Q6M0Q5 (Q6M0Q5_METMP) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Non-canonical purine NTP pyrophosphatase HAMAP MF_01405
EC=3.6.1.19 HAMAP MF_01405

Alternative name(s):
Non-standard purine NTP pyrophosphatase HAMAP MF_01405
Nucleoside-triphosphate diphosphatase HAMAP MF_01405
Nucleoside-triphosphate pyrophosphatase HAMAP MF_01405

Gene names

Ordered Locus Names:

MMP0214

Organism

Methanococcus maripaludis (strain S2 / LL) [Complete proteome] [HAMAP]

Taxonomic identifier

267377 [NCBI]

Taxonomic lineage

Archaea › Euryarchaeota › Methanococci › Methanococcales › Methanococcaceae › Methanococcus

Protein attributes

Sequence length	183 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP/dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions By similarity. HAMAP MF_01405
Catalytic activity	A nucleoside triphosphate + H2O = a nucleotide + diphosphate. HAMAP MF_01405
Cofactor	Binds 1 divalent metal cation ion per subunit; can use either magnesium or manganese By similarity. HAMAP MF_01405
Subunit structure	Homodimer By similarity. HAMAP MF_01405
Sequence similarities	Belongs to the HAM1 NTPase family. HAMAP MF_01405 RuleBase RU003781

Ontologies

Keywords
Biological process	Nucleotide metabolism HAMAP MF_01405
Ligand	Magnesium HAMAP MF_01405 Manganese HAMAP MF_01405 Metal-binding HAMAP MF_01405 Nucleotide-binding HAMAP MF_01405
Molecular function	Hydrolase HAMAP MF_01405 RuleBase RU003781 EMBL CAF29770.1
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	purine nucleotide metabolic process Inferred from electronic annotation. Source: HAMAP
Molecular function	nucleoside-triphosphatase activity Inferred from electronic annotation. Source: EC nucleoside-triphosphate diphosphatase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Regions
	Region	7 – 12	6	Substrate binding By similarity HAMAP MF_01405
	Region	64 – 65	2	Substrate binding By similarity HAMAP MF_01405
Sites
	Metal binding	36	1	Magnesium or manganese By similarity HAMAP MF_01405
	Metal binding	64	1	Magnesium or manganese By similarity HAMAP MF_01405
	Binding site	143	1	Substrate By similarity HAMAP MF_01405
	Binding site	163	1	Substrate By similarity HAMAP MF_01405
	Binding site	169	1	Substrate By similarity HAMAP MF_01405

Sequences

	Sequence		Length	Mass (Da)
	Q6M0Q5 [UniParc]. Last modified July 5, 2004. Version 1. Checksum: 734978AF46A79AA1	FASTA	183	20,952
	10 20 30 40 50 60 MKIYFATGNQ NKVDEAEIIL KEANCEIEQI EIPYAEVQGR LEEVSAFGVL EVFEKFNRPV 70 80 90 100 110 120 IVEDSGFFIE KLNDFPGTYS RFVQETIGNE GILKLLENET NRNAYFKTVI GYYDGDNIKL 130 140 150 160 170 180 FTGIVKGTIS TEIKDGGFGF AYDSIFIPEG KTKTFAEMTT EEKSEISHRK RAFYELKNYL ENL

References

[1]

"Complete genome sequence of the genetically tractable hydrogenotrophic methanogen Methanococcus maripaludis." Hendrickson E.L., Kaul R., Zhou Y., Bovee D., Chapman P., Chung J., Conway de Macario E., Dodsworth J.A., Gillett W., Graham D.E., Hackett M., Haydock A.K., Kang A., Land M.L., Levy R., Lie T.J., Major T.A., Moore B.C. , Porat I., Palmeiri A., Rouse G., Saenphimmachak C., Soell D., Van Dien S., Wang T., Whitman W.B., Xia Q., Zhang Y., Larimer F.W., Olson M.V., Leigh J.A. J. Bacteriol. 186:6956-6969(2004) [PubMed: 15466049] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: S2 / LL.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BX950229 Genomic DNA. Translation: CAF29770.1.
RefSeq	NP_987334.1. NC_005791.1.
3D structure databases
HSSP	HSSP built from PDB template 1B78 based on UniProtKB Q57679.
ProteinModelPortal	Q6M0Q5.
SMR	Q6M0Q5. Positions 2-180.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	2761131.
GenomeReviews	Gene locus MMP0214 in contig BX950229_GR.
KEGG	mmp:MMP0214.
NMPDR	fig|267377.1.peg.214.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG697237.
OMA	VEDSGFF.
ProtClustDB	PRK14821.
Family and domain databases
HAMAP	MF_01405. Non_canon_purine_NTPase. [Tree]
InterPro	IPR002637. Ham1p-like. IPR020922. Nucleoside-triphosphatase. [Graphical view]
KO	K02428.
PANTHER	PTHR11067. Ham1p_like. 1 hit.
Pfam	PF01725. Ham1p_like. 1 hit. [Graphical view]
TIGRFAMs	TIGR00042. TIGR00042. 1 hit.
ProtoNet	Search...

Entry information

Entry name

Q6M0Q5_METMP

Accession

Primary (citable) accession number: Q6M0Q5

Entry history

Integrated into UniProtKB/TrEMBL:	July 5, 2004
Last sequence update:	July 5, 2004
Last modified:	December 14, 2011
This is version 48 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)