Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q6M0G7

- AGOG_METMP

UniProt

Q6M0G7 - AGOG_METMP

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

N-glycosylase/DNA lyase

Gene

MMP0304

Organism
Methanococcus maripaludis (strain S2 / LL)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

DNA repair enzyme that is part of the base excision repair (BER) pathway; protects from oxidative damage by removing the major product of DNA oxidation, 8-oxoguanine (GO), from single- and double-stranded DNA substrates.UniRule annotation

Catalytic activityi

The C-O-P bond 3' to the apurinic or apyrimidinic site in DNA is broken by a beta-elimination reaction, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei32 – 3218-oxoguanineUniRule annotation
Binding sitei60 – 6018-oxoguanine; via carbonyl oxygenUniRule annotation
Binding sitei71 – 7118-oxoguanineUniRule annotation
Active sitei153 – 1531Schiff-base intermediate with DNAUniRule annotation
Binding sitei157 – 15718-oxoguanineUniRule annotation
Binding sitei183 – 18318-oxoguanine; via carbonyl oxygenUniRule annotation
Active sitei185 – 1851UniRule annotation
Binding sitei219 – 21918-oxoguanineUniRule annotation
Binding sitei223 – 22318-oxoguanineUniRule annotation

GO - Molecular functioni

  1. DNA-(apurinic or apyrimidinic site) lyase activity Source: UniProtKB-HAMAP
  2. oxidized base lesion DNA N-glycosylase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. base-excision repair Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Lyase

Keywords - Biological processi

DNA damage, DNA excision, DNA repair

Enzyme and pathway databases

BioCyciMMAR267377:GJ77-326-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
N-glycosylase/DNA lyaseUniRule annotation
Alternative name(s):
8-oxoguanine DNA glycosylaseUniRule annotation (EC:3.2.2.-UniRule annotation)
AGOGUniRule annotation
DNA-(apurinic or apyrimidinic site) lyaseUniRule annotation (EC:4.2.99.18UniRule annotation)
Short name:
AP lyaseUniRule annotation
Gene namesi
Ordered Locus Names:MMP0304
OrganismiMethanococcus maripaludis (strain S2 / LL)
Taxonomic identifieri267377 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanococciMethanococcalesMethanococcaceaeMethanococcus
ProteomesiUP000000590: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 252252N-glycosylase/DNA lyasePRO_0000185109Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi267377.MMP0304.

Structurei

3D structure databases

ProteinModelPortaliQ6M0G7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni129 – 19365Helix-hairpin-helixAdd
BLAST

Domaini

Contains two alpha-helical subdomains, with the 8-oxoguanine binding site located in a cleft at their interface. Contains a helix-hairpin-helix (HhH) structural motif and a Gly/Pro-rich sequence followed by a conserved Asp (HhH-GPD motif).

Sequence similaritiesi

Belongs to the archaeal N-glycosylase/DNA lyase (AGOG) family.UniRule annotation

Phylogenomic databases

eggNOGiCOG4047.
HOGENOMiHOG000254352.
KOiK01741.
OMAiVKMFGYA.

Family and domain databases

Gene3Di1.10.1670.10. 1 hit.
1.10.340.30. 1 hit.
HAMAPiMF_01168. AGOG.
InterProiIPR011257. DNA_glycosylase.
IPR023170. HTH_base_excis_C.
IPR015254. N-Glyclase/DNA_lyase-like_arc.
IPR016544. N-Glyclase/DNA_lyase_arc.
[Graphical view]
PfamiPF09171. DUF1886. 1 hit.
[Graphical view]
PIRSFiPIRSF008955. AGOG. 1 hit.
SUPFAMiSSF48150. SSF48150. 1 hit.

Sequencei

Sequence statusi: Complete.

Q6M0G7 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MRNLEKINEL LEIFGHFDVN FAKTMEEKID TQYFVLENLK NSMNNDEMFI
60 70 80 90 100
KLVILNSIVS YQLCTTGELW WEEFSKYWSK HDANNENLGE SYVNFLENSK
110 120 130 140 150
GNKRLLNVKI KRIERITPFL ENLNLLDFKT YYSDMEKLLE NLSKYLNSKK
160 170 180 190 200
NSKTVVFAVK MFGYASRIVF NEFFPYPMNI EIPKDSRIEK YTLKFTDENP
210 220 230 240 250
IKFWNEVSKT AKIPPLHIDS IIWPVLGRNF DFKSCENKLD ENFRYLLKLT

EL
Length:252
Mass (Da):30,106
Last modified:July 5, 2004 - v1
Checksum:i400E65728A8E63E9
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BX950229 Genomic DNA. Translation: CAF29860.1.
RefSeqiNP_987424.1. NC_005791.1.

Genome annotation databases

EnsemblBacteriaiCAF29860; CAF29860; MMP0304.
GeneIDi2761855.
KEGGimmp:MMP0304.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BX950229 Genomic DNA. Translation: CAF29860.1 .
RefSeqi NP_987424.1. NC_005791.1.

3D structure databases

ProteinModelPortali Q6M0G7.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 267377.MMP0304.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAF29860 ; CAF29860 ; MMP0304 .
GeneIDi 2761855.
KEGGi mmp:MMP0304.

Phylogenomic databases

eggNOGi COG4047.
HOGENOMi HOG000254352.
KOi K01741.
OMAi VKMFGYA.

Enzyme and pathway databases

BioCyci MMAR267377:GJ77-326-MONOMER.

Family and domain databases

Gene3Di 1.10.1670.10. 1 hit.
1.10.340.30. 1 hit.
HAMAPi MF_01168. AGOG.
InterProi IPR011257. DNA_glycosylase.
IPR023170. HTH_base_excis_C.
IPR015254. N-Glyclase/DNA_lyase-like_arc.
IPR016544. N-Glyclase/DNA_lyase_arc.
[Graphical view ]
Pfami PF09171. DUF1886. 1 hit.
[Graphical view ]
PIRSFi PIRSF008955. AGOG. 1 hit.
SUPFAMi SSF48150. SSF48150. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: S2 / LL.

Entry informationi

Entry nameiAGOG_METMP
AccessioniPrimary (citable) accession number: Q6M0G7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 10, 2006
Last sequence update: July 5, 2004
Last modified: October 29, 2014
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3