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Q6MAN0

- PKND_PARUW

UniProt

Q6MAN0 - PKND_PARUW

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Protein

Serine/threonine-protein kinase PknD

Gene

pknD

Organism
Protochlamydia amoebophila (strain UWE25)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Together with the serine/threonine kinase Pkn1, may play a role in the specific interactions with host proteins during intracellular growth.UniRule annotation

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei80 – 801ATPUniRule annotation
Active sitei186 – 1861Proton acceptorUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi57 – 659ATPUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. protein serine/threonine kinase activity Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciPAMO264201:GH0M-1681-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein kinase PknDUniRule annotation (EC:2.7.11.1UniRule annotation)
Gene namesi
Name:pknDUniRule annotation
Ordered Locus Names:pc1645
OrganismiProtochlamydia amoebophila (strain UWE25)
Taxonomic identifieri264201 [NCBI]
Taxonomic lineageiBacteriaChlamydiaeChlamydialesParachlamydiaceaeCandidatus Protochlamydia
ProteomesiUP000000529: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 982982Serine/threonine-protein kinase PknDPRO_0000239302Add
BLAST

Post-translational modificationi

Autophosphorylated on serine and threonine residues.UniRule annotation

Keywords - PTMi

Phosphoprotein

Interactioni

Protein-protein interaction databases

STRINGi264201.pc1645.

Structurei

3D structure databases

ProteinModelPortaliQ6MAN0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini51 – 342292Protein kinaseUniRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.UniRule annotation
Contains 1 protein kinase domain.UniRule annotation

Phylogenomic databases

eggNOGiCOG0515.
HOGENOMiHOG000115565.
KOiK08884.
OrthoDBiEOG6W45P7.

Family and domain databases

Gene3Di1.25.40.10. 2 hits.
HAMAPiMF_01957. PknD_kinase.
InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
IPR023507. Ser/Thr_kinase_PknD.
IPR011990. TPR-like_helical_dom.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6MAN0-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MPHSFPDYSF TCPFCKNNCK LSFAQCPAFC PFCGKSQKNE STGLPIQSDF
60 70 80 90 100
YQIIKSIGKG GMGEVFLAYD PCYERQIAIK KIRSDLLEHP QIKKRFLKEA
110 120 130 140 150
HMTSQLTHPA IIPIYTIRSD ADTAYYTMPF VEGDTLKQII RKTKLQEKNG
160 170 180 190 200
ETLDYLGGSI LALMRVFITI CQAVAYAHSK GVLHRDLKPE NIIIGKYGEV
210 220 230 240 250
LILDWGLAKF IDQSPEEELL ASFPESLTKQ KDITKIGKVV GTVAYMAPER
260 270 280 290 300
ALGQPATIQT DIYSLGVILY QLLTLKSPFK RGTLDEFRKN MSREEWQDPV
310 320 330 340 350
TAAPYREVPR MLASFTEKCL SLDLQNRYQS VEELIRDIEN YLEGRSEWFC
360 370 380 390 400
IANLNTKEKN DWEFQENVLI AEHVAITRMT DDAEWVSLMI SKQSFTGNTK
410 420 430 440 450
IEADVCLGEQ GHGIGFLLSV PEASAREHLI EGYCLWLGSD FSKTTKLLRS
460 470 480 490 500
NVEVVHAPDI FLKRQQTYHV RIEKVDKSIH VYINDNLQFS YIAHIPLIGT
510 520 530 540 550
HVGLLSRDAD FEISPLEIYV GNLNINVNCL AVPDAFLAHR DYNQALSEYR
560 570 580 590 600
RIAYSFPDRT EGREALFRAG LTFLEQAKTA ENKMPLLEEA LNEFEKLHGT
610 620 630 640 650
PSAPLEYLGK ALAYESINDS EEEIKCYELA YRRYPNHPIL PMLQEQIISR
660 670 680 690 700
LHEVSRMQRI TTYRFTLLTV RHLPLNKIDT HTKRLFNSLQ KHWEVLPFIE
710 720 730 740 750
YKSPSPLTTL STRFATPLAF WLAKPFILGE ILDDLIQSPP FPIEEVNNAL
760 770 780 790 800
LCLVELGSWE YAQEKLNTIQ TYLNLPQNPK WLDLKAFIAC HYQTLEDVYK
810 820 830 840 850
DFFFQIPSTN ADHLHAVLYF MDQCLDQLNT SLIYTLARQF EHAELSFEDR
860 870 880 890 900
LRLNCRRVWA YLLDKNWQDA GNLLYTYSVE TLNKDSSLLH FLYGCWLQVT
910 920 930 940 950
EGAEIANVHF AGVNPVMFPR TWTLGARFLT NNLSKDSYEK AFMWEKRQLC
960 970 980
KQLILYYHCV GNETKRIHFQ KLYQEQFIHA EL
Length:982
Mass (Da):113,378
Last modified:July 5, 2004 - v1
Checksum:iF3AAA39404B80D89
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX908798 Genomic DNA. Translation: CAF24369.1.
RefSeqiYP_008644.1. NC_005861.1.

Genome annotation databases

EnsemblBacteriaiCAF24369; CAF24369; pc1645.
GeneIDi2780931.
KEGGipcu:pc1645.
PATRICi31998702. VBICanPro72727_1680.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX908798 Genomic DNA. Translation: CAF24369.1 .
RefSeqi YP_008644.1. NC_005861.1.

3D structure databases

ProteinModelPortali Q6MAN0.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 264201.pc1645.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAF24369 ; CAF24369 ; pc1645 .
GeneIDi 2780931.
KEGGi pcu:pc1645.
PATRICi 31998702. VBICanPro72727_1680.

Phylogenomic databases

eggNOGi COG0515.
HOGENOMi HOG000115565.
KOi K08884.
OrthoDBi EOG6W45P7.

Enzyme and pathway databases

BioCyci PAMO264201:GH0M-1681-MONOMER.

Family and domain databases

Gene3Di 1.25.40.10. 2 hits.
HAMAPi MF_01957. PknD_kinase.
InterProi IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
IPR023507. Ser/Thr_kinase_PknD.
IPR011990. TPR-like_helical_dom.
[Graphical view ]
Pfami PF00069. Pkinase. 1 hit.
[Graphical view ]
SUPFAMi SSF56112. SSF56112. 1 hit.
PROSITEi PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: UWE25.

Entry informationi

Entry nameiPKND_PARUW
AccessioniPrimary (citable) accession number: Q6MAN0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 13, 2006
Last sequence update: July 5, 2004
Last modified: October 29, 2014
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3