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Protein

Protein-L-isoaspartate O-methyltransferase

Gene

pcm

Organism
Methanococcus maripaludis (strain S2 / LL)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and/or degradation of damaged proteins.UniRule annotation

Catalytic activityi

S-adenosyl-L-methionine + protein L-isoaspartate = S-adenosyl-L-homocysteine + protein L-isoaspartate alpha-methyl ester.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei60UniRule annotation1

GO - Molecular functioni

Keywordsi

Molecular functionMethyltransferase, Transferase
LigandS-adenosyl-L-methionine

Enzyme and pathway databases

BioCyciMMAR267377:G1G3S-115-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Protein-L-isoaspartate O-methyltransferaseUniRule annotation (EC:2.1.1.77UniRule annotation)
Alternative name(s):
L-isoaspartyl protein carboxyl methyltransferaseUniRule annotation
Protein L-isoaspartyl methyltransferaseUniRule annotation
Protein-beta-aspartate methyltransferaseUniRule annotation
Short name:
PIMTUniRule annotation
Gene namesi
Name:pcmUniRule annotation
Ordered Locus Names:MMP0102
OrganismiMethanococcus maripaludis (strain S2 / LL)
Taxonomic identifieri267377 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanococciMethanococcalesMethanococcaceaeMethanococcus
Proteomesi

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001119191 – 212Protein-L-isoaspartate O-methyltransferaseAdd BLAST212

Proteomic databases

PRIDEiQ6M116

Interactioni

Protein-protein interaction databases

STRINGi267377.MMP0102

Structurei

3D structure databases

ProteinModelPortaliQ6M116
SMRiQ6M116
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG00976 Archaea
COG2518 LUCA
HOGENOMiHOG000257189
KOiK00573
OMAiPYTVAFQ
OrthoDBiPOG093Z09AU

Family and domain databases

HAMAPiMF_00090 PIMT, 1 hit
InterProiView protein in InterPro
IPR000682 PCMT
IPR029063 SAM-dependent_MTases
PANTHERiPTHR11579 PTHR11579, 1 hit
SUPFAMiSSF53335 SSF53335, 1 hit
TIGRFAMsiTIGR00080 pimt, 1 hit
PROSITEiView protein in PROSITE
PS01279 PCMT, 1 hit

Sequencei

Sequence statusi: Complete.

Q6M116-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPLNEIIPVI ENLISRGYIK KQSVIDAILS VPRHKFISKS MESYAYVDSP
60 70 80 90 100
LEIGYGQTIS AIHMVGIMCE ELDLDEGQNV LEVGTGSGYH AAVVSKIVGE
110 120 130 140 150
SGKVTTIERI PELFENSKKT LSELGYNNVE VVLGDGTKGY LENAPYDRIY
160 170 180 190 200
VTASGPDVPK ALFKQLNDGG ILLAPVGAHF QTLMRYTKIN GSISEEKLLE
210
VAFVPLIGEN GF
Length:212
Mass (Da):23,108
Last modified:July 5, 2004 - v1
Checksum:iDE8C3CB5A70DBA28
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX950229 Genomic DNA Translation: CAF29658.1
RefSeqiWP_011170046.1, NC_005791.1

Genome annotation databases

EnsemblBacteriaiCAF29658; CAF29658; MMP0102
GeneIDi2762127
KEGGimmp:MMP0102
PATRICifig|267377.15.peg.103

Entry informationi

Entry nameiPIMT_METMP
AccessioniPrimary (citable) accession number: Q6M116
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 9, 2004
Last sequence update: July 5, 2004
Last modified: May 23, 2018
This is version 79 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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