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Q6MCC8

- SYL_PARUW

UniProt

Q6MCC8 - SYL_PARUW

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Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Protochlamydia amoebophila (strain UWE25)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei626 – 6261ATPUniRule annotation

GO - Molecular functioni

  1. aminoacyl-tRNA editing activity Source: InterPro
  2. ATP binding Source: UniProtKB-HAMAP
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciPAMO264201:GH0M-1074-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
Ordered Locus Names:pc1047
OrganismiProtochlamydia amoebophila (strain UWE25)
Taxonomic identifieri264201 [NCBI]
Taxonomic lineageiBacteriaChlamydiaeChlamydialesParachlamydiaceaeCandidatus Protochlamydia
ProteomesiUP000000529: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 845845Leucine--tRNA ligasePRO_0000152058Add
BLAST

Proteomic databases

PRIDEiQ6MCC8.

Interactioni

Protein-protein interaction databases

STRINGi264201.pc1047.

Structurei

3D structure databases

ProteinModelPortaliQ6MCC8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi40 – 5112"HIGH" regionAdd
BLAST
Motifi623 – 6275"KMSKS" region

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200748.
KOiK01869.
OMAiHISHELW.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 1 hit.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6MCC8-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKYDHQQIEA KWQKFWQDNQ TYRSDDNFQK PKYYVLDMFP YPSGAGLHVG
60 70 80 90 100
HVVGYTATDI IARYMRTKGY NVMHPMGWDS FGLPAEQYAI RTGTHPAEST
110 120 130 140 150
QENINNYRRQ LRALGFSYDW NRELATSDPN YYKWTQWIFT KLYEKGLAYE
160 170 180 190 200
AEMLVNYCPA LGTVLANEEI ENGKTKDGGH PVERRPLKQW ILKITAYADR
210 220 230 240 250
LLQDLDLLDW PESLKKLQIN WIGKSEGAYV QFIEKTTQEA FSVFTTRPDT
260 270 280 290 300
LFGVSYLVLA PEHPLVSHIT ASSQQQAVRA YQAQIASKSD LDRTELNRDK
310 320 330 340 350
TGVFTGAYAV NPVNHKEIPI WISDYVLMNV GTGAIMAVPA HDERDFEFAK
360 370 380 390 400
TFKLPIIPVY DPVCEEITIR NQVLAGQQCW PGHGICVNSA CGDLSLNGLN
410 420 430 440 450
LDQAKKIVIN WLEINHKGKS ATTYKLRDWL FSRQRYWGEP FPLLKFEDGS
460 470 480 490 500
VRLLDEDELP LCPPAITNYK PTGDGKGPLT QIKEWVEIID TKTGKKAFRD
510 520 530 540 550
TNIMPQWAGS CWYYLRFCDP HNTEKAFSPE KEKYWLPVDL YIGGVEHAVL
560 570 580 590 600
HLLYARFWHK VLYDCGYVHT LEPFQTLRNQ GLVVARSYQN KMRVYVEPRY
610 620 630 640 650
VEQRDGKYFD SRTGEELTSQ IDKMSKSKLN GESPDEIIQE YGADALRLYE
660 670 680 690 700
MFMGPLEKEK VWNTDAVSGT RRFLNRFYEM AFSDKVTNET SEEGLKLGHR
710 720 730 740 750
LVHSVMKDME LLQFNTAIAK MMEFINEFTK LVTYPKQVIQ MATQVLAPFA
760 770 780 790 800
PHLAEEVWEH LKCEGSLSFT PYPQVEEKYL QENVITYVVQ INGKVRGRFD
810 820 830 840
LPKDQTQENV LEAAKNNPHI QQYINKKEIG KVVFVPNKLL SIVLR
Length:845
Mass (Da):97,641
Last modified:July 5, 2004 - v1
Checksum:i518041736EAB1249
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX908798 Genomic DNA. Translation: CAF23771.1.
RefSeqiYP_008046.1. NC_005861.1.

Genome annotation databases

EnsemblBacteriaiCAF23771; CAF23771; pc1047.
GeneIDi2780786.
KEGGipcu:pc1047.
PATRICi31997445. VBICanPro72727_1060.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX908798 Genomic DNA. Translation: CAF23771.1 .
RefSeqi YP_008046.1. NC_005861.1.

3D structure databases

ProteinModelPortali Q6MCC8.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 264201.pc1047.

Proteomic databases

PRIDEi Q6MCC8.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAF23771 ; CAF23771 ; pc1047 .
GeneIDi 2780786.
KEGGi pcu:pc1047.
PATRICi 31997445. VBICanPro72727_1060.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000200748.
KOi K01869.
OMAi HISHELW.
OrthoDBi EOG63Z74X.

Enzyme and pathway databases

BioCyci PAMO264201:GH0M-1074-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
Pfami PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 1 hit.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view ]
PRINTSi PR00985. TRNASYNTHLEU.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: UWE25.

Entry informationi

Entry nameiSYL_PARUW
AccessioniPrimary (citable) accession number: Q6MCC8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 1, 2005
Last sequence update: July 5, 2004
Last modified: October 29, 2014
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3