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Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Methanococcus maripaludis (strain S2 / LL)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei650ATPUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciMMAR267377:G1G3S-731-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
Ordered Locus Names:MMP0697
OrganismiMethanococcus maripaludis (strain S2 / LL)
Taxonomic identifieri267377 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanococciMethanococcalesMethanococcaceaeMethanococcus
Proteomesi
  • UP000000590 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001521341 – 955Leucine--tRNA ligaseAdd BLAST955

Interactioni

Protein-protein interaction databases

STRINGi267377.MMP0697

Structurei

3D structure databases

ProteinModelPortaliQ6LZD2
SMRiQ6LZD2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi51 – 61"HIGH" regionAdd BLAST11
Motifi647 – 651"KMSKS" region5

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG00809 Archaea
COG0495 LUCA
HOGENOMiHOG000216620
KOiK01869
OMAiHVTGTPI
OrthoDBiPOG093Z006D

Family and domain databases

Gene3Di3.40.50.620, 2 hits
3.90.740.10, 1 hit
HAMAPiMF_00049_A Leu_tRNA_synth_A, 1 hit
InterProiView protein in InterPro
IPR001412 aa-tRNA-synth_I_CS
IPR002300 aa-tRNA-synth_Ia
IPR020791 Leu-tRNA-lgase_arc
IPR004493 Leu-tRNA-synth_Ia_arc/euk
IPR013155 M/V/L/I-tRNA-synth_anticd-bd
IPR015413 Methionyl/Leucyl_tRNA_Synth
IPR014729 Rossmann-like_a/b/a_fold
IPR009080 tRNAsynth_Ia_anticodon-bd
IPR009008 Val/Leu/Ile-tRNA-synth_edit
PANTHERiPTHR11946:SF51 PTHR11946:SF51, 1 hit
PfamiView protein in Pfam
PF08264 Anticodon_1, 1 hit
PF00133 tRNA-synt_1, 1 hit
PF09334 tRNA-synt_1g, 1 hit
SUPFAMiSSF47323 SSF47323, 1 hit
SSF50677 SSF50677, 2 hits
TIGRFAMsiTIGR00395 leuS_arch, 1 hit
PROSITEiView protein in PROSITE
PS00178 AA_TRNA_LIGASE_I, 1 hit

Sequencei

Sequence statusi: Complete.

Q6LZD2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDQKEVIGET GHKSVDLIKI MDKWQKKWTE AKIFEAEHDS RDKFFITAAF
60 70 80 90 100
PYLNGVLHAG HLRTFTIPET IARYQRMKNK NVLWTFGFHV TGTPILGLAN
110 120 130 140 150
QIKERKEDII WAYNNLHNIP MDELLKLNTP EAIVECFSKK ATEAFKRMGF
160 170 180 190 200
SLDWRRNFKT DDKVFSKFIE WQFYKLKEMG HITKGSHPVR YCPKCENPVE
210 220 230 240 250
DHDLLHGEES TTVEYSLIKF TSKFDGKEII MPMATLRPET VFGVTNAWVN
260 270 280 290 300
PNEIYVMAEV HDEIQKLDSE DVDLKYNGIW IIGKECADKL KEQDRKIEIL
310 320 330 340 350
KEIKGSELLG LKIKNPVTKK EVPLLPADFV EMGIGTGCVM SVPAHAPYDY
360 370 380 390 400
VALRDLGKVE EVGLIPLIEI EGYDKYPAKE IVEKLGIKDQ NDEELLEQAT
410 420 430 440 450
SKIYKDEFHK GKLNENCGEY TGISVKDIKE KLTKDYINSN IAEIMYEFSE
460 470 480 490 500
QKVVCRCGEK CIIKTVKGQW FINYSDENWK KLAHECIDNM NFAPEGIRQE
510 520 530 540 550
FHNKVDWMKD KACARKRGLG TILPFDENWI IESLSDSTIY MAYYTIARFI
560 570 580 590 600
NEGLTPEQLI PELFDYVYLG NGNAEEIAKN SKIQAETIEE MRKEFLYYYP
610 620 630 640 650
LDWRCSAKDL IPNHLTFMIF NHVALFGREH WPRGIEINGY VTIEGKKLSK
660 670 680 690 700
SKGPVLPVSE VAENFGADVA RFYITTCAEL PQDADVKFKE MEKARDNLIK
710 720 730 740 750
LYDLAVSVME EESAEKELSL IDKWLLHKTY SSINSAETAY EEFQLRKIGL
760 770 780 790 800
MFYELINDLR WYKRRGGENN SVLKEVVEIW TKLLSPVTPH LCEEIWEKLG
810 820 830 840 850
YAGFISQEMY PVSKPELINE DLELGEEFIK SAMEDIRNIK GVAKINPEKM
860 870 880 890 900
YLYTADDWKY DLLEFMNENA EKNVKALIPM VMKEDKFKRH GKEVMKLINE
910 920 930 940 950
IMKIGVKKAI AEVEILENAK TFIESEFDCK VIVNGEDVKG KKKFAIPYKP

AIYME
Length:955
Mass (Da):110,690
Last modified:July 5, 2004 - v1
Checksum:iE0C03FBAA1C7E93F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX950229 Genomic DNA Translation: CAF30253.1
RefSeqiWP_011170641.1, NC_005791.1

Genome annotation databases

EnsemblBacteriaiCAF30253; CAF30253; MMP0697
GeneIDi2761186
KEGGimmp:MMP0697
PATRICifig|267377.15.peg.714

Similar proteinsi

Entry informationi

Entry nameiSYL_METMP
AccessioniPrimary (citable) accession number: Q6LZD2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 1, 2005
Last sequence update: July 5, 2004
Last modified: March 28, 2018
This is version 93 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

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