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Protein

Phospho-N-acetylmuramoyl-pentapeptide-transferase

Gene

mraY

Organism
Protochlamydia amoebophila (strain UWE25)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan.UniRule annotation

Catalytic activityi

UDP-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala) + undecaprenyl phosphate = UMP + Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol.UniRule annotation

Pathwayi: peptidoglycan biosynthesis

This protein is involved in the pathway peptidoglycan biosynthesis, which is part of Cell wall biogenesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway peptidoglycan biosynthesis and in Cell wall biogenesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase
Biological processCell cycle, Cell division, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

Enzyme and pathway databases

UniPathwayiUPA00219.

Names & Taxonomyi

Protein namesi
Recommended name:
Phospho-N-acetylmuramoyl-pentapeptide-transferaseUniRule annotation (EC:2.7.8.13UniRule annotation)
Alternative name(s):
UDP-MurNAc-pentapeptide phosphotransferaseUniRule annotation
Gene namesi
Name:mraYUniRule annotation
Ordered Locus Names:pc1252
OrganismiProtochlamydia amoebophila (strain UWE25)
Taxonomic identifieri264201 [NCBI]
Taxonomic lineageiBacteriaChlamydiaeParachlamydialesParachlamydiaceaeCandidatus Protochlamydia
Proteomesi
  • UP000000529 Componenti: Chromosome

Subcellular locationi

  • Cell inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei27 – 47HelicalUniRule annotationAdd BLAST21
Transmembranei77 – 97HelicalUniRule annotationAdd BLAST21
Transmembranei99 – 119HelicalUniRule annotationAdd BLAST21
Transmembranei140 – 160HelicalUniRule annotationAdd BLAST21
Transmembranei213 – 233HelicalUniRule annotationAdd BLAST21
Transmembranei248 – 268HelicalUniRule annotationAdd BLAST21
Transmembranei288 – 308HelicalUniRule annotationAdd BLAST21
Transmembranei312 – 332HelicalUniRule annotationAdd BLAST21
Transmembranei337 – 357HelicalUniRule annotationAdd BLAST21
Transmembranei389 – 409HelicalUniRule annotationAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001088621 – 410Phospho-N-acetylmuramoyl-pentapeptide-transferaseAdd BLAST410

Interactioni

Protein-protein interaction databases

STRINGi264201.pc1252.

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyltransferase 4 family. MraY subfamily.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105CPY. Bacteria.
COG0472. LUCA.
HOGENOMiHOG000275122.
KOiK01000.
OMAiLMSPLHH.
OrthoDBiPOG091H00VH.

Family and domain databases

CDDicd06852. GT_MraY. 1 hit.
HAMAPiMF_00038. MraY. 1 hit.
InterProiView protein in InterPro
IPR000715. Glycosyl_transferase_4.
IPR003524. PNAcMuramoyl-5peptid_Trfase.
IPR018480. PNAcMuramoyl-5peptid_Trfase_CS.
PANTHERiPTHR22926. PTHR22926. 1 hit.
PfamiView protein in Pfam
PF00953. Glycos_transf_4. 1 hit.
PF10555. MraY_sig1. 1 hit.
TIGRFAMsiTIGR00445. mraY. 1 hit.
PROSITEiView protein in PROSITE
PS01347. MRAY_1. 1 hit.
PS01348. MRAY_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q6MBS3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MILFAIDYLE RVWTLKVPSV FSYYSTRMIL AAITSLLLSI FLGPYFIRKL
60 70 80 90 100
YELKIGQSIR KEDCPLLGQL HEKKQNTPTM GGILILSSML VSLVLWMDLT
110 120 130 140 150
HIFTLILFVT TVFLGLIGGR DDYLKLKYKN TKGMSARGKL FFQFVLSAAI
160 170 180 190 200
ASYFLLSSVN EMFEKWTWFQ PPVIKEQIVV KNSETLQEMP SQTKSISLKE
210 220 230 240 250
YASRLYIPFF KEPVVTFGGI SLILMAFFIF FVITGSSNAA NLTDGLDGLL
260 270 280 290 300
AGCLVTAAGS LCLIAFVSNH VDIARYLNIL YIEGSGEIAI YLCALIGASL
310 320 330 340 350
GFLWYNGYPA QVFMGDTGSL TLGGILGVSA VLLRREFLLG IVGGIFVAEA
360 370 380 390 400
LSVILQVASY RLRNKKRIFL CAPLHHHFEY KGWPETKVVI RFWIMSLLFA
410
IIGIASLKFQ
Length:410
Mass (Da):45,905
Last modified:July 5, 2004 - v1
Checksum:i0974D590E5CCA3B3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX908798 Genomic DNA. Translation: CAF23976.1.
RefSeqiWP_011175802.1. NC_005861.1.

Genome annotation databases

EnsemblBacteriaiCAF23976; CAF23976; pc1252.
KEGGipcu:pc1252.

Similar proteinsi

Entry informationi

Entry nameiMRAY_PARUW
AccessioniPrimary (citable) accession number: Q6MBS3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: July 5, 2004
Last modified: June 7, 2017
This is version 92 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families