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Q6MBP0

- TRMB_PARUW

UniProt

Q6MBP0 - TRMB_PARUW

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Protein

tRNA (guanine-N(7)-)-methyltransferase

Gene

trmB

Organism
Protochlamydia amoebophila (strain UWE25)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.UniRule annotation

Catalytic activityi

S-adenosyl-L-methionine + guanine(46) in tRNA = S-adenosyl-L-homocysteine + N(7)-methylguanine(46) in tRNA.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei56 – 561S-adenosyl-L-methionineUniRule annotation
Binding sitei81 – 811S-adenosyl-L-methionineUniRule annotation
Binding sitei108 – 1081S-adenosyl-L-methionineUniRule annotation
Active sitei131 – 1311By similarity
Binding sitei131 – 1311S-adenosyl-L-methionineUniRule annotation
Binding sitei135 – 1351SubstrateUniRule annotation
Binding sitei167 – 1671SubstrateUniRule annotation

GO - Molecular functioni

  1. tRNA (guanine-N7-)-methyltransferase activity Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Biological processi

tRNA processing

Keywords - Ligandi

S-adenosyl-L-methionine

Enzyme and pathway databases

BioCyciPAMO264201:GH0M-1315-MONOMER.
UniPathwayiUPA00989.

Names & Taxonomyi

Protein namesi
Recommended name:
tRNA (guanine-N(7)-)-methyltransferaseUniRule annotation (EC:2.1.1.33UniRule annotation)
Alternative name(s):
tRNA (guanine(46)-N(7))-methyltransferaseUniRule annotation
tRNA(m7G46)-methyltransferaseUniRule annotation
Gene namesi
Name:trmBUniRule annotation
Ordered Locus Names:pc1285
OrganismiProtochlamydia amoebophila (strain UWE25)
Taxonomic identifieri264201 [NCBI]
Taxonomic lineageiBacteriaChlamydiaeChlamydialesParachlamydiaceaeCandidatus Protochlamydia
ProteomesiUP000000529: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 225225tRNA (guanine-N(7)-)-methyltransferasePRO_0000171367Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi264201.pc1285.

Structurei

3D structure databases

ProteinModelPortaliQ6MBP0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0220.
HOGENOMiHOG000034940.
KOiK03439.
OMAiIVELAMN.
OrthoDBiEOG6K6VBC.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
HAMAPiMF_01057. tRNA_methyltr_TrmB.
InterProiIPR029063. SAM-dependent_MTases-like.
IPR003358. tRNA_(Gua-N-7)_MeTrfase.
[Graphical view]
PfamiPF02390. Methyltransf_4. 1 hit.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 1 hit.
PROSITEiPS51625. SAM_MT_TRMB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6MBP0-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKPKDLKSPF KWEHRQIVIQ DRVWYVPDQH LSDIPFIFPG WTHDQTFAQD
60 70 80 90 100
KPIYLEYCSG NGAWIASKAI EQSQYNWVGI EKKFDRTRKI WSKIKKFELD
110 120 130 140 150
NLLTICGEGF HVTRDFFANE SVDAVFINFP DPWPKKRHAK HRIVQPAFVK
160 170 180 190 200
EIHRILKSDK LFTLVTDDAA YSKIMIDVIY QTGGFISLFE APYYTTSYPG
210 220
YGSSYFEELW REKGKSIHYH VFRKI
Length:225
Mass (Da):26,668
Last modified:July 5, 2004 - v1
Checksum:iFD16CA5200615259
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX908798 Genomic DNA. Translation: CAF24009.1.
RefSeqiYP_008284.1. NC_005861.1.

Genome annotation databases

EnsemblBacteriaiCAF24009; CAF24009; pc1285.
GeneIDi2780395.
KEGGipcu:pc1285.
PATRICi31997960. VBICanPro72727_1314.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX908798 Genomic DNA. Translation: CAF24009.1 .
RefSeqi YP_008284.1. NC_005861.1.

3D structure databases

ProteinModelPortali Q6MBP0.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 264201.pc1285.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAF24009 ; CAF24009 ; pc1285 .
GeneIDi 2780395.
KEGGi pcu:pc1285.
PATRICi 31997960. VBICanPro72727_1314.

Phylogenomic databases

eggNOGi COG0220.
HOGENOMi HOG000034940.
KOi K03439.
OMAi IVELAMN.
OrthoDBi EOG6K6VBC.

Enzyme and pathway databases

UniPathwayi UPA00989 .
BioCyci PAMO264201:GH0M-1315-MONOMER.

Family and domain databases

Gene3Di 3.40.50.150. 1 hit.
HAMAPi MF_01057. tRNA_methyltr_TrmB.
InterProi IPR029063. SAM-dependent_MTases-like.
IPR003358. tRNA_(Gua-N-7)_MeTrfase.
[Graphical view ]
Pfami PF02390. Methyltransf_4. 1 hit.
[Graphical view ]
SUPFAMi SSF53335. SSF53335. 1 hit.
PROSITEi PS51625. SAM_MT_TRMB. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: UWE25.

Entry informationi

Entry nameiTRMB_PARUW
AccessioniPrimary (citable) accession number: Q6MBP0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: July 5, 2004
Last modified: October 1, 2014
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3