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Reviewed, UniProtKB/Swiss-Prot Q6M0E6 (G3P_METMP)

Last modified November 3, 2009. Version 39. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Glyceraldehyde-3-phosphate dehydrogenase
      Short name=GAPDH
    EC=1.2.1.59
Alternative name(s):
    NAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase
Gene names
Name: gap
Ordered Locus Names: MMP0325
OrganismMethanococcus maripaludis [Complete proteome] [HAMAP]
Taxonomic identifier39152 [NCBI]
Taxonomic lineageArchaeaEuryarchaeotaMethanococciMethanococcalesMethanococcaceaeMethanococcus

Protein attributes

Sequence length340 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceInferred from homology.

General annotation (Comments)

Catalytic activity

D-glyceraldehyde 3-phosphate + phosphate + NAD(P)+ = 3-phospho-D-glyceroyl phosphate + NAD(P)H. HAMAP MF_00559

Pathway

Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 1/5. HAMAP MF_00559

Subunit structure

Homotetramer By similarity.

Subcellular location

Cytoplasm By similarity.

Sequence similarities

Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 340340Glyceraldehyde-3-phosphate dehydrogenase HAMAP MF_00559
PRO_0000232389

Regions

Nucleotide binding11 – 122NAD By similarity
Region140 – 1423Glyceraldehyde 3-phosphate binding By similarity
Region195 – 1962Glyceraldehyde 3-phosphate binding By similarity

Sites

Active site1411Nucleophile By similarity
Binding site1111NAD; via amide nitrogen By similarity
Binding site1691NAD By similarity
Binding site3031NAD; via carbonyl oxygen By similarity

Sequences

Sequence LengthMass (Da)Tools
Q6M0E6-1 [UniParc].

Last modified July 5, 2004. Version 1.
Checksum: 4300AFA62BC6AD0B

FASTA34037,270
        10         20         30         40         50         60 
MANVLINGYG SIGKRVADAV AKQDDMKVIG VTKTKPDFEA KMAVEKGYKL FAAIPERKHL 

        70         80         90        100        110        120 
FEEAGIPVEG TLDDIIEDAD IVVDGAPKKI GKANLENVYK KHGVKAIIQG GEKAGDAQDS 

       130        140        150        160        170        180 
FNSLWSYDRC YGKDYIRLVS CNTTGLCRSM YAINSVADIL KARIVLIRRA ADPNDIKTGP 

       190        200        210        220        230        240 
VNAIVPNPVT VPSHHGPDVV SVIPELDGKI MTSAVIVPTT LMHMHSIMVE TSGTNRDEII 

       250        260        270        280        290        300 
DALAKTPRIL TVKASEGFDS TAKIIEYARD LGRSRYDLNE IAVWEESVNV VDNEVYMMQA 

       310        320        330        340 
IHQESDVIPE NVDCIRAMLE MESDNLKSIE KTNKALGLIK 

« Hide

References

Cross-references

Sequence databases

BX950229 Genomic DNA. Translation: CAF29881.1.
RefSeqNP_987445.1.

3D structure databases

HSSPHSSP built from PDB template 1B7G based on UniProtKB P39460.
ModBaseSearch...

Genome annotation databases

GeneID2761030.
GenomeReviewsGene locus MMP0325 in contig BX950229_GR.
KEGGmmp:MMP0325.
NMPDRfig|267377.1.peg.325.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMQ6M0E6.
OMAAIFQGGE.

Enzyme and pathway databases

BioCycMMAR267377:MMP0325-MON.
BRENDA1.2.1.59. 20956.

Family and domain databases

HAMAPMF_00559.
[Tree]
InterProIPR000173. GlycerAld_3-P_DH.
IPR006436. Glyceraldehyde-3-P_DH_2_arc.
[Graphical view]
PfamPF02800. Gp_dh_C. 1 hit.
PF00044. Gp_dh_N. 1 hit.
[Graphical view]
PIRSFPIRSF000149. GAP_DH. 1 hit.
ProDomPD007761. GAPDH_like. 1 hit.
[Graphical view] [Entries sharing at least one domain]
TIGRFAMsTIGR01546. GAPDH-II_archae. 1 hit.
PROSITEPS00071. GAPDH. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameG3P_METMP
AccessionPrimary (citable) accession number: Q6M0E6
Entry history
Integrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: July 5, 2004
Last modified: November 3, 2009
This is version 39 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents