Q6MBL3 (Q6MBL3_PARUW) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Putative lipid A-disaccharide synthase EMBL CAF24036.1

Gene names

Name:	lpxB EMBL CAF24036.1
Ordered Locus Names:	pc1312

Organism

Protochlamydia amoebophila (strain UWE25) [Complete proteome] [HAMAP]

Taxonomic identifier

264201 [NCBI]

Taxonomic lineage

Bacteria › Chlamydiae › Chlamydiales › Parachlamydiaceae › Candidatus Protochlamydia

Protein attributes

Sequence length	375 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell By similarity. SAAS SAAS003835
Catalytic activity	UDP-2,3-bis(3-hydroxytetradecanoyl)glucosamine + 2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate = UDP + 2,3-bis(3-hydroxytetradecanoyl)-D-glucosaminyl-1,6-beta-D-2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate. SAAS SAAS003835
Pathway	Glycolipid biosynthesis; lipid IV(A) biosynthesis; lipid IV(A) from (3R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] and UDP-N-acetyl-alpha-D-glucosamine: step 5/6. SAAS SAAS003835

Ontologies

Keywords
Biological process	Lipid A biosynthesis SAAS SAAS003835 Lipid synthesis
Molecular function	Glycosyltransferase SAAS SAAS003835 Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	lipid A biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	lipid-A-disaccharide synthase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q6MBL3 [UniParc]. Last modified July 5, 2004. Version 1. Checksum: EC46EA17747DA06A	FASTA	375	43,171
	10 20 30 40 50 60 MHGSRLMRAL KEQFVFSSLN GVGGPLMRLE GLEVLYPMEE FQVMGFTDVL KAFPKLYKLF 70 80 90 100 110 120 YAIRKHILKT NPSCVILIDY PGFNLRLTKS LRKVGYKGKI IQFICPTVWA HGKKRIDTMV 130 140 150 160 170 180 KHLDLLLTIY PFEAAFFSHT PLKVRYVGNP LVETVSNYPY KENWKSICGI PHNQKLLAIF 190 200 210 220 230 240 PGSRIGEIQR HLPQQLEVAQ LLIKNHPSIH FAISCSDDRL LSFIKTHIHN TSLQMGLNIH 250 260 270 280 290 300 LVPRFFSYEL MKDCHCSLAK SGTVTLELAL HQKPTVVLYT LTQLNYLLAK YWMHLNLPHY 310 320 330 340 350 360 CIVNILLERT VYPEFIGKKL DIYQIFKQIE KLFINQDHYD SVIGDCAILR QQLGDGIASS 370 LASREIQELL NAKKT

References

[1]

"Illuminating the evolutionary history of chlamydiae." Horn M., Collingro A., Schmitz-Esser S., Beier C.L., Purkhold U., Fartmann B., Brandt P., Nyakatura G.J., Droege M., Frishman D., Rattei T., Mewes H.-W., Wagner M. Science 304:728-730(2004) [PubMed: 15073324] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	BX908798 Genomic DNA. Translation: CAF24036.1.
RefSeq	YP_008311.2. NC_005861.1.
3D structure databases
ProteinModelPortal	Q6MBL3.
ModBase	Search...
Protein-protein interaction databases
STRING	Q6MBL3.
Protein family/group databases
CAZy	GT19. Glycosyltransferase Family 19.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	2781442.
GenomeReviews	Gene locus pc1312 in contig BX908798_GR.
KEGG	pcu:pc1312.
NMPDR	fig|264201.1.peg.1312.
PATRIC	31998010. VBICanPro72727_1339.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0763.
OMA	PDFNLGL.
PhylomeDB	Q6MBL3.
ProtClustDB	CLSK2797440.
Family and domain databases
InterPro	IPR003835. Glyco_trans_19. [Graphical view]
KO	K00748.
Pfam	PF02684. LpxB. 1 hit. [Graphical view]
TIGRFAMs	TIGR00215. LpxB. 1 hit.
ProtoNet	Search...

Entry information

Entry name

Q6MBL3_PARUW

Accession

Primary (citable) accession number: Q6MBL3

Entry history

Integrated into UniProtKB/TrEMBL:	July 5, 2004
Last sequence update:	July 5, 2004
Last modified:	December 14, 2011
This is version 49 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)