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Q6MCC8 (SYL_PARUW) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 74. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Leucine--tRNA ligase

EC=6.1.1.4
Alternative name(s):
Leucyl-tRNA synthetase
Short name=LeuRS
Gene names
Name:leuS
Ordered Locus Names:pc1047
OrganismProtochlamydia amoebophila (strain UWE25) [Complete proteome] [HAMAP]
Taxonomic identifier264201 [NCBI]
Taxonomic lineageBacteriaChlamydiaeChlamydialesParachlamydiaceaeCandidatus Protochlamydia

Protein attributes

Sequence length845 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu). HAMAP-Rule MF_00049

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00049.

Sequence similarities

Belongs to the class-I aminoacyl-tRNA synthetase family.

Ontologies

Keywords
   Biological processProtein biosynthesis
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionAminoacyl-tRNA synthetase
Ligase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processleucyl-tRNA aminoacylation

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

aminoacyl-tRNA editing activity

Inferred from electronic annotation. Source: InterPro

leucine-tRNA ligase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 845845Leucine--tRNA ligase HAMAP-Rule MF_00049
PRO_0000152058

Regions

Motif40 – 5112"HIGH" region HAMAP-Rule MF_00049
Motif623 – 6275"KMSKS" region HAMAP-Rule MF_00049

Sites

Binding site6261ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
Q6MCC8 [UniParc].

Last modified July 5, 2004. Version 1.
Checksum: 518041736EAB1249

FASTA84597,641
        10         20         30         40         50         60 
MKYDHQQIEA KWQKFWQDNQ TYRSDDNFQK PKYYVLDMFP YPSGAGLHVG HVVGYTATDI 

        70         80         90        100        110        120 
IARYMRTKGY NVMHPMGWDS FGLPAEQYAI RTGTHPAEST QENINNYRRQ LRALGFSYDW 

       130        140        150        160        170        180 
NRELATSDPN YYKWTQWIFT KLYEKGLAYE AEMLVNYCPA LGTVLANEEI ENGKTKDGGH 

       190        200        210        220        230        240 
PVERRPLKQW ILKITAYADR LLQDLDLLDW PESLKKLQIN WIGKSEGAYV QFIEKTTQEA 

       250        260        270        280        290        300 
FSVFTTRPDT LFGVSYLVLA PEHPLVSHIT ASSQQQAVRA YQAQIASKSD LDRTELNRDK 

       310        320        330        340        350        360 
TGVFTGAYAV NPVNHKEIPI WISDYVLMNV GTGAIMAVPA HDERDFEFAK TFKLPIIPVY 

       370        380        390        400        410        420 
DPVCEEITIR NQVLAGQQCW PGHGICVNSA CGDLSLNGLN LDQAKKIVIN WLEINHKGKS 

       430        440        450        460        470        480 
ATTYKLRDWL FSRQRYWGEP FPLLKFEDGS VRLLDEDELP LCPPAITNYK PTGDGKGPLT 

       490        500        510        520        530        540 
QIKEWVEIID TKTGKKAFRD TNIMPQWAGS CWYYLRFCDP HNTEKAFSPE KEKYWLPVDL 

       550        560        570        580        590        600 
YIGGVEHAVL HLLYARFWHK VLYDCGYVHT LEPFQTLRNQ GLVVARSYQN KMRVYVEPRY 

       610        620        630        640        650        660 
VEQRDGKYFD SRTGEELTSQ IDKMSKSKLN GESPDEIIQE YGADALRLYE MFMGPLEKEK 

       670        680        690        700        710        720 
VWNTDAVSGT RRFLNRFYEM AFSDKVTNET SEEGLKLGHR LVHSVMKDME LLQFNTAIAK 

       730        740        750        760        770        780 
MMEFINEFTK LVTYPKQVIQ MATQVLAPFA PHLAEEVWEH LKCEGSLSFT PYPQVEEKYL 

       790        800        810        820        830        840 
QENVITYVVQ INGKVRGRFD LPKDQTQENV LEAAKNNPHI QQYINKKEIG KVVFVPNKLL 


SIVLR 

« Hide

References

[1]"Illuminating the evolutionary history of chlamydiae."
Horn M., Collingro A., Schmitz-Esser S., Beier C.L., Purkhold U., Fartmann B., Brandt P., Nyakatura G.J., Droege M., Frishman D., Rattei T., Mewes H.-W., Wagner M.
Science 304:728-730(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: UWE25.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BX908798 Genomic DNA. Translation: CAF23771.1.
RefSeqYP_008046.1. NC_005861.1.

3D structure databases

ProteinModelPortalQ6MCC8.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING264201.pc1047.

Proteomic databases

PRIDEQ6MCC8.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAF23771; CAF23771; pc1047.
GeneID2780786.
KEGGpcu:pc1047.
PATRIC31997445. VBICanPro72727_1060.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0495.
HOGENOMHOG000200748.
KOK01869.
OMAHISHELW.
OrthoDBEOG63Z74X.

Enzyme and pathway databases

BioCycPAMO264201:GH0M-1074-MONOMER.

Family and domain databases

Gene3D1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPMF_00049_B. Leu_tRNA_synth_B.
InterProIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 1 hit.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view]
PRINTSPR00985. TRNASYNTHLEU.
SUPFAMSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsTIGR00396. leuS_bact. 1 hit.
PROSITEPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameSYL_PARUW
AccessionPrimary (citable) accession number: Q6MCC8
Entry history
Integrated into UniProtKB/Swiss-Prot: March 1, 2005
Last sequence update: July 5, 2004
Last modified: May 14, 2014
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Aminoacyl-tRNA synthetases

List of aminoacyl-tRNA synthetase entries