEGRGVI IYLRGHEGRG 300
    IGIGHKLKAY NLQDQGKDTL EANLELGFPI DSREYGIGAQ ILVDLGLSTI 350
    RLMTNNLAKY NGLAGYDLEI TERVPLPVCV TKENKHYLQT KKDKLGHLID 400
    LSEDKLEIHH ST 412
    Length:412
    Mass (Da):46,075
    Last modified:July 5, 2004 - v1
    Checksum:i5D48E399C35CF8B0
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BX908798 Genomic DNA. Translation: CAF23614.1.
    RefSeqiYP_007889.1. NC_005861.1.

    Genome annotation databases

    EnsemblBacteriaiCAF23614; CAF23614; pc0890.
    GeneIDi2780041.
    KEGGipcu:pc0890.
    PATRICi31997129. VBICanPro72727_0904.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BX908798 Genomic DNA. Translation: CAF23614.1 .
    RefSeqi YP_007889.1. NC_005861.1.

    3D structure databases

    ProteinModelPortali Q6MCT5.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 264201.pc0890.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAF23614 ; CAF23614 ; pc0890 .
    GeneIDi 2780041.
    KEGGi pcu:pc0890.
    PATRICi 31997129. VBICanPro72727_0904.

    Phylogenomic databases

    eggNOGi COG0108.
    HOGENOMi HOG000115440.
    KOi K14652.
    OMAi GKGLICM.
    OrthoDBi EOG679TK8.

    Enzyme and pathway databases

    UniPathwayi UPA00275 ; UER00399 .
    UPA00275 ; UER00400 .
    BioCyci PAMO264201:GH0M-914-MONOMER.

    Family and domain databases

    Gene3Di 3.90.870.10. 1 hit.
    HAMAPi MF_00179. RibA.
    MF_00180. RibB.
    MF_01283. RibBA.
    InterProi IPR017945. DHBP_synth_RibB-like_a/b_dom.
    IPR000422. DHBP_synthase_RibB.
    IPR000926. GTP_CycHdrlaseII_RibA.
    IPR016299. Riboflavin_synth_RibBA.
    [Graphical view ]
    Pfami PF00926. DHBP_synthase. 1 hit.
    PF00925. GTP_cyclohydro2. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF001259. RibA. 1 hit.
    SUPFAMi SSF55821. SSF55821. 1 hit.
    TIGRFAMsi TIGR00505. ribA. 1 hit.
    TIGR00506. ribB. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: UWE25Imported.

    Entry informationi

    Entry nameiQ6MCT5_PARUW
    AccessioniPrimary (citable) accession number: Q6MCT5
    Entry historyi
    Integrated into UniProtKB/TrEMBL: July 5, 2004
    Last sequence update: July 5, 2004
    Last modified: October 1, 2014
    This is version 71 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Multifunctional enzymeUniRule annotation, Reference proteomeImported

    External Data

    Dasty 3