Q6M0E4 (TYPH_METMP) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Putative thymidine phosphorylase
EC=2.4.2.4

Alternative name(s):
TdRPase

Gene names

Ordered Locus Names:

MMP0327

Organism

Methanococcus maripaludis (strain S2 / LL) [Complete proteome] [HAMAP]

Taxonomic identifier

267377 [NCBI]

Taxonomic lineage

cellular organisms › Archaea › Euryarchaeota › Methanococci › Methanococcales › Methanococcaceae › Methanococcus › Methanococcus maripaludis

Protein attributes

Sequence length	505 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Thymidine + phosphate = thymine + 2-deoxy-alpha-D-ribose 1-phosphate. HAMAP-Rule MF_00703
Sequence similarities	Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family. Type 2 subfamily.

Ontologies

Keywords
Molecular function	Glycosyltransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	pyrimidine deoxyribonucleoside metabolic process Inferred from electronic annotation. Source: InterPro pyrimidine nucleobase metabolic process Inferred from electronic annotation. Source: InterPro
Molecular_function	phosphorylase activity Inferred from electronic annotation. Source: InterPro thymidine phosphorylase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 505	505	Putative thymidine phosphorylase HAMAP-Rule MF_00703		PRO_0000314722

Sequences

	Sequence		Length	Mass (Da)
	Q6M0E4 [UniParc]. Last modified July 5, 2004. Version 1. Checksum: 466AEE8D187F9B8C	FASTA	505	54,597
	10 20 30 40 50 60 MLFLNAKFID LDLGENAVIV NEDDLKGTSY YPQDRVLIES HAGSVIGNIY STKTMVQKGE 70 80 90 100 110 120 VGMLVSELAE ISISEGEEVK LRHAEKPESI PFIKKKMDGQ VLNPHEIRTI IDEIVSKKLS 130 140 150 160 170 180 NIELSAFVSS TYINGMNMDE IGEMTKRIAE TGDMISWEKN LVVDIHSIGG VPGNKYALLS 190 200 210 220 230 240 IPILAAAGIT IPKTSSRAIT SPAGTADVME VLTNVELKED EIKRIVKTTN GCLVWGGGVN 250 260 270 280 290 300 LAPADDIIIN VERPVSIDPQ PQLLASVMAK KIATGIKYSV IDIPVGKGVK IKNEAEGAKL 310 320 330 340 350 360 ARKFIELGEL LNIKVECVLT YGGQPLGRAI GPALEAKEAI EALQDPKNAP KSLIEKALSL 370 380 390 400 410 420 AGILLELGGA AQIGEGQNLA WEILESGRAL EKFNQIIIEQ GGTPKKPEEI ELGDYIEEII 430 440 450 460 470 480 APIDGYVTDI NNTGITNVVK EAGAPRDKKA GLLLNSKIGN KVKKGDVLYT IYSGSEERLV 490 500 SAVNLARRVY PVKVEGMLIE RISKF

References

[1]

"Complete genome sequence of the genetically tractable hydrogenotrophic methanogen Methanococcus maripaludis." Hendrickson E.L., Kaul R., Zhou Y., Bovee D., Chapman P., Chung J., Conway de Macario E., Dodsworth J.A., Gillett W., Graham D.E., Hackett M., Haydock A.K., Kang A., Land M.L., Levy R., Lie T.J., Major T.A., Moore B.C. , Porat I., Palmeiri A., Rouse G., Saenphimmachak C., Soell D., Van Dien S., Wang T., Whitman W.B., Xia Q., Zhang Y., Larimer F.W., Olson M.V., Leigh J.A. J. Bacteriol. 186:6956-6969(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: S2 / LL.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BX950229 Genomic DNA. Translation: CAF29883.1.
RefSeq	NP_987447.1. NC_005791.1.
3D structure databases
HSSP	HSSP built from PDB template 1BRW based on UniProtKB P77836.
ProteinModelPortal	Q6M0E4.
ModBase	Search...
Protein-protein interaction databases
STRING	267377.MMP0327.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	CAF29883; CAF29883; MMP0327.
GeneID	2761854.
KEGG	mmp:MMP0327.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0213.
HOGENOM	HOG000252767.
KO	K00758.
OMA	VHSIGGV.
ProtClustDB	PRK04350.
Enzyme and pathway databases
BioCyc	MMAR267377:GJ77-349-MONOMER.
Family and domain databases
Gene3D	3.40.1030.10. 1 hit. 3.90.1170.30. 1 hit.
HAMAP	MF_00703. Thymid_phosp_2.
InterPro	IPR017713. AMP_phosphorylase. IPR000312. Glycosyl_Trfase_fam3. IPR017459. Glycosyl_Trfase_fam3_N_dom. IPR013102. PYNP_C. IPR000053. Pyrmidine_PPase. IPR017872. Pyrmidine_PPase_CS. IPR013466. Thymidine_Pase_type2. [Graphical view]
PANTHER	PTHR10515. PTHR10515. 1 hit.
Pfam	PF02885. Glycos_trans_3N. 1 hit. PF00591. Glycos_transf_3. 1 hit. PF07831. PYNP_C. 1 hit. [Graphical view]
PIRSF	PIRSF000478. TP_PyNP. 1 hit.
SMART	SM00941. PYNP_C. 1 hit. [Graphical view]
SUPFAM	SSF47648. Glyco_trans_3. 1 hit. SSF52418. Glyco_trans_3. 1 hit. SSF54680. PYNP_C. 1 hit.
TIGRFAMs	TIGR03327. AMP_phos. 1 hit. TIGR02645. ARCH_P_rylase. 1 hit.
PROSITE	PS00647. THYMID_PHOSPHORYLASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

TYPH_METMP

Accession

Primary (citable) accession number: Q6M0E4

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	July 5, 2004
Last modified:	May 1, 2013
This is version 64 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program