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Q6M0T5 (Q6M0T5_METMP) Unreviewed, UniProtKB/TrEMBL

Last modified November 16, 2011. Version 51. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
3,4-dihydroxy-2-butanone 4-phosphate synthase HAMAP MF_00180
Short name=DHBP synthase HAMAP MF_00180
EC=4.1.99.12 HAMAP MF_00180
Gene names
Name:ribB HAMAP MF_00180 EMBL CAF29739.1
Ordered Locus Names:MMP0183
OrganismMethanococcus maripaludis (strain S2 / LL) [Complete proteome] [HAMAP]
Taxonomic identifier267377 [NCBI]
Taxonomic lineageArchaea › Euryarchaeota › Methanococci › Methanococcales › Methanococcaceae › Methanococcus

Protein attributes

Sequence length247 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate By similarity. HAMAP MF_00180

Catalytic activity

D-ribulose 5-phosphate = formate + L-3,4-dihydroxybutan-2-one 4-phosphate. HAMAP MF_00180

Cofactor

Binds 2 divalent metal cations per subunit. Magnesium or manganese By similarity. HAMAP MF_00180

Pathway

Cofactor biosynthesis; riboflavin biosynthesis; 2-hydroxy-3-oxobutyl phosphate from D-ribulose 5-phosphate: step 1/1. HAMAP MF_00180 RuleBase RU003843

Subunit structure

Homodimer By similarity. HAMAP MF_00180

Sequence similarities

Belongs to the DHBP synthase family. HAMAP MF_00180 RuleBase RU003843

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Region45 – 462Substrate binding By similarity HAMAP MF_00180
Region181 – 1855Substrate binding By similarity HAMAP MF_00180

Sites

Metal binding461Magnesium or manganese 1 By similarity HAMAP MF_00180
Metal binding461Magnesium or manganese 2 By similarity HAMAP MF_00180
Metal binding1841Magnesium or manganese 2 By similarity HAMAP MF_00180
Binding site501Substrate By similarity HAMAP MF_00180
Binding site2051Substrate By similarity HAMAP MF_00180
Site1671Essential for catalytic activity By similarity HAMAP MF_00180
Site2051Essential for catalytic activity By similarity HAMAP MF_00180

Sequences

Sequence LengthMass (Da)Tools
Q6M0T5 [UniParc].

Last modified July 5, 2004. Version 1.
Checksum: E2F611DE8EBDB6AC

FASTA24727,803
        10         20         30         40         50         60 
MTTDSKNARN SEVKIQGDEK ISNVEKAIDA LKSGKMVLLY DSDDREGETD MVVASEFITP 

        70         80         90        100        110        120 
EYIREMRKNA GGLICTCLHS DFCDKLGIPF MVDILDVASE KYPVLKELYP NDIPYDEKST 

       130        140        150        160        170        180 
FALYANHRTT FTGITDNDRA LTVKKITELC SEERFKDFGK EFRCPGHVAF LRATEGLVKN 

       190        200        210        220        230        240 
RQGHTEMTVA LAEMAGLTPI TTICEMMGDN GKAMSKDLVK KYAEENGLVT INGQELIEYY 


LKEFSKE

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References

[1]"Complete genome sequence of the genetically tractable hydrogenotrophic methanogen Methanococcus maripaludis."
Hendrickson E.L., Kaul R., Zhou Y., Bovee D., Chapman P., Chung J., Conway de Macario E., Dodsworth J.A., Gillett W., Graham D.E., Hackett M., Haydock A.K., Kang A., Land M.L., Levy R., Lie T.J., Major T.A., Moore B.C. expand/collapse author list , Porat I., Palmeiri A., Rouse G., Saenphimmachak C., Soell D., Van Dien S., Wang T., Whitman W.B., Xia Q., Zhang Y., Larimer F.W., Olson M.V., Leigh J.A.
J. Bacteriol. 186:6956-6969(2004) [PubMed: 15466049] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: S2 / LL.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		BX950229 Genomic DNA. Translation: CAF29739.1.
RefSeqNP_987303.1. NC_005791.1.

3D structure databases

HSSPHSSP built from PDB template 1K4P based on UniProtKB Q8TG90.
ProteinModelPortalQ6M0T5.
SMRQ6M0T5. Positions 22-240.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID2761081.
GenomeReviewsGene locus MMP0183 in contig BX950229_GR.
KEGGmmp:MMP0183.
NMPDRfig|267377.1.peg.183.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG735778.
OMAGDMIFAA.
ProtClustDBCLSK876051.

Family and domain databases

HAMAPMF_00180. RibB.
[Tree]
InterProIPR017945. DHBP_synth_RibB-like_a/b_dom.
IPR000422. DHBP_synthase_RibB.
[Graphical view]
Gene3DG3DSA:3.90.870.10. DHBP_synth_RibB-like_a/b_dom. 1 hit.
KOK02858.
PfamPF00926. DHBP_synthase. 1 hit.
[Graphical view]
SUPFAMSSF55821. DHBP_synth_RibB-like_a/b_dom. 1 hit.
TIGRFAMsTIGR00506. RibB. 1 hit.
ProtoNetSearch...

Entry information

Entry nameQ6M0T5_METMP
AccessionPrimary (citable) accession number: Q6M0T5
Entry history
Integrated into UniProtKB/TrEMBL: July 5, 2004
Last sequence update: July 5, 2004
Last modified: November 16, 2011
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info