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Q6LZP8 (DAPA_METMP) Reviewed, UniProtKB/Swiss-Prot

Last modified November 16, 2011. Version 51. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Dihydrodipicolinate synthase
Short name=DHDPS
EC=4.2.1.52
Gene names
Name:dapA
Ordered Locus Names:MMP0576
OrganismMethanococcus maripaludis (strain S2 / LL) [Complete proteome] [HAMAP]
Taxonomic identifier267377 [NCBI]
Taxonomic lineageArchaea › Euryarchaeota › Methanococci › Methanococcales › Methanococcaceae › Methanococcus

Protein attributes

Sequence length289 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

L-aspartate 4-semialdehyde + pyruvate = dihydrodipicolinate + 2 H2O. HAMAP MF_00418

Pathway

Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; (S)-tetrahydrodipicolinate from L-aspartate: step 3/4. HAMAP MF_00418

Subcellular location

Cytoplasm By similarity HAMAP MF_00418.

Sequence similarities

Belongs to the DHDPS family.

Ontologies

Keywords
   Biological processAmino-acid biosynthesis
Diaminopimelate biosynthesis
Lysine biosynthesis
   Cellular componentCytoplasm
   LigandSchiff base
   Molecular functionLyase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processdiaminopimelate biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functiondihydrodipicolinate synthase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 289289Dihydrodipicolinate synthase HAMAP MF_00418
PRO_0000103200

Regions

Region46 – 472Pyruvate binding By similarity

Sites

Active site1601Schiff-base intermediate with substrate By similarity
Binding site1041Pyruvate By similarity
Site1311Involved in proton transfer during cleavage By similarity

Sequences

Sequence LengthMass (Da)Tools
Q6LZP8 [UniParc].

Last modified July 5, 2004. Version 1.
Checksum: A5EAA59A4678503D

FASTA28931,584
        10         20         30         40         50         60 
MQGVYPAIIT PLKENKVDYD GLRNNIDFLI ENGVSGVIPV GTTGESPTLT PLEHEKVVEK 

        70         80         90        100        110        120 
VVEFVDGRVE VIAGTGSNST SEALEFSQYA EDVGVDGVLL ITPYYNKPTQ EGLKRHFGEI 

       130        140        150        160        170        180 
ANSINVPIVL YNVPSRTALN IEPETIKYLF NEYSNISAVK EANPNLSQVS EVLDSCDIDI 

       190        200        210        220        230        240 
LSGNDELTLP IISLGGKGVV SVIANIAPKE FVQMVDFANA GKFDKAKEIH YKLFPLMKLM 

       250        260        270        280 
FVETNPIPIK TAMNMLGMPS GELRLPLCEM AESNKLKLQN ALNNLGLLK

« Hide

References

[1]"Complete genome sequence of the genetically tractable hydrogenotrophic methanogen Methanococcus maripaludis."
Hendrickson E.L., Kaul R., Zhou Y., Bovee D., Chapman P., Chung J., Conway de Macario E., Dodsworth J.A., Gillett W., Graham D.E., Hackett M., Haydock A.K., Kang A., Land M.L., Levy R., Lie T.J., Major T.A., Moore B.C. expand/collapse author list , Porat I., Palmeiri A., Rouse G., Saenphimmachak C., Soell D., Van Dien S., Wang T., Whitman W.B., Xia Q., Zhang Y., Larimer F.W., Olson M.V., Leigh J.A.
J. Bacteriol. 186:6956-6969(2004) [PubMed: 15466049] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: S2 / LL.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		BX950229 Genomic DNA. Translation: CAF30132.1.
RefSeqNP_987696.1. NC_005791.1.

3D structure databases

ProteinModelPortalQ6LZP8.
SMRQ6LZP8. Positions 2-288.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID2761834.
GenomeReviewsGene locus MMP0576 in contig BX950229_GR.
KEGGmmp:MMP0576.
NMPDRfig|267377.1.peg.576.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG358848.
OMAFMLCGGH.
ProtClustDBPRK03170.

Enzyme and pathway databases

BioCycMMAR267377:MMP0576-MONOMER.

Family and domain databases

HAMAPMF_00418. DapA.
[Tree]
InterProIPR013785. Aldolase_TIM.
IPR002220. Dihydrodipicolinate_synth-like.
IPR020625. Dihydrodipicolinate_synth_AS.
IPR020624. Dihydrodipicolinate_synth_CS.
IPR005263. Dihydrodipicolinate_synth_DapA.
[Graphical view]
Gene3DG3DSA:3.20.20.70. Aldolase_TIM. 1 hit.
KOK01714.
PANTHERPTHR12128. DHDPS. 1 hit.
PfamPF00701. DHDPS. 1 hit.
[Graphical view]
PIRSFPIRSF001365. DHDPS. 1 hit.
PRINTSPR00146. DHPICSNTHASE.
TIGRFAMsTIGR00674. DapA. 1 hit.
PROSITEPS00665. DHDPS_1. 1 hit.
PS00666. DHDPS_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameDAPA_METMP
AccessionPrimary (citable) accession number: Q6LZP8
Entry history
Integrated into UniProtKB/Swiss-Prot: August 30, 2005
Last sequence update: July 5, 2004
Last modified: November 16, 2011
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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