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Q6MCC8

- SYL_PARUW

UniProt

Q6MCC8 - SYL_PARUW

Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Protochlamydia amoebophila (strain UWE25)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 75 (01 Oct 2014)
      Sequence version 1 (05 Jul 2004)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei626 – 6261ATPUniRule annotation

    GO - Molecular functioni

    1. aminoacyl-tRNA editing activity Source: InterPro
    2. ATP binding Source: UniProtKB-HAMAP
    3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciPAMO264201:GH0M-1074-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
    Alternative name(s):
    Leucyl-tRNA synthetaseUniRule annotation
    Short name:
    LeuRSUniRule annotation
    Gene namesi
    Name:leuSUniRule annotation
    Ordered Locus Names:pc1047
    OrganismiProtochlamydia amoebophila (strain UWE25)
    Taxonomic identifieri264201 [NCBI]
    Taxonomic lineageiBacteriaChlamydiaeChlamydialesParachlamydiaceaeCandidatus Protochlamydia
    ProteomesiUP000000529: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 845845Leucine--tRNA ligasePRO_0000152058Add
    BLAST

    Proteomic databases

    PRIDEiQ6MCC8.

    Interactioni

    Protein-protein interaction databases

    STRINGi264201.pc1047.

    Structurei

    3D structure databases

    ProteinModelPortaliQ6MCC8.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi40 – 5112"HIGH" regionAdd
    BLAST
    Motifi623 – 6275"KMSKS" region

    Sequence similaritiesi

    Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0495.
    HOGENOMiHOG000200748.
    KOiK01869.
    OMAiHISHELW.
    OrthoDBiEOG63Z74X.

    Family and domain databases

    Gene3Di1.10.730.10. 1 hit.
    3.40.50.620. 3 hits.
    3.90.740.10. 1 hit.
    HAMAPiMF_00049_B. Leu_tRNA_synth_B.
    InterProiIPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR015413. Methionyl/Leucyl_tRNA_Synth.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view]
    PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
    PfamiPF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 1 hit.
    PF13603. tRNA-synt_1_2. 1 hit.
    PF09334. tRNA-synt_1g. 1 hit.
    [Graphical view]
    PRINTSiPR00985. TRNASYNTHLEU.
    SUPFAMiSSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
    PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q6MCC8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKYDHQQIEA KWQKFWQDNQ TYRSDDNFQK PKYYVLDMFP YPSGAGLHVG    50
    HVVGYTATDI IARYMRTKGY NVMHPMGWDS FGLPAEQYAI RTGTHPAEST 100
    QENINNYRRQ LRALGFSYDW NRELATSDPN YYKWTQWIFT KLYEKGLAYE 150
    AEMLVNYCPA LGTVLANEEI ENGKTKDGGH PVERRPLKQW ILKITAYADR 200
    LLQDLDLLDW PESLKKLQIN WIGKSEGAYV QFIEKTTQEA FSVFTTRPDT 250
    LFGVSYLVLA PEHPLVSHIT ASSQQQAVRA YQAQIASKSD LDRTELNRDK 300
    TGVFTGAYAV NPVNHKEIPI WISDYVLMNV GTGAIMAVPA HDERDFEFAK 350
    TFKLPIIPVY DPVCEEITIR NQVLAGQQCW PGHGICVNSA CGDLSLNGLN 400
    LDQAKKIVIN WLEINHKGKS ATTYKLRDWL FSRQRYWGEP FPLLKFEDGS 450
    VRLLDEDELP LCPPAITNYK PTGDGKGPLT QIKEWVEIID TKTGKKAFRD 500
    TNIMPQWAGS CWYYLRFCDP HNTEKAFSPE KEKYWLPVDL YIGGVEHAVL 550
    HLLYARFWHK VLYDCGYVHT LEPFQTLRNQ GLVVARSYQN KMRVYVEPRY 600
    VEQRDGKYFD SRTGEELTSQ IDKMSKSKLN GESPDEIIQE YGADALRLYE 650
    MFMGPLEKEK VWNTDAVSGT RRFLNRFYEM AFSDKVTNET SEEGLKLGHR 700
    LVHSVMKDME LLQFNTAIAK MMEFINEFTK LVTYPKQVIQ MATQVLAPFA 750
    PHLAEEVWEH LKCEGSLSFT PYPQVEEKYL QENVITYVVQ INGKVRGRFD 800
    LPKDQTQENV LEAAKNNPHI QQYINKKEIG KVVFVPNKLL SIVLR 845
    Length:845
    Mass (Da):97,641
    Last modified:July 5, 2004 - v1
    Checksum:i518041736EAB1249
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BX908798 Genomic DNA. Translation: CAF23771.1.
    RefSeqiYP_008046.1. NC_005861.1.

    Genome annotation databases

    EnsemblBacteriaiCAF23771; CAF23771; pc1047.
    GeneIDi2780786.
    KEGGipcu:pc1047.
    PATRICi31997445. VBICanPro72727_1060.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BX908798 Genomic DNA. Translation: CAF23771.1 .
    RefSeqi YP_008046.1. NC_005861.1.

    3D structure databases

    ProteinModelPortali Q6MCC8.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 264201.pc1047.

    Proteomic databases

    PRIDEi Q6MCC8.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAF23771 ; CAF23771 ; pc1047 .
    GeneIDi 2780786.
    KEGGi pcu:pc1047.
    PATRICi 31997445. VBICanPro72727_1060.

    Phylogenomic databases

    eggNOGi COG0495.
    HOGENOMi HOG000200748.
    KOi K01869.
    OMAi HISHELW.
    OrthoDBi EOG63Z74X.

    Enzyme and pathway databases

    BioCyci PAMO264201:GH0M-1074-MONOMER.

    Family and domain databases

    Gene3Di 1.10.730.10. 1 hit.
    3.40.50.620. 3 hits.
    3.90.740.10. 1 hit.
    HAMAPi MF_00049_B. Leu_tRNA_synth_B.
    InterProi IPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR015413. Methionyl/Leucyl_tRNA_Synth.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view ]
    PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
    Pfami PF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 1 hit.
    PF13603. tRNA-synt_1_2. 1 hit.
    PF09334. tRNA-synt_1g. 1 hit.
    [Graphical view ]
    PRINTSi PR00985. TRNASYNTHLEU.
    SUPFAMi SSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
    PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: UWE25.

    Entry informationi

    Entry nameiSYL_PARUW
    AccessioniPrimary (citable) accession number: Q6MCC8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 1, 2005
    Last sequence update: July 5, 2004
    Last modified: October 1, 2014
    This is version 75 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3