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Protein

DNA polymerase II large subunit

Gene

polC

Organism
Methanococcus maripaludis (strain S2 / LL)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Possesses two activities: a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3'- to 5'-direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase (By similarity).By similarity

Catalytic activityi

Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).UniRule annotation
Degradation of single-stranded DNA. It acts progressively in a 3'- to 5'-direction, releasing nucleoside 5'-phosphates.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

DNA-directed DNA polymerase, Exonuclease, Hydrolase, Nuclease, Nucleotidyltransferase, Transferase

Keywords - Biological processi

DNA replication

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
DNA polymerase II large subunitUniRule annotation (EC:2.7.7.7UniRule annotation)
Short name:
Pol IIUniRule annotation
Gene namesi
Name:polCUniRule annotation
Ordered Locus Names:MMP0026
OrganismiMethanococcus maripaludis (strain S2 / LL)
Taxonomic identifieri267377 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanococciMethanococcalesMethanococcaceaeMethanococcus
Proteomesi
  • UP000000590 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002946861 – 1131DNA polymerase II large subunitAdd BLAST1131

Interactioni

Subunit structurei

Heterodimer of a large subunit and a small subunit.UniRule annotation

Protein-protein interaction databases

STRINGi267377.MMP0026.

Family & Domainsi

Sequence similaritiesi

Belongs to the archaeal DNA polymerase II family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG04447. Archaea.
COG1933. LUCA.
HOGENOMiHOG000286435.
KOiK02322.
OMAiRNCDGDE.

Family and domain databases

HAMAPiMF_00324. DNApol_II_L_arch. 1 hit.
InterProiIPR004475. PolC_DP2.
IPR016033. PolC_DP2_N.
[Graphical view]
PfamiPF03833. PolC_DP2. 1 hit.
[Graphical view]
PIRSFiPIRSF016275. PolC_DP2. 1 hit.
TIGRFAMsiTIGR00354. polC. 1 hit.

Sequencei

Sequence statusi: Complete.

Q6M191-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLHVSASKGM TEYFKNILDD VSNLYNLAEE CRKNGYDVTD HVEIPLAKDM
60 70 80 90 100
ADRVEGIVGP KNVAERIREL VSEFGKEPAA LEIAKEIVEG KFGEFGREVG
110 120 130 140 150
AEQAVRTALA VITEGIVAAP LEGIAYVKIK KNSDNSEYLA IYFAGPIRSA
160 170 180 190 200
GGTAQALAVL VGDYVRKNMG LDRFKPTEDE VERYGEEVDL YQSEVTTFQY
210 220 230 240 250
QPKAEEIRVA VRNISVEITG EATDDVEVSG HRDLPRVETN QIRGGALLAL
260 270 280 290 300
VEGVLLKAPK ILRHVDKLNI EGWNWLKELK SKKEEVIEEL EEENDEYNYE
310 320 330 340 350
DEEDLSQYED YEVEAVTKFI GEVIAGRPVF SHPSKKGGFR LRYGRSRNTG
360 370 380 390 400
FATDGFHPAI MYLVDDFMAV GTQLKTERPG KATCVVPVDS IEGPIVKLND
410 420 430 440 450
GSVLKIDTVE KAKQYTDEVQ EILFLGDILV NYGDFLENNH TVLPSSWCTE
460 470 480 490 500
WYEKILKSQN LEYTEEFIKN PGQKEAVNYA KITKTPLHPK YTYFWHDISK
510 520 530 540 550
ENISTLRSWV IGGKYNPSND SWELNYDPED EEISNAKRYL ELIGCPHIVM
560 570 580 590 600
EEKVEIFEYY PFLYSLGYDF DEKRDMIDNI DEKLQNTKNN MHFINTIAPF
610 620 630 640 650
EIRRNAYIYV GARMGRPEKA AARKMKPPVN GLFPIGNAGA LVRLINKAVD
660 670 680 690 700
EGKTDEIEIA NVKCSCGKVS LYRTCPFCGN SVEPTGPSRI KLPIKDYWYK
710 720 730 740 750
TLENLKINKP GDVKCIKGMT SKDKIIEPLE KAILRAKNNI YVFKDGTTRF
760 770 780 790 800
DCTDVPVTHF KPVEIHVPIE KLKSLGYLKD IHGNPLENED QVLELKVQDV
810 820 830 840 850
IVPESCMDYF LNVSGFIDDL LEKYYKKDRF YNVNTREDLV GHLIIGMAPH
860 870 880 890 900
TSAGMVGRII GYSNANVGYA HPYFHASKRR NCDGDEDAFF LLLDAFMNFS
910 920 930 940 950
KRFLPDKRGG QMDAPLVLTT ILDPKEVDGE VHNMDSMWEY PLEFYEKSLE
960 970 980 990 1000
GIAPKEIKKM METIEDRLDK DSQYEGIGYT HETSKIDEGP PICAYKTLGS
1010 1020 1030 1040 1050
MMEKTSAQLA VAKKIRATDE RDVAEKVIQS HFVPDLIGNL RAFSRQGVRC
1060 1070 1080 1090 1100
KCGAKYRRMP LKGVCRKCGS RLILTVSKGA VEKYMNVSQT MAEKYDASDY
1110 1120 1130
IKQRLEIIKS GIDSLFVNDK RKQVKIEDFF K
Length:1,131
Mass (Da):128,381
Last modified:July 5, 2004 - v1
Checksum:i3A000B7DAC5961DE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX950229 Genomic DNA. Translation: CAF29582.1.
RefSeqiWP_011169970.1. NC_005791.1.

Genome annotation databases

EnsemblBacteriaiCAF29582; CAF29582; MMP0026.
GeneIDi2762226.
KEGGimmp:MMP0026.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX950229 Genomic DNA. Translation: CAF29582.1.
RefSeqiWP_011169970.1. NC_005791.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi267377.MMP0026.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAF29582; CAF29582; MMP0026.
GeneIDi2762226.
KEGGimmp:MMP0026.

Phylogenomic databases

eggNOGiarCOG04447. Archaea.
COG1933. LUCA.
HOGENOMiHOG000286435.
KOiK02322.
OMAiRNCDGDE.

Family and domain databases

HAMAPiMF_00324. DNApol_II_L_arch. 1 hit.
InterProiIPR004475. PolC_DP2.
IPR016033. PolC_DP2_N.
[Graphical view]
PfamiPF03833. PolC_DP2. 1 hit.
[Graphical view]
PIRSFiPIRSF016275. PolC_DP2. 1 hit.
TIGRFAMsiTIGR00354. polC. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiDP2L_METMP
AccessioniPrimary (citable) accession number: Q6M191
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 10, 2007
Last sequence update: July 5, 2004
Last modified: November 2, 2016
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Multifunctional enzyme, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.