Q6M1A3 (TRUD1_METMP) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable tRNA pseudouridine synthase D 1
EC=5.4.99.27

Alternative name(s):
tRNA pseudouridine(13) synthase
tRNA pseudouridylate synthase D 1
tRNA-uridine isomerase D 1

Gene names

Name:	truD1
Ordered Locus Names:	MMP0014

Organism

Methanococcus maripaludis (strain S2 / LL) [Complete proteome] [HAMAP]

Taxonomic identifier

267377 [NCBI]

Taxonomic lineage

cellular organisms › Archaea › Euryarchaeota › Methanococci › Methanococcales › Methanococcaceae › Methanococcus › Methanococcus maripaludis

Protein attributes

Sequence length	389 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Could be responsible for synthesis of pseudouridine from uracil-13 in transfer RNAs By similarity. HAMAP-Rule MF_01082
Catalytic activity	tRNA uridine13 = tRNA pseudouridine13. HAMAP-Rule MF_01082
Sequence similarities	Belongs to the pseudouridine synthase TruD family. Contains 1 TRUD domain.

Ontologies

Keywords
Biological process	tRNA processing
Molecular function	Isomerase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	pseudouridine synthesis Inferred from electronic annotation. Source: InterPro tRNA processing Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	RNA binding Inferred from electronic annotation. Source: InterPro pseudouridine synthase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 389	389	Probable tRNA pseudouridine synthase D 1 HAMAP-Rule MF_01082		PRO_0000152544
Regions
	Domain	135 – 345	211	TRUD
Sites
	Active site	63	1	Nucleophile By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q6M1A3 [UniParc]. Last modified July 5, 2004. Version 1. Checksum: 15F89137BFB03189	FASTA	389	46,201
	10 20 30 40 50 60 MKFRQKHEDF IVNEILEYEL NDYGNYFLYK LQKNGIENLK AISYLSKNFE VPTKEIGYCG 70 80 90 100 110 120 LKDRHAITTQ YVSIPKEYGK LSLDEDNLKL EYVGTIEKPL KIGRLYGNRF EIIARAVDKD 130 140 150 160 170 180 EFLKIADNIR NLSSGAPNYY DDQRFGSVFN GKFIAKEILK GNYEEVVKIL LTSYTKSEKK 190 200 210 220 230 240 QLKDLKRFIA KNWGNWDECL EYIDKKQIRS KMFRNMVKSL TYENDFKKAF KYVDNRLKEL 250 260 270 280 290 300 FISAYQSYLW NECLKEFLKE VIPKENRIYV DYSCGTFLFY ENIEEELFDK LKEMDFPTIV 310 320 330 340 350 360 SDVEYTDPEK RIIKAILKKE RIKISDFEKL DFGKLKYTKR PIISIPEDVN TGKFKSDELN 370 380 SKKYKIDLEF SLKKGSYATI ILKRVFNIL

References

[1]

"Complete genome sequence of the genetically tractable hydrogenotrophic methanogen Methanococcus maripaludis." Hendrickson E.L., Kaul R., Zhou Y., Bovee D., Chapman P., Chung J., Conway de Macario E., Dodsworth J.A., Gillett W., Graham D.E., Hackett M., Haydock A.K., Kang A., Land M.L., Levy R., Lie T.J., Major T.A., Moore B.C. , Porat I., Palmeiri A., Rouse G., Saenphimmachak C., Soell D., Van Dien S., Wang T., Whitman W.B., Xia Q., Zhang Y., Larimer F.W., Olson M.V., Leigh J.A. J. Bacteriol. 186:6956-6969(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: S2 / LL.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BX950229 Genomic DNA. Translation: CAF29570.1.
RefSeq	NP_987134.1. NC_005791.1.
3D structure databases
ProteinModelPortal	Q6M1A3.
ModBase	Search...
Protein-protein interaction databases
STRING	267377.MMP0014.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	CAF29570; CAF29570; MMP0014.
GeneID	2762446.
KEGG	mmp:MMP0014.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0585.
HOGENOM	HOG000254431.
KO	K06176.
OMA	AYQSYLW.
ProtClustDB	PRK00984.
Enzyme and pathway databases
BioCyc	MMAR267377:GJ77-20-MONOMER.
Family and domain databases
HAMAP	MF_01082. TruD. Divergent sequence.
InterPro	IPR020103. PsdUridine_synth_cat_dom. IPR001656. PsdUridine_synth_TruD. IPR020119. PsdUridine_synth_TruD_CS. IPR011760. PsdUridine_synth_TruD_insert. [Graphical view]
PANTHER	PTHR13326. PTHR13326. 1 hit.
Pfam	PF01142. TruD. 1 hit. [Graphical view]
SUPFAM	SSF55120. PsdUridine_synth_cat_dom. 1 hit.
TIGRFAMs	TIGR00094. tRNA_TruD_broad. 1 hit.
PROSITE	PS50984. TRUD. 1 hit. PS01268. UPF0024. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

TRUD1_METMP

Accession

Primary (citable) accession number: Q6M1A3

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 26, 2005
Last sequence update:	July 5, 2004
Last modified:	May 1, 2013
This is version 47 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program