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Q6LZD2

- SYL_METMP

UniProt

Q6LZD2 - SYL_METMP

Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Methanococcus maripaludis (strain S2 / LL)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 70 (01 Oct 2014)
      Sequence version 1 (05 Jul 2004)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei650 – 6501ATPUniRule annotation

    GO - Molecular functioni

    1. aminoacyl-tRNA editing activity Source: InterPro
    2. ATP binding Source: UniProtKB-HAMAP
    3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciMMAR267377:GJ77-725-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
    Alternative name(s):
    Leucyl-tRNA synthetaseUniRule annotation
    Short name:
    LeuRSUniRule annotation
    Gene namesi
    Name:leuSUniRule annotation
    Ordered Locus Names:MMP0697
    OrganismiMethanococcus maripaludis (strain S2 / LL)
    Taxonomic identifieri267377 [NCBI]
    Taxonomic lineageiArchaeaEuryarchaeotaMethanococciMethanococcalesMethanococcaceaeMethanococcus
    ProteomesiUP000000590: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 955955Leucine--tRNA ligasePRO_0000152134Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi267377.MMP0697.

    Structurei

    3D structure databases

    ProteinModelPortaliQ6LZD2.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi51 – 6111"HIGH" regionAdd
    BLAST
    Motifi647 – 6515"KMSKS" region

    Sequence similaritiesi

    Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0495.
    HOGENOMiHOG000216620.
    KOiK01869.
    OMAiIDKWLLH.

    Family and domain databases

    Gene3Di1.10.730.10. 1 hit.
    3.40.50.620. 2 hits.
    3.90.740.10. 1 hit.
    HAMAPiMF_00049_A. Leu_tRNA_synth_A.
    InterProiIPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR020791. Leu-tRNA-lgase_arc.
    IPR004493. Leu-tRNA-synth_Ia_arc/euk.
    IPR015413. Methionyl/Leucyl_tRNA_Synth.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view]
    PfamiPF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 1 hit.
    PF09334. tRNA-synt_1g. 1 hit.
    [Graphical view]
    SUPFAMiSSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 2 hits.
    TIGRFAMsiTIGR00395. leuS_arch. 1 hit.
    PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q6LZD2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDQKEVIGET GHKSVDLIKI MDKWQKKWTE AKIFEAEHDS RDKFFITAAF    50
    PYLNGVLHAG HLRTFTIPET IARYQRMKNK NVLWTFGFHV TGTPILGLAN 100
    QIKERKEDII WAYNNLHNIP MDELLKLNTP EAIVECFSKK ATEAFKRMGF 150
    SLDWRRNFKT DDKVFSKFIE WQFYKLKEMG HITKGSHPVR YCPKCENPVE 200
    DHDLLHGEES TTVEYSLIKF TSKFDGKEII MPMATLRPET VFGVTNAWVN 250
    PNEIYVMAEV HDEIQKLDSE DVDLKYNGIW IIGKECADKL KEQDRKIEIL 300
    KEIKGSELLG LKIKNPVTKK EVPLLPADFV EMGIGTGCVM SVPAHAPYDY 350
    VALRDLGKVE EVGLIPLIEI EGYDKYPAKE IVEKLGIKDQ NDEELLEQAT 400
    SKIYKDEFHK GKLNENCGEY TGISVKDIKE KLTKDYINSN IAEIMYEFSE 450
    QKVVCRCGEK CIIKTVKGQW FINYSDENWK KLAHECIDNM NFAPEGIRQE 500
    FHNKVDWMKD KACARKRGLG TILPFDENWI IESLSDSTIY MAYYTIARFI 550
    NEGLTPEQLI PELFDYVYLG NGNAEEIAKN SKIQAETIEE MRKEFLYYYP 600
    LDWRCSAKDL IPNHLTFMIF NHVALFGREH WPRGIEINGY VTIEGKKLSK 650
    SKGPVLPVSE VAENFGADVA RFYITTCAEL PQDADVKFKE MEKARDNLIK 700
    LYDLAVSVME EESAEKELSL IDKWLLHKTY SSINSAETAY EEFQLRKIGL 750
    MFYELINDLR WYKRRGGENN SVLKEVVEIW TKLLSPVTPH LCEEIWEKLG 800
    YAGFISQEMY PVSKPELINE DLELGEEFIK SAMEDIRNIK GVAKINPEKM 850
    YLYTADDWKY DLLEFMNENA EKNVKALIPM VMKEDKFKRH GKEVMKLINE 900
    IMKIGVKKAI AEVEILENAK TFIESEFDCK VIVNGEDVKG KKKFAIPYKP 950
    AIYME 955
    Length:955
    Mass (Da):110,690
    Last modified:July 5, 2004 - v1
    Checksum:iE0C03FBAA1C7E93F
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BX950229 Genomic DNA. Translation: CAF30253.1.
    RefSeqiNP_987817.1. NC_005791.1.

    Genome annotation databases

    EnsemblBacteriaiCAF30253; CAF30253; MMP0697.
    GeneIDi2761186.
    KEGGimmp:MMP0697.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BX950229 Genomic DNA. Translation: CAF30253.1 .
    RefSeqi NP_987817.1. NC_005791.1.

    3D structure databases

    ProteinModelPortali Q6LZD2.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 267377.MMP0697.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAF30253 ; CAF30253 ; MMP0697 .
    GeneIDi 2761186.
    KEGGi mmp:MMP0697.

    Phylogenomic databases

    eggNOGi COG0495.
    HOGENOMi HOG000216620.
    KOi K01869.
    OMAi IDKWLLH.

    Enzyme and pathway databases

    BioCyci MMAR267377:GJ77-725-MONOMER.

    Family and domain databases

    Gene3Di 1.10.730.10. 1 hit.
    3.40.50.620. 2 hits.
    3.90.740.10. 1 hit.
    HAMAPi MF_00049_A. Leu_tRNA_synth_A.
    InterProi IPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR020791. Leu-tRNA-lgase_arc.
    IPR004493. Leu-tRNA-synth_Ia_arc/euk.
    IPR015413. Methionyl/Leucyl_tRNA_Synth.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view ]
    Pfami PF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 1 hit.
    PF09334. tRNA-synt_1g. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 2 hits.
    TIGRFAMsi TIGR00395. leuS_arch. 1 hit.
    PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: S2 / LL.

    Entry informationi

    Entry nameiSYL_METMP
    AccessioniPrimary (citable) accession number: Q6LZD2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 1, 2005
    Last sequence update: July 5, 2004
    Last modified: October 1, 2014
    This is version 70 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3