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Protein

UDP-N-acetyl-D-mannosamine dehydrogenase

Gene

wecC

Organism
Methanococcus maripaludis (strain S2 / LL)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Catalyzes the four-electron oxidation of UDP-N-acetyl-D-mannosamine (UDP-ManNAc), reducing NAD+ and releasing UDP-N-acetylmannosaminuronic acid (UDP-ManNAcA). Cannot use NADP instead of NAD.1 Publication

Catalytic activityi

UDP-N-acetyl-alpha-D-mannosamine + 2 NAD+ + H2O = UDP-N-acetyl-alpha-D-mannosaminuronate + 2 NADH.1 Publication

Kineticsi

  1. KM=0.57 mM for NAD+1 Publication

    Sites

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Active sitei261By similarity1

    Regions

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Nucleotide bindingi11 – 28NADSequence analysisAdd BLAST18

    GO - Molecular functioni

    GO - Biological processi

    Complete GO annotation...

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    NAD

    Enzyme and pathway databases

    BRENDAi1.1.1.336. 3262.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    UDP-N-acetyl-D-mannosamine dehydrogenase (EC:1.1.1.336)
    Alternative name(s):
    UDP-ManNAc 6-dehydrogenase
    Gene namesi
    Name:wecC
    Ordered Locus Names:MMP0706
    OrganismiMethanococcus maripaludis (strain S2 / LL)
    Taxonomic identifieri267377 [NCBI]
    Taxonomic lineageiArchaeaEuryarchaeotaMethanococciMethanococcalesMethanococcaceaeMethanococcus
    Proteomesi
    • UP000000590 Componenti: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    ChainiPRO_00003378361 – 427UDP-N-acetyl-D-mannosamine dehydrogenaseAdd BLAST427

    Interactioni

    Subunit structurei

    Homotetramer.1 Publication

    Protein-protein interaction databases

    STRINGi267377.MMP0706.

    Structurei

    3D structure databases

    ProteinModelPortaliQ6LZC3.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiarCOG00252. Archaea.
    COG0677. LUCA.
    HOGENOMiHOG000153774.
    KOiK02472.
    OMAiREMMATE.

    Family and domain databases

    Gene3Di3.40.50.720. 2 hits.
    InterProiIPR008927. 6-PGluconate_DH_C-like.
    IPR016040. NAD(P)-bd_dom.
    IPR017476. UDP-Glc/GDP-Man.
    IPR014027. UDP-Glc/GDP-Man_DH_C.
    IPR014026. UDP-Glc/GDP-Man_DH_dimer.
    IPR001732. UDP-Glc/GDP-Man_DH_N.
    IPR028359. UDP_ManNAc/GlcNAc_DH.
    [Graphical view]
    PANTHERiPTHR11374. PTHR11374. 1 hit.
    PfamiPF00984. UDPG_MGDP_dh. 1 hit.
    PF03720. UDPG_MGDP_dh_C. 1 hit.
    PF03721. UDPG_MGDP_dh_N. 1 hit.
    [Graphical view]
    PIRSFiPIRSF500136. UDP_ManNAc_DH. 1 hit.
    PIRSF000124. UDPglc_GDPman_dh. 1 hit.
    SMARTiSM00984. UDPG_MGDP_dh_C. 1 hit.
    [Graphical view]
    SUPFAMiSSF48179. SSF48179. 1 hit.
    SSF51735. SSF51735. 1 hit.
    SSF52413. SSF52413. 1 hit.
    TIGRFAMsiTIGR03026. NDP-sugDHase. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q6LZC3-1 [UniParc]FASTAAdd to basket

    « Hide

            10         20         30         40         50
    MEKHGDYDIK KICVIGLGYI GLPTASMLAN HGYDVVGVDV NEKRVNQIKN
    60 70 80 90 100
    GELKIEEPGL LTLVKGAINS KNLNVRTSAT EADAFIICVP TPALAKEDGS
    110 120 130 140 150
    KKCDLSYVMS AVEAILPFVK DGNLIVIEST IPPETTKKIY ETLNKKIYVA
    160 170 180 190 200
    HCPERVLPGK ILKELVENDR IIGGINKKSA EMAKEIYKSF VEGQIYTTDS
    210 220 230 240 250
    NTAEMVKLME NTYRDINIAL ANEFAKICDE IGVNVWDAIK IANKHPRVNI
    260 270 280 290 300
    LNPGPGVGGH CISIDPWFIV EKTNNAKFIR AARELNDNMP AYVCNSVLSE
    310 320 330 340 350
    LKKLGIEKPK ISIFGATYKG NVEDTRESPS KNVIKMLLEN GATVSTYDPH
    360 370 380 390 400
    ASYFEYPLST LDECISGSDC IVVLTDHDVF KTIKKDDIDE ICPKLKNKIV
    410 420
    FDTKNILEHS LWKKAGFTVK LLGNGAW
    Length:427
    Mass (Da):47,252
    Last modified:July 5, 2004 - v1
    Checksum:i1B5780FBFDAF6634
    GO

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    BX950229 Genomic DNA. Translation: CAF30262.1.
    RefSeqiWP_011170650.1. NC_005791.1.

    Genome annotation databases

    EnsemblBacteriaiCAF30262; CAF30262; MMP0706.
    GeneIDi2761881.
    KEGGimmp:MMP0706.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    BX950229 Genomic DNA. Translation: CAF30262.1.
    RefSeqiWP_011170650.1. NC_005791.1.

    3D structure databases

    ProteinModelPortaliQ6LZC3.
    ModBaseiSearch...
    MobiDBiSearch...

    Protein-protein interaction databases

    STRINGi267377.MMP0706.

    Protocols and materials databases

    Structural Biology KnowledgebaseSearch...

    Genome annotation databases

    EnsemblBacteriaiCAF30262; CAF30262; MMP0706.
    GeneIDi2761881.
    KEGGimmp:MMP0706.

    Phylogenomic databases

    eggNOGiarCOG00252. Archaea.
    COG0677. LUCA.
    HOGENOMiHOG000153774.
    KOiK02472.
    OMAiREMMATE.

    Enzyme and pathway databases

    BRENDAi1.1.1.336. 3262.

    Family and domain databases

    Gene3Di3.40.50.720. 2 hits.
    InterProiIPR008927. 6-PGluconate_DH_C-like.
    IPR016040. NAD(P)-bd_dom.
    IPR017476. UDP-Glc/GDP-Man.
    IPR014027. UDP-Glc/GDP-Man_DH_C.
    IPR014026. UDP-Glc/GDP-Man_DH_dimer.
    IPR001732. UDP-Glc/GDP-Man_DH_N.
    IPR028359. UDP_ManNAc/GlcNAc_DH.
    [Graphical view]
    PANTHERiPTHR11374. PTHR11374. 1 hit.
    PfamiPF00984. UDPG_MGDP_dh. 1 hit.
    PF03720. UDPG_MGDP_dh_C. 1 hit.
    PF03721. UDPG_MGDP_dh_N. 1 hit.
    [Graphical view]
    PIRSFiPIRSF500136. UDP_ManNAc_DH. 1 hit.
    PIRSF000124. UDPglc_GDPman_dh. 1 hit.
    SMARTiSM00984. UDPG_MGDP_dh_C. 1 hit.
    [Graphical view]
    SUPFAMiSSF48179. SSF48179. 1 hit.
    SSF51735. SSF51735. 1 hit.
    SSF52413. SSF52413. 1 hit.
    TIGRFAMsiTIGR03026. NDP-sugDHase. 1 hit.
    ProtoNetiSearch...

    Entry informationi

    Entry nameiWECC_METMP
    AccessioniPrimary (citable) accession number: Q6LZC3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 10, 2008
    Last sequence update: July 5, 2004
    Last modified: November 2, 2016
    This is version 93 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    Similar proteinsi

    Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
    100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
    90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
    50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.