Q6MAN0 (PKND_PARUW) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Serine/threonine-protein kinase PknD
EC=2.7.11.1

Gene names

Name:	pknD
Ordered Locus Names:	pc1645

Organism

Protochlamydia amoebophila (strain UWE25) [Complete proteome] [HAMAP]

Taxonomic identifier

264201 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Chlamydiae/Verrucomicrobia group › Chlamydiae › Chlamydiia › Chlamydiales › Parachlamydiaceae › Candidatus Protochlamydia › Candidatus Protochlamydia amoebophila

Protein attributes

Sequence length	982 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Together with the serine/threonine kinase pkn1, may play a role in the specific interactions with host proteins during intracellular growth By similarity. HAMAP-Rule MF_01957
Catalytic activity	ATP + a protein = ADP + a phosphoprotein. HAMAP-Rule MF_01957
Post-translational modification	Autophosphorylated on serine and threonine residues By similarity. HAMAP-Rule MF_01957
Sequence similarities	Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Contains 1 protein kinase domain.

Ontologies

Keywords
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Serine/threonine-protein kinase Transferase
PTM	Phosphoprotein
Technical term	Complete proteome
Gene Ontology (GO)
Molecular_function	ATP binding Inferred from electronic annotation. Source: HAMAP protein serine/threonine kinase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 982	982	Serine/threonine-protein kinase PknD HAMAP-Rule MF_01957		PRO_0000239302
Regions
	Domain	51 – 342	292	Protein kinase
	Nucleotide binding	57 – 65	9	ATP By similarity
Sites
	Active site	186	1	Proton acceptor By similarity
	Binding site	80	1	ATP By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q6MAN0 [UniParc]. Last modified July 5, 2004. Version 1. Checksum: F3AAA39404B80D89	FASTA	982	113,378
	10 20 30 40 50 60 MPHSFPDYSF TCPFCKNNCK LSFAQCPAFC PFCGKSQKNE STGLPIQSDF YQIIKSIGKG 70 80 90 100 110 120 GMGEVFLAYD PCYERQIAIK KIRSDLLEHP QIKKRFLKEA HMTSQLTHPA IIPIYTIRSD 130 140 150 160 170 180 ADTAYYTMPF VEGDTLKQII RKTKLQEKNG ETLDYLGGSI LALMRVFITI CQAVAYAHSK 190 200 210 220 230 240 GVLHRDLKPE NIIIGKYGEV LILDWGLAKF IDQSPEEELL ASFPESLTKQ KDITKIGKVV 250 260 270 280 290 300 GTVAYMAPER ALGQPATIQT DIYSLGVILY QLLTLKSPFK RGTLDEFRKN MSREEWQDPV 310 320 330 340 350 360 TAAPYREVPR MLASFTEKCL SLDLQNRYQS VEELIRDIEN YLEGRSEWFC IANLNTKEKN 370 380 390 400 410 420 DWEFQENVLI AEHVAITRMT DDAEWVSLMI SKQSFTGNTK IEADVCLGEQ GHGIGFLLSV 430 440 450 460 470 480 PEASAREHLI EGYCLWLGSD FSKTTKLLRS NVEVVHAPDI FLKRQQTYHV RIEKVDKSIH 490 500 510 520 530 540 VYINDNLQFS YIAHIPLIGT HVGLLSRDAD FEISPLEIYV GNLNINVNCL AVPDAFLAHR 550 560 570 580 590 600 DYNQALSEYR RIAYSFPDRT EGREALFRAG LTFLEQAKTA ENKMPLLEEA LNEFEKLHGT 610 620 630 640 650 660 PSAPLEYLGK ALAYESINDS EEEIKCYELA YRRYPNHPIL PMLQEQIISR LHEVSRMQRI 670 680 690 700 710 720 TTYRFTLLTV RHLPLNKIDT HTKRLFNSLQ KHWEVLPFIE YKSPSPLTTL STRFATPLAF 730 740 750 760 770 780 WLAKPFILGE ILDDLIQSPP FPIEEVNNAL LCLVELGSWE YAQEKLNTIQ TYLNLPQNPK 790 800 810 820 830 840 WLDLKAFIAC HYQTLEDVYK DFFFQIPSTN ADHLHAVLYF MDQCLDQLNT SLIYTLARQF 850 860 870 880 890 900 EHAELSFEDR LRLNCRRVWA YLLDKNWQDA GNLLYTYSVE TLNKDSSLLH FLYGCWLQVT 910 920 930 940 950 960 EGAEIANVHF AGVNPVMFPR TWTLGARFLT NNLSKDSYEK AFMWEKRQLC KQLILYYHCV 970 980 GNETKRIHFQ KLYQEQFIHA EL

References

[1]

"Illuminating the evolutionary history of chlamydiae." Horn M., Collingro A., Schmitz-Esser S., Beier C.L., Purkhold U., Fartmann B., Brandt P., Nyakatura G.J., Droege M., Frishman D., Rattei T., Mewes H.-W., Wagner M. Science 304:728-730(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: UWE25.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BX908798 Genomic DNA. Translation: CAF24369.1.
RefSeq	YP_008644.1. NC_005861.1.
3D structure databases
ProteinModelPortal	Q6MAN0.
ModBase	Search...
Protein-protein interaction databases
STRING	264201.pc1645.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	CAF24369; CAF24369; pc1645.
GeneID	2780931.
KEGG	pcu:pc1645.
PATRIC	31998702. VBICanPro72727_1680.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0515.
HOGENOM	HOG000115565.
KO	K08884.
Enzyme and pathway databases
BioCyc	PAMO264201:GH0M-1646-MONOMER.
Family and domain databases
Gene3D	1.25.40.10. 2 hits.
HAMAP	MF_01957. PknD_kinase.
InterPro	IPR011009. Kinase-like_dom. IPR000719. Prot_kinase_cat_dom. IPR017441. Protein_kinase_ATP_BS. IPR008271. Ser/Thr_kinase_AS. IPR023507. Ser/Thr_kinase_PknD. IPR011990. TPR-like_helical. [Graphical view]
Pfam	PF00069. Pkinase. 1 hit. [Graphical view]
SUPFAM	SSF56112. Kinase_like. 1 hit.
PROSITE	PS00107. PROTEIN_KINASE_ATP. 1 hit. PS50011. PROTEIN_KINASE_DOM. 1 hit. PS00108. PROTEIN_KINASE_ST. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PKND_PARUW

Accession

Primary (citable) accession number: Q6MAN0

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 13, 2006
Last sequence update:	July 5, 2004
Last modified:	May 1, 2013
This is version 63 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program