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Q6M0E4

- AMPPA_METMP

UniProt

Q6M0E4 - AMPPA_METMP

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Protein
AMP phosphorylase
Gene
MMP0327
Organism
Methanococcus maripaludis (strain S2 / LL)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the conversion of AMP and phosphate to adenine and ribose 1,5-bisphosphate (R15P). Exhibits phosphorylase activity toward CMP and UMP in addition to AMP. Functions in an archaeal AMP degradation pathway, together with R15P isomerase and RubisCO By similarity.UniRule annotation

Catalytic activityi

AMP + phosphate = adenine + alpha-D-ribose 1,5-bisphosphate.UniRule annotation
CMP + phosphate = cytosine + alpha-D-ribose 1,5-bisphosphate.UniRule annotation
UMP + phosphate = uracil + alpha-D-ribose 1,5-bisphosphate.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei170 – 1701AMP; via amide nitrogen By similarity
Binding sitei205 – 2051AMP; via amide nitrogen By similarity
Active sitei258 – 2581Proton donor By similarity
Binding sitei266 – 2661AMP By similarity
Binding sitei290 – 2901AMP By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi196 – 2016AMP By similarity

GO - Molecular functioni

  1. AMP binding Source: UniProtKB-HAMAP
  2. phosphorylase activity Source: InterPro
  3. thymidine phosphorylase activity Source: InterPro

GO - Biological processi

  1. AMP catabolic process Source: UniProtKB-HAMAP
  2. pyrimidine deoxyribonucleoside metabolic process Source: InterPro
  3. pyrimidine nucleobase metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Enzyme and pathway databases

BioCyciMMAR267377:GJ77-349-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
AMP phosphorylase (EC:2.4.2.57)
Short name:
AMPpase
Alternative name(s):
Nucleoside monophosphate phosphorylase
Short name:
NMP phosphorylase
Gene namesi
Ordered Locus Names:MMP0327
OrganismiMethanococcus maripaludis (strain S2 / LL)
Taxonomic identifieri267377 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanococciMethanococcalesMethanococcaceaeMethanococcus
ProteomesiUP000000590: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 505505AMP phosphorylaseUniRule annotation
PRO_0000314722Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi267377.MMP0327.

Structurei

3D structure databases

ProteinModelPortaliQ6M0E4.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0213.
HOGENOMiHOG000252767.
KOiK00758.
OMAiFINGVRD.

Family and domain databases

Gene3Di3.40.1030.10. 1 hit.
3.90.1170.30. 1 hit.
HAMAPiMF_02132. AMP_phosphorylase.
InterProiIPR017713. AMP_phosphorylase.
IPR000312. Glycosyl_Trfase_fam3.
IPR017459. Glycosyl_Trfase_fam3_N_dom.
IPR013102. PYNP_C.
IPR000053. Pyrmidine_PPase.
IPR017872. Pyrmidine_PPase_CS.
IPR013466. Thymidine/AMP_Pase.
[Graphical view]
PANTHERiPTHR10515. PTHR10515. 1 hit.
PfamiPF02885. Glycos_trans_3N. 1 hit.
PF00591. Glycos_transf_3. 1 hit.
PF07831. PYNP_C. 1 hit.
[Graphical view]
PIRSFiPIRSF000478. TP_PyNP. 1 hit.
SMARTiSM00941. PYNP_C. 1 hit.
[Graphical view]
SUPFAMiSSF47648. SSF47648. 1 hit.
SSF52418. SSF52418. 1 hit.
SSF54680. SSF54680. 1 hit.
TIGRFAMsiTIGR03327. AMP_phos. 1 hit.
TIGR02645. ARCH_P_rylase. 1 hit.
PROSITEiPS00647. THYMID_PHOSPHORYLASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6M0E4-1 [UniParc]FASTAAdd to Basket

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MLFLNAKFID LDLGENAVIV NEDDLKGTSY YPQDRVLIES HAGSVIGNIY    50
STKTMVQKGE VGMLVSELAE ISISEGEEVK LRHAEKPESI PFIKKKMDGQ 100
VLNPHEIRTI IDEIVSKKLS NIELSAFVSS TYINGMNMDE IGEMTKRIAE 150
TGDMISWEKN LVVDIHSIGG VPGNKYALLS IPILAAAGIT IPKTSSRAIT 200
SPAGTADVME VLTNVELKED EIKRIVKTTN GCLVWGGGVN LAPADDIIIN 250
VERPVSIDPQ PQLLASVMAK KIATGIKYSV IDIPVGKGVK IKNEAEGAKL 300
ARKFIELGEL LNIKVECVLT YGGQPLGRAI GPALEAKEAI EALQDPKNAP 350
KSLIEKALSL AGILLELGGA AQIGEGQNLA WEILESGRAL EKFNQIIIEQ 400
GGTPKKPEEI ELGDYIEEII APIDGYVTDI NNTGITNVVK EAGAPRDKKA 450
GLLLNSKIGN KVKKGDVLYT IYSGSEERLV SAVNLARRVY PVKVEGMLIE 500
RISKF 505
Length:505
Mass (Da):54,597
Last modified:July 5, 2004 - v1
Checksum:i466AEE8D187F9B8C
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BX950229 Genomic DNA. Translation: CAF29883.1.
RefSeqiNP_987447.1. NC_005791.1.
WP_011170271.1. NC_005791.1.

Genome annotation databases

EnsemblBacteriaiCAF29883; CAF29883; MMP0327.
GeneIDi2761854.
KEGGimmp:MMP0327.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BX950229 Genomic DNA. Translation: CAF29883.1 .
RefSeqi NP_987447.1. NC_005791.1.
WP_011170271.1. NC_005791.1.

3D structure databases

ProteinModelPortali Q6M0E4.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 267377.MMP0327.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAF29883 ; CAF29883 ; MMP0327 .
GeneIDi 2761854.
KEGGi mmp:MMP0327.

Phylogenomic databases

eggNOGi COG0213.
HOGENOMi HOG000252767.
KOi K00758.
OMAi FINGVRD.

Enzyme and pathway databases

BioCyci MMAR267377:GJ77-349-MONOMER.

Family and domain databases

Gene3Di 3.40.1030.10. 1 hit.
3.90.1170.30. 1 hit.
HAMAPi MF_02132. AMP_phosphorylase.
InterProi IPR017713. AMP_phosphorylase.
IPR000312. Glycosyl_Trfase_fam3.
IPR017459. Glycosyl_Trfase_fam3_N_dom.
IPR013102. PYNP_C.
IPR000053. Pyrmidine_PPase.
IPR017872. Pyrmidine_PPase_CS.
IPR013466. Thymidine/AMP_Pase.
[Graphical view ]
PANTHERi PTHR10515. PTHR10515. 1 hit.
Pfami PF02885. Glycos_trans_3N. 1 hit.
PF00591. Glycos_transf_3. 1 hit.
PF07831. PYNP_C. 1 hit.
[Graphical view ]
PIRSFi PIRSF000478. TP_PyNP. 1 hit.
SMARTi SM00941. PYNP_C. 1 hit.
[Graphical view ]
SUPFAMi SSF47648. SSF47648. 1 hit.
SSF52418. SSF52418. 1 hit.
SSF54680. SSF54680. 1 hit.
TIGRFAMsi TIGR03327. AMP_phos. 1 hit.
TIGR02645. ARCH_P_rylase. 1 hit.
PROSITEi PS00647. THYMID_PHOSPHORYLASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: S2 / LL.

Entry informationi

Entry nameiAMPPA_METMP
AccessioniPrimary (citable) accession number: Q6M0E4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: July 5, 2004
Last modified: September 3, 2014
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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