Q6MCA1 (Q6MCA1_PARUW) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
DNA gyrase subunit A HAMAP MF_01897
EC=5.99.1.3 HAMAP MF_01897

Gene names

Name:	gyrA HAMAP MF_01897 EMBL CAF23798.1
Ordered Locus Names:	pc1074

Organism

Protochlamydia amoebophila (strain UWE25) [Complete proteome] [HAMAP]

Taxonomic identifier

264201 [NCBI]

Taxonomic lineage

Bacteria › Chlamydiae › Chlamydiales › Parachlamydiaceae › Candidatus Protochlamydia

Protein attributes

Sequence length	856 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	DNA gyrase negatively supercoils closed circular double-stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings By similarity. SAAS SAAS006691 HAMAP MF_01897
Catalytic activity	ATP-dependent breakage, passage and rejoining of double-stranded DNA. SAAS SAAS006691 HAMAP MF_01897
Subunit structure	Made up of two chains. The A chain is responsible for DNA breakage and rejoining; the B chain catalyzes ATP hydrolysis. The enzyme forms an A2B2 tetramer By similarity. HAMAP MF_01897
Subcellular location	Cytoplasm By similarity SAAS SAAS006691 HAMAP MF_01897.
Sequence similarities	Belongs to the topoisomerase GyrA/ParC subunit family. HAMAP MF_01897

Ontologies

Keywords
Cellular component	Cytoplasm SAAS SAAS006691 HAMAP MF_01897
Ligand	ATP-binding SAAS SAAS006691 HAMAP MF_01897 DNA-binding SAAS SAAS006691 HAMAP MF_01897 Nucleotide-binding
Molecular function	Isomerase Topoisomerase SAAS SAAS006691 HAMAP MF_01897
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	DNA topological change Inferred from electronic annotation. Source: InterPro DNA-dependent DNA replication Inferred from electronic annotation. Source: HAMAP regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: InterPro
Cellular component	chromosome Inferred from electronic annotation. Source: InterPro cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: HAMAP DNA topoisomerase (ATP-hydrolyzing) activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q6MCA1 [UniParc]. Last modified July 5, 2004. Version 1. Checksum: 1EB614549D81FFA7	FASTA	856	96,946
	10 20 30 40 50 60 MSYTKDEVIV SRNVEDEMKD SYLRYSMSVI ISRALPDARD GLKPSQRRIL YAMRQLNLGP 70 80 90 100 110 120 NGKHRKCAKI SGDTSGDYHP HGEMVIYPTL VRMAQKWIMR YNLVDGQGNF GSVDGDPPAA 130 140 150 160 170 180 MRYTEARLTT AAVQLMDDLD KDTVEMVPNY DETKKEPTVF PSKFPNLLCN GSSGIAVGMA 190 200 210 220 230 240 TNIPPHNLNE LIKATLLLLE NPTTSIDDIM KVMPGPDFPT GGMICGYRGI KEAFHTGRGK 250 260 270 280 290 300 LILRGVIRVE ENEDNPDRSR LAIDEIPYNV NKSRLIEHIA ELINNKTITG ISDLRDESDK 310 320 330 340 350 360 DGMRIVIELK RGEVPEVIIN QLYKFSDLQI TFGCNMLALD KGLPRTMNVK QLISVWIEHR 370 380 390 400 410 420 IDVVRRRTRF ELNKAEARAH ILEGYLKAID HLDEVVRLIR ASSNRDEARI ELIKQFEFTE 430 440 450 460 470 480 RQANAILDLR LYQLTGLERD KINDEYQELL KKIDYLRAVL ASEAMVKEII REELLDIQKH 490 500 510 520 530 540 HKSERQTQII AAETEVNMED LIANEPVIIT ISQDDYIKRM PVNTFREQRR GGQGVTGMQL 550 560 570 580 590 600 KREEDVIKGL YVATTHDYLL IFTNLGRCYW LKVWQIPETG RKSKGKPLIN LLEDIRPEEK 610 620 630 640 650 660 IATIQRVSSF EEEACILMAT KRAVVKKSLL NEFSNPRRKG IWALDIDEGD ELVAARLVKP 670 680 690 700 710 720 EQQVMLFTHQ GMAVRFEESN VRPMGRTARG VKGATLRGEN DYIVGCEVVN GDESILVVCE 730 740 750 760 770 780 NGFGKRSQVD DFRQTNRGGV GVRSIITSER NGKVIGALCV TDEDGMVMMS ATGQTVRINM 790 800 810 820 830 840 NDLRVMGRNT QGVKLANLKE NDYLVAIQKL QGSENQSEEL LASDTIELNE NNVSFESPEI 850 KMSVKPSSEE ITDQSE

References

[1]

"Illuminating the evolutionary history of chlamydiae." Horn M., Collingro A., Schmitz-Esser S., Beier C.L., Purkhold U., Fartmann B., Brandt P., Nyakatura G.J., Droege M., Frishman D., Rattei T., Mewes H.-W., Wagner M. Science 304:728-730(2004) [PubMed: 15073324] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	BX908798 Genomic DNA. Translation: CAF23798.1.
RefSeq	YP_008073.1. NC_005861.1.
3D structure databases
HSSP	HSSP built from PDB template 1AB4 based on UniProtKB P09097.
ProteinModelPortal	Q6MCA1.
ModBase	Search...
Protein-protein interaction databases
STRING	Q6MCA1.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	2780174.
GenomeReviews	Gene locus pc1074 in contig BX908798_GR.
KEGG	pcu:pc1074.
NMPDR	fig|264201.1.peg.1074.
PATRIC	31997515. VBICanPro72727_1095.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0188.
HOGENOM	HBG635183.
OMA	TSIPPHR.
ProtClustDB	PRK05560.
Family and domain databases
HAMAP	MF_01897. GyrA. [Tree]
InterPro	IPR005743. GyrA. IPR006691. GyrA/parC_pinwhl. IPR002205. Topo_IIA_A/C. IPR013758. Topo_IIA_A/C_ab. IPR013757. Topo_IIA_A_a. IPR013760. Topo_IIA_cen. [Graphical view]
Gene3D	G3DSA:3.90.199.10. Topo_IIA_A/C_ab. 1 hit. G3DSA:1.10.268.10. Topo_IIA_A_a. 1 hit.
KO	K02469.
Pfam	PF03989. DNA_gyraseA_C. 6 hits. PF00521. DNA_topoisoIV. 1 hit. [Graphical view]
SMART	SM00434. TOP4c. 1 hit. [Graphical view]
SUPFAM	SSF56719. Topo_IIA_cen. 1 hit.
TIGRFAMs	TIGR01063. GyrA. 1 hit.
ProtoNet	Search...

Entry information

Entry name

Q6MCA1_PARUW

Accession

Primary (citable) accession number: Q6MCA1

Entry history

Integrated into UniProtKB/TrEMBL:	July 5, 2004
Last sequence update:	July 5, 2004
Last modified:	January 25, 2012
This is version 54 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)