Reviewed, UniProtKB/Swiss-Prot Q6M0X3 (APT1_METMP)

Names and origin

Protein names

Recommended name:
    Adenine phosphoribosyltransferase 1
      Short name=APRT 1
    EC=2.4.2.7

Gene names

Name:	apt1
Ordered Locus Names:	MMP0145

Organism

Methanococcus maripaludis [Complete proteome] [HAMAP]

Taxonomic identifier

39152 [NCBI]

Taxonomic lineage

Archaea › Euryarchaeota › Methanococci › Methanococcales › Methanococcaceae › Methanococcus

Protein attributes

Sequence length	185 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. HAMAP MF_00004
Catalytic activity	AMP + diphosphate = adenine + 5-phospho-alpha-D-ribose 1-diphosphate. HAMAP MF_00004
Pathway	Purine metabolism; AMP biosynthesis via salvage pathway; AMP from adenine: step 1/1. HAMAP MF_00004
Subunit structure	Homodimer By similarity.
Subcellular location	Cytoplasm. HAMAP MF_00004
Sequence similarities	Belongs to the purine/pyrimidine phosphoribosyltransferase family.

Ontologies

Keywords
Biological process	Purine salvage
Cellular component	Cytoplasm
Molecular function	Glycosyltransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	adenine salvage Inferred from electronic annotation. Source: HAMAP purine ribonucleoside salvage Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	adenine phosphoribosyltransferase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 185	185	Adenine phosphoribosyltransferase 1 HAMAP MF_00004		PRO_0000149498

Sequences

	Sequence		Length	Mass (Da)
	Q6M0X3-1 [UniParc]. Last modified July 5, 2004. Version 1. Checksum: 4E99371CB6FE0EC2	FASTA	185	20,402
	10 20 30 40 50 60 MSKLLEESLK TCPIVKRGEY HYFIHPISDG VPLVEPELLR DVSTRVIKMI DTDVDKIVTA 70 80 90 100 110 120 EAMGIPIVTA VSIATDIPYV IMRKREYLLE GEIPVHQETG YSKGELYLNG INKGDKVIIL 130 140 150 160 170 180 DDVISTGGTL VAIINALKRA GADIKDVLCI IDRGNGQNIV EEKTGYKVKT IVKIEVVDGK VNILE

References

[1]

"Complete genome sequence of the genetically tractable hydrogenotrophic methanogen Methanococcus maripaludis." Hendrickson E.L., Kaul R., Zhou Y., Bovee D., Chapman P., Chung J., Conway de Macario E., Dodsworth J.A., Gillett W., Graham D.E., Hackett M., Haydock A.K., Kang A., Land M.L., Levy R., Lie T.J., Major T.A., Moore B.C. , Porat I., Palmeiri A., Rouse G., Saenphimmachak C., Soell D., Van Dien S., Wang T., Whitman W.B., Xia Q., Zhang Y., Larimer F.W., Olson M.V., Leigh J.A. J. Bacteriol. 186:6956-6969(2004) [PubMed: 15466049] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: S2 / LL.

Cross-references

Sequence databases
EMBLGenBankDDBJ	BX950229 Genomic DNA. Translation: CAF29701.1.
RefSeq	NP_987265.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	2762740.
GenomeReviews	Gene locus MMP0145 in contig BX950229_GR.
KEGG	mmp:MMP0145.
NMPDR	fig|267377.1.peg.145.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q6M0X3.
OMA	FIHPISD.
Enzyme and pathway databases
BioCyc	MMAR267377:MMP0145-MON.
BRENDA	2.4.2.7. 20956.
Family and domain databases
HAMAP	MF_00004. [Tree]
InterPro	IPR005764. Ade_phspho_trans. IPR002375. Pr/py_Pribosyl_transf_CS. IPR000836. PRibTrfase. [Graphical view]
Pfam	PF00156. Pribosyltran. 1 hit. [Graphical view]
PROSITE	PS00103. PUR_PYR_PR_TRANSFER. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

APT1_METMP

Accession

Primary (citable) accession number: Q6M0X3

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 15, 2005
Last sequence update:	July 5, 2004
Last modified:	November 3, 2009
This is version 34 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)