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Q6MCC8

- SYL_PARUW

UniProt

Q6MCC8 - SYL_PARUW

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Protein

Leucine--tRNA ligase

Gene
leuS, pc1047
Organism
Protochlamydia amoebophila (strain UWE25)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei626 – 6261ATP By similarity

GO - Molecular functioni

  1. aminoacyl-tRNA editing activity Source: InterPro
  2. ATP binding Source: UniProtKB-HAMAP
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciPAMO264201:GH0M-1074-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligase (EC:6.1.1.4)
Alternative name(s):
Leucyl-tRNA synthetase
Short name:
LeuRS
Gene namesi
Name:leuS
Ordered Locus Names:pc1047
OrganismiProtochlamydia amoebophila (strain UWE25)
Taxonomic identifieri264201 [NCBI]
Taxonomic lineageiBacteriaChlamydiaeChlamydialesParachlamydiaceaeCandidatus Protochlamydia
ProteomesiUP000000529: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 845845Leucine--tRNA ligaseUniRule annotationPRO_0000152058Add
BLAST

Proteomic databases

PRIDEiQ6MCC8.

Interactioni

Protein-protein interaction databases

STRINGi264201.pc1047.

Structurei

3D structure databases

ProteinModelPortaliQ6MCC8.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi40 – 5112"HIGH" regionUniRule annotationAdd
BLAST
Motifi623 – 6275"KMSKS" regionUniRule annotation

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200748.
KOiK01869.
OMAiHISHELW.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 1 hit.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6MCC8-1 [UniParc]FASTAAdd to Basket

« Hide

MKYDHQQIEA KWQKFWQDNQ TYRSDDNFQK PKYYVLDMFP YPSGAGLHVG    50
HVVGYTATDI IARYMRTKGY NVMHPMGWDS FGLPAEQYAI RTGTHPAEST 100
QENINNYRRQ LRALGFSYDW NRELATSDPN YYKWTQWIFT KLYEKGLAYE 150
AEMLVNYCPA LGTVLANEEI ENGKTKDGGH PVERRPLKQW ILKITAYADR 200
LLQDLDLLDW PESLKKLQIN WIGKSEGAYV QFIEKTTQEA FSVFTTRPDT 250
LFGVSYLVLA PEHPLVSHIT ASSQQQAVRA YQAQIASKSD LDRTELNRDK 300
TGVFTGAYAV NPVNHKEIPI WISDYVLMNV GTGAIMAVPA HDERDFEFAK 350
TFKLPIIPVY DPVCEEITIR NQVLAGQQCW PGHGICVNSA CGDLSLNGLN 400
LDQAKKIVIN WLEINHKGKS ATTYKLRDWL FSRQRYWGEP FPLLKFEDGS 450
VRLLDEDELP LCPPAITNYK PTGDGKGPLT QIKEWVEIID TKTGKKAFRD 500
TNIMPQWAGS CWYYLRFCDP HNTEKAFSPE KEKYWLPVDL YIGGVEHAVL 550
HLLYARFWHK VLYDCGYVHT LEPFQTLRNQ GLVVARSYQN KMRVYVEPRY 600
VEQRDGKYFD SRTGEELTSQ IDKMSKSKLN GESPDEIIQE YGADALRLYE 650
MFMGPLEKEK VWNTDAVSGT RRFLNRFYEM AFSDKVTNET SEEGLKLGHR 700
LVHSVMKDME LLQFNTAIAK MMEFINEFTK LVTYPKQVIQ MATQVLAPFA 750
PHLAEEVWEH LKCEGSLSFT PYPQVEEKYL QENVITYVVQ INGKVRGRFD 800
LPKDQTQENV LEAAKNNPHI QQYINKKEIG KVVFVPNKLL SIVLR 845
Length:845
Mass (Da):97,641
Last modified:July 5, 2004 - v1
Checksum:i518041736EAB1249
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BX908798 Genomic DNA. Translation: CAF23771.1.
RefSeqiYP_008046.1. NC_005861.1.

Genome annotation databases

EnsemblBacteriaiCAF23771; CAF23771; pc1047.
GeneIDi2780786.
KEGGipcu:pc1047.
PATRICi31997445. VBICanPro72727_1060.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BX908798 Genomic DNA. Translation: CAF23771.1 .
RefSeqi YP_008046.1. NC_005861.1.

3D structure databases

ProteinModelPortali Q6MCC8.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 264201.pc1047.

Proteomic databases

PRIDEi Q6MCC8.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAF23771 ; CAF23771 ; pc1047 .
GeneIDi 2780786.
KEGGi pcu:pc1047.
PATRICi 31997445. VBICanPro72727_1060.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000200748.
KOi K01869.
OMAi HISHELW.
OrthoDBi EOG63Z74X.

Enzyme and pathway databases

BioCyci PAMO264201:GH0M-1074-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
Pfami PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 1 hit.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view ]
PRINTSi PR00985. TRNASYNTHLEU.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: UWE25.

Entry informationi

Entry nameiSYL_PARUW
AccessioniPrimary (citable) accession number: Q6MCC8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 1, 2005
Last sequence update: July 5, 2004
Last modified: May 14, 2014
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi